{ "uniprot_canonical_ac": "O00910-1", "uniprot_ac": "O00910", "uniprot_id": "STATA_DICDI", "mass": { "chemical_mass": 79792.0, "monoisotopic_mass": 79792.0 }, "refseq": { "ac": "XP_640661", "name": "signal transducer and activator of transcription family protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640661" }, "gene_names": [ { "name": "dstA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00910", "id": "O00910" }, { "name": "DDB_G0281381", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00910", "id": "O00910" }, { "name": "dstA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640661", "id": "XP_640661" }, { "name": "stat5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00910", "id": "O00910" }, { "name": "statA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00910", "id": "O00910" } ], "protein_names": [ { "name": "Signal transducer and activator of transcription A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00910" }, { "name": "Dd-STATa", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00910" }, { "name": "STAT5 homolog A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00910" }, { "name": "signal transducer and activator of transcription family protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640661", "id": "XP_640661" } ], "function": [ { "annotation": "Transcription factor that binds to 5'-TTGAATTGA-3' elements in the promoter region of target genes. 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"sequence_org": "RK", "sequence_mut": "DD", "comment": "About 3-fold reduced DNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" }, { "database": "PubMed", "id": "15053873", "url": "https://glygen.org/publication/PubMed/15053873" } ] }, { "start_pos": 484, "end_pos": 484, "sequence_org": "N", "sequence_mut": "A", "comment": "Loss of DNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" }, { "database": "PubMed", "id": "15053873", "url": "https://glygen.org/publication/PubMed/15053873" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "dstA", "url": "https://www.uniprot.org/uniprot/O00910", "locus": {} } ], 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"https://www.reactome.org/PathwayBrowser/#R-DDI-8985947", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9008059", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9008059", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9020591", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9020591", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9020933", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9020933", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9020956", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9020956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-909733", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-909733", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9701898", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9701898", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_640661", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00910-1", "url": "https://www.uniprot.org/uniprot/O00910-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSAEFSMDDFEDTFDSNATISTKDLFEGSDRLPLNQSINTTIQNLYLPNGGFAIGDQSQQQYYQAMPPLNQSDQFNLGRSNNLTPRTNQLQQLQQQQQQQQQPQQQQQQQTYGTQSPIHMSQTPSSPLSSPLPSPTPFSRQQSYNNNNSNNTSSSQNYNNNNININNNNNNNNTNNNNNNNNGNNSNGNNGNNNNNNNNNNNNNTNNNNNNNQQQQQQQQQQQQQQQQQQQQQQQGNPNLSSPQPILDTIYKLLSEQEQTLVQMIHEQSLLLNRLPPTLDENSLAPLKSLSQKQITLSGQMNTEMSALDATKKGMILEPTDLAKLFALKQDLQIQFKQLSLLHNEIQSILNPQHSAPKPNVALVLKSQPFPVVISKGKQLGENQLVVLVLTGARSNFHINGPVKATMICDSHPTNKNNPTTPLEMDSQPIYPATLTAHFPLKFLAGTRKCSVNLKFGVNIRDLDNVTTTVESDASNPFVVITNECQWEGSAGVLLKKDAFDGQLEITWAQFINTLQRHFLIATKQDPVRPKRPLSSYDLKYIQTHFFGNRSIIHQQDFDKFWVWFGKSMQTLRYQRHISTLWQEGIIYGYMGRQEVNDALQNQDPGTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAAAKKTFPDFLSEHSQFVNLLQWTKDTNGAPRFLKLHKDTALGSFAPKRTAPVPVGGYEPLNS", "length": 707, "header": "sp|O00910-1|STATA_DICDI Isoform 1 of Signal transducer and activator of transcription A OS=Dictyostelium discoideum OX=44689 GN=dstA PE=1 SV=1 CANONICAL=O00910-1" }, "isoforms": [ { "isoform_ac": "O00910-1", "url": "", "sequence": { "sequence": "MSSAEFSMDDFEDTFDSNATISTKDLFEGSDRLPLNQSINTTIQNLYLPNGGFAIGDQSQQQYYQAMPPLNQSDQFNLGRSNNLTPRTNQLQQLQQQQQQQQQPQQQQQQQTYGTQSPIHMSQTPSSPLSSPLPSPTPFSRQQSYNNNNSNNTSSSQNYNNNNININNNNNNNNTNNNNNNNNGNNSNGNNGNNNNNNNNNNNNNTNNNNNNNQQQQQQQQQQQQQQQQQQQQQQQGNPNLSSPQPILDTIYKLLSEQEQTLVQMIHEQSLLLNRLPPTLDENSLAPLKSLSQKQITLSGQMNTEMSALDATKKGMILEPTDLAKLFALKQDLQIQFKQLSLLHNEIQSILNPQHSAPKPNVALVLKSQPFPVVISKGKQLGENQLVVLVLTGARSNFHINGPVKATMICDSHPTNKNNPTTPLEMDSQPIYPATLTAHFPLKFLAGTRKCSVNLKFGVNIRDLDNVTTTVESDASNPFVVITNECQWEGSAGVLLKKDAFDGQLEITWAQFINTLQRHFLIATKQDPVRPKRPLSSYDLKYIQTHFFGNRSIIHQQDFDKFWVWFGKSMQTLRYQRHISTLWQEGIIYGYMGRQEVNDALQNQDPGTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAAAKKTFPDFLSEHSQFVNLLQWTKDTNGAPRFLKLHKDTALGSFAPKRTAPVPVGGYEPLNS", "length": 707, "header": "sp|O00910-1|STATA_DICDI Isoform 1 of Signal transducer and activator of transcription A OS=Dictyostelium discoideum OX=44689 GN=dstA PE=1 SV=1 CANONICAL=O00910-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 702, "end_pos": 702, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" }, { "database": "PubMed", "id": "9670017", "url": "https://glygen.org/publication/PubMed/9670017" } ], "site_lbl": "Tyr702" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis.", "journal": "Development (Cambridge, England)", "date": "1999-08", "authors": "Mohanty S, Jermyn K A, Early A, Kawata T, Aubry L, Ceccarelli A, Schaap P, Williams J G, Firtel R A", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "10393118", "url": "https://glygen.org/publication/PubMed/10393118" } ] }, { "title": "Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for proper cell-type proportioning.", "journal": "Developmental biology", "date": "2001-04-01", "authors": "Early A, Gamper M, Moniakis J, Kim E, Hunter T, Williams J G, Firtel R A", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "11254360", "url": "https://glygen.org/publication/PubMed/11254360" } ] }, { "title": "The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation.", "journal": "Dev. Biol.", "date": "2001", "authors": "Briscoe C, Moniakis J, Kim J Y, Brown J M, Hereld D, Devreotes P N, Firtel R A", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "11319871", "url": "https://glygen.org/publication/PubMed/11319871" } ] }, { "title": "Structure of an activated Dictyostelium STAT in its DNA-unbound form.", "journal": "Molecular cell", "date": "2004-03-26", "authors": "Soler-Lopez Montserrat, Petosa Carlo, Fukuzawa Masashi, Ravelli Raimond, Williams Jeffrey G, M\u00fcller Christoph W", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "15053873", "url": "https://glygen.org/publication/PubMed/15053873" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium.", "journal": "Cell", "date": "1997-06-13", "authors": "Kawata T, Shevchenko A, Fukuzawa M, Jermyn K A, Totty N F, Zhukovskaya N V, Sterling A E, Mann M, Williams J G", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "9200609", "url": "https://glygen.org/publication/PubMed/9200609" } ] }, { "title": "Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.", "journal": "The EMBO journal", "date": "1998-07-15", "authors": "Araki T, Gamper M, Early A, Fukuzawa M, Abe T, Kawata T, Kim E, Firtel R A, Williams J G", "evidence": [ { "database": "UniProtKB", "id": "O00910", "url": "https://www.uniprot.org/uniprot/O00910" } ], "reference": [ { "type": "PubMed", "id": "9670017", "url": "https://glygen.org/publication/PubMed/9670017" } ] } ], "pathway": [ { "id": "ddi:DDB_G0281381", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0281381", "resource": "KEGG Pathway" }, { "id": "R-DDI-1059683", "name": "Interleukin-6 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1059683", "resource": "Reactome", "description": "Interleukin-6 signaling" }, { "id": "R-DDI-1169408", "name": "ISG15 antiviral mechanism", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" }, { "id": "R-DDI-201556", "name": "Signaling by ALK", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-201556", "resource": "Reactome", "description": "Signaling by ALK" }, 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