{ "uniprot_canonical_ac": "O14756-1", "uniprot_ac": "O14756", "uniprot_id": "H17B6_HUMAN", "mass": { "chemical_mass": 35966.0, "monoisotopic_mass": 35966.0 }, "refseq": { "ac": "NP_003716", "name": "17-beta-hydroxysteroid dehydrogenase type 6 precursor", "summary": "The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716" }, "gene_names": [ { "name": "HSD17B6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14756", "id": "O14756" }, { "name": "HSD17B6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716", "id": "NP_003716" }, { "name": "HSE; RODH; SDR9C6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716", "id": "NP_003716" }, { "name": "RODH", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14756", "id": "O14756" }, { "name": "SDR9C6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14756", "id": "O14756" } ], "protein_names": [ { "name": "17-beta-hydroxysteroid dehydrogenase type 6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14756" }, { "name": "1.1.1.105", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "1.1.1.209", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "1.1.1.239", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "1.1.1.53", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "1.1.1.62", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "17-beta-HSD 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "17-beta-HSD6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "17-beta-hydroxysteroid dehydrogenase type 6 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716", "id": "NP_003716" }, { "name": "3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; retinol dehydrogenase; oxidoreductase; 17-beta-HSD 6; 3-alpha->beta-HSE; hydroxysteroid (17-beta) dehydrogenase 6 homolog; short chain dehydrogenase/reductase family 9C member 6; 17-beta-hydroxysteroid dehydrogenase type 6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716", "id": "NP_003716" }, { "name": "3-alpha->beta-HSE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "3-alpha->beta-hydroxysteroid epimerase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "Oxidative 3-alpha hydroxysteroid dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" }, { "name": "Short chain dehydrogenase/reductase family 9C member 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14756" } ], "function": [ { "annotation": "HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.", "evidence": [ { "database": "RefSeq", "id": "NP_003716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716" }, { "database": "PubMed", "id": "37330135", "url": "https://glygen.org/publication/PubMed/37330135" } ] }, { "annotation": "Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46,XY with hypospadias.", "evidence": [ { "database": "RefSeq", "id": "NP_003716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716" }, { "database": "PubMed", "id": "32732174", "url": "https://glygen.org/publication/PubMed/32732174" } ] }, { "annotation": "NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756#function" }, { "database": "PubMed", "id": "11360992", "url": "https://glygen.org/publication/PubMed/11360992" }, { "database": "PubMed", "id": "10896656", "url": "https://glygen.org/publication/PubMed/10896656" }, { "database": "PubMed", "id": "11513953", "url": "https://glygen.org/publication/PubMed/11513953" } ] }, { "annotation": "No significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls.", "evidence": [ { "database": "RefSeq", "id": "NP_003716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716" }, { "database": "PubMed", "id": "25422294", "url": "https://glygen.org/publication/PubMed/25422294" } ] }, { "annotation": "The CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716" }, { "database": "PubMed", "id": "24244276", "url": "https://glygen.org/publication/PubMed/24244276" } ] }, { "annotation": "The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_003716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs930853688", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs930853688" }, { "id": "rs930853688", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs930853688#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 139, "end_pos": 139, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLI->NLT).", "chr_id": "12", "chr_pos": "56782076", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I139", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O14756", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14756" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 163, "end_pos": 163, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NVS->NVC).", "chr_id": "12", "chr_pos": "56782148", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "S163", "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs757749628", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757749628" }, { "id": "rs757749628", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757749628" }, { "id": "rs757749628", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757749628" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIS->NIS).", "chr_id": "12", "chr_pos": "56784880", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O14756", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14756" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 215, "end_pos": 215, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "H", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NMT->HMT).", "chr_id": "12", "chr_pos": "56784923", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N215", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "O14756", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14756" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 215, "end_pos": 215, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NMT->TMT).", "chr_id": "12", "chr_pos": "56784924", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N215", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1233787315", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1233787315" }, { "id": "rs1233787315", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1233787315" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 224, "end_pos": 224, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KQS->NQS).", "chr_id": "12", "chr_pos": "56784952", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K224", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O14756", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14756" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 256, "end_pos": 256, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NCS->TCS).", "chr_id": "12", "chr_pos": "56787155", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N256", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": 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"ENSG00000025423", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000025423" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O14756", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14756" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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"" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", 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"Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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GN=HSD17B6 PE=1 SV=1 CANONICAL=O14756-1" }, "locus": { "chromosome": "12", "start_pos": 56774116, "end_pos": 56773853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000554155.1", "url": "https://www.ensembl.org/id/ENST00000554155.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000451497.1", "url": "https://www.ensembl.org/id/ENSP00000451497.1" } ] } }, { "isoform_ac": "G3V508-1", "url": "", "sequence": { "sequence": "MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD", "length": 75, "header": "tr|G3V508-1|H17B6_HUMAN Computationally mapped isoform of 17-beta-hydroxysteroid dehydrogenase type 6 OS=Homo sapiens OX=9606 GN=HSD17B6 PE=1 SV=1 CANONICAL=O14756-1" }, "locus": { "chromosome": "12", "start_pos": 56774077, "end_pos": 56773853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000556650.5", "url": "https://www.ensembl.org/id/ENST00000556650.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000452103.1", "url": "https://www.ensembl.org/id/ENSP00000452103.1" } ] } }, { "isoform_ac": "O14756-1", "url": "", "sequence": { "sequence": "MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV", "length": 317, "header": "sp|O14756-1|H17B6_HUMAN Isoform 1 of 17-beta-hydroxysteroid dehydrogenase type 6 OS=Homo sapiens OX=9606 GN=HSD17B6 PE=1 SV=1 CANONICAL=O14756-1" }, "locus": { "chromosome": "12", "start_pos": 56787339, "end_pos": 56773853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000554643.5", "url": "https://www.ensembl.org/id/ENST00000554643.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000451406.1", "url": "https://www.ensembl.org/id/ENSP00000451406.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 161, "start_aa": "Asn", "end_pos": 161, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn161", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 215, "start_aa": "Asn", "end_pos": 215, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn215", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 256, "start_aa": "Asn", "end_pos": 256, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn256", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O14756", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14756" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter 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dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Rattner A, Smallwood PM, Nathans J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2453902", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2453902" } ], "reference": [ { "type": "PubMed", "id": "10753906", "url": "https://glygen.org/publication/PubMed/10753906" } ] }, { "title": "Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase.", "journal": "The Journal of biological chemistry", "date": "2000-09-22", "authors": "Huang X F, Luu-The V", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "reference": [ { "type": "PubMed", "id": "10896656", "url": "https://glygen.org/publication/PubMed/10896656" } ] }, { "title": "The C-terminal nucleotide binding domain of the human retinal ABCR protein is an adenosine triphosphatase.", "journal": "Biochemistry", "date": "2000", "authors": "Biswas EE, Biswas SB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2453902", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2453902" } ], "reference": [ { "type": "PubMed", "id": "11123914", "url": "https://glygen.org/publication/PubMed/11123914" } ] }, { "title": "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R", "evidence": [ { "database": "Reactome", "id": "R-HSA-2453902", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2453902" } ], "reference": [ { "type": "PubMed", "id": "11274389", "url": "https://glygen.org/publication/PubMed/11274389" } ] }, { "title": "Further characterization of human microsomal 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chemistry", "date": "1999", "authors": "Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D", "evidence": [ { "database": "Reactome", "id": "R-HSA-2453902", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2453902" } ], "reference": [ { "type": "PubMed", "id": "9920938", "url": "https://glygen.org/publication/PubMed/9920938" } ] } ], "pathway": [ { "id": "hsa:8630", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8630", "resource": "KEGG Pathway" }, { "id": "R-HSA-2453902", "name": "The canonical retinoid cycle in rods (twilight vision)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2453902", "resource": "Reactome", "description": "The canonical retinoid cycle in rods (twilight vision)" } ], "orthologs": [ { "uniprot_canonical_ac": "O54753-1", "protein_name": "17-beta-hydroxysteroid dehydrogenase type 6", "gene_name": "Hsd17b6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 317 }, "evidence": [ { "id": "45934052", "url": "http://www.informatics.jax.org/homology/45934052", "database": "MGI" }, { "id": "O14756", "url": "https://omabrowser.org/oma/group/O14756/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "androgen catabolic process", "id": "GO:0006710", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006710", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "retinol metabolic process", "id": "GO:0042572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "androgen biosynthetic process", "id": "GO:0006702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006702", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "steroid metabolic process", "id": "GO:0008202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "brexanolone catabolic process", "id": "GO:0062175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062175", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "electron transfer activity", "id": "GO:0009055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "NAD-retinol dehydrogenase activity", "id": "GO:0004745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004745", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "id": "GO:0004303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004303", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "androsterone dehydrogenase activity", "id": "GO:0047023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047023", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "testosterone dehydrogenase (NAD+) activity", "id": "GO:0047035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047035", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "testosterone 17-beta-dehydrogenase (NADP+) activity", "id": "GO:0047045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047045", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity", "id": "GO:0047024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047024", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" }, { "name": "androstan-3-alpha,17-beta-diol dehydrogenase activity", "id": "GO:0047044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047044", "evidence": [ { "database": "UniProtKB", "id": "O14756", "url": "https://www.uniprot.org/uniprot/O14756" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14929", "name": "", "equation": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62730-1", "Q6MGB5-1", "O54753-1", "O70351-1", "P42330-1", "Q92506-1", "P37059-1", "O14756-1", "P17516-1", "Q99714-1", "P50171-1", "P51658-1", "Q9R092-1", "O08756-1", "O18404-1" ], "evidence": [ { "id": "14929", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14929" } ] }, { "id": "20381", "name": "", "equation": "androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VD48-1", "Q6AYQ2-1", "P50170-1", "O54753-1", "Q9BPW9-1", "Q92781-1", "O75452-1", "O14756-1", "Q91WR5-1", "Q58NB6-1", "O55240-1", "O54909-1", "Q9R092-1" ], "evidence": [ { "id": "20381", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20381" } ] }, { "id": "21284", "name": "", "equation": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "Q64563-1", "Q8VD48-1", "P41682-1", "P50170-1", "O54753-1", "D3ZGP9-1", "P08319-1", "P40394-1", "P00325-1", "Q9BPW9-1", "O75452-1", "Q7Z5P4-1", "O14756-1", "A6NNS2-1", "Q64437-1", "Q9QYY9-1", "Q58NB6-1", "Q9R092-1", "Q8VCR2-1", "Q8CHS7-1" ], "evidence": [ { "id": "21284", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21284" } ] }, { "id": "24612", "name": "", "equation": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "Q62730-1", "Q6MGB5-1", "Q6P7R8-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O70351-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "Q92506-1", "P37059-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q7Z5P4-1", "Q5T2L2-1", "Q9BPX1-1", "Q99714-1", "P50171-1", "P51656-1", "P51658-1", "O70503-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "O08756-1", "Q8VCR2-1", "O18404-1" ], "evidence": [ { "id": "24612", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24612" } ] }, { "id": "24616", "name": "", "equation": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7R8-1", "Q62904-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O54939-1", "C9JRZ8-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "P56937-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q5T2L2-1", "P37058-1", "P51656-1", "O70503-1", "O88736-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "P70385-1" ], "evidence": [ { "id": "24616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24616" } ] }, { "id": "41980", "name": "", "equation": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VD48-1", "O54753-1", "O70351-1", "Q9BPW9-1", "O14756-1", "Q99714-1", "Q58NB6-1", "O08756-1", "Q9R092-1" ], "evidence": [ { "id": "41980", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41980" } ] }, { "id": "42004", "name": "", "equation": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VD48-1", "P50170-1", "O54753-1", "O70351-1", "Q9BPW9-1", "Q92781-1", "O75452-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "O14756-1", "Q99714-1", "Q58NB6-1", "O55240-1", "O54909-1", "O08756-1", "Q9R092-1", "O18404-1" ], "evidence": [ { "id": "42004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42004" } ] }, { "id": "42184", "name": "", "equation": "5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22071-1", "O54753-1", "P14060-1", "O14756-1", "P24815-1", "Q9R092-1" ], "evidence": [ { "id": "42184", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42184" } ] }, { "id": "42188", "name": "", "equation": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54753-1", "O14756-1", "Q9R092-1" ], "evidence": [ { "id": "42188", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42188" } ] }, { "id": "48488", "name": "", "equation": "all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P55006-1", "P50170-1", "O54753-1", "O14756-1", "Q8N3Y7-1", "O75452-1", "Q9R092-1", "O88451-1", "Q7TQA3-1", "O54909-1" ], "evidence": [ { "id": "48488", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48488" } ] }, { "id": "R-HSA-2454081", "name": "RDH5 oxidises 11cROL to 11cRAL", "equation": "", "summary": "Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BPW9-1", "O14756-1", "O75452-1", "Q92781-1", "Q8NEX9-1" ], "evidence": [ { "id": "R-HSA-2454081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2454081" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A6NNS2", "gene_name": "DHRS7C", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "A6NNS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNS2" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "A6NNS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNS2" } ] } ] }, { "uniprot_ac": "C9JRZ8", "gene_name": "AKR1B15", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.216", "activity": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] } ] }, { "uniprot_ac": "D3ZGP9", "gene_name": "Dhrs7c", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "D3ZGP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGP9" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "D3ZGP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGP9" } ] } ] }, { "uniprot_ac": "O08756", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] } ] }, { "uniprot_ac": "O14756", "gene_name": "HSD17B6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] } ] }, { "uniprot_ac": "O18404", "gene_name": "scu", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.201", "activity": "a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.36", "activity": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] } ] }, { "uniprot_ac": "O54753", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] } ] }, { "uniprot_ac": "O54909", "gene_name": "Rdh16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] } ] }, { "uniprot_ac": "O54939", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] } ] }, { "uniprot_ac": "O55240", "gene_name": "Rdh5", "activity": [ { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] } ] }, { "uniprot_ac": "O70351", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] } ] }, { "uniprot_ac": "O70503", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] } ] }, { "uniprot_ac": "O75452", "gene_name": "RDH16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] } ] }, { "uniprot_ac": "O88451", "gene_name": "Rdh7", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O88451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88451" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O88451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88451" } ] } ] }, { "uniprot_ac": "O88736", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] } ] }, { "uniprot_ac": "P00325", "gene_name": "ADH1B", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P00325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00325" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P00325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00325" } ] } ] }, { "uniprot_ac": "P08319", "gene_name": "ADH4", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P08319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08319" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P08319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08319" } ] } ] }, { "uniprot_ac": "P14060", "gene_name": "HSD3B1", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] }, { "ec_number": "1.1.1.145", "activity": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] }, { "ec_number": "5.3.3.1", "activity": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] } ] }, { "uniprot_ac": "P14061", "gene_name": "HSD17B1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] } ] }, { "uniprot_ac": "P17516", "gene_name": "AKR1C4", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.225", "activity": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] } ] }, { "uniprot_ac": "P22071", "gene_name": "Hsd3b1", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] }, { "ec_number": "1.1.1.145", "activity": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] }, { "ec_number": "5.3.3.1", "activity": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] } ] }, { "uniprot_ac": "P24815", "gene_name": "Hsd3b1", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] }, { "ec_number": "1.1.1.145", "activity": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] }, { "ec_number": "5.3.3.1", "activity": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] } ] }, { "uniprot_ac": "P37058", "gene_name": "HSD17B3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] } ] }, { "uniprot_ac": "P37059", "gene_name": "HSD17B2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37059" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P37059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37059" } ] } ] }, { "uniprot_ac": "P40394", "gene_name": "ADH7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] } ] }, { "uniprot_ac": "P41682", "gene_name": "Adh7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] } ] }, { "uniprot_ac": "P42330", "gene_name": "AKR1C3", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.188", "activity": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] } ] }, { "uniprot_ac": "P50170", "gene_name": "Rdh16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] } ] }, { "uniprot_ac": "P50171", "gene_name": "Hsd17b8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] } ] }, { "uniprot_ac": "P51656", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] } ] }, { "uniprot_ac": "P51657", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] } ] }, { "uniprot_ac": "P51658", "gene_name": "Hsd17b2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] } ] }, { "uniprot_ac": "P52895", "gene_name": "AKR1C2", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] } ] }, { "uniprot_ac": "P55006", "gene_name": "Rdh7", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P55006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55006" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P55006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55006" } ] } ] }, { "uniprot_ac": "P56937", "gene_name": "HSD17B7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] } ] }, { "uniprot_ac": "P70385", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] } ] }, { "uniprot_ac": "Q04828", "gene_name": "AKR1C1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.149", "activity": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] } ] }, { "uniprot_ac": "Q3U0B3", "gene_name": "Dhrs11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] } ] }, { "uniprot_ac": "Q53GQ0", "gene_name": "HSD17B12", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] } ] }, { "uniprot_ac": "Q58NB6", "gene_name": "Dhrs9", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] } ] }, { "uniprot_ac": "Q5M875", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] } ] }, { "uniprot_ac": "Q5T2L2", "gene_name": "AKR1C8", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5T2L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T2L2" } ] } ] }, { "uniprot_ac": "Q62730", "gene_name": "Hsd17b2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] } ] }, { "uniprot_ac": "Q62904", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] } ] }, { "uniprot_ac": "Q64437", "gene_name": "Adh7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] } ] }, { "uniprot_ac": "Q64563", "gene_name": "Adh4", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q64563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64563" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q64563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64563" } ] } ] }, { "uniprot_ac": "Q6AYQ2", "gene_name": "Akr1c21", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q6AYQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYQ2" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q6AYQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYQ2" } ] } ] }, { "uniprot_ac": "Q6AYS8", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] } ] }, { "uniprot_ac": "Q6MGB5", "gene_name": "Hsd17b8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] } ] }, { "uniprot_ac": "Q6P7R8", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] } ] }, { "uniprot_ac": "Q6UWP2", "gene_name": "DHRS11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] } ] }, { "uniprot_ac": "Q7TQA3", "gene_name": "Sdr16c5", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q7TQA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TQA3" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q7TQA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TQA3" } ] } ] }, { "uniprot_ac": "Q7Z5P4", "gene_name": "HSD17B13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] } ] }, { "uniprot_ac": "Q8CHS7", "gene_name": "Dhrs7c", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8CHS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHS7" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q8CHS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHS7" } ] } ] }, { "uniprot_ac": "Q8N3Y7", "gene_name": "SDR16C5", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8N3Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3Y7" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q8N3Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3Y7" } ] } ] }, { "uniprot_ac": "Q8NBQ5", "gene_name": "HSD17B11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] } ] }, { "uniprot_ac": "Q8NEX9", "gene_name": "SDR9C7", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q8NEX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEX9" } ] } ] }, { "uniprot_ac": "Q8VCR2", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] } ] }, { "uniprot_ac": "Q8VD48", "gene_name": "Dhrs9", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD48" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q8VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD48" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q8VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD48" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q8VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD48" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q8VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD48" } ] } ] }, { "uniprot_ac": "Q91WR5", "gene_name": "Akr1c21", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q91WR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WR5" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q91WR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WR5" } ] } ] }, { "uniprot_ac": "Q92506", "gene_name": "HSD17B8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] } ] }, { "uniprot_ac": "Q92781", "gene_name": "RDH5", "activity": [ { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "Q92781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92781" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q92781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92781" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q92781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92781" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "Q92781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92781" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q92781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92781" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q92781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92781" } ] } ] }, { "uniprot_ac": "Q99714", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": 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