{ "uniprot_canonical_ac": "O14880-1", "uniprot_ac": "O14880", "uniprot_id": "MGST3_HUMAN", "mass": { "chemical_mass": 16516.0, "monoisotopic_mass": 16516.0 }, "refseq": { "ac": "NP_004519", "name": "glutathione S-transferase 3, mitochondrial", "summary": "This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519" }, "gene_names": [ { "name": "MGST3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14880", "id": "O14880" }, { "name": "GST-3; GST-III", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519", "id": "NP_004519" }, { "name": "MGST3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519", "id": "NP_004519" } ], "protein_names": [ { "name": "Glutathione S-transferase 3, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14880" }, { "name": "1.11.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14880" }, { "name": "2.5.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14880" }, { "name": "4.4.1.20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14880" }, { "name": "GST-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14880" }, { "name": "Glutathione peroxidase MGST3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14880" }, { "name": "LTC4 synthase MGST3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14880" }, { "name": "glutathione S-transferase 3, mitochondrial", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519", "id": "NP_004519" }, { "name": "microsomal glutathione S-transferase III; microsomal GST-3; microsomal GST-III; LTC4 synthase MGST3; glutathione peroxidase MGST3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519", "id": "NP_004519" } ], "function": [ { "annotation": "Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:9278457, PubMed:36370807). Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response (PubMed:9278457, PubMed:36370807). Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides (PubMed:9278457).", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880#function" }, { "database": "PubMed", "id": "9278457", "url": "https://glygen.org/publication/PubMed/9278457" }, { "database": "PubMed", "id": "36370807", "url": "https://glygen.org/publication/PubMed/36370807" } ] }, { "annotation": "This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_004519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519" } ] }, { "annotation": "Variants in MGST3 are associated with differences inn hippocampus size in both human brain data sets (ENIGMA MRI) and in the BXD family of mice. MGST3 is also statistically associated to genes linked to neurodegenerative disorders, including Parkinson's, Huntington's, and Alzheimer's diseases. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004519" }, { "database": "PubMed", "id": "25280473", "url": "https://glygen.org/publication/PubMed/25280473" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 150, "end_pos": 150, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes S-acylation; when associated with S-151.", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" }, { "database": "PubMed", "id": "21044946", "url": "https://glygen.org/publication/PubMed/21044946" } ] }, { "start_pos": 151, "end_pos": 151, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes S-acylation; when associated with S-150.", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" }, { "database": "PubMed", "id": "21044946", "url": "https://glygen.org/publication/PubMed/21044946" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "97.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "97.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "98.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "96.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "98.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "99.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "99.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "98.65", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "98.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "97.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "96.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "98.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "98.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000143198", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000143198" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O14880", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14880" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, 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"DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"https://glygen.org/publication/PubMed/35083852" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.", "journal": "Journal of molecular biology", "date": "1999", "authors": "Bruns CM, Hubatsch I, Ridderstrom M, Mannervik B, Tainer JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "10329152", "url": "https://glygen.org/publication/PubMed/10329152" } ] }, { "title": "An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.", "journal": "Biochemistry", "date": "1999", "authors": "Patskovsky YV, Patskovska LN, Listowsky I", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "10587441", "url": "https://glygen.org/publication/PubMed/10587441" } ] }, { "title": "Identification, characterization, and crystal structure of the Omega class glutathione transferases.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "10783391", "url": "https://glygen.org/publication/PubMed/10783391" } ] }, { "title": "Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.", "journal": "Biochemistry", "date": "2001", "authors": "Polekhina G, Board PG, Blackburn AC, Parker MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "11327815", "url": "https://glygen.org/publication/PubMed/11327815" } ] }, { "title": "Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.", "journal": "Chemical research in toxicology", "date": "2001", "authors": "Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5423646", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646" } ], "reference": [ { "type": "PubMed", "id": "11409944", "url": "https://glygen.org/publication/PubMed/11409944" } ] }, { "title": "The 3-D structure of microsomal glutathione transferase 1 at 6 A resolution as determined by electron crystallography of p22(1)2(1) crystals.", "journal": "Biochimica et biophysica acta", "date": "2002", "authors": "Holm PJ, Morgenstern R, Hebert H", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "11904223", "url": "https://glygen.org/publication/PubMed/11904223" } ] }, { "title": "The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.", "journal": "Pharmacogenetics", "date": "2002", "authors": "Morel F, Rauch C, Coles B, Le Ferrec E, Guillouzo A", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "12042665", "url": "https://glygen.org/publication/PubMed/12042665" } ] }, { "title": "Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis.", "journal": "Journal of molecular biology", "date": "2002", "authors": "Nitanai Y, Satow Y, Adachi H, Tsujimoto M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5423646", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646" } ], "reference": [ { "type": "PubMed", "id": "12144777", "url": "https://glygen.org/publication/PubMed/12144777" } ] }, { "title": "1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site.", "journal": "Proteins", "date": "2002", "authors": "Le Trong I, Stenkamp RE, Ibarra C, Atkins WM, Adman ET", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "12211029", "url": "https://glygen.org/publication/PubMed/12211029" } ] }, { "title": "Mechanism of metal activation of human hematopoietic 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Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter.", "journal": "Carcinogenesis", "date": "2003", "authors": "Ellis EM, Slattery CM, Hayes JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5423646", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646" } ], "reference": [ { "type": "PubMed", "id": "12727802", "url": "https://glygen.org/publication/PubMed/12727802" } ] }, { "title": "Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Lindner HA, Lunin VV, Alary A, Hecker R, Cygler M, Menard R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5423646", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646" } ], "reference": [ { "type": "PubMed", "id": "12933810", "url": "https://glygen.org/publication/PubMed/12933810" } ] }, { "title": "Gene and 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Effects of lattice packing on conformational heterogeneity.", "journal": "Journal of molecular biology", "date": "1994", "authors": "Raghunathan S, Chandross RJ, Kretsinger RH, Allison TJ, Penington CJ, Rule GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "8182750", "url": "https://glygen.org/publication/PubMed/8182750" } ] }, { "title": "A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.", "journal": "Archives of biochemistry and biophysics", "date": "1994", "authors": "Comstock KE, Widersten M, Hao XY, Henner WD, Mannervik B", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "8203914", "url": "https://glygen.org/publication/PubMed/8203914" } ] }, { "title": "Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.", "journal": "Journal of molecular biology", "date": "1993", "authors": "Sinning I, Kleywegt GJ, Cowan SW, Reinemer P, Dirr HW, Huber R, Gilliland GL, Armstrong RN, Ji X, Board PG, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "8331657", "url": "https://glygen.org/publication/PubMed/8331657" } ] }, { "title": "Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver.", "journal": "Biochimica et biophysica acta", "date": "1993", "authors": "Ahmad H, Singhal SS, Saxena M, Awasthi YC", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "8431482", 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"1998", "authors": "Rossjohn J, McKinstry WJ, Oakley AJ, Verger D, Flanagan J, Chelvanayagam G, Tan KL, Board PG, Parker MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "9551553", "url": "https://glygen.org/publication/PubMed/9551553" } ] }, { "title": "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.", "journal": "The Biochemical journal", "date": "1998", "authors": "Ireland LS, Harrison DJ, Neal GE, Hayes JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5423646", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646" } ], "reference": [ { "type": "PubMed", "id": "9576847", "url": "https://glygen.org/publication/PubMed/9576847" } ] }, { "title": "Purification and characterization of a novel alpha-class glutathione transferase from human liver.", "journal": "The international journal of biochemistry & cell biology", "date": "1998", "authors": "Pastore A, Lo Bello M, Aureli G, Federici G, Ricci G, Di Ilio C, Petruzzelli R", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "9839448", "url": "https://glygen.org/publication/PubMed/9839448" } ] } ], "pathway": [ { "id": "hsa:4259", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4259", "resource": "KEGG Pathway" }, { "id": "R-HSA-156590", "name": "Glutathione conjugation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590", "resource": "Reactome", "description": "Glutathione conjugation" }, { "id": "R-HSA-5423646", "name": "Aflatoxin activation and detoxification", "url": 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"MAVLSKEYGFVLLTGAASFVMVLHLAINVGKARKKYKVEYPVMYSTDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGVYHPRIASGLGLAWIIGRVLYAYGYYTGDPSKRYRGAVGSLALFALMGTTVCSAFQHLGWIRPGLGYGSRSCHH", "length": 153 }, "evidence": [ { "id": "45931456", "url": "http://www.informatics.jax.org/homology/45931456", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "glutathione transferase activity", "id": "GO:0004364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" } ], "pmid": "" }, { "name": "leukotriene-C4 synthase activity", "id": "GO:0004464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004464", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": 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metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" } ], "pmid": "" }, { "name": "leukotriene biosynthetic process", "id": "GO:0019370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019370", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" } ], "pmid": "" }, { "name": "arachidonic acid metabolic process", "id": "GO:0019369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019369", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" } ], "pmid": "" }, { "name": "prostanoid metabolic process", "id": "GO:0006692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006692", "evidence": [ { "database": "UniProtKB", "id": "O14880", "url": "https://www.uniprot.org/uniprot/O14880" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17617", "name": "", "equation": "leukotriene C4 = glutathione + leukotriene A4", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q925U2-1", "Q5BK56-1", "Q16873-1", "O14880-1", "Q03013-1", "Q99735-1", "Q60860-1", "A2RST1-1", "Q8R5I6-1", "Q9CPU4-1" ], "evidence": [ { "id": "17617", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17617" } ] }, { "id": "48620", "name": "", "equation": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JHF3-1", "P04041-1", "P83645-1", "P36970-1", "O14880-1", "Q99735-1", "O14684-1", "P18283-1", "P07203-1", "P36969-1", "Q9CPU4-1", "A2RST1-1", "Q9JM51-1", "P11352-1", "Q9JHC0-1", "O70325-1" ], "evidence": [ { "id": "48620", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48620" } ] }, { "id": "75963", "name": "", "equation": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O14880-1", "Q9CPU4-1" ], "evidence": [ { "id": "75963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75963" } ] }, { "id": "R-HSA-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "equation": "", "summary": "The microsomal glutathione S-transferases (MGSTs) catalyse the nucleophilic attack by reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic C, N, or S atom. Three major families of proteins are widely distributed in nature. The cytosolic and mitochondrial GST families comprise soluble enzymes that are only distantly related whilst the third family comprises microsomal GST, referred to as membrane-associated proteins in eicosanoid and glutathione (MAPEG) metabolism. Three members of this family function as detoxification enzymes, MGST1-3 (DeJong et al. 1988, Kelner et al. 1996, Jakobsson et al. 1996, Jakobsson et al. 1997). Electron crystallography studies in rat Mgst1 indicate these enzymes function as homotrimers (Holm et al. 2002). Both aflatoxin B1 exo- and endo-epoxides (AFXBO and AFNBO) conjugate with glutathione. These conjugates are eventually excreted in urine as mercapturic acids.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99735-1", "O14880-1", "P10620-1" ], "evidence": [ { "id": "R-HSA-176059", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-176059" } ] }, { "id": "R-HSA-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "equation": "", "summary": "The microsomal glutathione S-transferases (MGSTs) catalyse the nucleophilic attack by reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic C, N, or S atom. Three major families of proteins are widely distributed in nature. The cytosolic and mitochondrial GST families comprise soluble enzymes that are only distantly related whilst the third family comprises microsomal GST, referred to as membrane-associated proteins in eicosanoid and glutathione (MAPEG) metabolism. Three members of this family function as detoxification enzymes, MGST1-3 (DeJong et al. 1988, Kelner et al. 1996, Jakobsson et al. 1996, Jakobsson et al. 1997). Electron crystallography studies in rat Mgst1 indicate these enzymes function as homotrimers (Holm et al. 2002). Both aflatoxin B1 exo- and endo-epoxides (AFXBO and AFNBO) conjugate with glutathione. These conjugates are eventually excreted in urine as mercapturic acids.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99735-1", "O14880-1", "P10620-1" ], "evidence": [ { "id": "R-HSA-5423653", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423653" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2RST1", "gene_name": "Mgst2", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "A2RST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RST1" } ] }, { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = glutathione + leukotriene A4.", "evidence": [ { "id": "A2RST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RST1" } ] }, { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "A2RST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RST1" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A2RST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RST1" } ] } ] }, { "uniprot_ac": "O14684", "gene_name": "PTGES", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "O14684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14684" } ] }, { "ec_number": "5.3.99.3", "activity": "prostaglandin H2 = prostaglandin E2.", "evidence": [ { "id": "O14684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14684" } ] }, { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "O14684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14684" } ] }, { "ec_number": "5.3.99.3", "activity": "", "evidence": [ { "id": "O14684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14684" } ] } ] }, { "uniprot_ac": "O14880", "gene_name": "MGST3", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "O14880", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14880" } ] }, { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = glutathione + leukotriene A4.", "evidence": [ { "id": "O14880", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14880" } ] }, { "ec_number": "2.5.1.-", "activity": "", "evidence": [ { "id": "O14880", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14880" } ] } ] }, { "uniprot_ac": "O70325", "gene_name": "Gpx4", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "O70325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70325" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "O70325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70325" } ] }, { "ec_number": "1.11.1.12", "activity": "", "evidence": [ { "id": "O70325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70325" } ] } ] }, { "uniprot_ac": "P04041", "gene_name": "Gpx1", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "P04041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04041" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P04041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04041" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P04041", "database": "UniProtKB", "url": 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