{ "uniprot_canonical_ac": "O14494-1", "uniprot_ac": "O14494", "uniprot_id": "PLPP1_HUMAN", "mass": { "chemical_mass": 32156.0, "monoisotopic_mass": 32156.0 }, "refseq": { "ac": "NP_003702", "name": "phospholipid phosphatase 1 isoform 1", "summary": "The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702" }, "gene_names": [ { "name": "PLPP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14494", "id": "O14494" }, { "name": "LLP1a; LPP1; PAP-2a; PAP2; PPAP2A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702", "id": "NP_003702" }, { "name": "LPP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14494", "id": "O14494" }, { "name": "PLPP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702", "id": "NP_003702" }, { "name": "PPAP2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14494", "id": "O14494" } ], "protein_names": [ { "name": "Phospholipid phosphatase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14494" }, { "name": "3.1.3.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "3.1.3.106", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "3.1.3.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "3.6.1.75", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "Lipid phosphate phosphohydrolase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "PAP-2a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "PAP2-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "PAP2a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "Phosphatidate phosphohydrolase type 2a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "Phosphatidic acid phosphatase 2a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14494" }, { "name": "phosphatidic acid phosphohydrolase type 2a; lipid phosphate phosphohydrolase 1a; type-2 phosphatidic acid phosphatase alpha; phosphatidic acid phosphatase type 2A; phosphatidic acid phosphatase 2a; phosphatidate phosphohydrolase type 2a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702", "id": "NP_003702" }, { "name": "phospholipid phosphatase 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702", "id": "NP_003702" } ], "function": [ { "annotation": "Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494#function" }, { "database": "PubMed", "id": "10962286", "url": "https://glygen.org/publication/PubMed/10962286" }, { "database": "PubMed", "id": "9305923", "url": "https://glygen.org/publication/PubMed/9305923" }, { "database": "UniProtKB", "id": "O08564", "url": "https://www.uniprot.org/uniprot/O08564#function" }, { "database": "PubMed", "id": "12909631", "url": "https://glygen.org/publication/PubMed/12909631" }, { "database": "PubMed", "id": "9607309", "url": "https://glygen.org/publication/PubMed/9607309" }, { "database": "PubMed", "id": "17379599", "url": "https://glygen.org/publication/PubMed/17379599" }, { "database": "PubMed", "id": "15461590", "url": "https://glygen.org/publication/PubMed/15461590" }, { "database": "PubMed", "id": "9705349", "url": "https://glygen.org/publication/PubMed/9705349" } ] }, { "annotation": "Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association", "evidence": [ { "database": "RefSeq", "id": "NP_003702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702" }, { "database": "PubMed", "id": "23426360", "url": "https://glygen.org/publication/PubMed/23426360" } ] }, { "annotation": "The first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702" }, { "database": "PubMed", "id": "23936490", "url": "https://glygen.org/publication/PubMed/23936490" } ] }, { "annotation": "The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_003702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1561234540", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1561234540" }, { "id": "rs1561234540", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1561234540" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 142, "end_pos": 142, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCS->SCS).", "chr_id": "5", "chr_pos": "55467935", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N142", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1579944466", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1579944466" }, { "id": "rs1579944466", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1579944466" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 84, "end_pos": 84, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLL->NLS).", "chr_id": "5", "chr_pos": "55468109", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L84", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1012487534", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1012487534" }, { "id": "rs1012487534", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1012487534" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 94, "end_pos": 94, "sequence_org": "Y", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNY->NNS).", "chr_id": "5", "chr_pos": "55468079", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "Y94", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 217, "end_pos": 217, "sequence_org": "R", "sequence_mut": "K", "comment": "Decreased lipid phosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" }, { "database": "PubMed", "id": "15461590", "url": "https://glygen.org/publication/PubMed/15461590" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "96.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "89.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "94.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "97.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "97.96", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "96.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "96.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "98.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "97.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "92.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "99.21", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "96.21", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067113" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the 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"https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", 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"BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "O14494", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14494" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that 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Biochem.", "date": "2006", "authors": "Kai M, Sakane F, Jia YJ, Imai S, Yasuda S, Kanoh H", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "reference": [ { "type": "PubMed", "id": "17005594", "url": "https://glygen.org/publication/PubMed/17005594" } ] }, { "title": "Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.", "journal": "The Journal of biological chemistry", "date": "2007-05-11", "authors": "Zhao Yutong, Kalari Satish K, Usatyuk Peter V, Gorshkova Irina, He Donghong, Watkins Tonya, Brindley David N, Sun Chaode, Bittman Robert, Garcia Joe G N, Berdyshev Evgeni V, Natarajan Viswanathan", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" }, { "database": "Reactome", "id": "R-HSA-9845614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9845614" } ], 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Ingvorsen Camilla, Galli Antonella, Green Angela, Gleeson Diane, Ryder Ed, Glover Leanne, Vizcay-Barrena Gema, Karp Natasha A, Arends Mark J, Brenn Thomas, Spiegel Sarah, Adams David J, Watt Fiona M, van der Weyden Louise", "evidence": [ { "database": "Reactome", "id": "R-HSA-9845614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9845614" } ], "reference": [ { "type": "PubMed", "id": "27126290", "url": "https://glygen.org/publication/PubMed/27126290" } ] }, { "title": "Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.", "journal": "Cell death and differentiation", "date": "2018", "authors": "Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9845614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9845614" } ], "reference": [ { "type": "PubMed", "id": "29229990", "url": "https://glygen.org/publication/PubMed/29229990" } ] }, { "title": "Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1.", "journal": "Clinical kidney journal", "date": "2018", "authors": "Linhares ND, Arantes RR, Araujo SA, Pena SDJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9845614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9845614" } ], "reference": [ { "type": "PubMed", "id": "30090628", "url": "https://glygen.org/publication/PubMed/30090628" } ] }, { "title": "Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy.", "journal": "Nature communications", "date": "2018", "authors": "Vasiliauskaite-Brooks I, Healey RD, Rochaix P, Saint-Paul J, Sounier R, Grison C, Waltrich-Augusto T, Fortier M, Hoh F, Saied EM, Arenz C, Basu S, Leyrat C, Granier S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9845614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9845614" } ], "reference": [ { "type": "PubMed", "id": "30575723", "url": 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phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic Adenocarcinoma cell line LNCaP.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Ulrix W, Swinnen JV, Heyns W, Verhoeven G", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "reference": [ { "type": "PubMed", "id": "9468526", "url": "https://glygen.org/publication/PubMed/9468526" } ] }, { "title": "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.", "journal": "DNA Cell Biol.", "date": "1998", "authors": "Leung DW, Tompkins CK, White T", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "reference": [ { "type": "PubMed", "id": "9570154", "url": "https://glygen.org/publication/PubMed/9570154" } ] }, { "title": "Identification of a novel human phosphatidic acid phosphatase type 2 isoform.", "journal": "FEBS letters", "date": "1998", "authors": "Hooks SB, Ragan SP, Lynch KR", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "reference": [ { "type": "PubMed", "id": "9607309", "url": "https://glygen.org/publication/PubMed/9607309" } ] }, { "title": "Human type 2 phosphatidic acid phosphohydrolases. 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"name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "regulation of lipid metabolic process", "id": "GO:0019216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019216", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "sphingolipid biosynthetic process", "id": "GO:0030148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030148", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "ceramide metabolic process", "id": "GO:0006672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006672", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "androgen receptor signaling pathway", "id": "GO:0030521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030521", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "intracellular steroid hormone receptor signaling pathway", "id": "GO:0030518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030518", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "phospholipid dephosphorylation", "id": "GO:0046839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046839", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "phosphatidate phosphatase activity", "id": "GO:0008195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008195", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "lipid phosphatase activity", "id": "GO:0042577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042577", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "sphingosine-1-phosphate phosphatase activity", "id": "GO:0042392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042392", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "ceramide-1-phosphate phosphatase activity", "id": "GO:0106235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106235", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" }, { "name": "diacylglycerol diphosphate phosphatase activity", "id": "GO:0000810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000810", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated (PubMed:9305923, PubMed:10962286). N-linked sugars are of the complex type. N-glycosylation is not required for the phosphatase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O14494", "url": "https://www.uniprot.org/uniprot/O14494" }, { "database": "PubMed", "id": "10962286", "url": "https://glygen.org/publication/PubMed/10962286" }, { "database": "PubMed", "id": "9305923", "url": "https://glygen.org/publication/PubMed/9305923" } ] } ], "interactions": [], "reactions": [ { "id": "27429", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "D3ZYB4-1", "F7FDH2-1", "A0A8I6AUU1-1", "Q92539-1", "Q14693-1", "Q9BQK8-1", "Q8NEB5-1", "O14494-1", "O14495-1", "O43688-1", "Q5VZY2-1", "Q91ZP3-1", "Q99PI4-1", "Q99PI5-1", "Q61469-1", "Q99JY8-1", "Q0VBU9-1", "Q3UMZ3-1", "Q9DAX2-1", "P53933-1", "P32567-1", "Q04396-1", "Q05521-1", "Q9V576-1", "Q8SXP0-1" ], "evidence": [ { "id": "27429", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27429" } ] }, { "id": "27449", "name": "", "equation": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "Q8NEB5-1", "O14494-1", "Q5VZY2-1", "Q0VBU9-1", "Q61469-1", "Q3UMZ3-1", "Q04396-1", "Q05521-1" ], "evidence": [ { "id": "27449", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27449" } ] }, { "id": "27518", "name": "", "equation": "H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99P55-1", "O08564-1", "P97544-1", "Q8K593-1", "Q8IWX5-1", "Q9BX95-1", "O14494-1", "O14495-1", "O43688-1", "Q810K3-1", "Q9JI99-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1" ], "evidence": [ { "id": "27518", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27518" } ] }, { "id": "33155", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "O14494-1", "Q61469-1", "Q04396-1", "Q05521-1" ], "evidence": [ { "id": "33155", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33155" } ] }, { "id": "33743", "name": "", "equation": "an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "O14494-1", "O14495-1", "O43688-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1" ], "evidence": [ { "id": "33743", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33743" } ] }, { "id": "39835", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P80299-1", "P20646-1", "Q9NPH0-1", "P15309-1", "P34913-1", "O14494-1", "Q5VZY2-1", "Q8NEB5-1", "Q8BP40-1", "Q8CE08-1", "Q61469-1", "Q0VBU9-1", "Q3UMZ3-1", "P34914-1" ], "evidence": [ { "id": "39835", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39835" } ] }, { "id": "41255", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "Q14693-1", "O14494-1", "Q61469-1", "Q91ZP3-1" ], "evidence": [ { "id": "41255", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41255" } ] }, { "id": "43236", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "Q66H88-1", "Q14693-1", "O14494-1", "O14495-1", "O43688-1", "Q8IY26-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1", "Q91ZP3-1", "Q9D4F2-1" ], "evidence": [ { "id": "43236", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43236" } ] }, { "id": "43244", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "Q14693-1", "O14494-1", "O14495-1", "O43688-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1", "Q91ZP3-1", "P53933-1" ], "evidence": [ { "id": "43244", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43244" } ] }, { "id": "46736", "name": "", "equation": "H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "O14494-1", "O14495-1", "O43688-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1" ], "evidence": [ { "id": "46736", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46736" } ] }, { "id": "50884", "name": "", "equation": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "O14494-1", "O14495-1", "O43688-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1" ], "evidence": [ { "id": "50884", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50884" } ] }, { "id": "62040", "name": "", "equation": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "O14494-1", "O14495-1", "O43688-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1" ], "evidence": [ { "id": "62040", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/62040" } ] }, { "id": "62160", "name": "", "equation": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08564-1", "P97544-1", "Q8K593-1", "O14494-1", "O14495-1", "O43688-1", "Q61469-1", "Q99JY8-1", "Q9DAX2-1" ], "evidence": [ { "id": "62160", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/62160" } ] }, { "id": "R-HSA-428690", "name": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate", "equation": "", "summary": "Phospholipid phosphatase 2 (PLPP2, PPAP2A, LPP3) enzyme associated with the plasma membrane catalyzes the hydrolysis of extracellular sphingosine 1-phosphate (S1P) to form sphingosine and orthophosphate. The reaction is essential for removing S1P from plasma and cell uptake of sphingosine (Roberts et al., 1998; Zhao et al., 2007; reviewed by Tang et al., 2015).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [ "R-ALL-419305" ], "output_participant_list": [ "R-ALL-1132148" ], "enzyme_list": [ "O14494-1" ], "evidence": [ { "id": "R-HSA-428690", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-428690" } ] }, { "id": "R-HSA-428696", "name": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate", "equation": "", "summary": "Phospholipid phosphatases 1 (PLPP1, PPAP2A, LPP1), 2 (PLPP2, LPP2, PPAP2C), and 3 (PLPP3, LPP3, PPAP2B) associated with the plasma membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate to form sphingosine and orthophosphate (Roberts et al. 1998). PLPPs have roles in angiogenesis and cancer (reviewed by Tang et al., 2015; Tang & Brindley, 2020).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-428203" ], "output_participant_list": [], "enzyme_list": [ "O43688-1", "O14495-1", "O14494-1" ], "evidence": [ { "id": "R-HSA-428696", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-428696" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1132148", "participant_name": "sphingosine [cytoplasm]", "crossref": [ { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" }, { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" }, { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" }, { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" }, { "id": "57756", "database": "ChEBI", "url": "" }, { "id": "000008195650", "database": "ZINC", "url": "" }, { "id": "HMDB0062807", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-419305", "participant_name": "C18-S1P [extracellular region]", "crossref": [ { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-428203", "participant_name": "C18-S1P [cytosol]", "crossref": [ { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" }, { "id": "000008860500", "database": "ZINC", "url": "" }, { "id": "60119", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6AUU1", "gene_name": "Lpin3", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0A8I6AUU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AUU1" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "A0A8I6AUU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AUU1" } ] } ] }, { "uniprot_ac": "D3ZYB4", "gene_name": "Lpin2", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "D3ZYB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZYB4" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "D3ZYB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZYB4" } ] } ] }, { "uniprot_ac": "F7FDH2", "gene_name": "Lpin1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "F7FDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FDH2" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "F7FDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FDH2" } ] } ] }, { "uniprot_ac": "O08564", "gene_name": "Plpp1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate.", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O08564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08564" } ] } ] }, { "uniprot_ac": "O14494", "gene_name": "PLPP1", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate.", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "O14494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14494" } ] } ] }, { "uniprot_ac": "O14495", "gene_name": "PLPP3", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O14495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14495" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "O14495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14495" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "O14495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14495" } ] } ] }, { "uniprot_ac": "O43688", "gene_name": "PLPP2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O43688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43688" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "O43688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43688" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "O43688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43688" } ] } ] }, { "uniprot_ac": "P15309", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] } ] }, { "uniprot_ac": "P20646", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] } ] }, { "uniprot_ac": "P32567", "gene_name": "PAH1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "P32567", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32567" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "P32567", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32567" } ] } ] }, { "uniprot_ac": "P34913", "gene_name": "EPHX2", "activity": [ { "ec_number": "3.1.3.76", "activity": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate.", "evidence": [ { "id": "P34913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34913" } ] }, { "ec_number": "3.3.2.10", "activity": "an epoxide + H2O = an ethanediol.", "evidence": [ { "id": "P34913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34913" } ] } ] }, { "uniprot_ac": "P34914", "gene_name": "Ephx2", "activity": [ { "ec_number": "3.1.3.76", "activity": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate.", "evidence": [ { "id": "P34914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34914" } ] }, { "ec_number": "3.3.2.10", "activity": "an epoxide + H2O = an ethanediol.", "evidence": [ { "id": "P34914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34914" } ] } ] }, { "uniprot_ac": "P53933", "gene_name": "APP1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "P53933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53933" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "P53933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53933" } ] } ] }, { "uniprot_ac": "P80299", "gene_name": "Ephx2", "activity": [ { "ec_number": "3.1.3.76", "activity": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate.", "evidence": [ { "id": "P80299", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80299" } ] }, { "ec_number": "3.3.2.10", "activity": "an epoxide + H2O = an ethanediol.", "evidence": [ { "id": "P80299", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80299" } ] } ] }, { "uniprot_ac": "P97544", "gene_name": "Plpp3", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P97544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97544" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "P97544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97544" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "P97544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97544" } ] } ] }, { "uniprot_ac": "Q04396", "gene_name": "LPP1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q04396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04396" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q04396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04396" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate.", "evidence": [ { "id": "Q04396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04396" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "Q04396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04396" } ] } ] }, { "uniprot_ac": "Q05521", "gene_name": "DPP1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q05521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05521" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q05521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05521" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate.", "evidence": [ { "id": "Q05521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05521" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "Q05521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05521" } ] } ] }, { "uniprot_ac": "Q0VBU9", "gene_name": "Plpp4", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q0VBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VBU9" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate.", "evidence": [ { "id": "Q0VBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VBU9" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "Q0VBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VBU9" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q0VBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VBU9" } ] } ] }, { "uniprot_ac": "Q14693", "gene_name": "LPIN1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q14693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14693" } ] }, { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", 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