{ "uniprot_canonical_ac": "O00515-1", "uniprot_ac": "O00515", "uniprot_id": "LAD1_HUMAN", "mass": { "chemical_mass": 57131.0, "monoisotopic_mass": 57131.0 }, "refseq": { "ac": "NP_005549", "name": "ladinin-1", "summary": "The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" }, "gene_names": [ { "name": "LAD1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00515", "id": "O00515" }, { "name": "LAD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549", "id": "NP_005549" }, { "name": "LAD", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00515", "id": "O00515" }, { "name": "LadA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549", "id": "NP_005549" } ], "protein_names": [ { "name": "Ladinin-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00515" }, { "name": "LADA", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00515" }, { "name": "Lad-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00515" }, { "name": "Linear IgA disease antigen", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00515" }, { "name": "ladinin-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549", "id": "NP_005549" }, { "name": "linear IgA bullous dermatosis antigen; linear IgA disease antigen homolog; lad-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549", "id": "NP_005549" } ], "function": [ { "annotation": "Anchoring filament protein which is a component of the basement membrane zone.", "evidence": [ { "database": "UniProtKB", "id": "E9PDI4", "url": "https://www.uniprot.org/uniprot/E9PDI4#function" }, { "database": "UniProtKB", "id": "PIRNR038144", "url": "https://www.uniprot.org/uniprot/PIRNR038144#function" }, { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515#function" } ] }, { "annotation": "Basement membrane protein ladinin-1 and the MIF-CD44-beta1 integrin signaling axis are implicated in laryngeal cancer metastasis", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" }, { "database": "PubMed", "id": "27460703", "url": "https://glygen.org/publication/PubMed/27460703" } ] }, { "annotation": "High abundance of LAD1 is associated with breast cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" }, { "database": "PubMed", "id": "29382783", "url": "https://glygen.org/publication/PubMed/29382783" } ] }, { "annotation": "High expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa).", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" }, { "database": "PubMed", "id": "34516317", "url": "https://glygen.org/publication/PubMed/34516317" } ] }, { "annotation": "Ladinin 1 Shortens Survival via Promoting Proliferation and Enhancing Invasiveness in Lung Adenocarcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" }, { "database": "PubMed", "id": "36613882", "url": "https://glygen.org/publication/PubMed/36613882" } ] }, { "annotation": "The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" }, { "database": "PubMed", "id": "36770773", "url": "https://glygen.org/publication/PubMed/36770773" } ] }, { "annotation": "The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "85.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "91.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "88.19", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "75.6", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "59.66", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "96.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "85.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "82.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "72.07", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "64.45", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "78.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "86.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "78.25", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000159166", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000159166" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00515", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00515" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000631576.1", "url": "https://www.ensembl.org/id/ENST00000631576.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488829.1", "url": "https://www.ensembl.org/id/ENSP00000488829.1" } ] } }, { "isoform_ac": "E9PDI4-1", "url": "", "sequence": { "sequence": "MRLCLGRPHPRGHSRVGKSERGRGARGLARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDRQASASERLPSVEEAEVPKPLPPASKDEDEDIQSILRTRQERRQRRQVVEAAQAPIQERLEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSREQRGPWALEEESLVGREPEERKKGVPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEKVLASEKTSLSEKIAVSEKRNSSEKKSVLEKTSVSEKSLAPGMALGSGRRLVSEKASIFEKALASEKSPTADAKPAPKRATASEQPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPVTLQVKIPSKEEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRSASMKLPDNTVKLGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELAGQSRAEPASSRKENLRLSGVVTSRLNLWISRTQESGDQDPQEAQKASSATERTQWGQKSDSSLDAEV", "length": 531, "header": "tr|E9PDI4-1|LAD1_HUMAN Computationally mapped isoform of Ladinin-1 OS=Homo sapiens OX=9606 GN=LAD1 PE=1 SV=1 CANONICAL=O00515-1" }, "locus": { "chromosome": "1", "start_pos": 201399489, "end_pos": 201381891, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000367313.4", "url": "https://www.ensembl.org/id/ENST00000367313.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000356282.3", "url": "https://www.ensembl.org/id/ENSP00000356282.3" } ] } }, { "isoform_ac": "O00515-1", "url": "", "sequence": { "sequence": "MAVSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDRQASASERLPSVEEAEVPKPLPPASKDEDEDIQSILRTRQERRQRRQVVEAAQAPIQERLEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSREQRGPWALEEESLVGREPEERKKGVPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEKVLASEKTSLSEKIAVSEKRNSSEKKSVLEKTSVSEKSLAPGMALGSGRRLVSEKASIFEKALASEKSPTADAKPAPKRATASEQPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPVTLQVKIPSKEEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRSASMKLPDNTVKLGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELAGQSRAEPASSRKENLRLSGVVTSRLNLWISRTQESGDQDPQEAQKASSATERTQWGQKSDSSLDAEV", "length": 517, "header": "sp|O00515-1|LAD1_HUMAN Isoform 1 of Ladinin-1 OS=Homo sapiens OX=9606 GN=LAD1 PE=1 SV=2 CANONICAL=O00515-1" }, "locus": { "chromosome": "1", "start_pos": 201399306, "end_pos": 201381891, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000391967.7", "url": "https://www.ensembl.org/id/ENST00000391967.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000375829.2", "url": "https://www.ensembl.org/id/ENSP00000375829.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 121, "end_pos": 121, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "site_lbl": "Ser121" }, { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "site_lbl": "Ser123" }, { "start_pos": 177, "end_pos": 177, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" }, { "database": "PubMed", "id": "16083285", "url": "https://glygen.org/publication/PubMed/16083285" }, { "database": "phospho.ELM", "id": "O00515", "url": "http://phospho.elm.eu.org/byAccession/O00515.html" } ], "site_lbl": "Ser177" }, { "start_pos": 269, "end_pos": 269, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ], "site_lbl": "Ser269" }, { "start_pos": 272, "end_pos": 272, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ], "site_lbl": "Ser272" }, { "start_pos": 347, "end_pos": 347, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "site_lbl": "Ser347" }, { "start_pos": 355, "end_pos": 355, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser355" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser356" }, { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "site_lbl": "Ser38" }, { "start_pos": 392, "end_pos": 392, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser392" }, { "start_pos": 394, "end_pos": 394, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "site_lbl": "Ser394" }, { "start_pos": 485, "end_pos": 485, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "site_lbl": "Ser485" }, { "start_pos": 64, "end_pos": 64, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "site_lbl": "Ser64" }, { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "site_lbl": "Ser78" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.", "journal": "Journal of proteome research", "date": "2005", "authors": "Kim JE, Tannenbaum SR, White FM", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "reference": [ { "type": "PubMed", "id": "16083285", "url": "https://glygen.org/publication/PubMed/16083285" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" }, { "database": "iPTMnet", "id": "O00515", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00515" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Basement membrane protein ladinin-1 and the MIF-CD44-beta1 integrin signaling axis are implicated in laryngeal cancer metastasis.", "journal": "Biochimica et biophysica acta", "date": "2016", "authors": "Klobucar M, Sedic M, Gehrig P, Grossmann J, Bilic M, Kovac-Bilic L, Pavelic K, Kraljevic Pavelic S", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" } ], "reference": [ { "type": "PubMed", "id": "27460703", "url": "https://glygen.org/publication/PubMed/27460703" } ] }, { "title": "SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.", "journal": "Science signaling", "date": "2018", "authors": "Roth L, Srivastava S, Lindzen M, Sas-Chen A, Sheffer M, Lauriola M, Enuka Y, Noronha A, Mancini M, Lavi S, Tarcic G, Pines G, Nevo N, Heyman O, Ziv T, Rueda OM, Gnocchi D, Pikarsky E, Admon A, Caldas C, Yarden Y", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" } ], "reference": [ { "type": "PubMed", "id": "29382783", "url": "https://glygen.org/publication/PubMed/29382783" } ] }, { "title": "High expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa).", "journal": "Bioengineered", "date": "2021", "authors": "Li J, Wang Z, Tie C", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" } ], "reference": [ { "type": "PubMed", "id": "34516317", "url": "https://glygen.org/publication/PubMed/34516317" } ] }, { "title": "Ladinin 1 Shortens Survival via Promoting Proliferation and Enhancing Invasiveness in Lung Adenocarcinoma.", "journal": "International journal of molecular sciences", "date": "2022-12-27", "authors": "Chang Chao-Yuan, Huang Yung-Chi, Chiang Hung-Hsing, Wu Yu-Yuan, Wu Kuan-Li, Chang Yung-Yun, Liu Lian-Xiu, Tsai Ying-Ming, Hsu Ya-Ling", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" } ], "reference": [ { "type": "PubMed", "id": "36613882", "url": "https://glygen.org/publication/PubMed/36613882" } ] }, { "title": "The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target.", "journal": "Molecules (Basel, Switzerland)", "date": "2023-01-22", "authors": "Hu Lei, Liu Yu, Fu Changfang, Zhao Jiarong, Cui Qianwen, Sun Qiuyan, Wang Hongqiang, Lu Li, Dai Haiming, Xu Xiaohui, Yang Wulin", "evidence": [ { "database": "RefSeq", "id": "NP_005549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549" } ], "reference": [ { "type": "PubMed", "id": "36770773", "url": "https://glygen.org/publication/PubMed/36770773" } ] } ], "pathway": [ { "id": "hsa:3898", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3898", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GI64-1", "protein_name": "Ladinin 1", "gene_name": "Lad1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LCPNNLYWSAPGLARQRTLEDEEEQERERRRRHRNLSSTTEDESPKLTQNGAQRSVERLPSVEEAEVSKPSPPASKDEGEEFQAILRTRKGRRQRQQVVGAVQAPGQEKVEAEEERDSLGPEQTVSQPLVPKKKVESLPRRRLSREQRGPWAQEEECLKSRELVEGEKGRPEETAAQQKSPVSEKTPVSAKRLVSEKACPSEKGTATEKASPTEKRPEKLVPERTSVTEKSPAPEKTLVSLKTAAPERRSPPVLEKATVSEKMQERKLVSEKASIFEKPLVSETKLTPKKAAVSEQPQTPGGSQATTREVSGRALPGKSPPSSAEQSAPDPPTKASRFLPVTLQVKIPSKDEDADISSPTLTYSSSLKRSSPRTISFRMSLKKDNPETTLTRSASVRLPASTVKLGEKLERYHTAIQRSESVRSPGSSRTEVLVTPAGVASKRHLFEKELSGQNRTEPTSIRKENLRLSGVVTSKLNLWISRTQDSGDHGPQEVRKEASATKRAQWGNKSTTSLDAEVSGAGGTGPKIQWKAPKPIQVLTLKRVAVWSCVV", "length": 551 }, "evidence": [ { "id": "45918544", "url": "http://www.informatics.jax.org/homology/45918544", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P57016-1", "protein_name": "Ladinin-1", "gene_name": "Lad1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDESPKLTQNGAQRSVERLPSVEEAEVSKPSPPASKDEDEDFQAILRTRKERRQRRQVVEAVQAPVQERPEAEEERDSLGPEQTSSQPLVPKKKVEALPRRRLSREQRGPWAQDEERLKNRELAEGEKRLPEETVAQQKTLVSEKTPVSEKTPVPAKRLVSEKACPSEKGTATEKASLTEKRHSPEKLVPEKTSVTEKSPVPEKTLVSLKTAAPERRSPPVLEKAIVSEKMQERKLVSEKASIFEKSLVSEAKLTPKKAAVSEQPQTTGGSQATTREPRGRALPDKSPPSSAEQSTPAPPTKASRFPPITLQVKIPSKDEDADTPSPTLLTYSSSLKRSSPRTISFRMSPRKDNSETPLTRSASVRLPASTVKLGEKLERYHTAIQRSESVRSPGSSRTEVLVTPAGVASKRHLFEKELSGQNRTEPTSIRKENLRLSGVVTSRLNLWISKTQDSGDHGSQEVRKEASVTKRAQWGSKPSTSLDAEV", "length": 528 }, "evidence": [ { "id": "45918544", "url": "http://www.informatics.jax.org/homology/45918544", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "O00515", "url": "https://www.uniprot.org/uniprot/O00515" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 38, 64, 78, 121, 123, 177, 269, 272, 347, 355, 356, 392, 394, 485 ], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 36, "end_pos": 38 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 14 }, { "field": "total_sites", "count": 14 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }