{ "uniprot_canonical_ac": "O00748-1", "uniprot_ac": "O00748", "uniprot_id": "EST2_HUMAN", "mass": { "chemical_mass": 61807.0, "monoisotopic_mass": 61807.0 }, "refseq": { "ac": "NP_003860", "name": "cocaine esterase isoform 1 precursor", "summary": "This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" }, "gene_names": [ { "name": "CES2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00748", "id": "O00748" }, { "name": "CE-2; CES2A1; iCE; PCE-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860", "id": "NP_003860" }, { "name": "CES2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860", "id": "NP_003860" }, { "name": "ICE", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00748", "id": "O00748" } ], "protein_names": [ { "name": "Cocaine esterase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00748" }, { "name": "3.1.1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "3.1.1.56", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "3.1.1.84", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "CE-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "Carboxylesterase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "Methylumbelliferyl-acetate deacetylase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "cocaine esterase isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860", "id": "NP_003860" }, { "name": "hCE-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00748" }, { "name": "intestinal carboxylesterase; liver carboxylesterase-2; carboxylesterase 2 (intestine, liver); cocaine esterase; methylumbelliferyl-acetate deacetylase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860", "id": "NP_003860" } ], "function": [ { "annotation": "Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" }, { "database": "PubMed", "id": "36113774", "url": "https://glygen.org/publication/PubMed/36113774" } ] }, { "annotation": "Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays.", "evidence": [ { "database": "RefSeq", "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" }, { "database": "PubMed", "id": "33291124", "url": "https://glygen.org/publication/PubMed/33291124" } ] }, { "annotation": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748#function" }, { "database": "PubMed", "id": "9169443", "url": "https://glygen.org/publication/PubMed/9169443" }, { "database": "PubMed", "id": "21049984", "url": "https://glygen.org/publication/PubMed/21049984" }, { "database": "PubMed", "id": "28677105", "url": "https://glygen.org/publication/PubMed/28677105" } ] }, { "annotation": "LncRNA KCNQ1OT1 ameliorates the liver injury induced by acetaminophen through the regulation of miR-122-5p/CES2 axis.", "evidence": [ { "database": "RefSeq", "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" }, { "database": "PubMed", "id": "32779042", "url": "https://glygen.org/publication/PubMed/32779042" } ] }, { "annotation": "Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" }, { "database": "PubMed", "id": "31981591", "url": "https://glygen.org/publication/PubMed/31981591" } ] }, { "annotation": "The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro.", "evidence": [ { "database": "RefSeq", "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" }, { "database": "PubMed", "id": "35790245", "url": "https://glygen.org/publication/PubMed/35790245" } ] }, { "annotation": "This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs567376681", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs567376681" }, { "id": "rs567376681", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs567376681" }, { "id": "rs567376681", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs567376681" }, { "id": "rs567376681", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs567376681" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 111, "end_pos": 111, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NMT->DMT).", "chr_id": "16", "chr_pos": "66939266", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "N111", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs148026549", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148026549" }, { "id": "rs148026549", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148026549" }, { "id": "rs148026549", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148026549" }, { "id": "rs148026549", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148026549#frequency_tab" }, { "id": "rs148026549", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148026549" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 111, "end_pos": 111, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NMT->SMT).", "chr_id": "16", "chr_pos": "66939267", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000799", "site_lbl": "N111", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs148026549", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148026549" }, { "id": "rs148026549", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148026549" }, { "id": "rs148026549", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148026549" }, { "id": "rs148026549", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148026549#frequency_tab" }, { "id": "rs148026549", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148026549" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 111, "end_pos": 111, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NMT->TMT).", "chr_id": "16", "chr_pos": "66939267", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.000799", "site_lbl": "N111", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs112732183", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs112732183" }, { "id": "rs112732183", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs112732183" }, { "id": "rs112732183", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs112732183#frequency_tab" }, { "id": "rs112732183", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs112732183" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 213, "end_pos": 213, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIA->NIT).", "chr_id": "16", "chr_pos": "66940516", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A213", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs781015392", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781015392" }, { "id": "rs781015392", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs781015392#frequency_tab" }, { "id": "rs781015392", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781015392" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 276, "end_pos": 276, "sequence_org": "N", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->ILS).", "chr_id": "16", "chr_pos": "66941134", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N276", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs781015392", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781015392" }, { "id": "rs781015392", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs781015392#frequency_tab" }, { "id": "rs781015392", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781015392" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 276, "end_pos": 276, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->SLS).", "chr_id": "16", "chr_pos": "66941134", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N276", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1286209979", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1286209979" }, { "id": "rs1286209979", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1286209979" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 306, "end_pos": 306, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKP->NKT).", "chr_id": "16", "chr_pos": "66941506", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P306", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs554309591", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs554309591" }, { "id": "rs554309591", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs554309591" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 449, "end_pos": 449, "sequence_org": "R", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIR->NIT).", "chr_id": "16", "chr_pos": "66942711", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R449", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs575132823", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs575132823" }, { "id": "rs575132823", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs575132823" }, { "id": "rs575132823", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs575132823" }, { "id": "rs575132823", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs575132823" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 495, "end_pos": 495, "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFA->NFS).", "chr_id": "16", "chr_pos": "66943361", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "A495", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs575132823", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs575132823" }, { "id": "rs575132823", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs575132823" }, { "id": "rs575132823", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs575132823" }, { "id": "rs575132823", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs575132823" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 495, "end_pos": 495, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFA->NFT).", "chr_id": "16", "chr_pos": "66943361", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "A495", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1597011640", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1597011640" }, { "id": "rs1597011640", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1597011640" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 499, "end_pos": 499, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGN->NGT).", "chr_id": "16", "chr_pos": "66943841", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N499", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "97.21", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "95.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "91.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "90.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "88.46", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "98.6", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "99.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "89.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "86.52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "98.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.6", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "89.08", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00748", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00748" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", 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"https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00748", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00748" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00748" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "common_name": "Human" } ], "gene": [ { "name": "CES2", "url": "https://www.uniprot.org/uniprot/O00748", "locus": { "chromosome": "16", "start_pos": 66945096, "end_pos": 66934444, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000172831", "url": "https://www.ensembl.org/id/ENSG00000172831" } ] } } ], "crossref": [ { "id": "ENSG00000172831", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172831", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.1.1.1", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.1&UniProtAcc=O00748", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "3.1.1.84", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.84&UniProtAcc=O00748", 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"WHTSGRI", "url": "https://omabrowser.org/oma/group/WHTSGRI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4386at2759", "url": "http://www.orthodb.org/?query=4386at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11559", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11559", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11559:SF416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11559:SF416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00135", "url": "http://pfam.xfam.org/family/PF00135", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O00748", "url": "https://pharos.nih.gov/targets/O00748", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O00748", "url": "http://purl.obolibrary.org/obo/PR_O00748", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-211945", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211945", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_003860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003860", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12208", "url": "https://www.rhea-db.org/rhea/12208", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "21164", "url": "https://www.rhea-db.org/rhea/21164", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "26132", "url": "https://www.rhea-db.org/rhea/26132", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "27506", "url": "https://www.rhea-db.org/rhea/27506", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48296", "url": "https://www.rhea-db.org/rhea/48296", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48300", "url": "https://www.rhea-db.org/rhea/48300", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "H3BUN5", "url": "https://www.uniprot.org/uniprot/H3BUN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BUN5-1", "url": "https://www.uniprot.org/uniprot/H3BUN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QLP1", "url": "https://www.uniprot.org/uniprot/J3QLP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QLP1-1", "url": "https://www.uniprot.org/uniprot/J3QLP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QSC0", "url": "https://www.uniprot.org/uniprot/J3QSC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QSC0-1", "url": "https://www.uniprot.org/uniprot/J3QSC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00748-1", "url": "https://www.uniprot.org/uniprot/O00748-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00748-2", "url": "https://www.uniprot.org/uniprot/O00748-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00748-4", "url": "https://www.uniprot.org/uniprot/O00748-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00748-5", "url": "https://www.uniprot.org/uniprot/O00748-5", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL", "length": 559, "header": "sp|O00748-1|EST2_HUMAN Isoform 1 of Cocaine esterase OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1 CANONICAL=O00748-1" }, "isoforms": [ { "isoform_ac": "H3BUN5-1", "url": "", "sequence": { "sequence": "MRLHRLRARLSAVACGLLLLLVRGQGEAPSEGRQGPGSDLPNAAEAEPDSAGGQAPGR", "length": 58, "header": "tr|H3BUN5-1|H3BUN5_HUMAN Computationally mapped isoform of Carboxylesterase 2 OS=Homo sapiens OX=9606 GN=CES2 PE=4 SV=2 CANONICAL=O00748-1" }, "locus": {} }, { "isoform_ac": "J3QLP1-1", "url": "", "sequence": { "sequence": "MCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGN", "length": 125, "header": "tr|J3QLP1-1|J3QLP1_HUMAN Computationally mapped isoform of Carboxylesterase 2 OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1 CANONICAL=O00748-1" }, "locus": { "chromosome": "16", "start_pos": 66940533, "end_pos": 66938240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000561697.5", "url": "https://www.ensembl.org/id/ENST00000561697.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000463641.1", "url": "https://www.ensembl.org/id/ENSP00000463641.1" } ] } }, { "isoform_ac": "J3QSC0-1", "url": "", "sequence": { "sequence": "XVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNG", "length": 201, "header": "tr|J3QSC0-1|J3QSC0_HUMAN Computationally mapped isoform of Carboxylesterase 2 OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1 CANONICAL=O00748-1" }, "locus": { "chromosome": "16", "start_pos": 66943373, "end_pos": 66941152, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000564420.1", "url": "https://www.ensembl.org/id/ENST00000564420.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000464620.1", "url": "https://www.ensembl.org/id/ENSP00000464620.1" } ] } }, { "isoform_ac": "O00748-1", "url": "", "sequence": { "sequence": "MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL", "length": 559, "header": "sp|O00748-1|EST2_HUMAN Isoform 1 of Cocaine esterase OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1 CANONICAL=O00748-1" }, "locus": { "chromosome": "16", "start_pos": 66944022, "end_pos": 66935636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000317091.10", "url": "https://www.ensembl.org/id/ENST00000317091.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000317842.5", "url": "https://www.ensembl.org/id/ENSP00000317842.5" } ] } }, { "isoform_ac": "O00748-2", "url": "", "sequence": { "sequence": "MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL", "length": 543, "header": "sp|O00748-2|EST2_HUMAN Isoform 2 of Cocaine esterase OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1 CANONICAL=O00748-1" }, "locus": { "chromosome": "16", "start_pos": 66944022, "end_pos": 66935636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000417689.6", "url": 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CANONICAL=O00748-1" }, "locus": {} }, { "isoform_ac": "O00748-5", "url": "", "sequence": { "sequence": "MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL", "length": 607, "header": "sp|O00748-5|EST2_HUMAN Isoform 5 of Cocaine esterase OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1 CANONICAL=O00748-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", 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"type": "PubMed", "id": "9169443", "url": "https://glygen.org/publication/PubMed/9169443" } ] }, { "title": "Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man.", "journal": "The Journal of biological chemistry", "date": "1976", "authors": "Webster LT, Siddiqui UA, Lucas SV, Strong JM, Mieyal JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "931988", "url": "https://glygen.org/publication/PubMed/931988" } ] }, { "title": "Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase.", "journal": "Archives of biochemistry and biophysics", "date": "1997", "authors": "Wu K, Knox R, Sun XZ, Joseph P, Jaiswal AK, Zhang D, Deng PS, Chen S", "evidence": [ { "database": "Reactome", "id": "R-HSA-211945", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211945" } ], "reference": [ { "type": "PubMed", "id": "9367528", "url": "https://glygen.org/publication/PubMed/9367528" } ] }, { "title": "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver.", "journal": "FEBS letters", "date": "1998", "authors": "Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "9650585", "url": "https://glygen.org/publication/PubMed/9650585" } ] }, { "title": "Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule.", "journal": "The Journal of experimental medicine", "date": "1998", "authors": "Smith DJ, Salmi M, Bono P, Hellman J, Leu T, Jalkanen S", "evidence": [ { "database": "Reactome", "id": "R-HSA-211945", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211945" } ], "reference": [ { "type": "PubMed", "id": "9653080", "url": "https://glygen.org/publication/PubMed/9653080" } ] }, { "title": "Protein binding of salicylate in uremic and normal plasma.", "journal": "Clinical pharmacology and therapeutics", "date": "1976", "authors": "Borga O, Cederlof IO, Ringberger VA, Norlin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "975718", "url": "https://glygen.org/publication/PubMed/975718" } ] } ], "pathway": [ { "id": "hsa:8824", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8824", "resource": "KEGG Pathway" }, { "id": "R-HSA-211945", "name": "Phase I - Functionalization of compounds", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211945", "resource": "Reactome", "description": "Phase I - Functionalization of compounds" }, { "id": "R-HSA-9749641", "name": "Aspirin ADME", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641", "resource": "Reactome", "description": "Aspirin ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0C1-1", "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2g", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQNKLHSWLNAVLFGLLLLLIHVQGQHSPESSPIRNTHTGQVQGKLTHSKDFKSGVHTFLGIPFAKAPVGPLRFAPPEAPEPWSGVRDGTSQSNICPQNVRMNMEGLKEMKLTLPPVSMSEDCLYLNIYAPAHAHEGSHLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVTIQYRLGVLGFFSTGDHHARGNWGYLDQVAALRWVQQNIAHFGGNPDCVTIFGESAGGLSVSSHVVSPMSKGLFHRAIMESGVALMPGTIFNFSEMVYQMVVKLSGCEAMDPESLVHCLRGKSEEQITVISKEFQMIPAVVDGEFLPNHPQELLASADFHPVPSIIGFNNDEYGWIVPKVIGSAQTIKGITRENLQAFLKDTAPQMMLPPECSDLLMEEYMGDIEDPQTLQAQFTEMMEDFMFVIPSLQVARFQRSHAPVYFYEFQHQSSFLKDIRPPHVKADHGDEVPFVFGSFFWGMKLNLTEGEKLLNRRMMKYWANFARYGNPNSNSLPYWPVFDYDEQYLQLNTQPAVGRIQKARKLQFWTKTLPQKIEELKRSQNMHKEL", "length": 560 }, "evidence": [ { "id": "45930094", "url": 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"uniprot_canonical_ac": "E9PV38-1", "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRNQMHSWLDAVFFGLLLLLGHVQGHDSPETSPIRSTHSGQVQGRLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAICPQNVTMNMEGLKELKLTLPPVSMSEDCLYLNIYTPAHAQEGSNLPVMVWIHGGALTVGMASMYDGSVLAATEDVVVVAIQYRLGVLGFFSTGDEHARGNWGFLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGISVSSHVVSPMSKGLFHRAIMESGVALLPGTIFSFSEVVYQTVAKLSGCEAMDSEALVRCLRGKSEEEILAISKNFQMIPGVVDGEFLPKHPQELLASADFHPVPSIIGFNNDEYGWIVPKVIGSTQTIKGITRENLQAVLKDTAPQMMLPPECSDLLMEEYMEDIEDPKTLQIQFTEMMEDFMFVIPSLQVAYFQRSHAPVYFYEFQHQSSFLKDVRPPHVNADHGDEVPFVFGSFFWGMKLNLTEEEKLLNRRMMKYWANFARHGNPNSESLPYWPVFDHDEQYLQLNIQPAVGQFQKARKLQFWTKTLPRKIEELKRSQNVHKEL", "length": 560 }, "evidence": [ { "id": "45930094", "url": "http://www.informatics.jax.org/homology/45930094", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "F6Z9B9-1", "protein_name": "Carboxylic ester hydrolase", "gene_name": 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"MARKQPHSWLNAVLFGLLLILIHVWGQDSPESSSIRTTHTGQVRGKLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTPAHAHEGSNLPVMVCIHGGALVIGMASMCDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVSTTVAKLSGCEATDSETLVRCLRAKSGAEILVINKVFKMIPAVVDGEFLPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLPPECGDLLMEEYMGNTDDPQTLQIQYAEMMGDFLFVIPALQVAHFQRSHAPVYFYEFQHAPSYFKNVRPPHVKADHADEVPFVFGSFFWGIKVDFTEEEKLLSRRMMKYWANFARHGNPNSEGLPYWPVLDHDEQYLQLDTQPAVDRALKARRLQFWTKTLPQKIQELNGAQKNHAEL", "length": 561 }, "evidence": [ { "id": "45930089", "url": "http://www.informatics.jax.org/homology/45930089", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08ED5-1", "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVHRLPGWLDAAACGLLVLLLHVKGLDSSEASPIRNTHTGQVRGKFVHLTDIKAGAHNFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAMCLQNDDIVNLEGLKIIKMILPPFSMSEDCLYLNIYTPAHAQEGSNLPVMVWLHGGGLVAGMASMYDGSVLAATEDVVVVVTQYRLGIPGFYSTGDEQARGNWGFLDQTAALHWVQQNIANFGGNPDSVTLFGQSAGGTSVSFHVLSPVSQGLFHRAIMESGVALLPTIIPDSPEMIFTKVANLSGCETSNSEALVRCLRGKSEAEILAMSKAFRFMPAVVDGKFLPRHPKKLLASADFHPVPSIIGVNNDEYGWIIPKIFKFSQTIRKINRNNLKAIMKITTEQMMLPSECGDLLIEEYLRDTEDPWTLQMQFREMIGDFLIIIPALQVARFQRSHAPVYFYEFQHRSSLLKYFRPWHVKADHGDELYLIFGSFFWGLKFSFTAEEKLLSRKMMKYWANFARYGNPNSEDLPYWPASNQDDLYLQLDIHPSVGHALKARRLPFWTKTLPQKMLELKGNHDKIKAV", "length": 561 }, "evidence": [ { "id": "45930099", "url": "http://www.informatics.jax.org/homology/45930099", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q32Q55-1", "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2h", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLKQIHARLTTAACGLLLLLQVQGQDSLSPIRTTHTGQILGSLIHMKGLDVGVHSFLGIPFAKPPIGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYTPNHAHEGSNLPVMVWIHGGALVIGMASLYDGSMLAAMENVVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSRGLFHGAIMESGVALMSSLISVSSDVVYRTVANLSGCEQVDSKALVNCLRGKSEEEIMSINKAFRIISGIVDGIFLPRHPKELLASADFHPIPSIIGVNNDEYGWIIPSSMTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEYMGDSEDPQFLQVQFKEMMEDFTFVIPALQVAHFQRSNAPVYFYEFQHRPSFFKDSKPPHVKADHGDEILFIFRSFWGGTQVDLTEEEELLSRRMMKYWANFARQGNPNSEGLPYWPVFDHDEQYLQLDTQPAVGRALKAKRLQFWTKTLPEKIRELKDTEDRHTEL", "length": 558 }, "evidence": [ { "id": "45930084", "url": "http://www.informatics.jax.org/homology/45930084", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PDB7-1", "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRSQMHNWLDVLLFGLLLLLGHVQGQDSPEASPIRNTHTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGGLVAGMASMYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARGNWGFLDQVAALRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLITDTSEMVSTTVAKLSGCEAMDSEALVRCLRGKSEAEILAINKLVQMIPAVVDGEFFPRHPKELLASEDFHPVPSIIGVNNDEFGWTIPVVMGSAQTIKEITRENLQAVLKNTTAQLMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMEDFMFVIPALQVAYFQRSHASVYFYEFQHQIASLKDVRPTHVKADHADEIPFVFGYFFWDMKLDFTEGEKLLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDTQPAVGRALKSRRLQFWTKTLSQKIQELRASQDKHTEL", "length": 556 }, "evidence": [ { "id": "45930087", "url": "http://www.informatics.jax.org/homology/45930087", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BK48-1", "protein_name": "Pyrethroid hydrolase Ces2e", "gene_name": "Ces2e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLYKLLGWLNAVACGVLLLVLHVQGQDSASPIRNTHTGQVRGSLVHVKDTDIAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMGSEDLKMMNLILPPISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTGDQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSEMVHRIVANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPGVVDGEFLPKHPQELMASKDFHPVPSIIGINNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTALKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMKGDFMFVIPALQVAHFQRSHAPVYFYEFQHRPSFFKDFRPPYVKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRIMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDIQPSVGRALKARRLQFWTKTLPQKIQELKGSQERHKEL", "length": 559 }, "evidence": [ { "id": "45930100", "url": "http://www.informatics.jax.org/homology/45930100", "database": "MGI" }, { "id": "O00748", "url": "https://omabrowser.org/oma/group/O00748/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8K3R0-1", "protein_name": "Pyrethroid hydrolase Ces2a", "gene_name": "Ces2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLARLPGWLYVVACGLLLLLQHVHGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEILAINQVFKMIPGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLPSFIKQVRPSHVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLPQKIQELKGSQSKHAEL", "length": 558 }, "evidence": [ { "id": "45930091", "url": "http://www.informatics.jax.org/homology/45930091", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8QZR3-1", "protein_name": "Pyrethroid hydrolase Ces2a", "gene_name": "Ces2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLARLPGWLCVVACGLLLLLQHVHGQDSASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAIQYRLGVLGFFSTGDQHARGNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTVANLSGCEATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLPKHPQELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPECSHLLVEEYMGDTEDPETLQAQFREMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLSSFIKHVRPSHVKADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNSEGLPSWPVLDHDEQYLQLDTQPAVGRALKARRLQFWTKTLPQKIQELKGSQDKHAEL", "length": 558 }, "evidence": [ { "id": "45930091", "url": "http://www.informatics.jax.org/homology/45930091", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q91WG0-1", "protein_name": "Acylcarnitine hydrolase", "gene_name": "Ces2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" }, { "name": "carboxylic ester hydrolase activity", "id": "GO:0052689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" }, { "name": "carboxylesterase activity", "id": "GO:0106435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106435", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "catabolic process", "id": "GO:0009056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009056", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" }, { "name": "prostaglandin metabolic process", "id": "GO:0006693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006693", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "O00748", "url": "https://www.uniprot.org/uniprot/O00748" }, { "database": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" }, { "database": "PubMed", "id": "9169443", "url": "https://glygen.org/publication/PubMed/9169443" } ] } ], "interactions": [], "reactions": [ { "id": "12208", "name": "", "equation": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O00748-1", "P10768-1", "P23141-1" ], "evidence": [ { "id": "12208", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12208" } ] }, { "id": "21164", "name": "", "equation": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10959-1", "P16303-1", "Q5GRG2-1", "Q63010-1", "Q63108-1", "Q64573-1", "Q6UWW8-1", "O00748-1", "Q6NT32-1", "P23141-1", "Q8VCT4-1", "Q91WU0-1", "Q64176-1", "Q8VCC2-1", "Q8VCU1-1", "P23953-1", "Q63880-1", "Q6AW46-1", "P08171-1", "P18167-1" ], "evidence": [ { "id": "21164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21164" } ] }, { "id": "26132", "name": "", "equation": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "P97612-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "P15304-1", "P07687-1", "Q8N2K0-1", "P08910-1", "Q9BV23-1", "O95870-1", "O00519-1", "Q99685-1", "O00748-1", "P23141-1", "P07099-1", "Q05469-1", "Q8IY17-4", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "Q9QXM0-1", "O08914-1", "O35678-1", "P54310-1", "Q3TRM4-1", "Q8VCC2-1", "Q9D379-1" ], "evidence": [ { "id": "26132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26132" } ] }, { "id": "27506", "name": "", "equation": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O00748-1" ], "evidence": [ { "id": "27506", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27506" } ] }, { "id": "48296", "name": "", "equation": "H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8R431-1", "Q9QYL8-1", "Q99685-1", "O00748-1", "P23141-1", "O95372-1", "O35678-1", "Q9WTL7-1", "Q8VCC2-1" ], "evidence": [ { "id": "48296", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48296" } ] }, { "id": "48300", "name": "", "equation": "H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8R431-1", "Q99685-1", "P23141-1", "O00748-1", "O35678-1", "Q8VCC2-1" ], "evidence": [ { "id": "48300", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48300" } ] }, { "id": "R-HSA-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "equation": "", "summary": "Cocaine (COCN) is an addictive, psychoactive alkaloid that is primarily inactivated by hydrolysis to benzoylecgonine (BEG), the major urinary metabolite of the drug. Human liver carboxylesterases 1 and 2 (CES1 and 2), located in the ER lumen, are involved in the detoxification of xenobiotics and can hydrolyse COCN to BEG (Brzezinski et al. 1994, Pindel et al. 1997). CES1 is functional as a homotrimer or homohexamer (Bencharit et al. 2003) whereas CES2 is monomeric.", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [ "R-ALL-5693702" ], "output_participant_list": [ "R-ALL-5693711", "R-ALL-5693712" ], "enzyme_list": [ "P23141-1", "O00748-1" ], "evidence": [ { "id": "R-HSA-5693691", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693691" } ] }, { "id": "R-HSA-9749647", "name": "CES2 hydrolyzes ASA-", "equation": "", "summary": "CES2 hydrolyzes acetylsalicylate (ASA-) in GI cells. Although ASA- is also hydrolyzed to salicylate (ST) without enzymatic assistance, this process is rather slow (Rowland et al, 1972; Dressman et al, 2012). In gastrointestinal mucosa cells the predominant esterase is carboxylesterase 2 (CES2) (Imai et al, 2006), and in liver it has weak activity. In liver the main aspirin esterase is CES1 (Inoue et al, 1980; Imai et al, 2006). Both enzymes hydrolyze ASA-, producing acetate and ST (Tang et al, 2006; Imai, 2006; Lian et al, 2017).", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [ "R-ALL-9749582" ], "output_participant_list": [ "R-ALL-9749588", "R-ALL-9749593" ], "enzyme_list": [ "O00748-1" ], "evidence": [ { "id": "R-HSA-9749647", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749647" } ] }, { "id": "R-HSA-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "equation": "", "summary": "CES1 and CES2 hydrolyze acetylsalicylate (ASA-) in hepatic cells. Although ASA- is also hydrolyzed to salicylate (ST) without enzymatic assistance, this process is rather slow (Rowland et al, 1972; Dressman et al, 2012). In gastrointestinal mucosa cells the predominant esterase is carboxylesterase 2 (CES2) (Imai et al, 2006), and in liver it has significant activity. In liver the main aspirin esterase is CES1, with minor presence of CES2 (Inoue et al, 1980; Imai et al, 2006; Schwer et al, 1997). Both enzymes hydrolyze ASA-, producing acetate and ST (Tang et al, 2006; Imai, 2006; Lian et al, 2017).", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [ "R-ALL-9749795" ], "output_participant_list": [ "R-ALL-9749790" ], "enzyme_list": [ "P23141-1", "O00748-1" ], "evidence": [ { "id": "R-HSA-9749792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749792" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5693702", "participant_name": "COCN [endoplasmic reticulum lumen]", "crossref": [ { "id": "2286", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0015043", "database": "HMDB Metabolite", "url": "" }, { "id": "27958", "database": "ChEBI", "url": "" }, { "id": "000003875336", "database": "ZINC", "url": "" }, { "id": "C01416", "database": "COMPOUND", "url": "" }, { "id": "27958", "database": "ChEBI", "url": "" }, { "id": "C01416", "database": "COMPOUND", "url": "" }, { "id": "2286", 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"ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] } ] }, { "uniprot_ac": "O08914", "gene_name": "Faah", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": 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"evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] } ] }, { "uniprot_ac": "O95870", "gene_name": "ABHD16A", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] } ] }, { "uniprot_ac": "P07099", "gene_name": "EPHX1", "activity": [ { "ec_number": "3.3.2.9", "activity": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol.", "evidence": [ { "id": "P07099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07099" } ] }, { "ec_number": "3.3.2.9", "activity": "", "evidence": [ { "id": "P07099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07099" } ] } ] }, { "uniprot_ac": "P07687", "gene_name": "Ephx1", "activity": [ { "ec_number": "3.3.2.9", "activity": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol.", "evidence": [ { "id": "P07687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07687" } ] }, { "ec_number": "3.3.2.9", "activity": "", "evidence": [ { "id": "P07687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07687" } ] } ] }, { "uniprot_ac": "P08171", "gene_name": "Est-6", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P08171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08171" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "P08171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08171" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P08171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08171" } ] } ] }, { "uniprot_ac": "P08910", "gene_name": "ABHD2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] } ] }, { "uniprot_ac": "P10768", "gene_name": "ESD", "activity": [ { "ec_number": "3.1.2.12", "activity": "H2O + S-formylglutathione = formate + glutathione + H(+).", "evidence": [ { "id": "P10768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10768" } ] }, { "ec_number": "3.1.2.12", "activity": "", "evidence": [ { "id": "P10768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10768" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "P10768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10768" } ] } ] }, { "uniprot_ac": "P10959", "gene_name": "Ces1c", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P10959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10959" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "P10959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10959" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P10959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10959" } ] } ] }, { "uniprot_ac": "P15304", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] } ] }, { "uniprot_ac": "P16303", "gene_name": "Ces1d", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P16303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16303" } ] }, { "ec_number": "3.1.1.67", "activity": "a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+).", "evidence": [ { "id": "P16303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16303" } ] } ] }, { "uniprot_ac": "P18167", "gene_name": "Est-P", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P18167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18167" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "P18167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18167" } ] } ] }, { "uniprot_ac": "P23141", "gene_name": "CES1", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] } ] }, { "uniprot_ac": "P23953", "gene_name": "Ces1c", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P23953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23953" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "P23953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23953" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P23953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23953" } ] } ] }, { "uniprot_ac": "P54310", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] } ] }, { "uniprot_ac": "P97612", "gene_name": "Faah", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] } ] }, { "uniprot_ac": "Q05469", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q5GRG2", "gene_name": "Ces5a", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q5GRG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GRG2" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q5GRG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GRG2" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q5GRG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GRG2" } ] } ] }, { "uniprot_ac": "Q5XI64", "gene_name": "Abhd6", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q5XI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI64" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q5XI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI64" } ] } ] }, { "uniprot_ac": "Q63010", "gene_name": "", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q63010", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63010" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q63010", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63010" } ] } ] }, { "uniprot_ac": "Q63108", "gene_name": "Ces1e", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q63108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63108" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q63108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63108" } ] } ] }, { "uniprot_ac": "Q63880", "gene_name": "Ces3a", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q63880", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63880" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q63880", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63880" } ] } ] }, { "uniprot_ac": "Q64176", "gene_name": "Ces1e", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q64176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64176" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q64176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64176" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q64176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64176" } ] } ] }, { "uniprot_ac": "Q64573", "gene_name": "Ces1f", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q64573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64573" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q64573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64573" } ] } ] }, { "uniprot_ac": "Q6AW46", "gene_name": "Ces5a", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6AW46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AW46" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q6AW46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AW46" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q6AW46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AW46" } ] } ] }, { "uniprot_ac": "Q6AYT7", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] } ] }, { "uniprot_ac": "Q6MG55", "gene_name": "Abhd16a", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6MG55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MG55" } ] }, { "ec_number": 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