{
    "uniprot_canonical_ac": "O14684-1",
    "uniprot_ac": "O14684",
    "uniprot_id": "PTGES_HUMAN",
    "mass": {
        "chemical_mass": 17102.0,
        "monoisotopic_mass": 17102.0
    },
    "refseq": {
        "ac": "NP_004869",
        "name": "prostaglandin E synthase",
        "summary": "The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869"
    },
    "gene_names": [
        {
            "name": "PTGES",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/O14684",
            "id": "O14684"
        },
        {
            "name": "MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1; PGES; PIG12; PP102; PP1294; TP53I12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869",
            "id": "NP_004869"
        },
        {
            "name": "MGST1L1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O14684",
            "id": "O14684"
        },
        {
            "name": "MPGES1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O14684",
            "id": "O14684"
        },
        {
            "name": "PGES",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O14684",
            "id": "O14684"
        },
        {
            "name": "PIG12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O14684",
            "id": "O14684"
        },
        {
            "name": "PTGES",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869",
            "id": "NP_004869"
        }
    ],
    "protein_names": [
        {
            "name": "Prostaglandin E synthase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "1.11.1.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "2.5.1.18",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "5.3.99.3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "Glutathione peroxidase PTGES",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "Glutathione transferase PTGES",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "MGST1-L1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "MPGES-1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "Microsomal glutathione S-transferase 1-like 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "Microsomal prostaglandin E synthase 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "microsomal glutathione S-transferase 1-like 1; tumor protein p53 inducible protein 12; p53-induced apoptosis protein 12; MGST1-like 1; microsomal prostaglandin E synthase-1; p53-induced gene 12 protein; glutathione peroxidase PTGES; glutathione transferase PTGES",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869",
            "id": "NP_004869"
        },
        {
            "name": "p53-induced gene 12 protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O14684"
        },
        {
            "name": "prostaglandin E synthase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869",
            "id": "NP_004869"
        }
    ],
    "function": [
        {
            "annotation": "Clinical data mining reveals analgesic effects of lapatinib in cancer patients. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_004869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869"
                },
                {
                    "database": "PubMed",
                    "id": "33574423",
                    "url": "https://glygen.org/publication/PubMed/33574423"
                }
            ]
        },
        {
            "annotation": "PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_004869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869"
                },
                {
                    "database": "PubMed",
                    "id": "37108468",
                    "url": "https://glygen.org/publication/PubMed/37108468"
                }
            ]
        },
        {
            "annotation": "Studied the role that microsomal prostaglandin E synthase-1 (mPGES-1) derived prostaglandin E2 (PGE2) plays in cell migration in the pathogenesis of Hirschsprung disease. Results showed mPGES-1 derived PGE2 decreased the relative expression of EP2 and ARP2/3 and caused damage to cytoskeleton.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_004869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869"
                },
                {
                    "database": "PubMed",
                    "id": "30814036",
                    "url": "https://glygen.org/publication/PubMed/30814036"
                }
            ]
        },
        {
            "annotation": "Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer cells to 5-fluorouracil.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_004869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869"
                },
                {
                    "database": "PubMed",
                    "id": "37358009",
                    "url": "https://glygen.org/publication/PubMed/37358009"
                }
            ]
        },
        {
            "annotation": "Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684#function"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                },
                {
                    "database": "PubMed",
                    "id": "12672824",
                    "url": "https://glygen.org/publication/PubMed/12672824"
                },
                {
                    "database": "PubMed",
                    "id": "10869354",
                    "url": "https://glygen.org/publication/PubMed/10869354"
                },
                {
                    "database": "PubMed",
                    "id": "12460774",
                    "url": "https://glygen.org/publication/PubMed/12460774"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9JM51",
                    "url": "https://www.uniprot.org/uniprot/Q9JM51#function"
                },
                {
                    "database": "PubMed",
                    "id": "12244105",
                    "url": "https://glygen.org/publication/PubMed/12244105"
                },
                {
                    "database": "PubMed",
                    "id": "10377395",
                    "url": "https://glygen.org/publication/PubMed/10377395"
                }
            ]
        },
        {
            "annotation": "The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_004869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004869"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 110,
            "end_pos": 110,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Loss of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                },
                {
                    "database": "PubMed",
                    "id": "10869354",
                    "url": "https://glygen.org/publication/PubMed/10869354"
                }
            ]
        },
        {
            "start_pos": 110,
            "end_pos": 110,
            "sequence_org": "R",
            "sequence_mut": "S",
            "comment": "Loss of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                },
                {
                    "database": "PubMed",
                    "id": "10869354",
                    "url": "https://glygen.org/publication/PubMed/10869354"
                }
            ]
        },
        {
            "start_pos": 110,
            "end_pos": 110,
            "sequence_org": "R",
            "sequence_mut": "T",
            "comment": "Retains 17.8% of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "16439136",
                    "url": "https://glygen.org/publication/PubMed/16439136"
                }
            ]
        },
        {
            "start_pos": 114,
            "end_pos": 114,
            "sequence_org": "T",
            "sequence_mut": "V",
            "comment": "Retains 21.3% activity of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "16439136",
                    "url": "https://glygen.org/publication/PubMed/16439136"
                }
            ]
        },
        {
            "start_pos": 117,
            "end_pos": 117,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Loss of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                }
            ]
        },
        {
            "start_pos": 117,
            "end_pos": 117,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No effect on protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                },
                {
                    "database": "PubMed",
                    "id": "10869354",
                    "url": "https://glygen.org/publication/PubMed/10869354"
                }
            ]
        },
        {
            "start_pos": 126,
            "end_pos": 126,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Loss of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "27684486",
                    "url": "https://glygen.org/publication/PubMed/27684486"
                }
            ]
        },
        {
            "start_pos": 126,
            "end_pos": 126,
            "sequence_org": "R",
            "sequence_mut": "K",
            "comment": "Loss of prostaglandin-E synthase activity. Transforms prostaglandin-E synthase activity to prostaglandin-F(2alpha)synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "26755582",
                    "url": "https://glygen.org/publication/PubMed/26755582"
                }
            ]
        },
        {
            "start_pos": 126,
            "end_pos": 126,
            "sequence_org": "R",
            "sequence_mut": "L",
            "comment": "Loss of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "27684486",
                    "url": "https://glygen.org/publication/PubMed/27684486"
                }
            ]
        },
        {
            "start_pos": 126,
            "end_pos": 126,
            "sequence_org": "R",
            "sequence_mut": "Q",
            "comment": "Loss of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "26755582",
                    "url": "https://glygen.org/publication/PubMed/26755582"
                }
            ]
        },
        {
            "start_pos": 127,
            "end_pos": 127,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "27684486",
                    "url": "https://glygen.org/publication/PubMed/27684486"
                },
                {
                    "database": "PubMed",
                    "id": "26755582",
                    "url": "https://glygen.org/publication/PubMed/26755582"
                }
            ]
        },
        {
            "start_pos": 130,
            "end_pos": 130,
            "sequence_org": "Y",
            "sequence_mut": "I",
            "comment": "Loss of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "16439136",
                    "url": "https://glygen.org/publication/PubMed/16439136"
                }
            ]
        },
        {
            "start_pos": 134,
            "end_pos": 134,
            "sequence_org": "Q",
            "sequence_mut": "E",
            "comment": "Keeps about 40-50% of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "16439136",
                    "url": "https://glygen.org/publication/PubMed/16439136"
                }
            ]
        },
        {
            "start_pos": 36,
            "end_pos": 36,
            "sequence_org": "Q",
            "sequence_mut": "E",
            "comment": "Keeps about 40-50% of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "16439136",
                    "url": "https://glygen.org/publication/PubMed/16439136"
                }
            ]
        },
        {
            "start_pos": 49,
            "end_pos": 49,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Loss of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "27684486",
                    "url": "https://glygen.org/publication/PubMed/27684486"
                }
            ]
        },
        {
            "start_pos": 49,
            "end_pos": 49,
            "sequence_org": "D",
            "sequence_mut": "N",
            "comment": "Loss of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "26755582",
                    "url": "https://glygen.org/publication/PubMed/26755582"
                }
            ]
        },
        {
            "start_pos": 66,
            "end_pos": 66,
            "sequence_org": "E",
            "sequence_mut": "A",
            "comment": "Reduces protaglandin-E synthase activity by 50%.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                }
            ]
        },
        {
            "start_pos": 67,
            "end_pos": 67,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Loss of prostaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                }
            ]
        },
        {
            "start_pos": 70,
            "end_pos": 70,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Slightly reduced protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                }
            ]
        },
        {
            "start_pos": 70,
            "end_pos": 70,
            "sequence_org": "R",
            "sequence_mut": "S",
            "comment": "No effect on protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "10869354",
                    "url": "https://glygen.org/publication/PubMed/10869354"
                }
            ]
        },
        {
            "start_pos": 72,
            "end_pos": 72,
            "sequence_org": "H",
            "sequence_mut": "A",
            "comment": "Reduces protaglandin-E synthase activity by 70%.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "18682561",
                    "url": "https://glygen.org/publication/PubMed/18682561"
                }
            ]
        },
        {
            "start_pos": 73,
            "end_pos": 73,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Retains partial of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "27684486",
                    "url": "https://glygen.org/publication/PubMed/27684486"
                }
            ]
        },
        {
            "start_pos": 73,
            "end_pos": 73,
            "sequence_org": "R",
            "sequence_mut": "L",
            "comment": "Loss of protaglandin-E synthase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14684",
                    "url": "https://www.uniprot.org/uniprot/O14684"
                },
                {
                    "database": "PubMed",
                    "id": "27684486",
                    "url": "https://glygen.org/publication/PubMed/27684486"
                }
            ]
        }
    ],
    "expression_tissue": [
        {
            "tissue": {
                "name": "Adult mammalian kidney",
                "namespace": "UBERON",
                "id": "0000082",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000082"
            },
            "score": "74.33",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Oral cavity",
                "namespace": "UBERON",
                "id": "0000167",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000167"
            },
            "score": "78.63",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Stomach",
                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "score": "68.57",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Uterus",
                "namespace": "UBERON",
                "id": "0000995",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000995"
            },
            "score": "82.58",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Esophagus",
                "namespace": "UBERON",
                "id": "0001043",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043"
            },
            "score": "89.64",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Rectum",
                "namespace": "UBERON",
                "id": "0001052",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001052"
            },
            "score": "75.91",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Colon",
                "namespace": "UBERON",
                "id": "0001155",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155"
            },
            "score": "58.42",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Urinary bladder",
                "namespace": "UBERON",
                "id": "0001255",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255"
            },
            "score": "81.48",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "score": "69.23",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Lung",
                "namespace": "UBERON",
                "id": "0002048",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048"
            },
            "score": "58.3",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Liver",
                "namespace": "UBERON",
                "id": "0002107",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107"
            },
            "score": "51.3",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Prostate gland",
                "namespace": "UBERON",
                "id": "0002367",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367"
            },
            "score": "78.66",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        },
        {
            "tissue": {
                "name": "Thoracic mammary gland",
                "namespace": "UBERON",
                "id": "0005200",
                "url": "http://purl.obolibrary.org/obo/UBERON_0005200"
            },
            "score": "89.47",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000148344",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000148344"
                }
            ]
        }
    ],
    "expression_disease": [
        {
            "significant": "Yes",
            "trend": "down",
            "name": "Prostate cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:10283",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:10283",
                    "recommended_name": {
                        "id": "DOID:10283",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10283",
                        "name": "prostate cancer",
                        "description": "A male reproductive organ cancer that is located_in the prostate."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "NGP - new growth of prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "malignant tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, type 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "HPC9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "EHBP1 familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "familial prostate cancer caused by mutation in EHBP1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, type 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "HPC12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, type 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "HPC5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, type 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, susceptibility to, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "HPC3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, type 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, susceptibility to, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "HPC4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, on chromosome 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "MSMB familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "familial prostate cancer caused by mutation in MSMB",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, type 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "HPC13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, type 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "HPC8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "predisposing for prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, type 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "HPC6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "HPC10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate carcinoma",
                            "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, hereditary",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "HPC7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer aggressiveness",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "RNASEL familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "familial prostate cancer caused by mutation in RNASEL",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, type 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "HPC1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "Prca1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "HPC11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "HPC14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "HPC15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "HPCX1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer susceptibility, X-linked",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "HPCX2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MIM:611868",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611868",
                            "name": "Prostate cancer, hereditary, 12",
                            "description": "Prostate cancer, hereditary, 12"
                        },
                        {
                            "id": "MIM:611928",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611928",
                            "name": "Prostate cancer, hereditary, 13",
                            "description": "Prostate cancer, hereditary, 13"
                        },
                        {
                            "id": "MIM:176807",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/176807",
                            "name": "Prostate cancer",
                            "description": "Prostate cancer"
                        },
                        {
                            "id": "MIM:601518",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/601518",
                            "name": "Prostate cancer, hereditary, 1",
                            "description": "Prostate cancer, hereditary, 1"
                        },
                        {
                            "id": "MIM:611955",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611955",
                            "name": "Prostate cancer, hereditary, 11",
                            "description": "Prostate cancer, hereditary, 11"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Stomach cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:10534",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:10534",
                    "recommended_name": {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "stomach cancer",
                        "description": "A gastrointestinal system cancer that is located_in the stomach."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10534",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "name": "gastric cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10534",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "name": "gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the stomach."
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "Ca lesser curvature - stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "cancer of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer risk after h. pylori infection",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant stomach neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of greater curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of greater curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "stomach cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "Ca body - stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "ca greater curvature of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer, intestinal",
                            "description": ""
                        },
                        {
                            "id": "MIM:613659",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/613659",
                            "name": "Gastric cancer",
                            "description": "Gastric cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Urinary bladder cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:11054",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Head and neck cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:11934",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck tumours",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head/neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "tumor of head and neck",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Lung cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1324",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Breast cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1612",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast cancer",
                        "description": "A thoracic cancer that originates in the mammary gland."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant tumor of the breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Thyroid cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1781",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1781",
                    "recommended_name": {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid cancer",
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid gland cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "Thyroid gland neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant tumour of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid neoplasm",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "down",
            "name": "Kidney cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:263",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:263",
                    "recommended_name": {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "kidney cancer",
                        "description": "A urinary system cancer that is located_in the kidney."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant neoplasm of kidney except pelvis",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant tumour of kidney",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "renal cancer",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Liver cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:3571",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:3571",
                    "recommended_name": {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "liver cancer",
                        "description": "A hepatobiliary system cancer that is located_in the liver."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Ca liver - primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Resectable malignant neoplasm of Liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant hepato-biliary neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant tumor of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "non-resectable primary hepatic malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary liver cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "resectable malignant neoplasm of the liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, not specified as primary or secondary",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Uterine cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:363",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:363",
                    "recommended_name": {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterine cancer",
                        "description": "A female reproductive organ cancer that is located_in the uterus."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "CA - cancer of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "Tumour of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterus neoplasm",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Esophageal cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:5041",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:5041",
                    "recommended_name": {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "esophageal cancer",
                        "description": "A gastrointestinal system cancer that is located_in the esophagus."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "Ca lower third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "Ca middle third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "esophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of lower third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of middle third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of upper third esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of Distal Third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of Proximal Third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of abdominal esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of the middle Third of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the esophagus."
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "cancer of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "cancer of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal carcinoma, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal squamous cell carcinoma, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophagus neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophagus tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant oesophagus neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant oesophagus tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "oesophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca lower third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca lower third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca middle third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca middle third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of distal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of lower third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of lower third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of middle third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of middle third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of proximal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of upper third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of upper third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of abdominal esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of the middle third of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of abdominal oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of distal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of proximal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of the middle third of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Aerodigestive tract cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Escc, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal squamous cell carcinoma, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "gastric cardia adenocarcinoma, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MIM:133239",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/133239",
                            "name": "Esophageal cancer",
                            "description": "Esophageal cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Colorectal cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:9256",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "O14684",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14684"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:9256",
                    "recommended_name": {
                        "id": "DOID:9256",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:9256",
                        "name": "colorectal cancer",
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
                    },
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O14684",
                                "url": "https://www.uniprot.org/uniprot/O14684"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O14684",
                                "url": "https://www.uniprot.org/uniprot/O14684"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "12893",
            "name": "",
            "equation": "prostaglandin H2 = prostaglandin E2",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P83868-1",
                "D4AE56-1",
                "Q9JHF3-1",
                "Q5PQL9-1",
                "Q9H7Z7-1",
                "O14684-1",
                "Q15185-1",
                "Q8BWM0-1",
                "Q9JM51-1",
                "Q9R0Q7-1"
            ],
            "evidence": [
                {
                    "id": "12893",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/12893"
                }
            ]
        },
        {
            "id": "48620",
            "name": "",
            "equation": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9JHF3-1",
                "P04041-1",
                "P83645-1",
                "P36970-1",
                "O14880-1",
                "Q99735-1",
                "O14684-1",
                "P18283-1",
                "P07203-1",
                "P36969-1",
                "Q9CPU4-1",
                "A2RST1-1",
                "Q9JM51-1",
                "P11352-1",
                "Q9JHC0-1",
                "O70325-1"
            ],
            "evidence": [
                {
                    "id": "48620",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/48620"
                }
            ]
        },
        {
            "id": "51220",
            "name": "",
            "equation": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9QX69-1",
                "Q5BK56-1",
                "Q9JHF3-1",
                "O43813-1",
                "Q03013-1",
                "Q99735-1",
                "O14684-1",
                "O89112-1",
                "A2RST1-1",
                "Q9JM51-1",
                "Q8R5I6-1",
                "P17695-1",
                "P25373-1"
            ],
            "evidence": [
                {
                    "id": "51220",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/51220"
                }
            ]
        },
        {
            "id": "53324",
            "name": "",
            "equation": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9JHF3-1",
                "O14684-1",
                "Q9JM51-1"
            ],
            "evidence": [
                {
                    "id": "53324",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/53324"
                }
            ]
        },
        {
            "id": "64364",
            "name": "",
            "equation": "prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9JHF3-1",
                "O14684-1",
                "Q9JM51-1"
            ],
            "evidence": [
                {
                    "id": "64364",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/64364"
                }
            ]
        },
        {
            "id": "R-HSA-2161660",
            "name": "PGH2 is isomerised to PGE2 by PTGES",
            "equation": "",
            "summary": "Prostaglandin E synthase (PTGES) requires glutathione (GSH) as an essential cofactor for its enzymatic activity, and together they isomerise prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2) (Jegerschold et al. 2008).  After PGH2 has been produced by the prostaglandin G/H synthases (PTGS1 and 2) on the lumenal side of the endoplasmic reticulum, it diffuses through the membrane to the active site of PTGES located on the cytoplasmic side.",
            "cellular_location": "cytosol, endoplasmic reticulum membrane",
            "input_participant_list": [
                "R-ALL-265283"
            ],
            "output_participant_list": [
                "R-ALL-265287"
            ],
            "enzyme_list": [
                "O14684-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-2161660",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161660"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-ALL-265283",
            "participant_name": "PGH2 [cytosol]",
            "crossref": [
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "15554",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "C00427",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "C00427",
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                },
                {
                    "id": "15554",
                    "database": "ChEBI",
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                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "C00427",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15554",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "15554",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "C00427",
                    "database": "COMPOUND",
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                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "C00427",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15554",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
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                },
                {
                    "id": "C00427",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15554",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "8143214",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "000008215926",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "C00427",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "HMDB0001381",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "4483",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "15554",
                    "database": "ChEBI",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-ALL-265287",
            "participant_name": "PGE2 [cytosol]",
            "crossref": [
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "15551",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0001220",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "000003830713",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "C00584",
                    "database": "COMPOUND",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A2RST1",
            "gene_name": "Mgst2",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2RST1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RST1"
                        }
                    ]
                },
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "A2RST1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RST1"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "A2RST1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RST1"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2RST1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RST1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D4AE56",
            "gene_name": "Ptges2",
            "activity": [
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "D4AE56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D4AE56"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "D4AE56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D4AE56"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O14684",
            "gene_name": "PTGES",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O14684",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14684"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "O14684",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14684"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "O14684",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14684"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O14684",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14684"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O14880",
            "gene_name": "MGST3",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O14880",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14880"
                        }
                    ]
                },
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "O14880",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14880"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O14880",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O14880"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O43813",
            "gene_name": "LANCL1",
            "activity": [
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "O43813",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O43813"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O43813",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O43813"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O70325",
            "gene_name": "Gpx4",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "O70325",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70325"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "O70325",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70325"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O70325",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70325"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O89112",
            "gene_name": "Lancl1",
            "activity": [
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "O89112",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O89112"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O89112",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O89112"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P04041",
            "gene_name": "Gpx1",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P04041",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P04041"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P04041",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P04041"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P04041",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P04041"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P07203",
            "gene_name": "GPX1",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P07203",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P07203"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P07203",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P07203"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P07203",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P07203"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P11352",
            "gene_name": "Gpx1",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P11352",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P11352"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P11352",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P11352"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P11352",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P11352"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P17695",
            "gene_name": "GRX2",
            "activity": [
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P17695",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17695"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "P17695",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17695"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P17695",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17695"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P17695",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17695"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P18283",
            "gene_name": "GPX2",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P18283",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P18283"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P18283",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P18283"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P18283",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P18283"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P25373",
            "gene_name": "GRX1",
            "activity": [
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P25373",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P25373"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "P25373",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P25373"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P25373",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P25373"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P25373",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P25373"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36969",
            "gene_name": "GPX4",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P36969",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36969"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36969",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36969"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P36969",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36969"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36970",
            "gene_name": "Gpx4",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P36970",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36970"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P36970",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36970"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36970",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36970"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P83645",
            "gene_name": "Gpx2",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "P83645",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P83645"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "P83645",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P83645"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P83645",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P83645"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P83868",
            "gene_name": "Ptges3",
            "activity": [
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "P83868",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P83868"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P83868",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P83868"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q03013",
            "gene_name": "GSTM4",
            "activity": [
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "Q03013",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q03013"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q03013",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q03013"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q03013",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q03013"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q15185",
            "gene_name": "PTGES3",
            "activity": [
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "Q15185",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q15185"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q15185",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q15185"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5BK56",
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            "activity": [
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q5BK56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5BK56"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5BK56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5BK56"
                        }
                    ]
                },
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "Q5BK56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5BK56"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5PQL9",
            "gene_name": "Ptges3l1",
            "activity": [
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "Q5PQL9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5PQL9"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5PQL9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5PQL9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BWM0",
            "gene_name": "Ptges2",
            "activity": [
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "Q8BWM0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BWM0"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BWM0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BWM0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8R5I6",
            "gene_name": "Gstm4",
            "activity": [
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q8R5I6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R5I6"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8R5I6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R5I6"
                        }
                    ]
                },
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "Q8R5I6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R5I6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99735",
            "gene_name": "MGST2",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99735"
                        }
                    ]
                },
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "Q99735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99735"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q99735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99735"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99735"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CPU4",
            "gene_name": "Mgst3",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CPU4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CPU4"
                        }
                    ]
                },
                {
                    "ec_number": "4.4.1.20",
                    "activity": "leukotriene C4 = glutathione + leukotriene A4.",
                    "evidence": [
                        {
                            "id": "Q9CPU4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CPU4"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CPU4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CPU4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9H7Z7",
            "gene_name": "PTGES2",
            "activity": [
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "Q9H7Z7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9H7Z7"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9H7Z7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9H7Z7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JHC0",
            "gene_name": "Gpx2",
            "activity": [
                {
                    "ec_number": "1.11.1.12",
                    "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.",
                    "evidence": [
                        {
                            "id": "Q9JHC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHC0"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.",
                    "evidence": [
                        {
                            "id": "Q9JHC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHC0"
                        }
                    ]
                },
                {
                    "ec_number": "1.11.1.9",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JHC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHC0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JHF3",
            "gene_name": "Ptges",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JHF3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHF3"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "Q9JHF3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHF3"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q9JHF3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHF3"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JHF3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JHF3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JM51",
            "gene_name": "Ptges",
            "activity": [
                {
                    "ec_number": "1.11.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JM51",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JM51"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "prostaglandin H2 = prostaglandin E2.",
                    "evidence": [
                        {
                            "id": "Q9JM51",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JM51"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q9JM51",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JM51"
                        }
                    ]
                },
                {
                    "ec_number": "5.3.99.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JM51",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JM51"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QX69",
            "gene_name": "Lancl1",
            "activity": [
                {
                    "ec_number": "2.5.1.18",
                    "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
                    "evidence": [
                        {
                            "id": "Q9QX69",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QX69"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.18",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QX69",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QX69"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9R0Q7",
            "gene_name": "Ptges3",
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