{ "uniprot_canonical_ac": "O14807-1", "uniprot_ac": "O14807", "uniprot_id": "RASM_HUMAN", "mass": { "chemical_mass": 23846.0, "monoisotopic_mass": 23846.0 }, "refseq": { "ac": "NP_001078518", "name": "ras-related protein M-Ras isoform 1 precursor", "summary": "This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" }, "gene_names": [ { "name": "MRAS", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14807", "id": "O14807" }, { "name": "M-RAs; NS11; R-RAS3; RRAS3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518", "id": "NP_001078518" }, { "name": "MRAS", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518", "id": "NP_001078518" }, { "name": "RRAS3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14807", "id": "O14807" } ], "protein_names": [ { "name": "Ras-related protein M-Ras", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14807" }, { "name": "3.6.5.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14807" }, { "name": "Ras-related protein R-Ras3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14807" }, { "name": "muscle and microspikes RAS; ras-related protein M-Ras; ras-related protein R-Ras3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518", "id": "NP_001078518" }, { "name": "ras-related protein M-Ras isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518", "id": "NP_001078518" } ], "function": [ { "annotation": "Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.", "evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" }, { "database": "PubMed", "id": "37277529", "url": "https://glygen.org/publication/PubMed/37277529" } ] }, { "annotation": "Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807#function" }, { "database": "PubMed", "id": "16630891", "url": "https://glygen.org/publication/PubMed/16630891" }, { "database": "PubMed", "id": "28289718", "url": "https://glygen.org/publication/PubMed/28289718" } ] }, { "annotation": "Structure of the MRAS-SHOC2-PP1C phosphatase complex.", "evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" }, { "database": "PubMed", "id": "35830882", "url": "https://glygen.org/publication/PubMed/35830882" } ] }, { "annotation": "Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.", "evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" }, { "database": "PubMed", "id": "36175670", "url": "https://glygen.org/publication/PubMed/36175670" } ] }, { "annotation": "Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.", "evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" }, { "database": "PubMed", "id": "35831509", "url": "https://glygen.org/publication/PubMed/35831509" } ] }, { "annotation": "This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" } ] } ], "disease": [ { "disease_id": "DOID:0112169", "recommended_name": { "id": "DOID:0112169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112169", "name": "Noonan syndrome 11", "description": "A Noonan syndrome characterized by clinical characteristics of Noonan syndrome, varying impairment of intellectual development, and cardiac hypertrophy that has_material_basis_in heterozygous mutation in the MRAS gene on chromosome 3q22.3." }, "synonyms": [ { "id": "DOID:0112169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112169", "name": "NS11", "description": "" }, { "id": "MONDO:0032786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032786", "name": "Noonan syndrome 11", "description": "" }, { "id": "MONDO:0032786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032786", "name": "NOONAN SYNDROME 11", "description": "" }, { "id": "MONDO:0032786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032786", "name": "NS11", "description": "" }, { "id": "MIM:618499", "resource": "MIM", "url": "https://www.omim.org/entry/618499", "name": "Noonan syndrome 11", "description": "Noonan syndrome 11" } ], "evidence": [ { "id": "618499", "database": "MIM", "url": "https://www.omim.org/entry/618499" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "78.9", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "66.12", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "80.31", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "85.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "91.4", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "79.22", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "68.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "82.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "90.46", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "63.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "76.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "83.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "90.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158186", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158186" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O14807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14807" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O14807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14807" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": 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"id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O14807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14807" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O14807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14807" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O14807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14807" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"C9J601", "url": "https://www.uniprot.org/uniprot/C9J601", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J601-1", "url": "https://www.uniprot.org/uniprot/C9J601-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J8Q6", "url": "https://www.uniprot.org/uniprot/C9J8Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J8Q6-1", "url": "https://www.uniprot.org/uniprot/C9J8Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14807-1", "url": "https://www.uniprot.org/uniprot/O14807-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14807-2", "url": "https://www.uniprot.org/uniprot/O14807-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL", "length": 208, "header": "sp|O14807-1|RASM_HUMAN Isoform 1 of Ras-related protein M-Ras OS=Homo sapiens OX=9606 GN=MRAS PE=1 SV=2 CANONICAL=O14807-1" }, "isoforms": [ { "isoform_ac": "C9J601-1", "url": "", "sequence": { "sequence": "MATSAVPSDNLPTYKLVVVGDGG", "length": 23, "header": "tr|C9J601-1|C9J601_HUMAN Computationally mapped isoform of Muscle RAS oncogene homolog OS=Homo sapiens OX=9606 GN=MRAS PE=1 SV=1 CANONICAL=O14807-1" }, "locus": { "chromosome": "3", "start_pos": 138372952, "end_pos": 138372884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000475711.5", "url": "https://www.ensembl.org/id/ENST00000475711.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000417092.1", "url": "https://www.ensembl.org/id/ENSP00000417092.1" } ] } }, { "isoform_ac": "C9J8Q6-1", "url": "", "sequence": { "sequence": "MREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKS", "length": 107, "header": "tr|C9J8Q6-1|C9J8Q6_HUMAN Computationally mapped isoform of Muscle RAS oncogene homolog OS=Homo sapiens OX=9606 GN=MRAS PE=1 SV=1 CANONICAL=O14807-1" }, "locus": { "chromosome": "3", "start_pos": 138402191, "end_pos": 138397359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000494949.5", "url": "https://www.ensembl.org/id/ENST00000494949.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000417685.1", "url": "https://www.ensembl.org/id/ENSP00000417685.1" } ] } }, { "isoform_ac": "O14807-1", "url": "", "sequence": { "sequence": "MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL", "length": 208, "header": "sp|O14807-1|RASM_HUMAN Isoform 1 of Ras-related protein M-Ras OS=Homo sapiens OX=9606 GN=MRAS PE=1 SV=2 CANONICAL=O14807-1" }, "locus": { "chromosome": "3", "start_pos": 138402266, "end_pos": 138372884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000423968.7", "url": "https://www.ensembl.org/id/ENST00000423968.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000389682.2", "url": "https://www.ensembl.org/id/ENSP00000389682.2" } ] } }, { "isoform_ac": "O14807-2", "url": "", "sequence": { "sequence": "MREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL", "length": 132, "header": "sp|O14807-2|RASM_HUMAN Isoform 2 of Ras-related protein M-Ras OS=Homo sapiens OX=9606 GN=MRAS PE=1 SV=2 CANONICAL=O14807-1" }, "locus": { "chromosome": "3", "start_pos": 138402266, "end_pos": 138397359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000614350.4", "url": "https://www.ensembl.org/id/ENST00000614350.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000484586.1", "url": "https://www.ensembl.org/id/ENSP00000484586.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O14807", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14807" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.", "journal": "The EMBO journal", "date": "1999", "authors": "Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "10205168", "url": "https://glygen.org/publication/PubMed/10205168" } ] }, { "title": "Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones.", "journal": "Blood", "date": "1999", "authors": "Louahed J, Grasso L, De Smet C, Van Roost E, Wildmann C, Nicolaides N C, Levitt R C, Renauld J C", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "reference": [ { "type": "PubMed", "id": "10477695", "url": "https://glygen.org/publication/PubMed/10477695" } ] }, { "title": "Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak.", "journal": "Current biology : CB", "date": "2000", "authors": "Sun H, King AJ, Diaz HB, Marshall MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "10712905", "url": "https://glygen.org/publication/PubMed/10712905" } ] }, { "title": "Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Muller J, Cacace AM, Lyons WE, McGill CB, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "10891492", "url": "https://glygen.org/publication/PubMed/10891492" } ] }, { "title": "Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.", "journal": "The EMBO journal", "date": "2000", "authors": "Zhang BH, Guan KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "11032810", "url": "https://glygen.org/publication/PubMed/11032810" } ] }, { "title": "Active Ras induces heterodimerization of cRaf and BRaf.", "journal": "Cancer research", "date": "2001", "authors": "Weber CK, Slupsky JR, Kalmes HA, Rapp UR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "11325826", "url": "https://glygen.org/publication/PubMed/11325826" } ] }, { "title": "Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions.", "journal": "Oncogene", "date": "2001", "authors": "Jaumot M, Hancock JF", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "11494123", "url": "https://glygen.org/publication/PubMed/11494123" } ] }, { "title": "C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.", "journal": "Molecular cell", "date": "2001", "authors": "Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "11741534", "url": "https://glygen.org/publication/PubMed/11741534" } ] }, { "title": "Dephosphorylation of Ser-259 regulates Raf-1 membrane association.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Kubicek M, Pacher M, Abraham D, Podar K, Eulitz M, Baccarini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "11756411", "url": "https://glygen.org/publication/PubMed/11756411" } ] }, { "title": "Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Xiang X, Zang M, Waelde CA, Wen R, Luo Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "12244094", "url": "https://glygen.org/publication/PubMed/12244094" } ] }, { "title": "Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Tran NH, Frost JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "12551923", "url": "https://glygen.org/publication/PubMed/12551923" } ] }, { "title": "Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.", "journal": "Current biology : CB", "date": "2003", "authors": "Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "12932319", "url": "https://glygen.org/publication/PubMed/12932319" } ] }, { "title": "Ras signaling: PP2A puts Ksr and Raf in the right place.", "journal": "Current biology : CB", "date": "2003", "authors": "Raabe T, Rapp UR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "12932339", "url": "https://glygen.org/publication/PubMed/12932339" } ] }, { "title": "Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Goetz CA, O'Neil JJ, Farrar MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "14530258", "url": "https://glygen.org/publication/PubMed/14530258" } ] }, { "title": "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.", "journal": "Cell", "date": "2004", "authors": "Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "15035987", "url": "https://glygen.org/publication/PubMed/15035987" } ] }, { "title": "MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.", "journal": "Nature cell biology", "date": "2004", "authors": "Chadee DN, Kyriakis JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "15258589", "url": "https://glygen.org/publication/PubMed/15258589" } ] }, { "title": "A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2004", "authors": "Chadee DN, Kyriakis JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "15467451", "url": "https://glygen.org/publication/PubMed/15467451" } ] }, { "title": "B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Tran NH, Wu X, Frost JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "15710605", "url": "https://glygen.org/publication/PubMed/15710605" } ] }, { "title": "Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.", "journal": "EMBO reports", "date": "2005", "authors": "Terai K, Matsuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "15711535", "url": "https://glygen.org/publication/PubMed/15711535" } ] }, { "title": "Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Edin ML, Juliano RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "15899852", "url": "https://glygen.org/publication/PubMed/15899852" } ] }, { "title": "Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.", "journal": "Nature cell biology", "date": "2005", "authors": "Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16041367", "url": "https://glygen.org/publication/PubMed/16041367" } ] }, { "title": "Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.", "journal": "Molecular biology of the cell", "date": "2005", "authors": "Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16093354", "url": "https://glygen.org/publication/PubMed/16093354" } ] }, { "title": "Ras-Raf signaling needs prohibitin.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2005", "authors": "Rajalingam K, Rudel T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16294014", "url": "https://glygen.org/publication/PubMed/16294014" } ] }, { "title": "Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.", "journal": "Molecular cell", "date": "2005", "authors": "Garnett MJ, Rana S, Paterson H, Barford D, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16364920", "url": "https://glygen.org/publication/PubMed/16364920" } ] }, { "title": "Regulation and role of Raf-1/B-Raf heterodimerization.", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Rushworth LK, Hindley AD, O'Neill E, Kolch W", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16508002", "url": "https://glygen.org/publication/PubMed/16508002" } ] }, { "title": "Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16537381", "url": "https://glygen.org/publication/PubMed/16537381" } ] }, { "title": "A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.", "journal": "Molecular cell", "date": "2006", "authors": "Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" }, { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "16630891", "url": "https://glygen.org/publication/PubMed/16630891" } ] }, { "title": "Regulation of RKIP binding to the N-region of the Raf-1 kinase.", "journal": "FEBS letters", "date": "2006", "authors": "Park S, Rath O, Beach S, Xiang X, Kelly SM, Luo Z, Kolch W, Yeung KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "17097642", "url": "https://glygen.org/publication/PubMed/17097642" } ] }, { "title": "The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.", "journal": "Cellular signalling", "date": "2008", "authors": "Rath O, Park S, Tang HH, Banfield MJ, Brady RL, Lee YC, Dignam JD, Sedivy JM, Kolch W, Yeung KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "18294816", "url": "https://glygen.org/publication/PubMed/18294816" } ] }, { "title": "Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Baljuls A, Schmitz W, Mueller T, Zahedi RP, Sickmann A, Hekman M, Rapp UR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "18662992", "url": "https://glygen.org/publication/PubMed/18662992" } ] }, { "title": "Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "19049963", "url": "https://glygen.org/publication/PubMed/19049963" } ] }, { "title": "Positive- and negative-feedback regulations coordinate the dynamic 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"evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" } ], "reference": [ { "type": "PubMed", "id": "36175670", "url": "https://glygen.org/publication/PubMed/36175670" } ] }, { "title": "Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.", "journal": "Nature cancer", "date": "2023-06-05", "authors": "Adachi Yuta, Kimura Ryo, Hirade Kentaro, Yanase Shogo, Nishioka Yuki, Kasuga Natsumi, Yamaguchi Rui, Ebi Hiromichi", "evidence": [ { "database": "RefSeq", "id": "NP_001078518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078518" } ], "reference": [ { "type": "PubMed", "id": "37277529", "url": "https://glygen.org/publication/PubMed/37277529" } ] }, { "title": "Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.", "journal": "The EMBO journal", "date": "1995", "authors": "Marais R, Light Y, Paterson HF, Marshall CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "7542586", "url": "https://glygen.org/publication/PubMed/7542586" } ] }, { "title": "Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Yamamori B, Kuroda S, Shimizu K, Fukui K, Ohtsuka T, Takai Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "7744815", "url": "https://glygen.org/publication/PubMed/7744815" } ] }, { "title": "KSR, a novel protein kinase required for RAS signal transduction.", "journal": "Cell", "date": "1995", "authors": "Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "8521512", "url": "https://glygen.org/publication/PubMed/8521512" } ] }, { "title": "The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.", "journal": "Cell", "date": "1995", "authors": "Sundaram M, Han M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "8521513", "url": "https://glygen.org/publication/PubMed/8521513" } ] }, { "title": "The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.", "journal": "Cell", "date": "1995", "authors": "Kornfeld K, Hom DB, Horvitz HR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "8521514", "url": "https://glygen.org/publication/PubMed/8521514" } ] }, { "title": "Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.", "journal": "Oncogene", "date": "1996", "authors": "Rommel C, Radziwill G, Lovric J, Noeldeke J, Heinicke T, Jones D, Aitken A, Moelling K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "8637718", "url": "https://glygen.org/publication/PubMed/8637718" } ] }, { "title": "The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1996", "authors": "Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "8876196", "url": "https://glygen.org/publication/PubMed/8876196" } ] }, { "title": "KSR modulates signal propagation within the MAPK cascade.", "journal": "Genes & development", "date": "1996", "authors": "Therrien M, Michaud NR, Rubin GM, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "8946910", "url": "https://glygen.org/publication/PubMed/8946910" } ] }, { "title": "Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "9020159", "url": "https://glygen.org/publication/PubMed/9020159" } ] }, { "title": "Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Diaz B, Barnard D, Filson A, MacDonald S, King A, Marshall M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "9234708", "url": "https://glygen.org/publication/PubMed/9234708" } ] }, { "title": "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution.", "journal": "Oncogene", "date": "1997", "authors": "Kimmelman A, Tolkacheva T, Lorenzi M V, Osada M, Chan A M", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "reference": [ { "type": "PubMed", "id": "9400994", "url": "https://glygen.org/publication/PubMed/9400994" } ] }, { "title": "Autoregulation of the Raf-1 serine/threonine kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Cutler RE Jr, Stephens RM, Saracino MR, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "9689060", "url": "https://glygen.org/publication/PubMed/9689060" } ] }, { "title": "The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.", "journal": "Nature", "date": "1998", "authors": "King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, Marshall MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "9823899", "url": "https://glygen.org/publication/PubMed/9823899" } ] }, { "title": "Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000" } ], "reference": [ { "type": "PubMed", "id": "9858547", "url": "https://glygen.org/publication/PubMed/9858547" } ] } ], "pathway": [ { "id": "hsa:22808", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:22808", "resource": "KEGG Pathway" }, { "id": "R-HSA-5673000", "name": "RAF activation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000", "resource": "Reactome", "description": "RAF activation" }, { "id": "R-HSA-9726840", "name": "SHOC2 M1731 mutant abolishes MRAS complex function", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726840", "resource": "Reactome", "description": "SHOC2 M1731 mutant abolishes MRAS complex function" }, { "id": "R-HSA-9726842", "name": "Gain-of-function MRAS complexes activate RAF signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842", "resource": "Reactome", "description": "Gain-of-function MRAS complexes activate RAF signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "O08989-1", "protein_name": "Ras-related protein M-Ras", "gene_name": "Mras", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATSAVPSENLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKVTRDQGKEMATKYNIPYIETSAKDPPLNVDKTFHDLVRVIRQQVPEKNQKKKKKTKWRGDRATGTHKLQCVIL", "length": 208 }, "evidence": [ { "id": "45931517", "url": "http://www.informatics.jax.org/homology/45931517", "database": "MGI" }, { "id": "O14807", "url": "https://omabrowser.org/oma/group/O14807/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P97538-1", "protein_name": "Ras-related protein M-Ras", "gene_name": "Mras", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKVTRDQGKEMATKYNIPYIETSAKDPPLNVDKTFHDLVRVIRQQVPEKNQKKKKKTKWRGDRATGTHKLQCVIL", "length": 208 }, "evidence": [ { "id": "45931517", "url": "http://www.informatics.jax.org/homology/45931517", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "GTP-dependent protein binding", "id": "GO:0030742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030742", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "cellular response to leukemia inhibitory factor", "id": "GO:1990830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990830", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "O14807", "url": "https://www.uniprot.org/uniprot/O14807" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08877-1", "Q6AYC2-1", "Q2TA68-1", "P61589-1", "Q6RUV5-1", "P23640-1", "O35303-1", "P21575-1", "P39052-1", "Q6AYF9-1", "Q8CFN2-1", "Q63663-1", "M0RC99-1", "Q99P74-1", "B2GUV7-1", "Q8R4Z9-1", "Q8R500-1", "D3ZQL7-1", "P97538-1", "Q6IMA3-1", "Q5BJQ5-1", "Q62636-1", "Q63486-1", "Q63487-1", "P61227-1", "P62836-1", "P63322-1", "Q04970-1", "P08644-1", "D3Z8L7-1", "P35281-1", "P36860-1", "Q6IMA7-1", "C9WPN6-1", "P20171-1", "P81795-1", "Q6AYZ1-1", "Q6AY56-1", "Q99MB4-1", "Q5XIF6-1", "P84079-1", "P68370-1", "Q68FR8-1", "Q6P9V9-1", "P51146-1", "O35509-1", "P62494-1", "Q6NYB7-1", "Q66HA6-1", "P09527-1", "P10536-1", "P05714-1", "Q8K586-1", "P62828-1", "P62332-1", "P35280-1", "P05712-1", "Q6AYB5-1", "Q6AXM7-1", "P05197-1", "P62630-1", "D3ZM99-1", "D3ZLK2-1", "Q5BJP6-1", "F1M2G3-1", "A0A8I5ZU96-1", "A0A8I6AHV4-1", "Q62639-1", "P97687-1", "P60953-2", "Q9UQ16-1", "P55039-1", "Q9Y295-1", "O00429-1", "Q05193-1", "P50570-1", "Q6NXR0-1", "Q96PP8-1", "P32455-1", "Q9H0R5-1", "Q96PP9-1", "P32456-1", "Q8N442-1", "O60841-1", "Q8IWA4-1", "O95140-1", "O60313-1", "Q8IVH4-1", "Q5S007-1", "O00194-1", "P51159-1", "P63000-1", "P20339-1", "P61586-1", "O94811-1", "P61018-1", "Q9H0U4-1", "P51148-1", "P51149-1", "Q9Y227-1", "P62820-1", "Q9NQZ7-1", "P20338-1", "P62491-1", "Q15907-1", "Q92928-1", "P61020-1", "Q9NVJ2-1", "A6NIZ1-1", "P61224-1", "A1A4Y4-1", "P61011-1", "P62834-1", "P11234-1", "Q2VIR3-1", "P41091-1", "P01112-1", "P61225-1", "Q9Y3L5-1", "Q96S79-1", "Q9NQL2-1", "Q9HB90-1", "Q9H628-1", "O14807-1", "P01116-1", "P60763-1", "P11233-1", "P01111-1", "Q99578-1", "Q96A58-1", "Q92737-1", "Q9BPW5-1", "Q7Z444-1", "P10114-1", "Q5VZM2-1", "P10301-1", "P62070-1", "Q6T310-1", "P61026-1", "Q92963-1", "Q7L523-1", "Q9NYN1-1", "P62826-1", "P62330-1", "Q8N8V2-1", "Q9NRW1-1", "Q6ZN66-1", "Q8WUD1-1", "P61006-1", "P61019-1", "Q9BSD7-1", "Q9NY65-1", "Q9H853-1", "P68366-1", "Q4V339-1", "Q8IUF1-1", "Q71U36-1", "Q9BQE3-1", "P68363-1", "Q5RIA9-1", "Q9BRT8-1", "A6NHL2-1", "Q5JTY5-1", "P84077-1", "Q6PEY2-1", "P13639-1", "P15170-1", "P0DPH7-1", "P0DPH8-1", "Q969S9-1", "Q15382-1", "P49961-1", "Q8IYD1-1", "P68104-1", "P61221-1", "Q9Y450-1", "P61021-1", "Q62293-1", "Q61107-1", "P60766-2", "Q8BZ98-1", "Q8CFB4-1", "P32233-1", "Q9QXB9-1", "Q01514-1", "Q8K1M6-1", "P39053-1", "P39054-1", "Q8C262-1", "Q5S006-1", "Q8C3X4-1", "Q9Z0E6-1", "Q9QZ85-1", "Q05D44-1", "P58281-1", "Q8C7H1-1", "Q80U63-1", "Q811U4-1", "Q99P58-1", "Q9QUI0-1", "Q9ERI2-1", "P63001-1", "Q3T9E4-1", "Q7TQD2-1", "Q9CQD1-1", "Q9CQW2-1", "P56371-1", "P62821-1", "P62492-1", "Q91ZR1-1", "P35278-1", "P46638-1", "P51150-1", "Q3TCT4-1", "Q9D1G1-1", "P61226-1", "P61027-1", "P62071-1", "Q99JI6-1", "Q8R367-1", "Q922H7-1", "Q8BU31-1", "Q80ZJ1-1", "Q80X95-1", "O08989-1", "P70426-1", "Q8K5A4-1", "P10833-1", "P70425-1", "Q61411-1", "Q5SSG5-1", "Q7TT45-1", "Q6NTA4-1", "Q99K70-1", "Q9JIW9-1", "Q08AT1-1", "P60764-1", "P62835-1", "P63321-1", "Q6IMB1-1", "P32883-1", "Q9Z0N2-1", "Q9Z0N1-1", "P08556-1", "Q7TN89-1", "A4UUI3-1", "Q8VEH6-1", "A0A0G2JDV3-1", "P68368-1", "Q91Z40-1", "Q60766-1", "A0A140LIF8-1", "Q9DCE9-1", "Q3UX10-1", "Q9JJZ2-1", "Q0GUM3-1", "E9PXC0-1", "P62331-1", "Q9CQA9-1", "P53994-1", "P59279-1", "P62827-1", "P68369-1", "P55258-1", "P61294-1", "Q61820-1", "P05214-1", "P84078-1", "Q69ZS7-1", "P05213-1", "P68373-1", "Q149F3-1", "Q8R050-1", "P14576-1", "Q921J2-1", "P55772-1", "Q8R2Q4-1", "B2RVE2-1", "P10126-1", "P61222-1", "P58252-1", "P13856-1", "P20606-1", "P01119-1", "P01120-1", "P05453-1", "P06780-1", "P06781-1", "P09733-1", "P09734-1", "P11076-1", "P19073-1", "P32324-1", "P32481-1", "P32769-1", "P53893-1", "P54861-1", "Q00246-1", "P39730-1", "P46943-1", "P38297-1", "P53729-1", "P20424-1", "P53290-1", "Q00582-1", "Q54Y30-1", "Q54XP6-1", "Q54XD8-1", "Q55CA9-1", "Q55CB0-1", "Q55CB7-1", "Q55CB8-1", "Q55CB9-1", "Q55CC0-1", "Q75K18-1", "Q869Q0-1", "Q86L51-1", "B0G189-1", "O00909-1", "P03967-1", "P0CT31-1", "P15064-1", "P15112-1", "P18613-1", "P32252-1", "P32253-1", "P32254-1", "P32255-1", "P36409-1", "P36411-1", "Q54MH8-1", "Q55AX0-1", "Q55BW0-1", "Q55F94-1", "P08645-1", "P08646-1", "P40793-1", "Q24208-1", "P04388-1", "P27619-1", "Q7YU24-1", "P48555-1", "Q9VRH6-1", "A1Z9N0-1", "O18412-1", "P06604-1", "P06606-1", "P61209-1", "P06603-1", "P06605-1", "Q9W074-1", "O18333-1", "Q9V3I2-1", "Q9VRY2-1", "O76742-1", "P13060-1", "Q9VM20-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-HSA-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "equation": "", "summary": "Activation of RAF upon growth factor stimulation depends on many factors including dephosphorylation, conformational change, dimerization, membrane recruitment and protein-protein interactions, among others (reviewed in Lavoie and Therien, 2015). In the inactive state, RAF1/CRAF is phosphorylated at S259 and S621 (corresponding to S365 and S729 in BRAF, and S214 and S582 in ARAF). These sites mediate the interaction with YWHAB/14-3-3 proteins (reviewed in Matallanas et al, 2011; Lavoie and Therien, 2015). Dephosphorylation of the S259 site by PP2A and or PP1 (also known as PPP1CC) disrupts interaction with 14-3-3 proteins and promotes a conformational change that exposes the membrane and RAS interacting RBD and CRD, facilitating recruitment of RAF to the plasma membrane (Kubicek et al, 2002; Goetz et al, 2003; Ory et al, 2003). PP1-mediated dephosphorylation occurs in the context of a ternary complex consisting of SHOC2 and the RAS protein family member MRAS in its GTP bound form (Rodriguez-Viciano et al, 2006; Young et al, 2013; reviewed in Simanshu et al, 2017). Consistent with a role of this ternary complex in activating RAF signaling, mutations in SHOC2, MRAS and PP1 are associated with increased RAF pathway activity in Noonan syndrome (Cordeddu et al, 2009; Gripp et al, 2016; Higgin et al, 2017; Young et al 2018).
Although S259 dephosphorylation is shown as occurring before both YWHAB displacement and recruitment of RAF to the plasma membrane, the order of and relationship between these events is not completely clear. In addition, the displacement of 14-3-3 and recruitment of RAF1 to the membrane is also promoted by a direct interaction with cell cycle protein Prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04049-1", "P10398-1", "P15056-1", "P62140-1", "P36873-1", "O14807-1" ], "evidence": [ { "id": "R-HSA-9658445", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9658445" } ] }, { "id": "R-HSA-9660536", "name": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex", "equation": "", "summary": "A loss-of-function mutation in SHOC2 has been identified in a patient with a Noonan-related syndrome (Hannig et al, 2014). SHOC2 M173I has impaired ability to interact with PPP1CC and reduces the MRAS-SHOC2-PP1-dependent dephosphorylation of RAF, which is required for RAF pathway activation (Rodriguez-Viciano et al, 2006; Hannig et al, 2014). How both loss and gain-of-function SHOC2 mutants can contribute to RAF pathway activation remains to be elucidated.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04049-1", "P10398-1", "P15056-1", "P62140-1", "P36873-1", "O14807-1" ], "evidence": [ { "id": "R-HSA-9660536", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660536" } ] }, { "id": "R-HSA-9660538", "name": "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs", "equation": "", "summary": "PP1-mediated dephosphorylation of RAF occurs in the context of a ternary complex consisting of SHOC2 and the RAS protein family member MRAS in its GTP-bound form (Rodriguez-Viciano et al, 2006; Young et al, 2013; reviewed in Simanshu et al, 2017). Consistent with a role of this ternary complex in promoting RAF signaling, activating mutations in SHOC2, MRAS and PP1 are associated with increased RAF pathway activity in Noonan syndrome (Cordeddu et al, 2009; Gripp et al, 2016; Motta et al, 2016; Higgin et al, 2017; Motta et al, 2019a,b; Young et al, 2018).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04049-1", "P10398-1", "P15056-1", "P62140-1", "P36873-1", "O14807-1" ], "evidence": [ { "id": "R-HSA-9660538", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660538" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JDV3", "gene_name": "Gbp6", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0A0G2JDV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3" } ] } ] }, { "uniprot_ac": "A0A140LIF8", "gene_name": "Irgm2", "activity": [ { 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"https://www.uniprot.org/uniprot/P05712" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P05712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05712" } ] } ] }, { "uniprot_ac": "P05714", "gene_name": "Rab4a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P05714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05714" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P05714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05714" } ] } ] }, { "uniprot_ac": "P06603", "gene_name": "alphaTub84B", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06603", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06603" } ] } ] }, { "uniprot_ac": "P06604", "gene_name": "alphaTub85E", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06604" } ] } ] }, { "uniprot_ac": "P06605", "gene_name": "alphaTub84D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06605" } ] } ] }, { "uniprot_ac": "P06606", "gene_name": "alphaTub67C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06606" } ] } ] }, { "uniprot_ac": "P06780", "gene_name": "RHO1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P06780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06780" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P06780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06780" } ] } ] }, { "uniprot_ac": "P06781", "gene_name": "RHO2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P06781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06781" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P06781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06781" } ] } ] }, { "uniprot_ac": "P08556", "gene_name": "Nras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08556" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08556" } ] } ] }, { "uniprot_ac": "P08644", "gene_name": "Kras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08644" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08644" } ] } ] }, { "uniprot_ac": "P08645", "gene_name": "Rap1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08645" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08645" } ] } ] }, { "uniprot_ac": "P08646", "gene_name": "Ras85D", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08646" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08646" } ] } ] }, { "uniprot_ac": "P09527", "gene_name": "Rab7a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P09527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09527" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P09527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09527" } ] } ] }, { "uniprot_ac": "P09733", "gene_name": "TUB1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P09733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09733" } ] } ] }, { "uniprot_ac": "P09734", "gene_name": "TUB3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P09734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09734" } ] } ] }, { "uniprot_ac": "P0CT31", "gene_name": "eef1a1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P0CT31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CT31" } ] } ] }, { "uniprot_ac": "P0DPH7", "gene_name": "TUBA3C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P0DPH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPH7" } ] } ] }, { "uniprot_ac": "P0DPH8", "gene_name": "TUBA3D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P0DPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPH8" } ] } ] }, { "uniprot_ac": "P10114", "gene_name": "RAP2A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P10114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10114" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10114" } ] } ] }, { "uniprot_ac": "P10126", "gene_name": "Eef1a1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P10126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10126" } ] } ] }, { "uniprot_ac": "P10301", "gene_name": "RRAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P10301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10301" } ] } ] }, { "uniprot_ac": "P10398", "gene_name": "ARAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P10398", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10398" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P10398", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10398" } ] } ] }, { "uniprot_ac": "P10536", "gene_name": "Rab1b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P10536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10536" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10536" } ] } ] }, { "uniprot_ac": "P10833", "gene_name": "Rras", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P10833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10833" } ] } ] }, { "uniprot_ac": "P11076", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P11076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11076" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11076" } ] } ] }, { "uniprot_ac": "P11233", "gene_name": "RALA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P11233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11233" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11233" } ] } ] }, { "uniprot_ac": "P11234", "gene_name": "RALB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P11234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11234" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11234" } ] } ] }, { "uniprot_ac": "P13060", "gene_name": "eEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P13060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13060" } ] } ] }, { "uniprot_ac": "P13639", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P13639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13639" } ] } ] }, { "uniprot_ac": "P13856", "gene_name": "RSR1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P13856", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13856" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P13856", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13856" } ] } ] }, { "uniprot_ac": "P14576", "gene_name": "Srp54", "activity": [ { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P14576", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14576" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "P14576", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14576" } ] } ] }, { "uniprot_ac": "P15056", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15056" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15056" } ] } ] }, { "uniprot_ac": "P15064", "gene_name": "rasG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P15064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15064" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P15064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15064" } ] } ] }, { "uniprot_ac": "P15112", "gene_name": "efbA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P15112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15112" } ] } ] }, { "uniprot_ac": "P15170", "gene_name": "GSPT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P15170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15170" } ] } ] }, { "uniprot_ac": "P18613", "gene_name": "rapA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P18613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18613" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P18613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18613" } ] } ] }, { "uniprot_ac": "P19073", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P19073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19073" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P19073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19073" } ] } ] }, { "uniprot_ac": "P20171", "gene_name": "Hras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20171" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P20171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20171" } ] } ] }, { "uniprot_ac": "P20338", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20338" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P20338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20338" } ] } ] }, { "uniprot_ac": "P20339", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20339" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P20339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20339" } ] } ] }, { "uniprot_ac": "P20424", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20424" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "P20424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20424" } ] } ] }, { "uniprot_ac": "P20606", "gene_name": "SAR1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P20606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20606" } ] } ] }, { "uniprot_ac": "P21575", "gene_name": "Dnm1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P21575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21575" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P21575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21575" } ] } ] }, { "uniprot_ac": "P23640", "gene_name": "Rab27a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P23640", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23640" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P23640", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23640" } ] } ] }, { "uniprot_ac": "P27619", "gene_name": "shi", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P27619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27619" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P27619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27619" } ] } ] }, { "uniprot_ac": "P32233", "gene_name": "Drg1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P32233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32233" } ] } ] }, { "uniprot_ac": "P32252", "gene_name": "rasB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P32252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32252" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P32252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32252" } ] } ] }, { "uniprot_ac": "P32253", "gene_name": "rasC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P32253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32253" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P32253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32253" } ] } ] }, { "uniprot_ac": "P32254", "gene_name": "rasS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P32254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32254" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P32254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32254" } ] } ] }, { "uniprot_ac": "P32255", "gene_name": "tubA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P32255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32255" } ] } ] }, { "uniprot_ac": "P32324", "gene_name": "EFT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P32324", "database": "UniProtKB", "url": 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"3.6.5.2", "activity": "", "evidence": [ { "id": "P36860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36860" } ] } ] }, { "uniprot_ac": "P36873", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P36873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36873" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P36873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36873" } ] } ] }, { "uniprot_ac": "P38297", "gene_name": "FZO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P38297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38297" } ] } ] }, { "uniprot_ac": "P39052", "gene_name": "Dnm2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P39052", "database": 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phosphate.", "evidence": [ { "id": "P41091", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41091" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P41091", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41091" } ] } ] }, { "uniprot_ac": "P46638", "gene_name": "Rab11b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P46638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46638" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P46638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46638" } ] } ] }, { "uniprot_ac": "P46943", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P46943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46943" } ] } ] }, { "uniprot_ac": "P48555", "gene_name": "Rala", "activity": [ { "ec_number": "3.6.5.2", 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phosphate.", "evidence": [ { "id": "P51159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51159" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P51159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51159" } ] } ] }, { "uniprot_ac": "P53290", "gene_name": "GTR2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P53290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53290" } ] } ] }, { "uniprot_ac": "P53729", "gene_name": "ZNG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P53729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53729" } ] } ] }, { "uniprot_ac": "P53893", "gene_name": "RIA1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P53893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53893" } ] } ] }, { "uniprot_ac": "P53994", "gene_name": "Rab2a", "activity": 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H(+) + phosphate.", "evidence": [ { "id": "P56371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56371" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P56371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56371" } ] } ] }, { "uniprot_ac": "P58252", "gene_name": "Eef2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P58252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58252" } ] } ] }, { "uniprot_ac": "P58281", "gene_name": "Opa1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P58281", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58281" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P58281", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58281" } ] } ] }, { "uniprot_ac": "P59279", "gene_name": "Rab2b", "activity": [ { "ec_number": 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"ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P60764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60764" } ] } ] }, { "uniprot_ac": "P60766", "gene_name": "Cdc42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P60766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60766" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P60766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60766" } ] } ] }, { "uniprot_ac": "P60953", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P60953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60953" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P60953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60953" } ] } ] }, { "uniprot_ac": "P61006", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61006" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61006" } ] } ] }, { "uniprot_ac": "P61011", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61011" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61011" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "P61011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61011" } ] } ] }, { "uniprot_ac": "P61018", "gene_name": "RAB4B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61018" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61018" } ] } ] }, { "uniprot_ac": "P61019", "gene_name": "RAB2A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61019" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61019" } ] } ] }, { "uniprot_ac": "P61020", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": 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"activity": "", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61225" } ] } ] }, { "uniprot_ac": "P61226", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61226" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61226" } ] } ] }, { "uniprot_ac": "P61227", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61227" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61227" } ] } ] }, { "uniprot_ac": "P61294", "gene_name": "Rab6b", 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"P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] }, { "ec_number": "3.1.3.53", "activity": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] } ] }, { "uniprot_ac": "P62330", "gene_name": "ARF6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62330" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62330" } ] } ] }, { "uniprot_ac": "P62331", "gene_name": "Arf6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62331" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62331" } ] } ] }, { "uniprot_ac": "P62332", "gene_name": "Arf6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62332" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62332" } ] } ] }, { "uniprot_ac": "P62491", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62491" } ] }, { "ec_number": 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"ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] } ] }, { "uniprot_ac": "P63001", "gene_name": "Rac1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63001", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63001" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63001", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63001" } ] } ] }, { "uniprot_ac": "P63321", "gene_name": "Rala", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63321" } ] 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