{ "uniprot_canonical_ac": "O14727-1", "uniprot_ac": "O14727", "uniprot_id": "APAF_HUMAN", "mass": { "chemical_mass": 141840.0, "monoisotopic_mass": 141840.0 }, "refseq": { "ac": "NP_001151", "name": "apoptotic protease-activating factor 1 isoform b", "summary": "This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" }, "gene_names": [ { "name": "APAF1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14727", "id": "O14727" }, { "name": "APAF-1; CED4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151", "id": "NP_001151" }, { "name": "APAF1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151", "id": "NP_001151" }, { "name": "KIAA0413", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14727", "id": "O14727" } ], "protein_names": [ { "name": "Apoptotic protease-activating factor 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14727" }, { "name": "APAF-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14727" }, { "name": "apoptotic protease-activating factor 1 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151", "id": "NP_001151" }, { "name": "apoptotic protease-activating factor 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151", "id": "NP_001151" } ], "function": [ { "annotation": "APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" }, { "database": "PubMed", "id": "35975461", "url": "https://glygen.org/publication/PubMed/35975461" } ] }, { "annotation": "Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" }, { "database": "PubMed", "id": "34507064", "url": "https://glygen.org/publication/PubMed/34507064" } ] }, { "annotation": "Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" }, { "database": "PubMed", "id": "35030371", "url": "https://glygen.org/publication/PubMed/35030371" } ] }, { "annotation": "Exosomal microRNA rectangle93 rectangle3p secreted by bone marrow mesenchymal stem cells downregulates apoptotic peptidase activating factor 1 to promote wound healing.", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" }, { "database": "PubMed", "id": "34898374", "url": "https://glygen.org/publication/PubMed/34898374" } ] }, { "annotation": "Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727#function" }, { "database": "PubMed", "id": "10393175", "url": "https://glygen.org/publication/PubMed/10393175" }, { "database": "PubMed", "id": "12804598", "url": "https://glygen.org/publication/PubMed/12804598" } ] }, { "annotation": "This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" } ] }, { "annotation": "Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" }, { "database": "PubMed", "id": "37108258", "url": "https://glygen.org/publication/PubMed/37108258" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O14727", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14727" } ], "glycoeffect": [], "start_pos": 1014, "end_pos": 1014, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "12", "chr_pos": "98715508", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D1014", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O14727", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14727" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14727" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O14727", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14727" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "O14727-1", "url": "https://www.uniprot.org/uniprot/O14727-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14727-2", "url": "https://www.uniprot.org/uniprot/O14727-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14727-3", "url": "https://www.uniprot.org/uniprot/O14727-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14727-4", "url": "https://www.uniprot.org/uniprot/O14727-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14727-5", "url": "https://www.uniprot.org/uniprot/O14727-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14727-6", "url": "https://www.uniprot.org/uniprot/O14727-6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1248, "header": "sp|O14727-1|APAF_HUMAN Isoform 1 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "isoforms": [ { "isoform_ac": "C9JLV4-1", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1163, "header": "tr|C9JLV4-1|C9JLV4_HUMAN Computationally mapped isoform of Apoptotic peptidase activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=1 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98732563, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000549007.1", "url": "https://www.ensembl.org/id/ENST00000549007.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000448161.1", "url": "https://www.ensembl.org/id/ENSP00000448161.1" } ] } }, { "isoform_ac": "F8VNZ0-1", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYGLYPLYLLSLCYQNCFGFVLL", "length": 130, "header": "tr|F8VNZ0-1|F8VNZ0_HUMAN Computationally mapped isoform of Apoptotic peptidase activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=1 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98648877, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000547743.1", "url": "https://www.ensembl.org/id/ENST00000547743.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000450175.1", "url": "https://www.ensembl.org/id/ENSP00000450175.1" } ] } }, { "isoform_ac": "O14727-1", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1248, "header": "sp|O14727-1|APAF_HUMAN Isoform 1 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98732563, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000551964.6", "url": "https://www.ensembl.org/id/ENST00000551964.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000448165.2", "url": "https://www.ensembl.org/id/ENSP00000448165.2" } ] } }, { "isoform_ac": "O14727-2", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1237, "header": "sp|O14727-2|APAF_HUMAN Isoform 2 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98732563, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000550527.5", "url": "https://www.ensembl.org/id/ENST00000550527.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000448449.1", "url": "https://www.ensembl.org/id/ENSP00000448449.1" } ] } }, { "isoform_ac": "O14727-3", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1194, "header": "sp|O14727-3|APAF_HUMAN Isoform 3 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98732563, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000359972.6", "url": "https://www.ensembl.org/id/ENST00000359972.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000353059.2", "url": "https://www.ensembl.org/id/ENSP00000353059.2" } ] } }, { "isoform_ac": "O14727-4", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1205, "header": "sp|O14727-4|APAF_HUMAN Isoform 4 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98732563, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000547045.5", "url": "https://www.ensembl.org/id/ENST00000547045.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000449791.1", "url": "https://www.ensembl.org/id/ENSP00000449791.1" } ] } }, { "isoform_ac": "O14727-5", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSETLGFESKKVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE", "length": 1171, "header": "sp|O14727-5|APAF_HUMAN Isoform 5 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "locus": {} }, { "isoform_ac": "O14727-6", "url": "", "sequence": { "sequence": "MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKVVERCHWGILTDLLHKWNQS", "length": 338, "header": "sp|O14727-6|APAF_HUMAN Isoform 6 of Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 CANONICAL=O14727-1" }, "locus": { "chromosome": "12", "start_pos": 98732478, "end_pos": 98648360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000552268.5", "url": "https://www.ensembl.org/id/ENST00000552268.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000448826.1", "url": "https://www.ensembl.org/id/ENSP00000448826.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O14727", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14727" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [ { "start_pos": 204, "end_pos": 204, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14727", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14727" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "phospho.ELM", "id": "O14727", "url": "http://phospho.elm.eu.org/byAccession/O14727.html" } ], "site_lbl": "Thr204" }, { "start_pos": 238, "end_pos": 238, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14727", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14727" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "O14727", "url": "http://phospho.elm.eu.org/byAccession/O14727.html" } ], "site_lbl": "Ser238" }, { "start_pos": 248, "end_pos": 248, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14727", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14727" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "O14727", "url": "http://phospho.elm.eu.org/byAccession/O14727.html" } ], "site_lbl": "Ser248" }, { "start_pos": 268, "end_pos": 268, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14727", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14727" }, { "database": "PubMed", "id": "22246185", "url": "https://glygen.org/publication/PubMed/22246185" }, { "database": "PubMed", "id": "29511177", "url": "https://glygen.org/publication/PubMed/29511177" } ], "site_lbl": "Ser268" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Zou H, Li Y, Liu X, Wang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-111459", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111459" } ], "reference": [ { "type": "PubMed", "id": "10206961", "url": "https://glygen.org/publication/PubMed/10206961" } ] }, { "title": "Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Saleh A, Srinivasula S M, Acharya S, Fishel R, Alnemri E S", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" } ], "reference": [ { "type": "PubMed", "id": "10364241", "url": "https://glygen.org/publication/PubMed/10364241" } ] }, { "title": "Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.", "journal": "The EMBO journal", "date": "1999", "authors": "Hu Y, Benedict MA, Ding L, Nunez G", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" }, { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "10393175", "url": "https://glygen.org/publication/PubMed/10393175" } ] }, { "title": "Three new types of Apaf-1 in mammalian cells.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1999", "authors": "Hahn C, Hirsch B, Jahnke D, D\u00fcrkop H, Stein H", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" } ], "reference": [ { "type": "PubMed", "id": "10441496", "url": "https://glygen.org/publication/PubMed/10441496" } ] }, { "title": "Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.", "journal": "J. Mol. Biol.", "date": "1999", "authors": "Vaughn D E, Rodriguez J, Lazebnik Y, Joshua-Tor L", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" } ], "reference": [ { "type": "PubMed", "id": "10543941", "url": "https://glygen.org/publication/PubMed/10543941" } ] }, { "title": "Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.", "journal": "Cell Death Differ.", "date": "1999", "authors": "Day C L, Dupont C, Lackmann M, Vaux D L, Hinds M G", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" } ], "reference": [ { "type": "PubMed", "id": "10578182", "url": "https://glygen.org/publication/PubMed/10578182" } ] }, { "title": "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.", "journal": "Cell", "date": "2000", "authors": "Du C, Fang M, Li Y, Li L, Wang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-111463", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111463" } ], "reference": [ { "type": "PubMed", "id": "10929711", "url": "https://glygen.org/publication/PubMed/10929711" } ] }, { "title": "Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.", "journal": "Molecular cell", "date": "2000", "authors": "Chau BN, Cheng EH, Kerr DA, Hardwick JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9627069", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9627069" } ], "reference": [ { "type": "PubMed", "id": "10949025", "url": "https://glygen.org/publication/PubMed/10949025" } ] }, { "title": "Structural and biochemical basis of apoptotic activation by Smac/DIABLO.", "journal": "Nature", "date": "2000", "authors": "Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-111463", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111463" } ], "reference": [ { "type": "PubMed", "id": "10972280", "url": "https://glygen.org/publication/PubMed/10972280" } ] }, { "title": "Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis.", "journal": "Nature genetics", "date": "2000", "authors": "Lin Y, Ma W, Benchimol S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "10973264", "url": "https://glygen.org/publication/PubMed/10973264" } ] }, { "title": "ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.", "journal": "Current biology : CB", "date": "2000", "authors": "Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-111463", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111463" } ], "reference": [ { "type": "PubMed", "id": "11084335", "url": "https://glygen.org/publication/PubMed/11084335" } ] }, { 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}, { "title": "Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells.", "journal": "Biochemical and biophysical research communications", "date": "2021", "authors": "Wang Z, Qu K, Zhou L, Ren L, Ren B, Meng F, Yu W, Wang H, Fan H", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" } ], "reference": [ { "type": "PubMed", "id": "34507064", "url": "https://glygen.org/publication/PubMed/34507064" } ] }, { "title": "Exosomal microRNA rectangle93 rectangle3p secreted by bone marrow mesenchymal stem cells downregulates apoptotic peptidase activating factor 1 to promote wound healing.", "journal": "Bioengineered", "date": "2022", "authors": "Shen C, Tao C, Zhang A, Li X, Guo Y, Wei H, Yin Q, Li Q, Jin P", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" } ], "reference": [ { "type": "PubMed", "id": 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Ruibao, Kang Wei, Xue Yuanchao, Mo Ran, Sun Beicheng, Wang Shouyu", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" } ], "reference": [ { "type": "PubMed", "id": "35975461", "url": "https://glygen.org/publication/PubMed/35975461" } ] }, { "title": "Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.", "journal": "International journal of molecular sciences", "date": "2023-04-12", "authors": "Chang Kuo-Hsuan, Liu Chia-Hsin, Wang Yi-Ru, Lo Yen-Shi, Chang Chun-Wei, Wu Hsiu-Chuan, Chen Chiung-Mei", "evidence": [ { "database": "RefSeq", "id": "NP_001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001151" } ], "reference": [ { "type": "PubMed", "id": "37108258", "url": "https://glygen.org/publication/PubMed/37108258" } ] }, { "title": "Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "DeGregori J, Kowalik T, Nevins JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8953750" } ], "reference": [ { "type": "PubMed", "id": "7623816", "url": "https://glygen.org/publication/PubMed/7623816" } ] }, { "title": "Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3.", "journal": "Cell", "date": "1993", "authors": "Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "8242741", "url": "https://glygen.org/publication/PubMed/8242741" } ] }, { "title": "Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1996", "authors": "Le Cabec V, Cowland JB, Calafat J, Borregaard N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695" } ], "reference": [ { "type": "PubMed", "id": "8692836", "url": "https://glygen.org/publication/PubMed/8692836" } ] }, { "title": "X-linked IAP is a direct inhibitor of cell-death proteases.", "journal": "Nature", "date": "1997", "authors": "Deveraux QL, Takahashi R, Salvesen GS, Reed JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-111463", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111463" } ], "reference": [ { "type": "PubMed", "id": "9230442", "url": "https://glygen.org/publication/PubMed/9230442" } ] }, { "title": "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.", "journal": "Cell", "date": "1997", "authors": "Zou H, Henzel WJ, Liu X, Lutschg A, Wang X", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" }, { "database": "Reactome", "id": "R-HSA-111458", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111458" } ], "reference": [ { "type": "PubMed", "id": "9267021", "url": "https://glygen.org/publication/PubMed/9267021" } ] }, { "title": "Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.", "journal": "Cell", "date": "1997", "authors": "Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-111459", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111459" } ], "reference": [ { "type": "PubMed", "id": "9390557", "url": "https://glygen.org/publication/PubMed/9390557" } ] }, { "title": "E2F-6, a member of the E2F family that can behave as a transcriptional repressor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8953750" } ], "reference": [ { "type": "PubMed", "id": "9501179", "url": "https://glygen.org/publication/PubMed/9501179" } ] }, { "title": "Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.", "journal": "Mol. Cell", "date": "1998", "authors": "Srinivasula S M, Ahmad M, Fernandes-Alnemri T, Alnemri E S", "evidence": [ { "database": "UniProtKB", "id": "O14727", "url": "https://www.uniprot.org/uniprot/O14727" } ], "reference": [ { "type": "PubMed", "id": "9651578", "url": "https://glygen.org/publication/PubMed/9651578" } ] }, { "title": "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Gaubatz S, Wood JG, Livingston DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8953750" } ], "reference": [ { "type": "PubMed", "id": "9689056", "url": "https://glygen.org/publication/PubMed/9689056" } ] }, { "title": "E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.", "journal": "Oncogene", "date": "1998", 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