{ "uniprot_canonical_ac": "O14917-1", "uniprot_ac": "O14917", "uniprot_id": "PCD17_HUMAN", "mass": { "chemical_mass": 126229.0, "monoisotopic_mass": 126229.0 }, "refseq": { "ac": "NP_001035519", "name": "protocadherin-17 precursor", "summary": "This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" }, "gene_names": [ { "name": "PCDH17", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14917", "id": "O14917" }, { "name": "PCDH17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519", "id": "NP_001035519" }, { "name": "PCDH68; PCH68", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519", "id": "NP_001035519" }, { "name": "PCDH68", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14917", "id": "O14917" }, { "name": "PCH68", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14917", "id": "O14917" } ], "protein_names": [ { "name": "Protocadherin-17", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14917" }, { "name": "Protocadherin-68", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14917" }, { "name": "protocadherin 68", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519", "id": "NP_001035519" }, { "name": "protocadherin-17 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519", "id": "NP_001035519" } ], "function": [ { "annotation": "MiR-23a-3p promoted G1/S cell cycle transition by targeting protocadherin17 in hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" }, { "database": "PubMed", "id": "31994011", "url": "https://glygen.org/publication/PubMed/31994011" } ] }, { "annotation": "PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" }, { "database": "PubMed", "id": "36698136", "url": "https://glygen.org/publication/PubMed/36698136" } ] }, { "annotation": "PCDH17 gene was silenced by DNA methylation in acute myeloid leukemia (AML). Low PCDH17 expression is associated with distinct clinical and biological features and improves risk stratification in patients with AML. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" }, { "database": "PubMed", "id": "30922328", "url": "https://glygen.org/publication/PubMed/30922328" } ] }, { "annotation": "Potential calcium-dependent cell-adhesion protein.", "evidence": [ { "database": "UniProtKB", "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917#function" } ] }, { "annotation": "Repression of protocadherin 17 is correlated with elevated angiogenesis and hypoxia markers in female patients with breast cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" }, { "database": "PubMed", "id": "33896826", "url": "https://glygen.org/publication/PubMed/33896826" } ] }, { "annotation": "This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O14917", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14917" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1051, "end_pos": 1051, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KGS->NGS).", "chr_id": "13", "chr_pos": "57724967", "ref_nt": "A", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "K1051", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O14917", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14917" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14917" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O14917", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14917" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "O14917", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14917" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917" } ], "common_name": "Human" } ], "gene": [ { "name": "PCDH17", "url": "https://www.uniprot.org/uniprot/O14917", "locus": { "chromosome": "13", "start_pos": 57729311, "end_pos": 57631744, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000118946", "url": "https://www.ensembl.org/id/ENSG00000118946" } ] } } ], "crossref": [ { "id": "ENSG00000118946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000118946", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O14917", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14917", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "PCDH17", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PCDH17", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "27253", "url": "https://www.ncbi.nlm.nih.gov/gene/27253", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "14267", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=14267", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O14917", "url": "https://www.ebi.ac.uk/intact/interactors/id:O14917*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:27253", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:27253", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "611760", "url": "http://www.omim.org/entry/611760", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O14917", "url": "https://www.nextprot.org/entry/NX_O14917", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "CYVPDRI", "url": "https://omabrowser.org/oma/group/CYVPDRI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4259465at2759", "url": "http://www.orthodb.org/?query=4259465at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6VFT", "url": "https://www.rcsb.org/structure/6VFT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00028", "url": "http://pfam.xfam.org/family/PF00028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08266", "url": "http://pfam.xfam.org/family/PF08266", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O14917", "url": "https://pharos.nih.gov/targets/O14917", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O14917", "url": "http://purl.obolibrary.org/obo/PR_O14917", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A087WXV2", "url": "https://www.uniprot.org/uniprot/A0A087WXV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WXV2-1", "url": "https://www.uniprot.org/uniprot/A0A087WXV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087X099", "url": "https://www.uniprot.org/uniprot/A0A087X099", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087X099-1", "url": "https://www.uniprot.org/uniprot/A0A087X099-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14917-1", "url": "https://www.uniprot.org/uniprot/O14917-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14917-2", "url": "https://www.uniprot.org/uniprot/O14917-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK", "length": 1159, "header": "sp|O14917-1|PCD17_HUMAN Isoform 1 of Protocadherin-17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=1 SV=2 CANONICAL=O14917-1" }, "isoforms": [ { "isoform_ac": "A0A087WXV2-1", "url": "", "sequence": { "sequence": "LDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK", "length": 546, "header": "tr|A0A087WXV2-1|A0A087WXV2_HUMAN Computationally mapped isoform of Protocadherin 17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=1 SV=1 CANONICAL=O14917-1" }, "locus": { "chromosome": "13", "start_pos": 57725291, "end_pos": 57634383, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000612954.4", "url": "https://www.ensembl.org/id/ENST00000612954.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000481329.1", "url": "https://www.ensembl.org/id/ENSP00000481329.1" } ] } }, { "isoform_ac": "A0A087X099-1", "url": "", "sequence": { "sequence": "LTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQAFPTLLSFAILTLHTITSRLQSVDLLPPEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTV", "length": 184, "header": "tr|A0A087X099-1|PCD17_HUMAN Computationally mapped isoform of Protocadherin-17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=1 SV=1 CANONICAL=O14917-1" }, "locus": { "chromosome": "13", "start_pos": 57724748, "end_pos": 57635013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000615375.1", "url": "https://www.ensembl.org/id/ENST00000615375.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000483215.1", "url": "https://www.ensembl.org/id/ENSP00000483215.1" } ] } }, { "isoform_ac": "O14917-1", "url": "", "sequence": { "sequence": "MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK", "length": 1159, "header": "sp|O14917-1|PCD17_HUMAN Isoform 1 of Protocadherin-17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=1 SV=2 CANONICAL=O14917-1" }, "locus": { "chromosome": "13", "start_pos": 57725291, "end_pos": 57632547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000377918.8", "url": "https://www.ensembl.org/id/ENST00000377918.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000367151.3", "url": "https://www.ensembl.org/id/ENSP00000367151.3" } ] } }, { "isoform_ac": "O14917-2", "url": "", "sequence": { "sequence": "MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSISVAPRLRTQKEPA", "length": 889, "header": "sp|O14917-2|PCD17_HUMAN Isoform 2 of Protocadherin-17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=1 SV=2 CANONICAL=O14917-1" }, "locus": { "chromosome": "13", "start_pos": 57666695, "end_pos": 57632547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000484979.5", "url": "https://www.ensembl.org/id/ENST00000484979.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000432899.1", "url": "https://www.ensembl.org/id/ENSP00000432899.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 22, "start_aa": "Asn", "end_pos": 22, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn22", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 266, "start_aa": "Asn", "end_pos": 266, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn266", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 439, "start_aa": "Asn", "end_pos": 439, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn439", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 453, "start_aa": "Asn", "end_pos": 453, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn453", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 504, "start_aa": "Asn", "end_pos": 504, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn504", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 566, "start_aa": "Asn", "end_pos": 566, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn566", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 590, "start_aa": "Asn", "end_pos": 590, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn590", "evidence": [ { "id": "O14917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14917#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Genome-wide analyses of human perisylvian cerebral cortical patterning.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Abrahams B S, Tentler D, Perederiy J V, Oldham M C, Coppola G, Geschwind D H", "evidence": [ { "database": "UniProtKB", "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917" } ], "reference": [ { "type": "PubMed", "id": "17978184", "url": "https://glygen.org/publication/PubMed/17978184" } ] }, { "title": "Integrated genomic analyses of ovarian carcinoma.", "journal": "Nature", "date": "2011", "authors": "Bell D, Berchuck A, Birrer M, Chien J, Cramer D, Dao F, Dhir R, DiSaia P, Gabra H, Glenn P, Godwin A, Gross J, Hartmann L, Huang M, Huntsman D, Iacocca M, Imielinski M, Kalloger S, Karlan B, Levine D, Mills G, Morrison C, Mutch D, Olvera N, Orsulic S, Park K, Petrelli N, Rabeno B, Rader J, Sikic B, Smith-McCune K, Sood A, Bowtell D, Penny R, Testa J, Chang K, Dinh H, Drummond J, Fowler G, Gunaratne P, Hawes A, Kovar C, Lewis L, Morgan M, Newsham I, Santibanez J, Reid J, Trevino L, Wu Y-, Wang M, Muzny D, Wheeler D, Gibbs R, Getz G, Lawrence M, Cibulskis K, Sivachenko A, Sougnez C, Voet D, Wilkinson J, Bloom T, Ardlie K, Fennell T, Baldwin J, Gabriel S, Lander E, Ding LL, Fulton R, Koboldt D, McLellan M, Wylie T, Walker J, O'Laughlin M, Dooling D, Fulton L, Abbott R, Dees N, Zhang Q, Kandoth C, Wendl M, Schierding W, Shen D, Harris C, Schmidt H, Kalicki J, Delehaunty K, Fronick C, Demeter R, Cook L, Wallis J, Lin L, Magrini V, Hodges J, Eldred J, Smith S, Pohl C, Vandin F, Raphael B, Weinstock G, Mardis E, Wilson R, Meyerson M, Winckler W, Getz G, Verhaak R, Carter S, Mermel C, Saksena G, Nguyen H, Onofrio R, Lawrence M, Hubbard D, Gupta S, Crenshaw A, Ramos A, Ardlie K, Chin L, Protopopov A, Zhang J, Kim T, Perna I, Xiao Y, Zhang H, Ren G, Sathiamoorthy N, Park R, Lee E, Park P, Kucherlapati R, Absher M, Waite L, Sherlock G, Brooks J, Li J, Xu J, Myers R, Laird PW, Cope L, Herman J, Shen H, Weisenberger D, Noushmehr H, Pan F, Triche T Jr, Berman B, Van Den Berg D, Buckley J, Baylin S, Spellman P, Purdom E, Neuvial P, Bengtsson H, Jakkula L, Durinck S, Han J, Dorton S, Marr H, Choi Y, Wang V, Wang N, Ngai J, Conboy J, Parvin B, Feiler H, Speed T, Gray J, Levine A, Socci N, Liang Y, Taylor B, Schultz N, Borsu L, Lash A, Brennan C, Viale A, Sander C, Ladanyi M, Hoadley K, Meng S, Du Y, Shi Y, Li L, Turman Y, Zang D, Helms E, Balu S, Zhou X, Wu J, Topal M, Hayes D, Perou C, Getz G, Voet D, Saksena G, Zhang J, Zhang H, Wu C, Shukla S, Cibulskis K, Lawrence M, Sivachenko A, Jing R, Park R, Liu Y, Park P, Noble M, Chin L, Carter H, Kim D, Karchin R, Spellman P, Purdom E, Neuvial P, Bengtsson H, Durinck S, Han J, Korkola J, Heiser L, Cho R, Hu Z, Parvin B, Speed T, Gray J, Schultz N, Cerami E, Taylor B, Olshen A, Reva B, Antipin Y, Shen R, Mankoo P, Sheridan R, Ciriello G, Chang W, Bernanke J, Borsu L, Levine D, Ladanyi M, Sander C, Haussler D, Benz C, Stuart J, Benz S, Sanborn J, Vaske C, Zhu J, Szeto C, Scott G, Yau C, Hoadley K, Du Y, Balu S, Hayes D, Perou C, Wilkerson M, Zhang N, Akbani R, Baggerly K, Yung W, Mills G, Weinstein J, Penny R, Shelton T, Grimm D, Hatfield M, Morris S, Yena P, Rhodes P, Sherman M, Paulauskis J, Millis S, Kahn A, Greene J, Sfeir R, Jensen M, Chen J, Whitmore J, Alonso S, Jordan J, Chu A, Zhang J, Barker A, Compton C, Eley G, Ferguson M, Fielding P, Gerhard D, Myles R, Schaefer C, Mills Shaw K, Vaught J, Vockley J, Good P, Guyer M, Ozenberger B, Peterson J, Thomson E", "evidence": [ { "database": "dbSNP", "id": "rs1466552019", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1466552019" } ], "reference": [ { "type": "PubMed", "id": "21720365", "url": "https://glygen.org/publication/PubMed/21720365" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia.", "journal": "Journal of translational medicine", "date": "2019", "authors": "Xu ZJ, Ma JC, Zhou JD, Wen XM, Yao DM, Zhang W, Ji RB, Wu DH, Tang LJ, Deng ZQ, Qian J, Lin J", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" } ], "reference": [ { "type": "PubMed", "id": "30922328", "url": "https://glygen.org/publication/PubMed/30922328" } ] }, { "title": "MiR-23a-3p promoted G1/S cell cycle transition by targeting protocadherin17 in hepatocellular carcinoma.", "journal": "Journal of physiology and biochemistry", "date": "2020", "authors": "Xiang Y, Yang Y, Lin C, Wu J, Zhang X", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" } ], "reference": [ { "type": "PubMed", "id": "31994011", "url": "https://glygen.org/publication/PubMed/31994011" } ] }, { "title": "Repression of protocadherin 17 is correlated with elevated angiogenesis and hypoxia markers in female patients with breast cancer.", "journal": "Cancer biomarkers : section A of Disease markers", "date": "2021", "authors": "El-Benhawy SA, Ebeid SA, Abd El Moneim NA, Arab ARR, Ramadan R", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" } ], "reference": [ { "type": "PubMed", "id": "33896826", "url": "https://glygen.org/publication/PubMed/33896826" } ] }, { "title": "PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer.", "journal": "BMC cancer", "date": "2023-01-25", "authors": "Elsharkawi Sherif Mohamed, Elkaffash Dalal, Moez Pacint, El-Etreby Nour, Sheta Eman, Taleb Raghda Saad Zaghloul", "evidence": [ { "database": "RefSeq", "id": "NP_001035519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519" } ], "reference": [ { "type": "PubMed", "id": "36698136", "url": "https://glygen.org/publication/PubMed/36698136" } ] } ], "pathway": [ { "id": "hsa:27253", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:27253", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZPN0-1", "protein_name": "Protocadherin 17", "gene_name": "Pcdh17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGKDARLQPGLPPAERGSGSGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFPSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFALDVKSRGDGTKFPELVIQKALDRELQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNYEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHSSFTGQGTNSSETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECINCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCASTKGSLDGCEAKAGALAEASSSYLPTDSQYPSPSKQPRDPSFMASEQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRKNNNGFDQTYIRTELMKLKEKGEKKEREREREEIGEKKKEDETSYLLTIC", "length": 1208 }, "evidence": [ { "id": "45922494", "url": "http://www.informatics.jax.org/homology/45922494", "database": "MGI" }, { "id": "O14917", "url": "https://omabrowser.org/oma/group/O14917/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "E9PXF0-1", "protein_name": "Protocadherin 17", "gene_name": "Pcdh17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGKDARLQPGLPPAERGSGSGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFPSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFALDVKSRGDGTKFPELVIQKALDRELQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGLGGPGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNYEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNSSETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECINCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCASTKGSLDGCEAKPGPLAEASSSYLPTDSQYPSPSKQPRDPSFMASDQMARVFADVHSRARRASSEMGAVLEQLEQPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK", 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"https://www.uniprot.org/uniprot/O14917" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O14917", "url": "https://www.uniprot.org/uniprot/O14917" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": 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