{ "uniprot_canonical_ac": "O14734-1", "uniprot_ac": "O14734", "uniprot_id": "ACOT8_HUMAN", "mass": { "chemical_mass": 35914.0, "monoisotopic_mass": 35914.0 }, "refseq": { "ac": "NP_005460", "name": "acyl-coenzyme A thioesterase 8", "summary": "The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460" }, "gene_names": [ { "name": "ACOT8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14734", "id": "O14734" }, { "name": "ACOT8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460", "id": "NP_005460" }, { "name": "ACTEIII", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14734", "id": "O14734" }, { "name": "PTE1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14734", "id": "O14734" }, { "name": "hACTE-III; HNAACTE; hTE; NAP1; PTE-1; PTE-2; PTE1; PTE2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460", "id": "NP_005460" } ], "protein_names": [ { "name": "Acyl-coenzyme A thioesterase 8", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14734" }, { "name": "3.1.2.11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "3.1.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "3.1.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "3.1.2.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "3.1.2.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "3.1.2.5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "Acyl-CoA thioesterase 8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "Choloyl-coenzyme A thioesterase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "HIV-Nef-associated acyl-CoA thioesterase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "PTE-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "PTE-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "Peroxisomal acyl-CoA thioesterase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "Peroxisomal acyl-coenzyme A thioester hydrolase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "Peroxisomal long-chain acyl-CoA thioesterase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "Thioesterase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "acyl-coenzyme A thioesterase 8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460", "id": "NP_005460" }, { "name": "choloyl-CoA hydrolase; peroxisomal acyl-CoA thioesterase 1; thioesterase III; palmitoyl-CoA hydrolase; long-chain fatty-acyl-CoA hydrolase; peroxisomal acyl-coenzyme A thioester hydrolase 1; peroxisomal long-chain acyl-CoA thioesterase 1; HIV-Nef associated acyl-CoA thioesterase; choloyl-coenzyme A thioesterase; Nef (lentivirus myristoylated factor) associated protein 1; peroxisomal acyl-CoA thioesterase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460", "id": "NP_005460" }, { "name": "hACTE-III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "hACTEIII", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" }, { "name": "hTE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14734" } ], "function": [ { "annotation": "(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).", "evidence": [ { "database": "UniProtKB", "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734#function" }, { "database": "PubMed", "id": "9153233", "url": "https://glygen.org/publication/PubMed/9153233" } ] }, { "annotation": "Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_005460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460" }, { "database": "PubMed", "id": "23540296", "url": "https://glygen.org/publication/PubMed/23540296" } ] }, { "annotation": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, PubMed:15194431). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).", "evidence": [ { "database": "UniProtKB", "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734#function" }, { "database": "UniProtKB", "id": "P58137", "url": "https://www.uniprot.org/uniprot/P58137#function" }, { "database": "PubMed", "id": "9153233", "url": "https://glygen.org/publication/PubMed/9153233" }, { "database": "PubMed", "id": "15194431", "url": "https://glygen.org/publication/PubMed/15194431" }, { "database": "PubMed", "id": "9299485", "url": "https://glygen.org/publication/PubMed/9299485" } ] }, { "annotation": "In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro.", "evidence": [ { "database": "RefSeq", "id": "NP_005460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460" }, { "database": "PubMed", "id": "24788990", "url": "https://glygen.org/publication/PubMed/24788990" } ] }, { "annotation": "The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_005460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005460" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 78, "end_pos": 78, "sequence_org": "H", "sequence_mut": "A", "comment": "Reduces Acyl-CoA thioesterase activity and peroxisome proliferation.", "evidence": [ { "database": "UniProtKB", "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734" }, { "database": "PubMed", "id": "15194431", "url": "https://glygen.org/publication/PubMed/15194431" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "80.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "76.29", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "71.49", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "88.4", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "88.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "79.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "81.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "87.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "74.71", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "82.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "90.64", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "85.2", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101473", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101473" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O14734", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14734" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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}, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O14734", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14734" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O14734", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14734" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"id": "E9PJN0-1", "url": "https://www.uniprot.org/uniprot/E9PJN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PRD4", "url": "https://www.uniprot.org/uniprot/E9PRD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PRD4-1", "url": "https://www.uniprot.org/uniprot/E9PRD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6VBM3", "url": "https://www.uniprot.org/uniprot/F6VBM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6VBM3-1", "url": "https://www.uniprot.org/uniprot/F6VBM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y698", "url": "https://www.uniprot.org/uniprot/H0Y698", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y698-1", "url": "https://www.uniprot.org/uniprot/H0Y698-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C5A7", "url": "https://www.uniprot.org/uniprot/H7C5A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C5A7-1", "url": "https://www.uniprot.org/uniprot/H7C5A7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14734-1", "url": "https://www.uniprot.org/uniprot/O14734-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BR14", "url": "https://www.uniprot.org/uniprot/Q9BR14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BR14-1", "url": "https://www.uniprot.org/uniprot/Q9BR14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL", "length": 319, "header": "sp|O14734-1|ACOT8_HUMAN Isoform 1 of Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "isoforms": [ { "isoform_ac": "A0A494C0N6-1", "url": "", "sequence": { "sequence": "MQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL", "length": 184, "header": "tr|A0A494C0N6-1|ACOT8_HUMAN Computationally mapped isoform of Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45848532, "end_pos": 45841841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000652771.1", "url": "https://www.ensembl.org/id/ENST00000652771.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000498636.1", "url": "https://www.ensembl.org/id/ENSP00000498636.1" } ] } }, { "isoform_ac": "E9PIS4-1", "url": "", "sequence": { "sequence": "MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAEQMPSCVLRRSPAEKSLWTFTGTRSCQYCTKWSGHEQGRASRCAL", "length": 132, "header": "tr|E9PIS4-1|ACOT8_HUMAN Computationally mapped isoform of Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857315, "end_pos": 45848604, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000486165.5", "url": "https://www.ensembl.org/id/ENST00000486165.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433923.1", "url": "https://www.ensembl.org/id/ENSP00000433923.1" } ] } }, { "isoform_ac": "E9PJN0-1", "url": "", "sequence": { "sequence": "MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGPELESPGAQG", "length": 226, "header": "tr|E9PJN0-1|E9PJN0_HUMAN Computationally mapped isoform of palmitoyl-CoA hydrolase OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857315, "end_pos": 45843741, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000461272.5", "url": "https://www.ensembl.org/id/ENST00000461272.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435581.1", "url": "https://www.ensembl.org/id/ENSP00000435581.1" } ] } }, { "isoform_ac": "E9PRD4-1", "url": "", "sequence": { "sequence": "MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGFGIFIFKMRG", "length": 171, "header": "tr|E9PRD4-1|E9PRD4_HUMAN Computationally mapped isoform of palmitoyl-CoA hydrolase OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857315, "end_pos": 45843367, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000483141.1", "url": "https://www.ensembl.org/id/ENST00000483141.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000434216.1", "url": "https://www.ensembl.org/id/ENSP00000434216.1" } ] } }, { "isoform_ac": "F6VBM3-1", "url": "", "sequence": { "sequence": "MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGPEAASTVPSGADTNRVELLGALCEGRATWEAHLHLPGLLPAGPAQPHAAPVLHAHCATTRRAA", "length": 107, "header": "tr|F6VBM3-1|ACOT8_HUMAN Computationally mapped isoform of Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857315, "end_pos": 45848483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000488679.5", "url": "https://www.ensembl.org/id/ENST00000488679.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435115.1", "url": "https://www.ensembl.org/id/ENSP00000435115.1" } ] } }, { "isoform_ac": "H0Y698-1", "url": "", "sequence": { "sequence": "XLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAEQMPSCVLRRSPAEKSLWTFTVCDLY", "length": 74, "header": "tr|H0Y698-1|ACOT8_HUMAN Computationally mapped isoform of Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857196, "end_pos": 45853906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000457981.5", "url": "https://www.ensembl.org/id/ENST00000457981.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000403862.1", "url": "https://www.ensembl.org/id/ENSP00000403862.1" } ] } }, { "isoform_ac": "H7C5A7-1", "url": "", "sequence": { "sequence": "XYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL", "length": 209, "header": "tr|H7C5A7-1|H7C5A7_HUMAN Computationally mapped isoform of palmitoyl-CoA hydrolase OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45855284, "end_pos": 45841840, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000487205.5", "url": "https://www.ensembl.org/id/ENST00000487205.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000419403.1", "url": "https://www.ensembl.org/id/ENSP00000419403.1" } ] } }, { "isoform_ac": "O14734-1", "url": "", "sequence": { "sequence": "MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL", "length": 319, "header": "sp|O14734-1|ACOT8_HUMAN Isoform 1 of Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857315, "end_pos": 45841841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000217455.9", "url": "https://www.ensembl.org/id/ENST00000217455.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000217455.4", "url": "https://www.ensembl.org/id/ENSP00000217455.4" } ] } }, { "isoform_ac": "Q9BR14-1", "url": "", "sequence": { "sequence": "SPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRADALMCSA", "length": 92, "header": "tr|Q9BR14-1|Q9BR14_HUMAN Computationally mapped isoform of palmitoyl-CoA hydrolase OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1 CANONICAL=O14734-1" }, "locus": { "chromosome": "20", "start_pos": 45857309, "end_pos": 45853960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000426915.1", "url": "https://www.ensembl.org/id/ENST00000426915.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000416217.1", "url": "https://www.ensembl.org/id/ENSP00000416217.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O14734", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14734" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14734", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14734" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and characterization of the human orthologue of yeast Pex14p.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Will GK, Soukupova M, Hong X, Erdmann KS, Kiel JA, Dodt G, Kunau WH, Erdmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033241" } ], "reference": [ { "type": "PubMed", "id": "10022913", "url": "https://glygen.org/publication/PubMed/10022913" } ] }, { "title": "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.", "journal": "Genomics", "date": "1999", "authors": "Gafvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Bjorkhem I, Eggertsen G", "evidence": [ { "database": "Reactome", "id": "R-HSA-193368", "url": 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Biol. 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"id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734" } ], "pmid": "" }, { "name": "hydroxymethylglutaryl-CoA hydrolase activity", "id": "GO:0047994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047994", "evidence": [ { "database": "UniProtKB", "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734" } ], "pmid": "" }, { "name": "glutaryl-CoA hydrolase activity", "id": "GO:0044466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044466", "evidence": [ { "database": "UniProtKB", "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisomal matrix", "id": "GO:0005782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005782", "evidence": [ { "database": "UniProtKB", "id": "O14734", "url": "https://www.uniprot.org/uniprot/O14734" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { 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"equation": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "15673", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15673" } ] }, { "id": "16305", "name": "", "equation": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "16305", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16305" } ] }, { "id": "16645", "name": "", "equation": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P80250-1", "P13437-1", "P97570-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "Q6ZUV0-1", "O00154-1", "Q14032-1", "Q8N1Q8-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "O60733-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "P97819-1", "Q8R197-1", "Q9CQR4-1", "P41903-1" ], "evidence": [ { "id": "16645", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16645" } ] }, { "id": "20289", "name": "", "equation": "acetyl-CoA + H2O = acetate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "Q99NB7-1", "P13437-1", "Q8WYK0-1", "O14734-1", "P42765-1", "P58137-1", "Q9DBK0-1", "Q8BWT1-1", "P32316-1", "P53208-1", "Q54K91-1", "Q9VAC1-1" ], "evidence": [ { "id": "20289", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20289" } ] }, { "id": "30135", "name": "", "equation": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "30135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30135" } ] }, { "id": "30139", "name": "", "equation": "H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "O00154-1", "Q14032-1", "Q8N1Q8-1", "Q68D91-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BL86-1" ], "evidence": [ { "id": "30139", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30139" } ] }, { "id": "30143", "name": "", "equation": "H2O + octanoyl-CoA = CoA + H(+) + octanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "O14734-1", "O00154-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "P58137-1", "Q6Q2Z6-1", "Q91V12-1", "Q8BWT1-1", "Q3UUI3-1", "Q9CQR4-1" ], "evidence": [ { "id": "30143", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30143" } ] }, { "id": "31511", "name": "", "equation": "chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63276-1", "Q8VHK0-1", "O14734-1", "Q14032-1", "P58137-1", "Q91X34-1" ], "evidence": [ { "id": "31511", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31511" } ] }, { "id": "40059", "name": "", "equation": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "O00154-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q8BWT1-1", "Q3UUI3-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "40059", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40059" } ] }, { "id": "40103", "name": "", "equation": "H2O + propanoyl-CoA = CoA + H(+) + propanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "P13437-1", "O14734-1", "P42765-1", "P58137-1", "Q8BWT1-1" ], "evidence": [ { "id": "40103", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40103" } ] }, { "id": "40111", "name": "", "equation": "butanoyl-CoA + H2O = butanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "Q99NB7-1", "P13437-1", "Q8WYK0-1", "O14734-1", "Q8WXI4-1", "P42765-1", "Q9NPJ3-1", "Q8VHQ9-1", "P58137-1", "Q9DBK0-1", "Q8BWT1-1", "Q9CQR4-1" ], "evidence": [ { "id": "40111", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40111" } ] }, { "id": "40115", "name": "", "equation": "H2O + hexanoyl-CoA = CoA + H(+) + hexanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "Q99NB7-1", "P13437-1", "Q8WYK0-1", "O14734-1", "P42765-1", "Q9NPJ3-1", "P58137-1", "Q9DBK0-1", "Q8BWT1-1", "Q9CQR4-1" ], "evidence": [ { "id": "40115", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40115" } ] }, { "id": "40119", "name": "", "equation": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "O00154-1", "Q14032-1", "Q8N1Q8-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "40119", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40119" } ] }, { "id": "40131", "name": "", "equation": "(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88267-1", "O55171-1", "Q8VHK0-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N1Q8-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1" ], "evidence": [ { "id": "40131", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40131" } ] }, { "id": "40135", "name": "", "equation": "(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40135" } ] }, { "id": "40139", "name": "", "equation": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q8VHK0-1", "Q64559-2", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "O00154-1", "Q8N1Q8-1", "Q5T1C6-1", "Q9NPJ3-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q3UUI3-1", "Q9CQR4-1" ], "evidence": [ { "id": "40139", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40139" } ] }, { "id": "40143", "name": "", "equation": "(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O55171-1", "Q8VHK0-1", "P49753-1", "O14734-1", "Q8N9L9-1", "Q8N1Q8-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "Q6Q2Z6-1", "Q9QYR9-1" ], "evidence": [ { "id": "40143", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40143" } ] }, { "id": "40147", "name": "", "equation": "eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q14032-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91X34-1" ], "evidence": [ { "id": "40147", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40147" } ] }, { "id": "40151", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "Q8VHK0-1", "O14734-1", "Q8N9L9-1", "Q8N1Q8-1", "Q5T1C6-1", "Q9NPJ3-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "Q6Q2Z6-1", "Q3UUI3-1" ], "evidence": [ { "id": "40151", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40151" } ] }, { "id": "40219", "name": "", "equation": "H2O + malonyl-CoA = CoA + H(+) + malonate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40219", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40219" } ] }, { "id": "40223", "name": "", "equation": "4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40223", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40223" } ] }, { "id": "40575", "name": "", "equation": "glutaryl-CoA + H2O = CoA + glutarate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "Q8N9L9-1", "P58137-1", "Q8BWN8-1" ], "evidence": [ { "id": "40575", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40575" } ] }, { "id": "40583", "name": "", "equation": "H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40583", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40583" } ] }, { "id": "40587", "name": "", "equation": "H2O + octanedioyl-CoA = CoA + H(+) + octanedioate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40587", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40587" } ] }, { "id": "40591", "name": "", "equation": "decanedioyl-CoA + H2O = CoA + decanedioate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40591", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40591" } ] }, { "id": "40595", "name": "", "equation": "dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "40595", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40595" } ] }, { "id": "40799", "name": "", "equation": "2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O14734-1" ], "evidence": [ { "id": "40799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40799" } ] }, { "id": "59936", "name": "", "equation": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "59936", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59936" } ] }, { "id": "59940", "name": "", "equation": "2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "59940", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59940" } ] }, { "id": "59948", "name": "", "equation": "H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "59948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59948" } ] }, { "id": "59952", "name": "", "equation": "2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VHK0-1", "O14734-1", "P58137-1" ], "evidence": [ { "id": "59952", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59952" } ] }, { "id": "R-HSA-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "equation": "", "summary": "The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8 (ACOT8) mediates the hydrolysis of choloyl-CoA to form cholate and CoASH (Jones et al. 1999, Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003).", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-192356" ], "output_participant_list": [ "R-ALL-193451" ], "enzyme_list": [ "O14734-1" ], "evidence": [ { "id": "R-HSA-193385", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193385" } ] }, { "id": "R-HSA-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "equation": "", "summary": "DHA-CoA preferentially moves back to the ER, perhaps as a free fatty acid. This conversion is usually catalysed by acyl-CoA thioesterases (ACOTs). No specific acyl-CoA thioesterase enzyme has been identified for the peroxisomal metabolism of DHA-CoA, but the peroxisomal ACOT8 has a wide substrate specificity and is likely to be responsible (Ferdinandusse et al. 2003, Hunt & Alexson. 2008).", "cellular_location": "peroxisomal matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-2066763" ], "enzyme_list": [ "O14734-1" ], "evidence": [ { "id": "R-HSA-2066779", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2066779" } ] }, { "id": "R-HSA-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "equation": "", "summary": "Peroxisomal ACOT8 catalyzes the hydrolysis of acetyl-CoA to form acetate and CoASH (Jones et al. 1999; Wanders and Waterham 2006).", "cellular_location": "peroxisomal matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-390305" ], "enzyme_list": [ "O14734-1" ], "evidence": [ { "id": "R-HSA-390304", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-390304" } ] }, { "id": "R-HSA-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "equation": "", "summary": "The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health.; Free fatty acids can act as detergents to disrupt membranes so their generation is normally tightly regulated to states where they will be rapidly consumed or sequestered. Acyl-coenzyme A (CoA) thioesterases (ACOTs) hydrolyse medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFA-CoA, LCFA-CoA) to their corresponding free fatty acids (MCFA, LCFA) and CoASH. ACOTs located in peroxisomes are ACOT4, 6 and 8 (Hunt et al. 2006, Hunt et al. 2002).", "cellular_location": "peroxisomal matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O14734-1", "Q8N9L9-1", "Q3I5F7-1" ], "evidence": [ { "id": "R-HSA-5690042", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5690042" } ] }, { "id": "R-HSA-9033233", "name": "PEX5S,L binds cargo proteins containing PTS1", "equation": "", "summary": "It is unclear how the long isoform of PEX5 (PEX5L) and the short isoform of PEX5 (PEX5S) are generated. A current hypothesis suggests alternative mRNA splicing. Both isoforms can bind the peroxisome targeting signal 1 (PTS1) located at the C-terminus of most of the proteins that are targeted to the peroxisomal matrix (Dodt et al. 1995, Fransen et al. 1995, Wiemer et al. 1995, Gatto et al. 2000, Brocard et al. 2003, Gatto et al. 2003, Harper et al. 2003, Ghosh and Berg 2010, Freitas et al. 2011, Okumoto et al. 2011). PTS1 typically contains Ser-Lys-Leu (SKL) at the C-terminus but substantial variation in sequences and affinities for PEX5 are observed and upstream residues can modulate binding to PEX5 (Lametschwandtner et al. 1998, Ghosh and Berg 2010, reviewed in Brocard and Hartig 2006).
A minority of peroxisomal matrix proteins contain PTS2. While the PEX5S isoform binds proteins containing PTS1, the PEX5L isoform binds either proteins containing PTS1 or PEX7 bound to proteins containing PTS2 (Braverman et al. 1998). Some proteins appear to be imported as oligomers, however this is rather inefficient as PEX5 appears to have a preference for monomeric substrates (Otera and Fujiki 2012, Freitas et al. 2011, Freitas et al. 2015, also inferred from mouse homologs). Mutations in PEX5 cause defects in peroxisomal import and comprise complementation group 2 of peroxisomal biogenesis disorders (also called Zellweger spectrum disorders) (Dodt et al. 1995, Wiemer et al. 1995). A specific mutation affecting only the PEX5L isoform is the cause of rhizomelic chondrodysplasia punctate type 5 (Bar\u00f8y et al. 2015).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22307-1", "P35914-1", "A8MXV4-1", "Q9NUI1-1", "Q9BTZ2-1", "Q9P0Z9-1", "O15228-1", "Q99489-1", "O14734-1", "P49753-1", "Q8N9L9-1", "P14920-1", "O15254-1", "Q99424-1", "Q15067-1", "Q9UHK6-1", "P04040-1", "P35228-1", "Q9UJM8-1", "Q9UKG9-1", "Q6QHF9-2", "P21549-1", "Q9BY49-1", "Q13011-1", "Q86WA8-1", "P43155-1", "O14975-1", "Q14032-1", "Q9Y2Q3-1", "P14735-1", "P0C024-1", "O75874-1", "Q9NYQ3-1", "Q9UJ83-1", "Q2T9J0-1" ], "evidence": [ { "id": "R-HSA-9033233", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033233" } ] }, { "id": "R-HSA-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "After binding the Docking and Translocation Module comprising PEX14, PEX13, PEX2, PEX10 and PEX12 , PEX5S or PEX5L bound to a cargo protein becomes localized to the membrane (Dodt et al. 1995, Wiemer et al. 1995, Alencastre et al. 2009, Francisco et al. 2013, Dias et al. 2017). In a reaction that is not yet fully characterized, the cargo protein is released into the peroxisomal matrix while PEX5S or PEX5L remains in the membrane (Dodt et al. 1995, Wiemer et al. 1995, Alencastre et al. 2009, Franscisco et al. 2013). One model for the reaction hypothesizes that PEX13:PEX14 (associated with PEX2:PEX10:PEX12) forms a barrel in the peroxisomal membrane while PEX5S or PEX5L acts as a plunger to guide the cargo through the barrel (Dias et al. 2017, Francisco et al. 2017). Notably, the reaction does not require a source of energy such as ATP (Oliveira et al. 2003). Mutations in PEX5 cause defects in import of PTS1-containing proteins or PTS2-containing proteins or both (Eberrink et al. 2009, Bar\u00f8y et al. 2015).", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22307-1", "P35914-1", "A8MXV4-1", "P28328-1", "Q9NUI1-1", "Q9BTZ2-1", "Q9P0Z9-1", "O15228-1", "Q99489-1", "O14734-1", "P49753-1", "Q8N9L9-1", "P14920-1", "O15254-1", "Q99424-1", "Q15067-1", "Q9UHK6-1", "P04040-1", "P35228-1", "Q9UJM8-1", "Q9UKG9-1", "Q6QHF9-2", "P21549-1", "O60683-1", "Q9BY49-1", "Q13011-1", "Q86WA8-1", "P43155-1", "O14975-1", "Q14032-1", "Q9Y2Q3-1", "P14735-1", "P0C024-1", "O75874-1", "Q9NYQ3-1", "Q9UJ83-1", "Q2T9J0-1" ], "evidence": [ { "id": "R-HSA-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033235" } ] }, { "id": "R-HSA-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "PEX5S or PEX5L bound to cargo proteins containing PTS1 interacts with the Docking and Translocation Module (PEX13:PEX14:PEX2:PEX10:PEX12) (Gould et al. 1996, Fransen et al. 1998, Will et al. 1999, Neufeld et al. 2009, Shiozawa et al. 2009, Freitas et al. 2011, Francisco et al. 2013, Neufeld et al. 2014, Dias et al. 2017).", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22307-1", "P35914-1", "A8MXV4-1", "P28328-1", "Q9NUI1-1", "Q9BTZ2-1", "Q9P0Z9-1", "O15228-1", "Q99489-1", "O14734-1", "P49753-1", "Q8N9L9-1", "P14920-1", "O15254-1", "Q99424-1", "Q15067-1", "Q9UHK6-1", "P04040-1", "P35228-1", "Q9UJM8-1", "Q9UKG9-1", "Q6QHF9-2", "P21549-1", "O60683-1", "Q9BY49-1", "Q13011-1", "Q86WA8-1", "P43155-1", "O14975-1", "Q14032-1", "Q9Y2Q3-1", "P14735-1", "P0C024-1", "O75874-1", "Q9NYQ3-1", "Q9UJ83-1", "Q2T9J0-1" ], "evidence": [ { "id": "R-HSA-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033236" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-192356", "participant_name": "choloyl-CoA [peroxisomal matrix]", "crossref": [ { "id": "57373", "database": "ChEBI", "url": "" }, { "id": "57373", "database": "ChEBI", "url": "" }, { "id": "57373", "database": "ChEBI", "url": "" }, { "id": "57373", "database": "ChEBI", "url": "" }, { "id": "57373", "database": "ChEBI", "url": "" }, { "id": "57373", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-193451", "participant_name": "cholate [peroxisomal matrix]", "crossref": [ { "id": "29747", "database": "ChEBI", "url": "" }, { "id": "000006858022", "database": "ZINC", "url": "" }, { "id": "29747", "database": "ChEBI", "url": "" }, { "id": "000006858022", "database": "ZINC", "url": "" }, { "id": "29747", "database": "ChEBI", "url": "" }, { "id": "000006858022", "database": "ZINC", "url": "" }, { "id": "29747", "database": "ChEBI", "url": "" }, { "id": "000006858022", "database": "ZINC", "url": "" }, { "id": "29747", "database": "ChEBI", "url": "" }, { "id": "000006858022", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-2066763", "participant_name": "DHA [peroxisomal matrix]", "crossref": [ { "id": "77016", "database": "ChEBI", "url": "" }, { "id": "000004474564", "database": "ZINC", "url": "" }, { "id": "000004474564", "database": "ZINC", "url": "" }, { "id": "77016", "database": "ChEBI", "url": "" }, { "id": "77016", "database": "ChEBI", "url": "" }, { "id": "000004474564", "database": "ZINC", "url": "" }, { "id": "77016", "database": "ChEBI", "url": "" }, { "id": "000004474564", "database": "ZINC", "url": "" }, { "id": "77016", "database": "ChEBI", "url": "" }, { "id": "000004474564", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-390305", "participant_name": "CH3COO- [peroxisomal matrix]", "crossref": [ { "id": "C00033", "database": "COMPOUND", "url": "" }, { "id": "15366", "database": "ChEBI", 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"ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] } ] }, { "uniprot_ac": "O14734", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] } ] }, { "uniprot_ac": "O14975", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] } ] }, { "uniprot_ac": "O15228", "gene_name": "GNPAT", "activity": [ { "ec_number": "2.3.1.42", "activity": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "O15228", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15228" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "O15228", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15228" } ] } ] }, { "uniprot_ac": "O15254", "gene_name": "ACOX3", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "O15254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15254" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "O15254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15254" } ] } ] }, { "uniprot_ac": "O55137", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O60683", "gene_name": "PEX10", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O60683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60683" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O60683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60683" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O75874", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "O75874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75874" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "O75874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75874" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "P04040", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "P04040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04040" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P04040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04040" } ] } ] }, { "uniprot_ac": "P08635", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] } ] }, { "uniprot_ac": "P0C024", "gene_name": "NUDT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "P0C024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C024" } ] } ] }, { "uniprot_ac": "P13437", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] } ] }, { "uniprot_ac": "P14735", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "P14735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14735" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "P14735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14735" } ] } ] }, { "uniprot_ac": "P14920", "gene_name": "DAO", "activity": [ { "ec_number": "1.4.3.3", "activity": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+).", "evidence": [ { "id": "P14920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14920" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "P14920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14920" } ] } ] }, { "uniprot_ac": "P21549", "gene_name": "AGXT", "activity": [ { "ec_number": "2.6.1.51", "activity": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.", "evidence": [ { "id": "P21549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21549" } ] }, { "ec_number": "2.6.1.44", "activity": "2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate.", "evidence": [ { "id": "P21549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21549" } ] }, { "ec_number": "2.6.1.44", "activity": "", "evidence": [ { "id": "P21549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21549" } ] } ] }, { "uniprot_ac": "P22307", "gene_name": "SCP2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "P22307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22307" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "P22307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22307" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P22307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22307" } ] }, { "ec_number": "2.3.1.155", "activity": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "P22307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22307" } ] } ] }, { "uniprot_ac": "P28328", "gene_name": "PEX2", "activity": [ { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "P28328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28328" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "P28328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28328" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P28328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28328" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P28328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28328" } ] } ] }, { "uniprot_ac": "P32316", "gene_name": "ACH1", "activity": [ { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P32316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32316" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "P32316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32316" } ] } ] }, { "uniprot_ac": "P35228", "gene_name": "NOS2", "activity": [ { "ec_number": "1.14.13.39", "activity": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide.", "evidence": [ { "id": "P35228", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35228" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "P35228", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35228" } ] } ] }, { "uniprot_ac": "P35914", "gene_name": "HMGCL", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "P35914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35914" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "P35914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35914" } ] } ] }, { "uniprot_ac": "P41903", "gene_name": "TES1", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] } ] }, { "uniprot_ac": "P42765", "gene_name": "ACAA2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] } ] }, { "uniprot_ac": "P43155", "gene_name": "CRAT", "activity": [ { "ec_number": "2.3.1.137", "activity": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine.", "evidence": [ { "id": "P43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43155" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine.", "evidence": [ { "id": "P43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43155" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "P43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43155" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "P43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43155" } ] } ] }, { "uniprot_ac": "P49753", "gene_name": "ACOT2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] } ] }, { "uniprot_ac": "P53208", "gene_name": "EAT1", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P53208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53208" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P53208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53208" } ] }, { "ec_number": "2.3.1.268", "activity": "acetyl-CoA + ethanol = CoA + ethyl acetate.", "evidence": [ { "id": "P53208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53208" } ] }, { "ec_number": "2.3.1.268", "activity": "", "evidence": [ { "id": "P53208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53208" } ] } ] }, { "uniprot_ac": "P58137", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] } ] }, { "uniprot_ac": "P80250", "gene_name": "", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "Q13011", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.-", "activity": "", "evidence": [ { "id": "Q13011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13011" } ] } ] }, { "uniprot_ac": "Q14032", "gene_name": "BAAT", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] } ] }, { "uniprot_ac": "Q15067", "gene_name": "ACOX1", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "Q15067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15067" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "Q15067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15067" } ] } ] }, { "uniprot_ac": "Q2T9J0", "gene_name": "TYSND1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q2T9J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2T9J0" } ] } ] }, { "uniprot_ac": "Q3I5F7", "gene_name": "ACOT6", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3I5F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3I5F7" } ] } ] }, { "uniprot_ac": "Q3UUI3", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] } ] }, { "uniprot_ac": "Q54K91", "gene_name": "ach1", "activity": [ { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q54K91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K91" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q54K91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K91" } ] } ] }, { "uniprot_ac": "Q566R0", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] } ] }, { "uniprot_ac": "Q5T1C6", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] } ] }, { "uniprot_ac": "Q63276", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] } ] }, { "uniprot_ac": "Q64559", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] } ] }, { "uniprot_ac": "Q68D91", "gene_name": "MBLAC2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] } ] }, { "uniprot_ac": "Q6Q2Z6", "gene_name": "Acot5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] } ] }, { "uniprot_ac": "Q6QHF9", "gene_name": "PAOX", "activity": [ { "ec_number": "1.5.3.13", "activity": "H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine.", "evidence": [ { "id": "Q6QHF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6QHF9" } ] }, { "ec_number": "1.5.3.13", "activity": "", "evidence": [ { "id": "Q6QHF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6QHF9" } ] } ] }, { "uniprot_ac": "Q6ZUV0", "gene_name": "ACOT7L", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] } ] }, { "uniprot_ac": "Q86TX2", "gene_name": "ACOT1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] } ] }, { "uniprot_ac": "Q86WA8", "gene_name": "LONP2", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q86WA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WA8" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q86WA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WA8" } ] } ] }, { "uniprot_ac": "Q8BL86", "gene_name": "Mblac2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] } ] }, { "uniprot_ac": "Q8BWN8", "gene_name": "Acot4", "activity": [ { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8BWN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWN8" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8BWN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWN8" } ] } ] }, { "uniprot_ac": "Q8BWT1", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] } ] }, { "uniprot_ac": "Q8N1Q8", "gene_name": "THEM5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] } ] }, { "uniprot_ac": "Q8N9L9", "gene_name": "ACOT4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] } ] }, { "uniprot_ac": "Q8R197", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] } ] }, { "uniprot_ac": "Q8VHK0", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] } ] }, { "uniprot_ac": "Q8VHQ9", "gene_name": "Acot11", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8VHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHQ9" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHQ9" } ] } ] }, { "uniprot_ac": "Q8WXI4", "gene_name": "ACOT11", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8WXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXI4" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8WXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXI4" } ] } ] }, { "uniprot_ac": "Q8WYK0", "gene_name": "ACOT12", "activity": [ { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8WYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q8WYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYK0" } ] } ] }, { "uniprot_ac": "Q91V12", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q91V12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V12" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q91V12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V12" } ] } ] }, { "uniprot_ac": "Q91X34", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] } ] }, { "uniprot_ac": "Q99424", "gene_name": "ACOX2", "activity": [ { "ec_number": "1.17.99.3", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2.", "evidence": [ { "id": "Q99424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99424" } ] }, { "ec_number": "1.17.99.3", "activity": "", "evidence": [ { "id": "Q99424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99424" } ] } ] }, { "uniprot_ac": "Q99489", "gene_name": "DDO", "activity": [ { "ec_number": "1.4.3.1", "activity": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate.", "evidence": [ { "id": "Q99489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99489" } ] }, { "ec_number": "1.4.3.1", "activity": "", "evidence": [ { "id": "Q99489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99489" } ] } ] }, { "uniprot_ac": "Q99NB7", "gene_name": "Acot12", "activity": [ { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q99NB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NB7" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q99NB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NB7" } ] } ] }, { "uniprot_ac": "Q9BTZ2", "gene_name": "DHRS4", "activity": [ { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "Q9BTZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTZ2" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q9BTZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTZ2" } ] } ] }, { "uniprot_ac": "Q9BY49", "gene_name": "PECR", "activity": [ { "ec_number": "1.3.1.38", "activity": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+).", "evidence": [ { "id": "Q9BY49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY49" } ] }, { "ec_number": "1.3.1.38", "activity": "", "evidence": [ { "id": "Q9BY49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY49" } ] } ] }, { "uniprot_ac": "Q9CQJ0", "gene_name": "Them5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9CQJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQJ0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q9CQJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQJ0" } ] } ] }, { "uniprot_ac": "Q9CQR4", "gene_name": "Acot13", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9CQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQR4" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9CQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQR4" } ] } ] }, { "uniprot_ac": "Q9DBK0", "gene_name": "Acot12", "activity": [ { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q9DBK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q9DBK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK0" } ] } ] }, { "uniprot_ac": "Q9NPJ3", "gene_name": "ACOT13", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9NPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NPJ3" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9NPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NPJ3" } ] } ] }, { "uniprot_ac": "Q9NUI1", "gene_name": "DECR2", "activity": [ { "ec_number": "1.3.1.124", "activity": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+).", "evidence": [ { "id": "Q9NUI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NUI1" } ] }, { "ec_number": "1.3.1.124", "activity": "", "evidence": [ { "id": "Q9NUI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NUI1" } ] } ] }, { "uniprot_ac": "Q9NV23", "gene_name": "OLAH", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "Q9NV23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV23" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "Q9NV23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV23" } ] } ] }, { "uniprot_ac": "Q9NYQ3", "gene_name": "HAO2", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q9NYQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NYQ3" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q9NYQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NYQ3" } ] } ] }, { "uniprot_ac": "Q9P0Z9", "gene_name": "PIPOX", "activity": [ { "ec_number": "1.5.3.1", "activity": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q9P0Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P0Z9" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q9P0Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P0Z9" } ] }, { "ec_number": "1.5.3.7", "activity": "L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate.", "evidence": [ { "id": "Q9P0Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P0Z9" } ] }, { "ec_number": "1.5.3.7", "activity": "", "evidence": [ { "id": "Q9P0Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P0Z9" } ] } ] }, { "uniprot_ac": "Q9QYR7", "gene_name": "Acot3", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9QYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR7" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q9QYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR7" } ] } ] }, { "uniprot_ac": "Q9QYR9", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9QYR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR9" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q9QYR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR9" } ] } ] }, { "uniprot_ac": "Q9UHK6", "gene_name": "AMACR", "activity": [ { "ec_number": "5.1.99.4", "activity": "a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA.", "evidence": [ { "id": "Q9UHK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHK6" } ] }, { "ec_number": "5.1.99.4", "activity": "", "evidence": [ { "id": "Q9UHK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHK6" } ] } ] }, { "uniprot_ac": "Q9UJ83", "gene_name": "HACL1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "Q9UJ83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UJ83" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "Q9UJ83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UJ83" } ] } ] }, { "uniprot_ac": "Q9UJM8", "gene_name": "HAO1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q9UJM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UJM8" } ] }, { "ec_number": "1.2.3.5", "activity": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate.", "evidence": [ { "id": "Q9UJM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UJM8" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q9UJM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UJM8" } ] } ] }, { "uniprot_ac": "Q9UKG9", "gene_name": "CROT", "activity": [ { "ec_number": "2.3.1.137", "activity": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine.", "evidence": [ { "id": "Q9UKG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKG9" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "Q9UKG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKG9" } ] } ] }, { "uniprot_ac": "Q9VAC1", "gene_name": "anon-WO0153538.36", "activity": [ { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q9VAC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VAC1" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q9VAC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VAC1" } ] } ] }, { "uniprot_ac": "Q9Y2Q3", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "Q9Y2Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2Q3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q9Y2Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2Q3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 3 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 128 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }