{ "uniprot_canonical_ac": "O14529-1", "uniprot_ac": "O14529", "uniprot_id": "CUX2_HUMAN", "mass": { "chemical_mass": 161677.0, "monoisotopic_mass": 161677.0 }, "refseq": { "ac": "NP_056082", "name": "homeobox protein cut-like 2 isoform 1", "summary": "This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" }, "gene_names": [ { "name": "CUX2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14529", "id": "O14529" }, { "name": "CDP2; CUTL2; DEE67; EIEE67", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082", "id": "NP_056082" }, { "name": "CUTL2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14529", "id": "O14529" }, { "name": "CUX2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082", "id": "NP_056082" }, { "name": "KIAA0293", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14529", "id": "O14529" } ], "protein_names": [ { "name": "Homeobox protein cut-like 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14529" }, { "name": "Homeobox protein cux-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14529" }, { "name": "homeobox protein cut-like 2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082", "id": "NP_056082" }, { "name": "homeobox protein cut-like 2; homeobox protein cux-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082", "id": "NP_056082" } ], "function": [ { "annotation": "CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" }, { "database": "PubMed", "id": "33093602", "url": "https://glygen.org/publication/PubMed/33093602" } ] }, { "annotation": "CUX2/KDM5B/SOX17 Axis Affects the Occurrence and Development of Breast Cancer. Erratum:[Endocrinology. 2022 Nov 14;164(1):. PMID: 36527259]", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" }, { "database": "PubMed", "id": "35881915", "url": "https://glygen.org/publication/PubMed/35881915" } ] }, { "annotation": "De novo variant c.1768G>A; p.(Glu590Lys) in CUX2 was identifies in a patient with intellectual disability, seizures, and autism spectrum disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" }, { "database": "PubMed", "id": "29795476", "url": "https://glygen.org/publication/PubMed/29795476" } ] }, { "annotation": "This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" } ] }, { "annotation": "This is the first study to explore and validate the relationships between seven SNPs in the FAM65B, AGBL4, and CUX2 genes and ATDH in a Chinese population. On the basis of this case-control study, SNP rs10946737 in FAM65B may be associated with susceptibility to ATDH in Chinese Han anti-TB treatment patients.", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" }, { "database": "PubMed", "id": "30720667", "url": "https://glygen.org/publication/PubMed/30720667" } ] }, { "annotation": "Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.", "evidence": [ { "database": "UniProtKB", "id": "O14529", "url": "https://www.uniprot.org/uniprot/O14529#function" }, { "database": "UniProtKB", "id": "P70298", "url": "https://www.uniprot.org/uniprot/P70298#function" } ] } ], "disease": [ { "disease_id": "DOID:0112203", "recommended_name": { "id": "DOID:0112203", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112203", "name": "developmental and epileptic encephalopathy 67", "description": "A developmental and epileptic encephalopathy characterized by onset in the first months of lifes of seizures, global developmental delay with impaired motor and intellectual development, poor or absent speech, movement disorders, and stereotypic or autistic behavior that has_material_basis_in heterozygous mutation in the CUX2 gene on chromosome 12q24.11-q24.12." }, "synonyms": [ { "id": "DOID:0112203", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112203", "name": "DEE67", "description": "" }, { "id": "DOID:0112203", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112203", "name": "early infantile epileptic encephalopathy 67", "description": "" }, { "id": "MONDO:0029138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0029138", "name": "developmental and epileptic encephalopathy, 67", "description": "" }, { "id": "MONDO:0029138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0029138", "name": "DEE67", "description": "" }, { "id": "MONDO:0029138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0029138", "name": "EIEE67", "description": "" }, { "id": "MONDO:0029138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0029138", "name": "developmental and epileptic encephalopathy 67", "description": "" }, { "id": "MONDO:0029138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0029138", "name": "epileptic encephalopathy, early infantile, 67", "description": "" }, { "id": "MIM:618141", "resource": "MIM", "url": "https://www.omim.org/entry/618141", "name": "Developmental and epileptic encephalopathy 67", "description": "Developmental and epileptic encephalopathy 67" } ], "evidence": [ { "id": "618141", "database": "MIM", "url": "https://www.omim.org/entry/618141" } ] } ], "snv": [ { "evidence": [ { "id": "O14529", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O14529" } ], "glycoeffect": [], "start_pos": 108, "end_pos": 108, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", "chr_id": "12", "chr_pos": "111291439", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A108", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", 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Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", 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"O14529-1", "url": "https://www.uniprot.org/uniprot/O14529-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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} ] } }, { "isoform_ac": "O14529-1", "url": "", "sequence": { "sequence": "MAANVGSMFQYWKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPELLSPKEQREGTSPAGPTLTEGSRLPGIPGKALLTETLLQRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPGQPLLGPSLGPDGTRTFSLSPFPSLASGERLMMPPAAFKGEAGGLLVFPPAFYGAKPPTAPATPAPGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQARREMQAQQQALLEMEVAPRGRSVPPSPPERPSLATASQNGAPALVKQEEGSGGPAQAPLPVLSPAAFVQSIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNGRAWPRGDEAPVPPEDEAAAGAEDEPPRTGELKAEGATAEAGARLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQAVGQQPGASQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSGKMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERAANREEALEWEF", "length": 1486, "header": "sp|O14529-1|CUX2_HUMAN Isoform 1 of Homeobox protein cut-like 2 OS=Homo sapiens OX=9606 GN=CUX2 PE=1 SV=4 CANONICAL=O14529-1" }, "locus": { "chromosome": "12", "start_pos": 111348322, "end_pos": 111034178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000261726.11", "url": "https://www.ensembl.org/id/ENST00000261726.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000261726.6", "url": "https://www.ensembl.org/id/ENSP00000261726.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O14529", "url": "https://www.uniprot.org/uniprot/O14529" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "O14529", "url": 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{ "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr157" }, { "start_pos": 159, "end_pos": 159, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr159" }, { "start_pos": 162, "end_pos": 162, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser162" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser26" }, { "start_pos": 635, "end_pos": 635, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser635" }, { "start_pos": 642, "end_pos": 642, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O14529", "url": 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"publication": [ { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O14529", "url": "https://www.uniprot.org/uniprot/O14529" }, { "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O14529", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14529" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant.", "journal": "Annals of neurology", "date": "2018", "authors": "Chatron N, Moller RS, Champaigne NL, Schneider AL, Kuechler A, Labalme A, Simonet T, Baggett L, Bardel C, Kamsteeg EJ, Pfundt R, Romano C, Aronsson J, Alberti A, Vinci M, Miranda MJ, Lacroix A, Marjanovic D, des Portes V, Edery P, Wieczorek D, Gardella E, Scheffer IE, Mefford H, Sanlaville D, Carvill GL, Lesca G", "evidence": [ { "database": "UniProtKB", "id": "O14529", "url": "https://www.uniprot.org/uniprot/O14529" } ], "reference": [ { "type": "PubMed", "id": "29630738", "url": "https://glygen.org/publication/PubMed/29630738" } ] }, { "title": "A recurrent de novo CUX2 missense variant associated with intellectual disability, seizures, and autism spectrum disorder.", "journal": "European journal of human genetics : EJHG", "date": "2018", "authors": "Barington M, Risom L, Ek J, Uldall P, Ostergaard E", "evidence": [ { "database": "UniProtKB", "id": "O14529", "url": "https://www.uniprot.org/uniprot/O14529" }, { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" } ], "reference": [ { "type": "PubMed", "id": "29795476", "url": "https://glygen.org/publication/PubMed/29795476" } ] }, { "title": "Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with susceptibility to antituberculosis drug-induced hepatotoxicity: validation study in a Chinese Han population.", "journal": "Pharmacogenetics and genomics", "date": "2019", "authors": "Pan H, Yang M, Lu L, Tao B, He X, Chen H, Yi H, Tang S", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" } ], "reference": [ { "type": "PubMed", "id": "30720667", "url": "https://glygen.org/publication/PubMed/30720667" } ] }, { "title": "CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption.", "journal": "Scientific reports", "date": "2020", "authors": "Chen IC, Kuo PH, Yang AC, Tsai SJ, Liu TH, Liu HJ, Lan TH, Chen HM, Huang HN, Chung RH, Liu YL", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" } ], "reference": [ { "type": "PubMed", "id": "33093602", "url": "https://glygen.org/publication/PubMed/33093602" } ] }, { "title": "CUX2/KDM5B/SOX17 Axis Affects the Occurrence and Development of Breast Cancer.", "journal": "Endocrinology", "date": "2022", "authors": "Li L, Zhu G, Tan K, Jiang L, Li Y, Zhu X, Lin Z, Zhang X, Chen J, Ma C", "evidence": [ { "database": "RefSeq", "id": "NP_056082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056082" } ], "reference": [ { "type": "PubMed", "id": "35881915", "url": "https://glygen.org/publication/PubMed/35881915" } ] }, { "title": "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.", "journal": "DNA Res.", "date": "1997", "authors": "Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N", "evidence": [ { "database": "UniProtKB", "id": "O14529", "url": "https://www.uniprot.org/uniprot/O14529" } ], "reference": [ { "type": "PubMed", "id": "9179496", "url": "https://glygen.org/publication/PubMed/9179496" } ] } ], "pathway": [ { "id": "hsa:23316", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23316", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M048-1", "protein_name": "Homeobox protein cut-like", "gene_name": "Cux2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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