{ "uniprot_canonical_ac": "O14641-1", "uniprot_ac": "O14641", "uniprot_id": "DVL2_HUMAN", "mass": { "chemical_mass": 78948.0, "monoisotopic_mass": 78948.0 }, "refseq": { "ac": "NP_004413", "name": "segment polarity protein dishevelled homolog DVL-2", "summary": "This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" }, "gene_names": [ { "name": "DVL2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14641", "id": "O14641" }, { "name": "DVL2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413", "id": "NP_004413" } ], "protein_names": [ { "name": "Segment polarity protein dishevelled homolog DVL-2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14641" }, { "name": "DSH homolog 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14641" }, { "name": "Dishevelled-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14641" }, { "name": "dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413", "id": "NP_004413" }, { "name": "segment polarity protein dishevelled homolog DVL-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413", "id": "NP_004413" } ], "function": [ { "annotation": "DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/beta-catenin signaling by DVL2.", "evidence": [ { "database": "RefSeq", "id": "NP_004413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" }, { "database": "PubMed", "id": "35187752", "url": "https://glygen.org/publication/PubMed/35187752" } ] }, { "annotation": "Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly.", "evidence": [ { "database": "RefSeq", "id": "NP_004413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" }, { "database": "PubMed", "id": "36342472", "url": "https://glygen.org/publication/PubMed/36342472" } ] }, { "annotation": "Dishevelled segment polarity protein 2 promotes gastric cancer progression through Wnt/beta-catenin pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_004413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" }, { "database": "PubMed", "id": "37257286", "url": "https://glygen.org/publication/PubMed/37257286" } ] }, { "annotation": "Inhibiting von Hippel-Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.", "evidence": [ { "database": "RefSeq", "id": "NP_004413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" }, { "database": "PubMed", "id": "36357669", "url": "https://glygen.org/publication/PubMed/36357669" } ] }, { "annotation": "Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.", "evidence": [ { "database": "RefSeq", "id": "NP_004413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" }, { "database": "PubMed", "id": "36720664", "url": "https://glygen.org/publication/PubMed/36720664" } ] }, { "annotation": "Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641#function" }, { "database": "PubMed", "id": "19252499", "url": "https://glygen.org/publication/PubMed/19252499" }, { "database": "UniProtKB", "id": "Q60838", "url": "https://www.uniprot.org/uniprot/Q60838#function" } ] }, { "annotation": "This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_004413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004413" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O14641", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14641" } ], "glycoeffect": [], "start_pos": 246, "end_pos": 246, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "17", "chr_pos": "7229598", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R246", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O14641", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14641" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14641" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O14641", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14641" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM", "length": 736, "header": "sp|O14641-1|DVL2_HUMAN Isoform 1 of Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1 CANONICAL=O14641-1" }, "isoforms": [ { "isoform_ac": "I3L0M7-1", "url": "", "sequence": { "sequence": "MLRVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSTGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDP", "length": 291, "header": "tr|I3L0M7-1|DVL2_HUMAN Computationally mapped isoform of Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1 CANONICAL=O14641-1" }, "locus": { "chromosome": "17", "start_pos": 7233943, "end_pos": 7228008, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000574143.1", "url": "https://www.ensembl.org/id/ENST00000574143.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000458209.1", "url": "https://www.ensembl.org/id/ENSP00000458209.1" } ] } }, { "isoform_ac": "I3L0Z8-1", "url": "", "sequence": { "sequence": "XNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRTYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPP", "length": 300, "header": "tr|I3L0Z8-1|DVL2_HUMAN Computationally mapped isoform of Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1 CANONICAL=O14641-1" }, "locus": { "chromosome": "17", "start_pos": 7229035, "end_pos": 7226137, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000575086.1", "url": "https://www.ensembl.org/id/ENST00000575086.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000458465.1", "url": "https://www.ensembl.org/id/ENSP00000458465.1" } ] } }, { "isoform_ac": "I3L2N2-1", "url": "", "sequence": { "sequence": "MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM", "length": 730, "header": "tr|I3L2N2-1|DVL2_HUMAN Computationally mapped isoform of Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1 CANONICAL=O14641-1" }, "locus": { "chromosome": "17", "start_pos": 7234262, "end_pos": 7225868, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000575458.5", "url": "https://www.ensembl.org/id/ENST00000575458.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000459797.1", "url": "https://www.ensembl.org/id/ENSP00000459797.1" } ] } }, { "isoform_ac": "I3L2W9-1", "url": "", "sequence": { "sequence": "MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSTGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPR", "length": 363, "header": "tr|I3L2W9-1|DVL2_HUMAN Computationally mapped isoform of Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1 CANONICAL=O14641-1" }, "locus": { "chromosome": "17", "start_pos": 7234262, "end_pos": 7227978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000575756.5", "url": "https://www.ensembl.org/id/ENST00000575756.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000459991.1", "url": "https://www.ensembl.org/id/ENSP00000459991.1" } ] } }, { "isoform_ac": "O14641-1", "url": "", "sequence": { "sequence": "MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM", "length": 736, "header": "sp|O14641-1|DVL2_HUMAN Isoform 1 of Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1 CANONICAL=O14641-1" }, "locus": { "chromosome": "17", "start_pos": 7234262, "end_pos": 7225868, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000005340.10", "url": "https://www.ensembl.org/id/ENST00000005340.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000005340.4", "url": "https://www.ensembl.org/id/ENSP00000005340.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O14641", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14641" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "P48730-1", "kinase_gene_name": "CSNK1D", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "22609948", "url": "https://glygen.org/publication/PubMed/22609948" } ], "site_lbl": "Ser143" }, { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "P49674-1", "kinase_gene_name": "CSNK1E", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "22609948", "url": "https://glygen.org/publication/PubMed/22609948" } ], "site_lbl": "Ser143" }, { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "29426949", "url": "https://glygen.org/publication/PubMed/29426949" } ], "site_lbl": "Ser143" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "29426949", "url": "https://glygen.org/publication/PubMed/29426949" } ], "site_lbl": "Ser194" }, { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "P53350-1", "kinase_gene_name": "PLK1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "20823832", "url": "https://glygen.org/publication/PubMed/20823832" } ], "site_lbl": "Thr206" }, { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "PRO", "id": "O14641", "url": "http://purl.obolibrary.org/obo/O14641" }, { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "20823832", "url": "https://glygen.org/publication/PubMed/20823832" } ], "site_lbl": "Thr206" }, { "start_pos": 211, "end_pos": 211, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" } ], "site_lbl": "Ser211" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser222" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "P48730-1", "kinase_gene_name": "CSNK1D", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "22609948", "url": "https://glygen.org/publication/PubMed/22609948" } ], "site_lbl": "Thr224" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "P49674-1", "kinase_gene_name": "CSNK1E", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "22609948", "url": "https://glygen.org/publication/PubMed/22609948" } ], "site_lbl": "Thr224" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "O14641", "url": "http://phospho.elm.eu.org/byAccession/O14641.html" } ], "site_lbl": "Ser227" }, { "start_pos": 228, "end_pos": 228, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "O14641", "url": "http://phospho.elm.eu.org/byAccession/O14641.html" } ], "site_lbl": "Ser228" }, { "start_pos": 230, "end_pos": 230, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser230" }, { "start_pos": 562, "end_pos": 562, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "29426949", "url": "https://glygen.org/publication/PubMed/29426949" } ], "site_lbl": "Ser562" }, { "start_pos": 618, "end_pos": 618, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "29426949", "url": "https://glygen.org/publication/PubMed/29426949" } ], "site_lbl": "Ser618" }, { "start_pos": 717, "end_pos": 717, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14641", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14641" }, { "database": "PubMed", "id": "29426949", "url": "https://glygen.org/publication/PubMed/29426949" } ], "site_lbl": "Ser717" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8856825" } ], "reference": [ { "type": "PubMed", "id": "10097102", "url": "https://glygen.org/publication/PubMed/10097102" } ] }, { "title": "beta-catenin can be transported into the nucleus in a Ran-unassisted manner.", "journal": "Molecular biology of the cell", "date": "1999", "authors": "Yokoya F, Imamoto N, Tachibana T, Yoneda Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "10198061", "url": "https://glygen.org/publication/PubMed/10198061" } ] }, { "title": "Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.", "journal": "Genes & development", "date": "1999", "authors": "Willert K, Shibamoto S, Nusse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641262" } ], "reference": [ { "type": "PubMed", "id": "10421629", "url": "https://glygen.org/publication/PubMed/10421629" } ] }, { "title": "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.", "journal": "The EMBO journal", "date": "1999", "authors": "Li L, Yuan H, Weaver CD, Mao J, Farr GH 3rd, Sussman DJ, Jonkers J, Kimelman D, Wu D", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641262" } ], "reference": [ { "type": "PubMed", "id": "10428961", "url": "https://glygen.org/publication/PubMed/10428961" } ] }, { "title": "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.", "journal": "Molecular biology of the cell", "date": "1999", "authors": "Tebar F, Bohlander SK, Sorkin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8856825" } ], "reference": [ { "type": "PubMed", "id": "10436022", "url": "https://glygen.org/publication/PubMed/10436022" } ] }, { "title": "A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.", "journal": "FEBS letters", "date": "1999", "authors": "Thomas GM, Frame S, Goedert M, Nathke I, Polakis P, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641262" } ], "reference": [ { "type": "PubMed", "id": "10481074", "url": "https://glygen.org/publication/PubMed/10481074" } ] }, { "title": "Casein kinase I transduces Wnt signals.", "journal": "Nature", "date": "1999", "authors": "Peters JM, McKay RM, McKay JP, Graff JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-201688", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201688" } ], "reference": [ { "type": "PubMed", "id": "10517632", "url": "https://glygen.org/publication/PubMed/10517632" } ] }, { "title": "Essential role of phosphoinositide metabolism in synaptic vesicle recycling.", "journal": "Cell", "date": "1999", "authors": "Cremona O, Di Paolo G, Wenk MR, Luthi A, Kim WT, Takei K, Daniell L, Nemoto Y, Shears SB, Flavell RA, McCormick DA, De Camilli P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8856828" } ], "reference": [ { "type": "PubMed", "id": "10535736", "url": "https://glygen.org/publication/PubMed/10535736" } ] }, { "title": "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.", 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170 kDa isoform with Eps15.", "journal": "FEBS letters", "date": "1997", "authors": "Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8856828" } ], "reference": [ { "type": "PubMed", "id": "9428629", "url": "https://glygen.org/publication/PubMed/9428629" } ] }, { "title": "Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.", "journal": "The EMBO journal", "date": "1998", "authors": "Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641262" } ], "reference": [ { "type": "PubMed", "id": "9482734", "url": "https://glygen.org/publication/PubMed/9482734" } ] }, { "title": 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"name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "Wnt signaling pathway, planar cell polarity pathway", "id": "GO:0060071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060071", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "segment specification", "id": "GO:0007379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007379", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "positive regulation of JUN kinase activity", "id": "GO:0043507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043507", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "outflow tract morphogenesis", "id": "GO:0003151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003151", "evidence": [ { "database": "UniProtKB", "id": "O14641", "url": "https://www.uniprot.org/uniprot/O14641" } ], "pmid": "" }, { "name": "convergent extension involved in neural plate 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