{
"uniprot_canonical_ac": "O00762-1",
"uniprot_ac": "O00762",
"uniprot_id": "UBE2C_HUMAN",
"mass": {
"chemical_mass": 19652.0,
"monoisotopic_mass": 19652.0
},
"refseq": {
"ac": "NP_001268670",
"name": "ubiquitin-conjugating enzyme E2 C isoform 6",
"summary": "The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
"gene_names": [
{
"name": "UBE2C",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O00762",
"id": "O00762"
},
{
"name": "UBCH10",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O00762",
"id": "O00762"
},
{
"name": "UBE2C",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670",
"id": "NP_001268670"
},
{
"name": "dJ447F3.2; UBCH10",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670",
"id": "NP_001268670"
},
{
"name": "hCG_38372",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O00762",
"id": "O00762"
}
],
"protein_names": [
{
"name": "Ubiquitin-conjugating enzyme E2 C",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O00762"
},
{
"name": "(E3-independent) E2 ubiquitin-conjugating enzyme C",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "2.3.2.23",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "2.3.2.24",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "E2 ubiquitin-conjugating enzyme C",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "UbcH10",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "Ubiquitin carrier protein C",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "Ubiquitin-protein ligase C",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00762"
},
{
"name": "ubiquitin-conjugating enzyme E2 C isoform 6",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670",
"id": "NP_001268670"
},
{
"name": "ubiquitin-protein ligase C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme C; (E3-independent) E2 ubiquitin-conjugating enzyme C; ubiquitin conjugating enzyme E2C",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670",
"id": "NP_001268670"
}
],
"function": [
{
"annotation": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762#function"
},
{
"database": "PubMed",
"id": "27259151",
"url": "https://glygen.org/publication/PubMed/27259151"
},
{
"database": "PubMed",
"id": "19820702",
"url": "https://glygen.org/publication/PubMed/19820702"
},
{
"database": "PubMed",
"id": "19822757",
"url": "https://glygen.org/publication/PubMed/19822757"
},
{
"database": "PubMed",
"id": "15558010",
"url": "https://glygen.org/publication/PubMed/15558010"
},
{
"database": "PubMed",
"id": "18485873",
"url": "https://glygen.org/publication/PubMed/18485873"
},
{
"database": "PubMed",
"id": "20061386",
"url": "https://glygen.org/publication/PubMed/20061386"
}
]
},
{
"annotation": "Comprehensive analysis of UBE2C expression and its potential roles and mechanisms in hepatocellular carcinoma.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
{
"database": "PubMed",
"id": "37580802",
"url": "https://glygen.org/publication/PubMed/37580802"
}
]
},
{
"annotation": "Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
{
"database": "PubMed",
"id": "37848988",
"url": "https://glygen.org/publication/PubMed/37848988"
}
]
},
{
"annotation": "Role of UBE2C in Brain Cancer Invasion and Dissemination. Review article Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
{
"database": "PubMed",
"id": "37958776",
"url": "https://glygen.org/publication/PubMed/37958776"
}
]
},
{
"annotation": "System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
{
"database": "PubMed",
"id": "37535572",
"url": "https://glygen.org/publication/PubMed/37535572"
}
]
},
{
"annotation": "The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
}
]
},
{
"annotation": "UbcH10 is highly expressed in various human primary tumors and UbcH10 has an ability to promote cell growth and malignant transformation.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
{
"database": "PubMed",
"id": "12874022",
"url": "https://glygen.org/publication/PubMed/12874022"
}
]
},
{
"annotation": "Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001268670",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268670"
},
{
"database": "PubMed",
"id": "38102624",
"url": "https://glygen.org/publication/PubMed/38102624"
}
]
}
],
"disease": [],
"snv": [],
"mutagenesis": [
{
"start_pos": 114,
"end_pos": 114,
"sequence_org": "C",
"sequence_mut": "S",
"comment": "Loss of function; inhibition of cyclin-B degradation.",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
},
{
"database": "PubMed",
"id": "15558010",
"url": "https://glygen.org/publication/PubMed/15558010"
},
{
"database": "PubMed",
"id": "9122200",
"url": "https://glygen.org/publication/PubMed/9122200"
}
]
}
],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "72.37",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "82.25",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "78.19",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "79.44",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "57.26",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "91.72",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "88.76",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "64.38",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "55.94",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "68.2",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "61.25",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "65.66",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "66.82",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000175063",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000175063"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
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}
],
"disease": [
{
"disease_id": "DOID:10534",
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"resource": "Disease Ontology",
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},
"synonyms": [
{
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"description": ""
},
{
"id": "DOID:10534",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"name": "ca greater curvature of stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
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"database": "BioXpress",
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},
{
"id": "DOID:11054",
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"url": "http://disease-ontology.org/term/DOID:11054",
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"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "O00762",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00762"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
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{
"id": "O00762",
"url": "https://omabrowser.org/oma/group/O00762/",
"database": "OMA"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q9VTY6-1",
"protein_name": "Ubiquitin-conjugating enzyme E2 C",
"gene_name": "vih",
"tax_id": 7227,
"organism": "Drosophila melanogaster",
"sequence": {
"sequence": "MAQNISPEQSGGAGGGGSKHSDDSMPVKDNHAVSKRLHKELMNLMMANERGISAFPDGENIFKWVGTIAGPRNTVYSGQTYRLSLDFPNSYPYAAPVVKFLTSCFHPNVDLQGAICLDILKDKWSALYDVRTILLSIQSLLGEPNNESPLNAQAAMMWNDQKEYKKYLDAFYEKHKDT",
"length": 178
},
"evidence": [
{
"id": "O00762",
"url": "https://omabrowser.org/oma/group/O00762/",
"database": "OMA"
}
],
"common_name": "Fruit fly"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 5,
"go_terms": [
{
"name": "ATP binding",
"id": "GO:0005524",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "ubiquitin protein ligase activity",
"id": "GO:0061630",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "ubiquitin-protein transferase activity",
"id": "GO:0004842",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "ubiquitin-like protein ligase binding",
"id": "GO:0044389",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044389",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "ubiquitin conjugating enzyme activity",
"id": "GO:0061631",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 6,
"go_terms": [
{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "nucleoplasm",
"id": "GO:0005654",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "anaphase-promoting complex",
"id": "GO:0005680",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "ubiquitin ligase complex",
"id": "GO:0000151",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 13,
"go_terms": [
{
"name": "cell division",
"id": "GO:0051301",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "protein ubiquitination",
"id": "GO:0016567",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "exit from mitosis",
"id": "GO:0010458",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010458",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "anaphase-promoting complex-dependent catabolic process",
"id": "GO:0031145",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "protein K11-linked ubiquitination",
"id": "GO:0070979",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "positive regulation of ubiquitin protein ligase activity",
"id": "GO:1904668",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904668",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "positive regulation of mitotic metaphase/anaphase transition",
"id": "GO:0045842",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045842",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "protein polyubiquitination",
"id": "GO:0000209",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "ubiquitin-dependent protein catabolic process",
"id": "GO:0006511",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "regulation of mitotic metaphase/anaphase transition",
"id": "GO:0030071",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030071",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "protein K48-linked ubiquitination",
"id": "GO:0070936",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "positive regulation of exit from mitosis",
"id": "GO:0031536",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031536",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
},
{
"name": "free ubiquitin chain polymerization",
"id": "GO:0010994",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010994",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [],
"ptm_annotation": [
{
"annotation": "Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.",
"evidence": [
{
"database": "UniProtKB",
"id": "O00762",
"url": "https://www.uniprot.org/uniprot/O00762"
},
{
"database": "PubMed",
"id": "15558010",
"url": "https://glygen.org/publication/PubMed/15558010"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "R-HSA-141423",
"name": "Binding of the MCC complex to the APC/C complex",
"equation": "",
"summary": "In the direct inhibition model, association of the MCC with APCC results in the inactivation of APC/C. However, the affinity between MCC and APC/C is not high, so that the inhibition is readily reversible. The role of unattached kinetochores is to sensitize the APC/C to prolonged inhibition by the MCC.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-141423",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-141423"
}
]
},
{
"id": "R-HSA-174057",
"name": "Multiubiquitination of APC/C-associated Cdh1",
"equation": "",
"summary": "Cdh1 is multiubiquitinated by the APC/C:Cdh1 complex prior to degradation by the 26S proteasome.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174057",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174057"
}
]
},
{
"id": "R-HSA-174058",
"name": "Degradation of multiubiquitinated Cdh1",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'multiubiquitinated Cdh1 associated with APC/C' is present. At the end of this reaction, 1 molecule of 'phosphorylated anaphase promoting complex (APC/C)', and 3 molecules of 'ubiquitin' are present.
This reaction takes place in the 'nucleoplasm' and is mediated by the 'endopeptidase activity' of '26S proteasome'.
",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O00487-1",
"P28074-1",
"Q99436-1",
"Q16763-1",
"P28072-1",
"P51668-1",
"P51965-1",
"P40306-1",
"P28065-1",
"P28062-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174058",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174058"
}
]
},
{
"id": "R-HSA-174070",
"name": "Association of Cdh1 with the APC/C",
"equation": "",
"summary": "Following its dephosphorylation in late mitosis, Cdh1 replaces Cdc20 as the APC/C activator.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174070",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174070"
}
]
},
{
"id": "R-HSA-174079",
"name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2",
"equation": "",
"summary": "At the G1/S transition, the Cdh1 subunit of the APC:Cdh1 complex is phosphorylated by Cyclin A:Cdk2 and dissociates from APC/C. This inactivates APC/C and permits the accumulation of cell cycle proteins required for DNA synthesis and entry into mitosis.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"P24941-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174079",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174079"
}
]
},
{
"id": "R-HSA-174088",
"name": "Association of cell cycle proteins with the APC/C:Cdh1 complex",
"equation": "",
"summary": "The APC/C:Cdh1 complex recognizes substrates containing a D box, a KEN box (Pfleger and Kirschner, 2000) or a D box activated (DAD) domain (Castro et al., 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q96GD4-1",
"Q16763-1",
"O14965-1",
"P53350-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174088",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174088"
}
]
},
{
"id": "R-HSA-174104",
"name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex",
"equation": "",
"summary": "Rape et al. have recently demonstrated that the order in which APC/C targeted proteins are degraded is determined by the processivity of multiubiquitination of these substrates. Processive substrates acquire a polyubiquitin chain upon binding to the APC/C once and are degraded. Distributive substrates bind, dissociate and reassociate with the APC/C multiple times before acquiring an ubiquitin chain of sufficient length to insure degradation. In addition, distributive substrates that dissociate from the APC/C with short ubiquitin chains are targeted for deubiquitination (Rape et al., 2006). Paradoxically, although the multiubiquitination of cyclin A is distributive and later substrates of APC-Cdc20 such as Securin are processive (Rape et al., 2006), Cyclin A is degraded prior to Securin and Cyclin B. The mechanisms insuring this order have not yet be determined.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P06493-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174104",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174104"
}
]
},
{
"id": "R-HSA-174105",
"name": "Degradation of multiubiquitinated cell cycle proteins",
"equation": "",
"summary": "Cell cycle proteins mulitubiquitinated by the APC/C are targeted for degradation by the 26S proteasome.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"A5LHX3-1",
"O00487-1",
"P28074-1",
"Q99436-1",
"Q96GD4-1",
"Q16763-1",
"O14965-1",
"P28072-1",
"P53350-1",
"P51668-1",
"P51965-1",
"P40306-1",
"P28065-1",
"P28062-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174105",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174105"
}
]
},
{
"id": "R-HSA-174119",
"name": "Free APC/C phosphorylated by Plk1",
"equation": "",
"summary": "Phosphorylation of the APC/C is believed to be required for its activation. While the identity of the essential phosphorylation sites and the kinase(s) responsible are not known with certainty, in vitro studies have shown that the Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7 are phosphorylated and that the Cdk1 and Plk1 kinases may play a role.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P53350-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174119",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174119"
}
]
},
{
"id": "R-HSA-174120",
"name": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex",
"equation": "",
"summary": "Cyclin B is believed to be recognized by the APC/C:Cdc20 complex through its D-box sequence.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P06493-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174120",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174120"
}
]
},
{
"id": "R-HSA-174121",
"name": "Association of Securin with Cdc20:APC/C complex",
"equation": "",
"summary": "Securin is thought to be recognized by the APC/C:Cdc20 complex through its conserved D-box sequence.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174121",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174121"
}
]
},
{
"id": "R-HSA-174132",
"name": "Free APC/C phosphorylated by Cyclin B:Cdc2",
"equation": "",
"summary": "Phosphorylation of the APC/C is believed to be required for its activation. While the identity of the essential phosphorylation sites and the kinase(s) responsible are not known with certainty, in vitro studies have shown that the Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7 are phosphorylated and that the Cdk1 and Plk1 kinases may play a role.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P06493-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174132",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174132"
}
]
},
{
"id": "R-HSA-174139",
"name": "Dissociation of phospho-Cdh1 from the APC/C complex",
"equation": "",
"summary": "Following its phosphorylation, Cdh1 dissociates from the APC/C, rendering the APC/C inactive. This allows the stabilization of proteins required for subsequent cell cycle progression.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174139",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174139"
}
]
},
{
"id": "R-HSA-174144",
"name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex",
"equation": "",
"summary": "Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 2002; Jin et al. 2008).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174144",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174144"
}
]
},
{
"id": "R-HSA-174157",
"name": "Degradation of multiubiquitinated Cyclin B",
"equation": "",
"summary": "Mulitubiquitinated Cyclin B is targeted for degradation by the 26S proteasome.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P06493-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174157",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174157"
}
]
},
{
"id": "R-HSA-174171",
"name": "Association of Cyclin A with the APC/C",
"equation": "",
"summary": "Cyclin A is believed to be recognized by the APC/C:Cdc20 complex through its D-box sequence, which is 10-20 residues longer than the D-box of cyclin B (Geley et al., 2001).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P06493-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174171",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174171"
}
]
},
{
"id": "R-HSA-174195",
"name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex",
"equation": "",
"summary": "At the beginning of this reaction, 3 molecules of 'ubiquitin', and 1 molecule of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated cell cycle protein:APC/C:Cdh1 complex' is present.
This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' (Rape et al.1996).
",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q96GD4-1",
"Q16763-1",
"O14965-1",
"P53350-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174195",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174195"
}
]
},
{
"id": "R-HSA-174202",
"name": "Degradation of multiubiquitinated Securin",
"equation": "",
"summary": "Following ubiquitination, securin is degraded by the 26S proteasome.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"A5LHX3-1",
"O00487-1",
"P28074-1",
"Q99436-1",
"Q16763-1",
"P28072-1",
"P51668-1",
"P51965-1",
"P40306-1",
"P28065-1",
"P28062-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174202",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174202"
}
]
},
{
"id": "R-HSA-174224",
"name": "Dissociation of Cdc20 from APC/C complex",
"equation": "",
"summary": "In late mitosis, Cdc20 dissociates from the APC/C and is replaced by the activator Cdh1 (Ballabeni et al. 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174224",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174224"
}
]
},
{
"id": "R-HSA-174227",
"name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex', and 3 molecules of 'ubiquitin' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex' is present.
This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'Cdc20:Phospho-APC/C'.
",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P06493-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174227",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174227"
}
]
},
{
"id": "R-HSA-174238",
"name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1",
"equation": "",
"summary": "One model ( the direct inhibition model) describing the inhibition of the APC/C during the mitotic spindle checkpoint suggests that the association of the hBUBR1:hBUB3:MAD2*:CDC20 mitotic checkpoint complex (MCC) with APC/C results in the inactivation of APC/C. The affinity between MCC and APC/C is not high, thus inhibition is readily reversible when the mitotic spindle checkpoint has been satisfied.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174238",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174238"
}
]
},
{
"id": "R-HSA-174255",
"name": "Degradation multiubiquitinated Cyclin A",
"equation": "",
"summary": "Following multiubiquitination, Cyclin A is targeted for destruction by the 26S proteasome.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"A5LHX3-1",
"O00487-1",
"P28074-1",
"Q99436-1",
"Q16763-1",
"P06493-1",
"P28072-1",
"P51668-1",
"P51965-1",
"O60566-1",
"P40306-1",
"P28065-1",
"P28062-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-174255",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174255"
}
]
},
{
"id": "R-HSA-179410",
"name": "Association of Nek2A with MCC:APC/C",
"equation": "",
"summary": "Nek2A does not appear to be recruited to the APC/C by Cdc20 but rather binds directly to the APC/C in an interaction involving the NEK2A C-terminal methionine\u2013arginine (MR) dipeptide tail (Hayes et al., 2006).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51955-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-179410",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-179410"
}
]
},
{
"id": "R-HSA-179417",
"name": "Multiubiquitination of Nek2A",
"equation": "",
"summary": "Nek2A is ubiquitinated by the APC/C-Cdc20 ubiquitin ligase.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51955-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-179417",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-179417"
}
]
},
{
"id": "R-HSA-179421",
"name": "Degradation of multiubiquitinated Nek2A",
"equation": "",
"summary": "Nek2A is degraded by the 26S proteasome following ubiquitylation by the E3 ubiquitin ligase APC/C: Cdc20.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51955-1",
"P51668-1",
"P51965-1",
"O60566-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-179421",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-179421"
}
]
},
{
"id": "R-HSA-188191",
"name": "APC/C:Cdh1-mediated degradation of Skp2",
"equation": "",
"summary": "SKP2 is degraded by the anaphase promoting complex/Cyclosome and its activator FZR1 (Cdh1) [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination SKP2 and, thus, plays a critical role in controlling the M/G1 transition (mitotic exit). APC/C:Cdh1-mediated degradation of SKP2 depends on RB1, as RB1 recruits SKP2 to the APC/C:Cdh1 complex, by simultaneously interacting with SKP2 and FZR1. RB1 does not undergo APC/C:Cdh1-mediated ubiquitination (Binne et al. 2007).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O00487-1",
"P28074-1",
"Q99436-1",
"Q16763-1",
"P28072-1",
"P51668-1",
"P51965-1",
"P40306-1",
"P28065-1",
"P28062-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-188191",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-188191"
}
]
},
{
"id": "R-HSA-188371",
"name": "Association of Cyclin A:Cdk2 with Cdh1",
"equation": "",
"summary": "Cyclin A-Cdk2 prevents unscheduled APC reactivation during S phase by binding and subsequently phosphorylating Cdh1. Phosphorylation-dependent dissociation of the Cdh1-activating subunit inhibits the APC/C.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"P24941-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-188371",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-188371"
}
]
},
{
"id": "R-HSA-3788705",
"name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2",
"equation": "",
"summary": "At the G1/S transition, the Cdh1 (FZR1) subunit of the APC/C:Cdh1 complex is phosphorylated by Cyclin A:Cdk2 (CCNA:CDK2) and dissociates from APC/C. This inactivates APC/C and permits the accumulation of cell cycle proteins required for DNA synthesis and entry into mitosis (Lukas et al. 1999). Activation of the ATM kinase by DNA damage in the form of double strand breaks results in TP53-mediated induction of CDKN1A (p21) expression. CDKN1A binds CCNA:CDK2 complex and prevents it from phosphorylating Cdh1 (Takahashi et al. 2012).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"P24941-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-3788705",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3788705"
}
]
},
{
"id": "R-HSA-3788708",
"name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1",
"equation": "",
"summary": "Cyclin A-Cdk2 (CCNA:CDK2) prevents unscheduled APC reactivation during S phase by binding and subsequently phosphorylating FZR1 (Cdh1). Phosphorylation-dependent dissociation of the Cdh1-activating subunit inhibits the APC/C (Sorensen et al. 2001). DNA damage activates ATM kinase, resulting in TP53-mediated induction of CDKN1A (p21) expression. CDKN1A binds CCNA:CDK2 complex and prevents its association with Cdh1 (Takahashi et al. 2012).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"P24941-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-3788708",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3788708"
}
]
},
{
"id": "R-HSA-3788724",
"name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2",
"equation": "",
"summary": "Cdh1:APC/C complex, stabilized by the DNA damage-induced ATM-TP53-CDKN1A axis, ubiquitinates EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases, targeting them for degradation (Takahashi et al. 2012).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"Q96KQ7-1",
"P51668-1",
"P51965-1",
"Q9H9B1-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-3788724",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3788724"
}
]
},
{
"id": "R-HSA-3788725",
"name": "Cdh1:APC/C complex binds EHMT1:EHMT2",
"equation": "",
"summary": "Cdh1 (FZR1) is able to bind both G9a (EHMT2) and GLP (EHMT1) (Takahashi et al. 2012). EHMT1 and EHMT2 histone methyltransferases were shown to function as a heterodimer in vivo (Tachibana et al. 2005).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"Q96KQ7-1",
"P51668-1",
"P51965-1",
"Q9H9B1-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-3788725",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3788725"
}
]
},
{
"id": "R-HSA-3790130",
"name": "Regulation of IL6 transcription",
"equation": "",
"summary": "Methylation of the IL6 promoter by EHMT1:EHMT2 (GLP:G9a) histone methyltransferases inhibits IL6 transcription, while Cdh1:APC/C-mediated degradation of EHTM1:EHTM2 downstream of the ATM-TP53-CDKN1A axis stimulates IL6 transcription (Takahashi et al. 2012). Oncogenic RAS signaling stimulates activation of the CEBPB transcription factor (C/EBP-beta) which binds IL6 promoter and stimulates IL6 transcription (Kuilman et al. 2008, Lee et al. 2010). NF kappa B transcription factor is also activated in senescent cells (Chien et al. 2011) through interleukin-1-alpha (IL1A) signaling (Jimi et al. 1996, Hartupee et al. 2008, Orjalo et al. 2009), and it cooperates with CEBPB in the activation of IL6 transcription (Shimizu et al. 1990, Libermann and Baltimore 1990, Matsusaka et al. 1993, Acosta et al. 2008). Autocrine IL6 signaling stimulates CEBPB expression (Kuilman et al. 2008), creating a positive feedback loop. STAT3, activated by IL6 signaling cascade is necessary for CEBPB transcription, but the direct binding of STAT3 to the CEBPB promoter has not been demonstrated (Niehof et al. 2001).
VENTX inhibits transcription of the Interleukin-6 (IL6) gene, thus promoting differentiation of primary monocytes into dendritic cells (Wu et al. 2014). The NFKB complex which competes with VENTX for binding to the IL6 gene promoter (Wu et al. 2014). It is not known whether histone H3K9 dimethylation at the VENTX promoter (Takahashi et al. 2012) is involved in VENTX-mediated transcriptional repression of IL6.",
"cellular_location": "extracellular region, nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"Q96KQ7-1",
"P51668-1",
"P51965-1",
"Q9H9B1-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-3790130",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3790130"
}
]
},
{
"id": "R-HSA-3790137",
"name": "Stimulation of IL8 transcription in senescent cells",
"equation": "",
"summary": "Methylation of the IL8 promoter by EHMT1:EHMT2 (GLP:G9a) histone methyltransferases inhibits IL8 transcription, while Cdh1:APC/C-mediated degradation of EHTM1:EHTM2 downstream of the ATM-TP53-CDKN1A axis stimulates IL8 transcription (Takahashi et al. 2012). CEBPB transcription factor, activated by oncogenic RAS signaling, binds IL8 promoter and stimulates IL8 transcription (Kuilman et al. 2008). The NF-kappa-B transcription factor is also activated in senescent cells (Chien et al. 2011) through interleukin-1-alpha (IL1A) signaling (Jimi et al. 1996, Hartupee et al. 2008, Orjalo et al. 2009), and it cooperates with CEBPB in the activation of IL8 transcription (Kunsch and Rosen 1993, Stein and Baldwin 1993, Matsusaka et al. 1993, Acosta et al. 2008).",
"cellular_location": "extracellular region, nucleoplasm",
"input_participant_list": [
"R-HSA-3788737"
],
"output_participant_list": [
"R-HSA-447095"
],
"enzyme_list": [
"Q16763-1",
"Q96KQ7-1",
"P51668-1",
"P51965-1",
"Q9H9B1-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-3790137",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3790137"
}
]
},
{
"id": "R-HSA-68712",
"name": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1",
"equation": "",
"summary": "From the end of anaphase and throughout G1, the Cdh1 (FZR1) containing anaphase-promoting complex (APC/C:Cdh1) ubiquitinates geminin (GMNN), targeting it for degradation and enabling release of CDT1 and the subsequent association of CDT1 with the replication origins.The presence of an APC destruction box in geminin and its APC/C-mediated ubiquitination and degradation was first demonstrated in Xenopus egg extracts (McGarry and Kirschner 1998) and was later confirmed in human cells, where it was shown to largely depend on Cdh1 and not Cdc20 component of the APC/C (Pfleger et al. 2001; Di Fiore and Pines 2007; Machida and Dutta 2007). Emi1 (FBXO5) mediated inhibition of the APC/C:Cdh1 complex in S and G2 phases is needed for stabilization of geminin and prevention of re-replication (Di Fiore and Pines 2007; Machida and Dutta 2007).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-68712",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-68712"
}
]
},
{
"id": "R-HSA-69015",
"name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'phosphorylated Cdc6', 1 molecule of 'ubiquitin', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'ubiquitinated Cdc6' is present.
This reaction takes place in the 'cytosol' and is mediated by the 'endopeptidase activity' of 'anaphase-promoting complex (APC)'.
",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-69015",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-69015"
}
]
},
{
"id": "R-HSA-8852129",
"name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes",
"equation": "",
"summary": "In the cytosol, the UBA1-ubiquitin thiol ester conjugate transfers ubiquitin from UBA1 to an internal cysteine residue of the E2 enzyme, forming a thiol ester conjugate between ubiquitin and the cysteine residue of E2 (Jin et al. 2007, inferred from the rabbit homologue in Hershko et al. 1983). The E2 then disengages from UBA1 (Eletr et al. 2005).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q969T4-1",
"P49427-1",
"P22314-1",
"Q16763-1",
"P60604-1",
"Q712K3-1",
"P68036-1",
"P51668-1",
"P62837-1",
"P62253-1",
"P61086-1",
"P62256-1",
"O00762-1",
"Q8WVN8-1"
],
"evidence": [
{
"id": "R-HSA-8852129",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8852129"
}
]
},
{
"id": "R-HSA-8852130",
"name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes",
"equation": "",
"summary": "In the nucleus (Grenfell et al. 1994), the UBA1-ubiquitin thiol ester conjugate transfers ubiquitin from UBA1 to an internal cysteine residue of the E2 enzyme, forming a thiol ester conjugate between ubiquitin and the cysteine residue of E2 (Jin et al. 2007, inferred from the rabbit homologue in Hershko et al. 1983, reviewed in Groettrup et al. 2008). The E2 then disengages from UBA1 (Eletr et al. 2005).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q969T4-1",
"P49427-1",
"P22314-1",
"Q16763-1",
"P68036-1",
"P49459-1",
"P51965-1",
"P62837-1",
"Q96B02-1",
"Q9NPD8-1",
"P63146-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-8852130",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8852130"
}
]
},
{
"id": "R-HSA-9686969",
"name": "APC/C:Cdh1 polyubiquitinates SKP2",
"equation": "",
"summary": "RB1-dependent polyubiquitination of SKP2 by the APC/C:Cdh1 complex is an important mechanism of RB1-mediated cell cycle exit, which contributes to the RB1 tumor suppressive role. ABC/C:Cdh1-mediated polyubiquitination targets SKP2 for proteasome-mediated degradation. RB1 and APC/C:Cdh1-dependent degradation of SKP2 allows accumulation of CDKN1B (p27Kip1) in the cell, as CDKN1B is a target of the SKP2-containing SCF ubiquitin ligase complex. CDKN1B acts as a CDK inhibitor, enabling mitotic exit (Ji et al. 2004, Binne et al. 2007).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-9686969",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9686969"
}
]
},
{
"id": "R-HSA-9686980",
"name": "RB1 recruits APC/C:Cdh1 complex to SKP2",
"equation": "",
"summary": "The pocket domain of the RB1 tumor suppressor protein binds to the N-terminal domain of SKP2, a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, whose targets include the cyclin-dependent kinase (CDK) inhibitor p27Kip1 (CDKN1B) (Ji et al. 2004, Binne et al. 2007). RB1 is able to simultanously interact with SKP2 and with FZR1 (Cdh1). FZR1 is a substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C). The interaction with FZR1 involves a different subregion of the pocket domain than the interaction with SKP2, and is partially dependent on the LxCxE binding cleft (Binne et al. 2007).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-9686980",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9686980"
}
]
},
{
"id": "R-HSA-9687377",
"name": "Defective RB1 does not form a complex with SKP2 and FZR1",
"equation": "",
"summary": "A tripartite complex formed between RB1, SKP2 and FZR1 (Cdh1) targets SKP2 for the anaphase promoting complex/cyclosome (APC/C:Cdh1)-mediated ubiquitination and subsequent proteasome-mediated degradation. Both SKP2 and FZR1 interact with the pocket domain of RB1, with amino acid residues 637\u2013738 and 772\u2013824 involved in SKP2 binding and the cleft region (amino acids 753\u2013761), containing the LxCxE motif, involved in FZR1 binding (Binne et al. 2007). RB1 T738_R775del (RB1 Ex22del) cancer mutant, which lacks exon 22, is able to associate with SKP2 but unable to bind FZR1. This mutant is defective in inducing accumulation of CDKN1B (p27Kip1) and promoting mitotic exit as it cannot prevent SKP2-mediated ubiquitination and degradation of CDKN1B (Ji et al. 2004, Binne et al. 2007). RB1 T738_R775del mutant is also defective in E2F binding (Ji et al. 2004). RB1 missense mutant, RB1 R661W, which causes low penetrance familial retinoblastoma, is unable to bind to E2Fs but retains the ability to bind to SKP2 and FZR2 and to induce CDKN1B accumulation (Ji et al. 2004, Binne et al. 2007).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16763-1",
"P51668-1",
"P51965-1",
"O00762-1"
],
"evidence": [
{
"id": "R-HSA-9687377",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9687377"
}
]
},
{
"id": "R-HSA-983140",
"name": "Transfer of Ub from E2 to substrate and release of E2",
"equation": "",
"summary": "Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9BYM8-1",
"Q9H832-1",
"Q969T4-1",
"Q7Z7E8-1",
"Q9UHC7-1",
"Q96PU5-1",
"Q9Y2X8-1",
"Q9Y4L5-1",
"Q8TDB6-1",
"Q9NQ86-1",
"O43255-1",
"Q96BH1-1",
"P49427-1",
"P61081-1",
"P62877-1",
"Q8WVD3-1",
"Q15386-1",
"Q5VVX9-1",
"Q86XS8-1",
"O94822-1",
"Q2Q1W2-1",
"O60291-1",
"Q5U5Q3-1",
"Q96AX9-1",
"Q96F44-1",
"Q9NVW2-1",
"O94874-1",
"Q7Z3V4-1",
"Q8IUQ4-1",
"Q13049-1",
"Q9UNE7-1",
"Q16763-1",
"Q86Y13-1",
"Q8TBB1-1",
"Q8WV44-1",
"Q96PM5-1",
"Q9C026-1",
"O60260-1",
"Q9UBS8-1",
"Q9Y252-1",
"P60604-1",
"Q712K3-1",
"Q969K3-1",
"O15033-1",
"O94972-1",
"Q86WT6-1",
"Q9H4P4-1",
"Q13191-1",
"Q14669-1",
"Q7Z6Z7-1",
"O14933-1",
"O95376-1",
"P68036-1",
"Q96LR5-1",
"Q7Z419-1",
"Q96J02-1",
"Q9BV68-1",
"Q969Q1-1",
"Q9H0M0-1",
"Q9HAU4-1",
"Q9HCE7-1",
"Q5T447-1",
"Q15751-1",
"Q9UII4-1",
"Q05086-1",
"O43164-1",
"Q86XT4-1",
"P78317-1",
"P49459-1",
"Q7Z6E9-1",
"Q5VTB9-1",
"Q5XPI4-1",
"Q63HN8-3",
"Q6ZMZ0-1",
"Q9C0C9-1",
"P51668-1",
"P61077-1",
"Q9Y508-1",
"P51965-1",
"P61088-1",
"P62837-1",
"Q6ZNA4-1",
"P62253-1",
"Q7Z6J8-1",
"Q8IWV8-1",
"Q8ND25-1",
"Q9Y385-1",
"Q5T4S7-1",
"Q8N7E2-1",
"Q8NHG8-1",
"Q9HCM9-1",
"P19474-1",
"Q8WY64-1",
"Q9Y4B6-1",
"Q6Q0C0-1",
"Q6UWE0-1",
"Q8N6D2-1",
"Q8TC41-1",
"Q9NV58-1",
"P61086-1",
"P46934-1",
"P41226-1",
"P62256-1",
"Q14139-1",
"Q96B02-1",
"Q9C037-1",
"Q8IYU2-1",
"Q9P2P5-1",
"O95714-1",
"Q15034-1",
"Q8NG27-1",
"Q9BWF2-1",
"O94941-1",
"P63146-1",
"Q5GLZ8-1",
"Q5U5R9-1",
"Q8IVU3-1",
"Q9ULT8-1",
"Q7Z6J0-1",
"Q9H9P5-4",
"Q8IWV7-1",
"Q8N2K1-1",
"Q969M7-1",
"O00762-1",
"Q8WVN8-1"
],
"evidence": [
{
"id": "R-HSA-983140",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983140"
}
]
},
{
"id": "R-HSA-983152",
"name": "Transfer of ubiquitin from E1 to E2",
"equation": "",
"summary": "Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"A0AVT1-1",
"Q9H832-1",
"Q969T4-1",
"Q7Z7E8-1",
"Q9Y2X8-1",
"P49427-1",
"P61081-1",
"P22314-1",
"Q5VVX9-1",
"Q16763-1",
"P60604-1",
"Q712K3-1",
"O14933-1",
"P68036-1",
"Q96LR5-1",
"P49459-1",
"Q9C0C9-1",
"P51668-1",
"P61077-1",
"P51965-1",
"P61088-1",
"P62837-1",
"P62253-1",
"Q9Y385-1",
"P61086-1",
"Q8TBC4-1",
"P41226-1",
"P62256-1",
"Q96B02-1",
"P63146-1",
"Q8N2K1-1",
"Q969M7-1",
"O00762-1",
"Q8WVN8-1"
],
"evidence": [
{
"id": "R-HSA-983152",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983152"
}
]
},
{
"id": "R-HSA-983156",
"name": "Polyubiquitination of substrate",
"equation": "",
"summary": "Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9BYM8-1",
"Q9H832-1",
"Q969T4-1",
"Q7Z7E8-1",
"Q9UHC7-1",
"Q96PU5-1",
"Q9Y2X8-1",
"Q9Y4L5-1",
"Q8TDB6-1",
"Q9NQ86-1",
"O43255-1",
"Q96BH1-1",
"P49427-1",
"P61081-1",
"P62877-1",
"Q8WVD3-1",
"Q15386-1",
"Q5VVX9-1",
"Q86XS8-1",
"O94822-1",
"Q2Q1W2-1",
"O60291-1",
"Q5U5Q3-1",
"Q96AX9-1",
"Q96F44-1",
"Q9NVW2-1",
"O94874-1",
"Q7Z3V4-1",
"Q8IUQ4-1",
"Q13049-1",
"Q9UNE7-1",
"Q16763-1",
"Q86Y13-1",
"Q8TBB1-1",
"Q8WV44-1",
"Q96PM5-1",
"Q9C026-1",
"O60260-1",
"Q9UBS8-1",
"Q9Y252-1",
"P60604-1",
"Q712K3-1",
"Q969K3-1",
"O15033-1",
"O94972-1",
"Q86WT6-1",
"Q9H4P4-1",
"Q13191-1",
"Q14669-1",
"Q7Z6Z7-1",
"O14933-1",
"O95376-1",
"P68036-1",
"Q96LR5-1",
"Q7Z419-1",
"Q96J02-1",
"Q9BV68-1",
"Q969Q1-1",
"Q9H0M0-1",
"Q9HAU4-1",
"Q9HCE7-1",
"Q5T447-1",
"Q15751-1",
"Q9UII4-1",
"Q05086-1",
"O43164-1",
"Q86XT4-1",
"P78317-1",
"P49459-1",
"Q7Z6E9-1",
"Q5VTB9-1",
"Q5XPI4-1",
"Q63HN8-3",
"Q6ZMZ0-1",
"Q9C0C9-1",
"P51668-1",
"P61077-1",
"Q9Y508-1",
"P51965-1",
"P61088-1",
"P62837-1",
"Q6ZNA4-1",
"P62253-1",
"Q7Z6J8-1",
"Q8IWV8-1",
"Q8ND25-1",
"Q9Y385-1",
"Q5T4S7-1",
"Q8N7E2-1",
"Q8NHG8-1",
"Q9HCM9-1",
"P19474-1",
"Q8WY64-1",
"Q9Y4B6-1",
"Q6Q0C0-1",
"Q6UWE0-1",
"Q8N6D2-1",
"Q8TC41-1",
"Q9NV58-1",
"P61086-1",
"P46934-1",
"P41226-1",
"P62256-1",
"Q14139-1",
"Q96B02-1",
"Q9C037-1",
"Q8IYU2-1",
"Q9P2P5-1",
"O95714-1",
"Q15034-1",
"Q8NG27-1",
"Q9BWF2-1",
"O94941-1",
"P63146-1",
"Q5GLZ8-1",
"Q5U5R9-1",
"Q8IVU3-1",
"Q9ULT8-1",
"Q7Z6J0-1",
"Q9H9P5-4",
"Q8IWV7-1",
"Q8N2K1-1",
"Q969M7-1",
"O00762-1",
"Q8WVN8-1"
],
"evidence": [
{
"id": "R-HSA-983156",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983156"
}
]
},
{
"id": "R-HSA-983157",
"name": "Interaction of E3 with substrate and E2-Ub complex",
"equation": "",
"summary": "Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9BYM8-1",
"Q9H832-1",
"Q969T4-1",
"Q7Z7E8-1",
"Q9UHC7-1",
"Q96PU5-1",
"Q9Y2X8-1",
"Q9Y4L5-1",
"Q8TDB6-1",
"Q9NQ86-1",
"O43255-1",
"Q96BH1-1",
"P49427-1",
"P61081-1",
"P62877-1",
"Q8WVD3-1",
"Q15386-1",
"Q5VVX9-1",
"Q86XS8-1",
"O94822-1",
"Q2Q1W2-1",
"O60291-1",
"Q5U5Q3-1",
"Q96AX9-1",
"Q96F44-1",
"Q9NVW2-1",
"O94874-1",
"Q7Z3V4-1",
"Q8IUQ4-1",
"Q13049-1",
"Q9UNE7-1",
"Q16763-1",
"Q86Y13-1",
"Q8TBB1-1",
"Q8WV44-1",
"Q96PM5-1",
"Q9C026-1",
"O60260-1",
"Q9UBS8-1",
"Q9Y252-1",
"P60604-1",
"Q712K3-1",
"Q969K3-1",
"O15033-1",
"O94972-1",
"Q86WT6-1",
"Q9H4P4-1",
"Q13191-1",
"Q14669-1",
"Q7Z6Z7-1",
"O14933-1",
"O95376-1",
"P68036-1",
"Q96LR5-1",
"Q7Z419-1",
"Q96J02-1",
"Q9BV68-1",
"Q969Q1-1",
"Q9H0M0-1",
"Q9HAU4-1",
"Q9HCE7-1",
"Q5T447-1",
"Q15751-1",
"Q9UII4-1",
"Q05086-1",
"O43164-1",
"Q86XT4-1",
"P78317-1",
"P49459-1",
"Q7Z6E9-1",
"Q5VTB9-1",
"Q5XPI4-1",
"Q63HN8-3",
"Q6ZMZ0-1",
"Q9C0C9-1",
"P51668-1",
"P61077-1",
"Q9Y508-1",
"P51965-1",
"P61088-1",
"P62837-1",
"Q6ZNA4-1",
"P62253-1",
"Q7Z6J8-1",
"Q8IWV8-1",
"Q8ND25-1",
"Q9Y385-1",
"Q5T4S7-1",
"Q8N7E2-1",
"Q8NHG8-1",
"Q9HCM9-1",
"P19474-1",
"Q8WY64-1",
"Q9Y4B6-1",
"Q6Q0C0-1",
"Q6UWE0-1",
"Q8N6D2-1",
"Q8TC41-1",
"Q9NV58-1",
"P61086-1",
"P46934-1",
"P41226-1",
"P62256-1",
"Q14139-1",
"Q96B02-1",
"Q9C037-1",
"Q8IYU2-1",
"Q9P2P5-1",
"O95714-1",
"Q15034-1",
"Q8NG27-1",
"Q9BWF2-1",
"O94941-1",
"P63146-1",
"Q5GLZ8-1",
"Q5U5R9-1",
"Q8IVU3-1",
"Q9ULT8-1",
"Q7Z6J0-1",
"Q9H9P5-4",
"Q8IWV7-1",
"Q8N2K1-1",
"Q969M7-1",
"O00762-1",
"Q8WVN8-1"
],
"evidence": [
{
"id": "R-HSA-983157",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983157"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-HSA-3788737",
"participant_name": "IL8 gene [nucleoplasm]",
"crossref": [
{
"id": "ENSG00000169429",
"database": "ENSEMBL",
"url": ""
}
]
},
{
"participant_id": "R-HSA-447095",
"participant_name": "IL8 [extracellular region]",
"crossref": [
{
"id": "ENST00000307407",
"database": "Ensembl",
"url": ""
},
{
"id": "6LFO",
"database": "PDB",
"url": ""
},
{
"id": "4XDX",
"database": "PDB",
"url": ""
},
{
"id": "6LFM",
"database": "PDB",
"url": ""
},
{
"id": "P10145",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "P10145",
"database": "PRO",
"url": ""
},
{
"id": "1QE6",
"database": "PDB",
"url": ""
},
{
"id": "IL8_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "IL8_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "3IL8",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000306512",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000169429",
"database": "OpenTargets",
"url": ""
},
{
"id": "1IKL",
"database": "PDB",
"url": ""
},
{
"id": "IL8_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "1IKM",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000169429-CXCL8",
"database": "HPA",
"url": ""
},
{
"id": "6WZM",
"database": "PDB",
"url": ""
},
{
"id": "P10145",
"database": "ZINC target",
"url": ""
},
{
"id": "HMDBP02377",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000169429",
"database": "Ensembl",
"url": ""
},
{
"id": "P10145",
"database": "GeneCards",
"url": ""
},
{
"id": "2IL8",
"database": "PDB",
"url": ""
},
{
"id": "1ILQ",
"database": "PDB",
"url": ""
},
{
"id": "1IL8",
"database": "PDB",
"url": ""
},
{
"id": "5WDZ",
"database": "PDB",
"url": ""
},
{
"id": "IL8_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "P10145",
"database": "UniProt",
"url": ""
},
{
"id": "NP_000575.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1ICW",
"database": "PDB",
"url": ""
},
{
"id": "5D14",
"database": "PDB",
"url": ""
},
{
"id": "1ROD",
"database": "PDB",
"url": ""
},
{
"id": "1ILP",
"database": "PDB",
"url": ""
},
{
"id": "6XMN",
"database": "PDB",
"url": ""
},
{
"id": "6N2U",
"database": "PDB",
"url": ""
},
{
"id": "8IC0",
"database": "PDB",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "A0AVT1",
"gene_name": "UBA6",
"activity": [
{
"ec_number": "6.2.1.45",
"activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.",
"evidence": [
{
"id": "A0AVT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0AVT1"
}
]
},
{
"ec_number": "6.2.1.45",
"activity": "",
"evidence": [
{
"id": "A0AVT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0AVT1"
}
]
}
]
},
{
"uniprot_ac": "A5LHX3",
"gene_name": "PSMB11",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "A5LHX3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A5LHX3"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "A5LHX3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A5LHX3"
}
]
}
]
},
{
"uniprot_ac": "O00487",
"gene_name": "PSMD14",
"activity": [
{
"ec_number": "3.4.19.-",
"activity": "",
"evidence": [
{
"id": "O00487",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00487"
}
]
}
]
},
{
"uniprot_ac": "O00762",
"gene_name": "UBE2C",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O00762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00762"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "O00762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00762"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "O00762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00762"
}
]
}
]
},
{
"uniprot_ac": "O14933",
"gene_name": "UBE2L6",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "O14933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14933"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "O14933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14933"
}
]
}
]
},
{
"uniprot_ac": "O14965",
"gene_name": "AURKA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14965"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14965"
}
]
}
]
},
{
"uniprot_ac": "O15033",
"gene_name": "AREL1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O15033",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15033"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "O15033",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15033"
}
]
}
]
},
{
"uniprot_ac": "O43164",
"gene_name": "PJA2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O43164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43164"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O43164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43164"
}
]
}
]
},
{
"uniprot_ac": "O43255",
"gene_name": "SIAH2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O43255",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43255"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O43255",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43255"
}
]
}
]
},
{
"uniprot_ac": "O60260",
"gene_name": "PRKN",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "O60260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60260"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "O60260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60260"
}
]
},
{
"ec_number": "6.3.2.19",
"activity": "",
"evidence": [
{
"id": "O60260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60260"
}
]
}
]
},
{
"uniprot_ac": "O60291",
"gene_name": "MGRN1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O60291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60291"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O60291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60291"
}
]
}
]
},
{
"uniprot_ac": "O60566",
"gene_name": "BUB1B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O60566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60566"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O60566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60566"
}
]
}
]
},
{
"uniprot_ac": "O94822",
"gene_name": "LTN1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O94822",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94822"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O94822",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94822"
}
]
}
]
},
{
"uniprot_ac": "O94874",
"gene_name": "UFL1",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "O94874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94874"
}
]
}
]
},
{
"uniprot_ac": "O94941",
"gene_name": "UBOX5",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O94941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94941"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O94941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94941"
}
]
}
]
},
{
"uniprot_ac": "O94972",
"gene_name": "TRIM37",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O94972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94972"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O94972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94972"
}
]
}
]
},
{
"uniprot_ac": "O95376",
"gene_name": "ARIH2",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "O95376",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95376"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "O95376",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95376"
}
]
}
]
},
{
"uniprot_ac": "O95714",
"gene_name": "HERC2",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O95714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95714"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "O95714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95714"
}
]
}
]
},
{
"uniprot_ac": "P06493",
"gene_name": "CDK1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
}
]
},
{
"uniprot_ac": "P19474",
"gene_name": "TRIM21",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P19474",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19474"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P19474",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19474"
}
]
}
]
},
{
"uniprot_ac": "P22314",
"gene_name": "UBA1",
"activity": [
{
"ec_number": "6.2.1.45",
"activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P22314",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22314"
}
]
},
{
"ec_number": "6.2.1.45",
"activity": "",
"evidence": [
{
"id": "P22314",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22314"
}
]
}
]
},
{
"uniprot_ac": "P24941",
"gene_name": "CDK2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24941"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P24941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24941"
}
]
}
]
},
{
"uniprot_ac": "P28062",
"gene_name": "PSMB8",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "P28062",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28062"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "P28062",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28062"
}
]
}
]
},
{
"uniprot_ac": "P28065",
"gene_name": "PSMB9",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "P28065",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28065"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "P28065",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28065"
}
]
}
]
},
{
"uniprot_ac": "P28072",
"gene_name": "PSMB6",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "P28072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28072"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "P28072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28072"
}
]
}
]
},
{
"uniprot_ac": "P28074",
"gene_name": "PSMB5",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "P28074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28074"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "P28074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28074"
}
]
}
]
},
{
"uniprot_ac": "P40306",
"gene_name": "PSMB10",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "P40306",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40306"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "P40306",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40306"
}
]
}
]
},
{
"uniprot_ac": "P41226",
"gene_name": "UBA7",
"activity": [
{
"ec_number": "6.2.1.-",
"activity": "",
"evidence": [
{
"id": "P41226",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41226"
}
]
}
]
},
{
"uniprot_ac": "P46934",
"gene_name": "NEDD4",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P46934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46934"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "P46934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46934"
}
]
}
]
},
{
"uniprot_ac": "P49427",
"gene_name": "CDC34",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P49427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49427"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P49427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49427"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P49427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49427"
}
]
}
]
},
{
"uniprot_ac": "P49459",
"gene_name": "UBE2A",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P49459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49459"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P49459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49459"
}
]
}
]
},
{
"uniprot_ac": "P51668",
"gene_name": "UBE2D1",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P51668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51668"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P51668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51668"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P51668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51668"
}
]
}
]
},
{
"uniprot_ac": "P51955",
"gene_name": "NEK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51955",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51955"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51955",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51955"
}
]
}
]
},
{
"uniprot_ac": "P51965",
"gene_name": "UBE2E1",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P51965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51965"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P51965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51965"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P51965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51965"
}
]
}
]
},
{
"uniprot_ac": "P53350",
"gene_name": "PLK1",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53350"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "P53350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53350"
}
]
}
]
},
{
"uniprot_ac": "P60604",
"gene_name": "UBE2G2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P60604",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60604"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P60604",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60604"
}
]
}
]
},
{
"uniprot_ac": "P61077",
"gene_name": "UBE2D3",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
},
{
"ec_number": "2.3.2.24",
"activity": "",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
}
]
},
{
"uniprot_ac": "P61081",
"gene_name": "UBE2M",
"activity": [
{
"ec_number": "2.3.2.34",
"activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.",
"evidence": [
{
"id": "P61081",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61081"
}
]
},
{
"ec_number": "2.3.2.34",
"activity": "",
"evidence": [
{
"id": "P61081",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61081"
}
]
}
]
},
{
"uniprot_ac": "P61086",
"gene_name": "UBE2K",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P61086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61086"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P61086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61086"
}
]
}
]
},
{
"uniprot_ac": "P61088",
"gene_name": "UBE2N",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P61088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61088"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P61088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61088"
}
]
}
]
},
{
"uniprot_ac": "P62253",
"gene_name": "UBE2G1",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P62253",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62253"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P62253",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62253"
}
]
}
]
},
{
"uniprot_ac": "P62256",
"gene_name": "UBE2H",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P62256",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62256"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P62256",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62256"
}
]
},
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P62256",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62256"
}
]
}
]
},
{
"uniprot_ac": "P62837",
"gene_name": "UBE2D2",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P62837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62837"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P62837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62837"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P62837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62837"
}
]
}
]
},
{
"uniprot_ac": "P62877",
"gene_name": "RBX1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
},
{
"ec_number": "2.3.2.32",
"activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
},
{
"ec_number": "2.3.2.32",
"activity": "",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
}
]
},
{
"uniprot_ac": "P63146",
"gene_name": "UBE2B",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P63146",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63146"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P63146",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63146"
}
]
}
]
},
{
"uniprot_ac": "P68036",
"gene_name": "UBE2L3",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P68036",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68036"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P68036",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68036"
}
]
}
]
},
{
"uniprot_ac": "P78317",
"gene_name": "RNF4",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P78317",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78317"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P78317",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78317"
}
]
}
]
},
{
"uniprot_ac": "Q05086",
"gene_name": "UBE3A",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q05086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05086"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q05086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05086"
}
]
}
]
},
{
"uniprot_ac": "Q13049",
"gene_name": "TRIM32",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q13049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13049"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q13049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13049"
}
]
}
]
},
{
"uniprot_ac": "Q13191",
"gene_name": "CBLB",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q13191",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13191"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q13191",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13191"
}
]
}
]
},
{
"uniprot_ac": "Q14139",
"gene_name": "UBE4A",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q14139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14139"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q14139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14139"
}
]
}
]
},
{
"uniprot_ac": "Q14669",
"gene_name": "TRIP12",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q14669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14669"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q14669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14669"
}
]
}
]
},
{
"uniprot_ac": "Q15034",
"gene_name": "HERC3",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q15034",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15034"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q15034",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15034"
}
]
}
]
},
{
"uniprot_ac": "Q15386",
"gene_name": "UBE3C",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q15386",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15386"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q15386",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15386"
}
]
}
]
},
{
"uniprot_ac": "Q15751",
"gene_name": "HERC1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q15751",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15751"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q15751",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15751"
}
]
}
]
},
{
"uniprot_ac": "Q16763",
"gene_name": "UBE2S",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q16763",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16763"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q16763",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16763"
}
]
}
]
},
{
"uniprot_ac": "Q2Q1W2",
"gene_name": "TRIM71",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q2Q1W2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2Q1W2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q2Q1W2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2Q1W2"
}
]
}
]
},
{
"uniprot_ac": "Q5GLZ8",
"gene_name": "HERC4",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5GLZ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5GLZ8"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q5GLZ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5GLZ8"
}
]
}
]
},
{
"uniprot_ac": "Q5T447",
"gene_name": "HECTD3",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5T447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T447"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q5T447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T447"
}
]
}
]
},
{
"uniprot_ac": "Q5T4S7",
"gene_name": "UBR4",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5T4S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T4S7"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5T4S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T4S7"
}
]
}
]
},
{
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"gene_name": "MEX3C",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5U5Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5Q3"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5U5Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5Q3"
}
]
}
]
},
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q5U5R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5R9"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q5U5R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5R9"
}
]
}
]
},
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5VTB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VTB9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5VTB9",
"database": "UniProtKB",
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}
]
}
]
},
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{
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"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
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{
"id": "Q5VVX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VVX9"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q5VVX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VVX9"
}
]
}
]
},
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5XPI4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XPI4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5XPI4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XPI4"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
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"activity": "",
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{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.-",
"activity": "",
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{
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"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q0C0"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q6Q0C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q0C0"
}
]
},
{
"ec_number": "2.3.2.27",
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{
"id": "Q6Q0C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q0C0"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q6UWE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6UWE0"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
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{
"id": "Q6UWE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6UWE0"
}
]
}
]
},
{
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"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
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{
"id": "Q6ZMZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZMZ0"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q6ZMZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZMZ0"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q6ZNA4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZNA4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q6ZNA4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZNA4"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.23",
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"evidence": [
{
"id": "Q712K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q712K3"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q712K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q712K3"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z3V4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z3V4"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q7Z3V4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z3V4"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "Q7Z419",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z419"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "Q7Z419",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z419"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6E9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q7Z6E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6E9"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J0"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q7Z6J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J0"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6J8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J8"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q7Z6J8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J8"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6Z7"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
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{
"id": "Q7Z6Z7",
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"url": "https://www.uniprot.org/uniprot/Q7Z6Z7"
}
]
}
]
},
{
"uniprot_ac": "Q7Z7E8",
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{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
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{
"id": "Q7Z7E8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z7E8"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q7Z7E8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z7E8"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q86WT6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86WT6"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q86WT6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86WT6"
}
]
}
]
},
{
"uniprot_ac": "Q86XS8",
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q86XS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XS8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
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{
"id": "Q86XS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XS8"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q86XT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XT4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
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{
"id": "Q86XT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XT4"
}
]
}
]
},
{
"uniprot_ac": "Q86Y13",
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q86Y13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Y13"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q86Y13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Y13"
}
]
}
]
},
{
"uniprot_ac": "Q8IUQ4",
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8IUQ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IUQ4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8IUQ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IUQ4"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8IVU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVU3"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q8IVU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVU3"
}
]
}
]
},
{
"uniprot_ac": "Q8IWV7",
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8IWV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWV7"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8IWV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWV7"
}
]
}
]
},
{
"uniprot_ac": "Q8IWV8",
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8IWV8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWV8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8IWV8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWV8"
}
]
}
]
},
{
"uniprot_ac": "Q8IYU2",
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8IYU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYU2"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q8IYU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYU2"
}
]
}
]
},
{
"uniprot_ac": "Q8N2K1",
"gene_name": "UBE2J2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q8N2K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N2K1"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q8N2K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N2K1"
}
]
}
]
},
{
"uniprot_ac": "Q8N6D2",
"gene_name": "RNF182",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8N6D2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N6D2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8N6D2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N6D2"
}
]
}
]
},
{
"uniprot_ac": "Q8N7E2",
"gene_name": "CBLL2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8N7E2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N7E2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8N7E2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N7E2"
}
]
}
]
},
{
"uniprot_ac": "Q8ND25",
"gene_name": "ZNRF1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8ND25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8ND25"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8ND25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8ND25"
}
]
}
]
},
{
"uniprot_ac": "Q8NG27",
"gene_name": "PJA1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8NG27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG27"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8NG27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG27"
}
]
}
]
},
{
"uniprot_ac": "Q8NHG8",
"gene_name": "ZNRF2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8NHG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NHG8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8NHG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NHG8"
}
]
}
]
},
{
"uniprot_ac": "Q8TBB1",
"gene_name": "LNX1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8TBB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TBB1"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8TBB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TBB1"
}
]
}
]
},
{
"uniprot_ac": "Q8TBC4",
"gene_name": "UBA3",
"activity": [
{
"ec_number": "6.2.1.64",
"activity": "ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.",
"evidence": [
{
"id": "Q8TBC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TBC4"
}
]
},
{
"ec_number": "6.2.1.64",
"activity": "",
"evidence": [
{
"id": "Q8TBC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TBC4"
}
]
}
]
},
{
"uniprot_ac": "Q8TC41",
"gene_name": "RNF217",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "Q8TC41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TC41"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "Q8TC41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TC41"
}
]
}
]
},
{
"uniprot_ac": "Q8TDB6",
"gene_name": "DTX3L",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8TDB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDB6"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8TDB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDB6"
}
]
}
]
},
{
"uniprot_ac": "Q8WV44",
"gene_name": "TRIM41",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8WV44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WV44"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8WV44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WV44"
}
]
}
]
},
{
"uniprot_ac": "Q8WVD3",
"gene_name": "RNF138",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8WVD3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVD3"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8WVD3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVD3"
}
]
}
]
},
{
"uniprot_ac": "Q8WVN8",
"gene_name": "UBE2Q2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q8WVN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVN8"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q8WVN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVN8"
}
]
}
]
},
{
"uniprot_ac": "Q8WY64",
"gene_name": "MYLIP",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8WY64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WY64"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8WY64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WY64"
}
]
}
]
},
{
"uniprot_ac": "Q969K3",
"gene_name": "RNF34",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q969K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969K3"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q969K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969K3"
}
]
}
]
},
{
"uniprot_ac": "Q969M7",
"gene_name": "UBE2F",
"activity": [
{
"ec_number": "2.3.2.32",
"activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.",
"evidence": [
{
"id": "Q969M7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969M7"
}
]
},
{
"ec_number": "2.3.2.32",
"activity": "",
"evidence": [
{
"id": "Q969M7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969M7"
}
]
}
]
},
{
"uniprot_ac": "Q969Q1",
"gene_name": "TRIM63",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q969Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969Q1"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q969Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969Q1"
}
]
}
]
},
{
"uniprot_ac": "Q969T4",
"gene_name": "UBE2E3",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q969T4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969T4"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q969T4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969T4"
}
]
}
]
},
{
"uniprot_ac": "Q96AX9",
"gene_name": "MIB2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96AX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96AX9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96AX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96AX9"
}
]
}
]
},
{
"uniprot_ac": "Q96B02",
"gene_name": "UBE2W",
"activity": [
{
"ec_number": "2.3.2.25",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
},
{
"ec_number": "2.3.2.25",
"activity": "",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
}
]
},
{
"uniprot_ac": "Q96BH1",
"gene_name": "RNF25",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96BH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BH1"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96BH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BH1"
}
]
}
]
},
{
"uniprot_ac": "Q96F44",
"gene_name": "TRIM11",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96F44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96F44"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96F44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96F44"
}
]
}
]
},
{
"uniprot_ac": "Q96GD4",
"gene_name": "AURKB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96GD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GD4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96GD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GD4"
}
]
}
]
},
{
"uniprot_ac": "Q96J02",
"gene_name": "ITCH",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96J02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96J02"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q96J02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96J02"
}
]
}
]
},
{
"uniprot_ac": "Q96KQ7",
"gene_name": "EHMT2",
"activity": [
{
"ec_number": "2.1.1.-",
"activity": "",
"evidence": [
{
"id": "Q96KQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96KQ7"
}
]
},
{
"ec_number": "2.1.1.367",
"activity": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine.",
"evidence": [
{
"id": "Q96KQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96KQ7"
}
]
},
{
"ec_number": "2.1.1.367",
"activity": "",
"evidence": [
{
"id": "Q96KQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96KQ7"
}
]
}
]
},
{
"uniprot_ac": "Q96LR5",
"gene_name": "UBE2E2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q96LR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96LR5"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q96LR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96LR5"
}
]
}
]
},
{
"uniprot_ac": "Q96PM5",
"gene_name": "RCHY1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96PM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PM5"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96PM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PM5"
}
]
}
]
},
{
"uniprot_ac": "Q96PU5",
"gene_name": "NEDD4L",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.36",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.36",
"activity": "",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
}
]
},
{
"uniprot_ac": "Q99436",
"gene_name": "PSMB7",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "Q99436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99436"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "Q99436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99436"
}
]
}
]
},
{
"uniprot_ac": "Q9BV68",
"gene_name": "RNF126",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9BV68",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BV68"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9BV68",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BV68"
}
]
}
]
},
{
"uniprot_ac": "Q9BWF2",
"gene_name": "TRAIP",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9BWF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BWF2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9BWF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BWF2"
}
]
}
]
},
{
"uniprot_ac": "Q9BYM8",
"gene_name": "RBCK1",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "Q9BYM8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYM8"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "Q9BYM8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYM8"
}
]
}
]
},
{
"uniprot_ac": "Q9C026",
"gene_name": "TRIM9",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9C026",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C026"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9C026",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C026"
}
]
}
]
},
{
"uniprot_ac": "Q9C037",
"gene_name": "TRIM4",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9C037",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C037"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9C037",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C037"
}
]
}
]
},
{
"uniprot_ac": "Q9C0C9",
"gene_name": "UBE2O",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9C0C9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C0C9"
}
]
},
{
"ec_number": "2.3.2.24",
"activity": "",
"evidence": [
{
"id": "Q9C0C9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C0C9"
}
]
}
]
},
{
"uniprot_ac": "Q9H0M0",
"gene_name": "WWP1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9H0M0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0M0"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9H0M0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0M0"
}
]
}
]
},
{
"uniprot_ac": "Q9H4P4",
"gene_name": "RNF41",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9H4P4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4P4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9H4P4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4P4"
}
]
}
]
},
{
"uniprot_ac": "Q9H832",
"gene_name": "UBE2Z",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q9H832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H832"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q9H832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H832"
}
]
}
]
},
{
"uniprot_ac": "Q9H9B1",
"gene_name": "EHMT1",
"activity": [
{
"ec_number": "2.1.1.-",
"activity": "",
"evidence": [
{
"id": "Q9H9B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H9B1"
}
]
},
{
"ec_number": "2.1.1.367",
"activity": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine.",
"evidence": [
{
"id": "Q9H9B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H9B1"
}
]
},
{
"ec_number": "2.1.1.367",
"activity": "",
"evidence": [
{
"id": "Q9H9B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H9B1"
}
]
}
]
},
{
"uniprot_ac": "Q9H9P5",
"gene_name": "UNKL",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "Q9H9P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H9P5"
}
]
}
]
},
{
"uniprot_ac": "Q9HAU4",
"gene_name": "SMURF2",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9HAU4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HAU4"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9HAU4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HAU4"
}
]
}
]
},
{
"uniprot_ac": "Q9HCE7",
"gene_name": "SMURF1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9HCE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCE7"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9HCE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCE7"
}
]
}
]
},
{
"uniprot_ac": "Q9HCM9",
"gene_name": "TRIM39",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9HCM9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCM9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9HCM9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCM9"
}
]
}
]
},
{
"uniprot_ac": "Q9NPD8",
"gene_name": "UBE2T",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q9NPD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NPD8"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q9NPD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NPD8"
}
]
}
]
},
{
"uniprot_ac": "Q9NQ86",
"gene_name": "TRIM36",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9NQ86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQ86"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9NQ86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQ86"
}
]
}
]
},
{
"uniprot_ac": "Q9NV58",
"gene_name": "RNF19A",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "Q9NV58",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NV58"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "Q9NV58",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NV58"
}
]
}
]
},
{
"uniprot_ac": "Q9NVW2",
"gene_name": "RLIM",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9NVW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NVW2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9NVW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NVW2"
}
]
}
]
},
{
"uniprot_ac": "Q9P2P5",
"gene_name": "HECW2",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9P2P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P2P5"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9P2P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P2P5"
}
]
}
]
},
{
"uniprot_ac": "Q9UBS8",
"gene_name": "RNF14",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "Q9UBS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBS8"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "Q9UBS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBS8"
}
]
}
]
},
{
"uniprot_ac": "Q9UHC7",
"gene_name": "MKRN1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9UHC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHC7"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9UHC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHC7"
}
]
}
]
},
{
"uniprot_ac": "Q9UII4",
"gene_name": "HERC5",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "Q9UII4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UII4"
}
]
}
]
},
{
"uniprot_ac": "Q9ULT8",
"gene_name": "HECTD1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9ULT8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ULT8"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9ULT8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ULT8"
}
]
}
]
},
{
"uniprot_ac": "Q9UNE7",
"gene_name": "STUB1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9UNE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UNE7"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9UNE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UNE7"
}
]
}
]
},
{
"uniprot_ac": "Q9Y252",
"gene_name": "RNF6",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9Y252",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y252"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9Y252",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y252"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2X8",
"gene_name": "UBE2D4",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q9Y2X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2X8"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q9Y2X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2X8"
}
]
}
]
},
{
"uniprot_ac": "Q9Y385",
"gene_name": "UBE2J1",
"activity": [
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