{ "uniprot_canonical_ac": "O00453-1", "uniprot_ac": "O00453", "uniprot_id": "LST1_HUMAN", "mass": { "chemical_mass": 10792.0, "monoisotopic_mass": 10792.0 }, "refseq": { "ac": "NP_001160010", "name": "leukocyte-specific transcript 1 protein isoform 6", "summary": "The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" }, "gene_names": [ { "name": "LST1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00453", "id": "O00453" }, { "name": "B144; D6S49E; LST-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010", "id": "NP_001160010" }, { "name": "B144", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00453", "id": "O00453" }, { "name": "LST1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010", "id": "NP_001160010" }, { "name": "hCG_43689", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00453", "id": "O00453" } ], "protein_names": [ { "name": "Leukocyte-specific transcript 1 protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00453" }, { "name": "Protein B144", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00453" }, { "name": "leukocyte-specific transcript 1 protein isoform 6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010", "id": "NP_001160010" }, { "name": "lymphocyte antigen 117; leukocyte-specific transcript 1 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010", "id": "NP_001160010" } ], "function": [ { "annotation": "Data indicate that the MHC class III gene LST1 5' untranslated regions (5'-UTR) contains several upstream open reading frames (uORFs). Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001160010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" }, { "database": "PubMed", "id": "24816991", "url": "https://glygen.org/publication/PubMed/24816991" } ] }, { "annotation": "Increased expression of LST1 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.", "evidence": [ { "database": "RefSeq", "id": "NP_001160010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" }, { "database": "PubMed", "id": "27384923", "url": "https://glygen.org/publication/PubMed/27384923" } ] }, { "annotation": "Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.", "evidence": [ { "database": "UniProtKB", "id": "O00453", "url": "https://www.uniprot.org/uniprot/O00453#function" }, { "database": "PubMed", "id": "11478849", "url": "https://glygen.org/publication/PubMed/11478849" }, { "database": "PubMed", "id": "10706707", "url": "https://glygen.org/publication/PubMed/10706707" } ] }, { "annotation": "Psoriasis was associated with promoter variant, rs9267502 of LST1.Promoter activity was examined and it was larger than that of the other genetic variants, most probably due to changes in binding affinity to transcription factors.", "evidence": [ { "database": "RefSeq", "id": "NP_001160010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" }, { "database": "PubMed", "id": "24803336", "url": "https://glygen.org/publication/PubMed/24803336" } ] }, { "annotation": "Significance of leukocyte-specific transcript 1 levels in nasal mucosal tissue to predict recurrence of nasal polyps.", "evidence": [ { "database": "RefSeq", "id": "NP_001160010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" }, { "database": "PubMed", "id": "36754676", "url": "https://glygen.org/publication/PubMed/36754676" } ] }, { "annotation": "The present review describes LST1 promotor, gene organization, splice variants and expression in human tissues, cell lines and cancer with the focus on LST1 expression in inflammation, autoimmune diseases and cancer Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001160010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" }, { "database": "PubMed", "id": "30055863", "url": "https://glygen.org/publication/PubMed/30055863" } ] }, { "annotation": "The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001160010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160010" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "74.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "80.51", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "82.94", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "80.18", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "88.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "77.88", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "75.36", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "72.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "79.9", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "82.21", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "79.28", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "79.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204482", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204482" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00453", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00453" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O00453", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00453" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O00453", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00453" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O00453", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00453" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"Protein" ] }, { "id": "Q5HYT5-1", "url": "https://www.uniprot.org/uniprot/Q5HYT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5STB1", "url": "https://www.uniprot.org/uniprot/Q5STB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5STB1-1", "url": "https://www.uniprot.org/uniprot/Q5STB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 97, "header": "sp|O00453-1|LST1_HUMAN Isoform 1 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "isoforms": [ { "isoform_ac": "A0A024RCT7-1", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 82, "header": "tr|A0A024RCT7-1|A0A024RCT7_HUMAN Computationally mapped isoform of Leukocyte specific transcript 1, isoform CRA_c OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_DBB_CTG1", "start_pos": 2836410, "end_pos": 2835035, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000448749.5", "url": "https://www.ensembl.org/id/ENST00000448749.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000407534.1", "url": "https://www.ensembl.org/id/ENSP00000407534.1" } ] } }, { "isoform_ac": "A0A0G2JHS1-1", "url": "", "sequence": { "sequence": "XSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRREAASAQQ", "length": 43, "header": "tr|A0A0G2JHS1-1|LST1_HUMAN Computationally mapped isoform of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 2930476, "end_pos": 2929199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000415262.1", "url": "https://www.ensembl.org/id/ENST00000415262.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000393046.1", "url": "https://www.ensembl.org/id/ENSP00000393046.1" } ] } }, { "isoform_ac": "A0A0G2JIG4-1", "url": "", "sequence": { "sequence": "YRGMMIYVSTGAWGWAGSCFWQWSFCPPACVGCIEERLPVPSS", "length": 43, "header": "tr|A0A0G2JIG4-1|A0A0G2JIG4_HUMAN Computationally mapped isoform of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=4 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2844406, "end_pos": 2843125, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000455553.1", "url": "https://www.ensembl.org/id/ENST00000455553.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000399203.1", "url": "https://www.ensembl.org/id/ENSP00000399203.1" } ] } }, { "isoform_ac": "A0A0G2JIN5-1", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRREHCLALEPL", "length": 46, "header": "tr|A0A0G2JIN5-1|A0A0G2JIN5_HUMAN Computationally mapped isoform of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=4 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 2892882, "end_pos": 2892341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419469.5", "url": "https://www.ensembl.org/id/ENST00000419469.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000393067.1", "url": "https://www.ensembl.org/id/ENSP00000393067.1" } ] } }, { "isoform_ac": "F2Z2M1-1", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWRLPVPSSEGPDLRGRDKRGTK", "length": 66, "header": "tr|F2Z2M1-1|F2Z2M1_HUMAN Computationally mapped isoform of Leukocyte specific transcript 1 OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "6", "start_pos": 31588625, "end_pos": 31587300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000396112.6", "url": "https://www.ensembl.org/id/ENST00000396112.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000379418.2", "url": "https://www.ensembl.org/id/ENSP00000379418.2" } ] } }, { "isoform_ac": "H7C4M3-1", "url": "", "sequence": { "sequence": "XGGLLLLAVVLLSACLCWLHRREAGEELEAASAQQ", "length": 35, "header": "tr|H7C4M3-1|H7C4M3_HUMAN Computationally mapped isoform of Leukocyte specific transcript 1 OS=Homo sapiens OX=9606 GN=LST1 PE=4 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "6", "start_pos": 31588584, "end_pos": 31587669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000464044.1", "url": "https://www.ensembl.org/id/ENST00000464044.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000417645.1", "url": "https://www.ensembl.org/id/ENSP00000417645.1" } ] } }, { "isoform_ac": "H7C4Z3-1", "url": "", "sequence": { "sequence": "XDICIYGGLGLGGLLLLAVVLLSACLCWLHRREAGEELGPGLLRAGTPLCISAEAASAQQ", "length": 60, "header": "tr|H7C4Z3-1|H7C4Z3_HUMAN Computationally mapped isoform of Leukocyte specific transcript 1 OS=Homo sapiens OX=9606 GN=LST1 PE=4 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "6", "start_pos": 31588583, "end_pos": 31587316, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000490742.5", "url": "https://www.ensembl.org/id/ENST00000490742.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000418578.1", "url": "https://www.ensembl.org/id/ENSP00000418578.1" } ] } }, { "isoform_ac": "O00453-1", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 97, "header": "sp|O00453-1|LST1_HUMAN Isoform 1 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 2893714, "end_pos": 2892341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430632.5", "url": "https://www.ensembl.org/id/ENST00000430632.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000392949.1", "url": "https://www.ensembl.org/id/ENSP00000392949.1" } ] } }, { "isoform_ac": "O00453-10", "url": "", "sequence": { "sequence": "MLSRNDVKRLERSWAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 66, "header": "sp|O00453-10|LST1_HUMAN Isoform 10 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2844496, "end_pos": 2843121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000400262.5", "url": "https://www.ensembl.org/id/ENST00000400262.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000383121.1", "url": "https://www.ensembl.org/id/ENSP00000383121.1" } ] } }, { "isoform_ac": "O00453-11", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWHLLSWSQAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 104, "header": "sp|O00453-11|LST1_HUMAN Isoform 11 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 2930566, "end_pos": 2929195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000436037.5", "url": "https://www.ensembl.org/id/ENST00000436037.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000398685.1", "url": "https://www.ensembl.org/id/ENSP00000398685.1" } ] } }, { "isoform_ac": "O00453-12", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRAPSVLVPGPGLLRAGTPLCISAEAASAQQ", "length": 66, "header": "sp|O00453-12|LST1_HUMAN Isoform 12 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2844405, "end_pos": 2843121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000383484.6", "url": "https://www.ensembl.org/id/ENST00000383484.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000372976.2", "url": "https://www.ensembl.org/id/ENSP00000372976.2" } ] } }, { "isoform_ac": "O00453-13", "url": "", "sequence": { "sequence": "MLSRNDVKRLERSWHLLSWSQAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 73, "header": "sp|O00453-13|LST1_HUMAN Isoform 13 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_SSTO_CTG1", "start_pos": 2887954, "end_pos": 2886581, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000450291.5", "url": "https://www.ensembl.org/id/ENST00000450291.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000404500.1", "url": "https://www.ensembl.org/id/ENSP00000404500.1" } ] } }, { "isoform_ac": "O00453-2", "url": "", "sequence": { "sequence": "MIYVSTGAWGWAGSCFWQWSFCPPACVGCIEEHLLSWSQAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 91, "header": "sp|O00453-2|LST1_HUMAN Isoform 2 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": {} }, { "isoform_ac": "O00453-3", "url": "", "sequence": { "sequence": "MIYVSTGAWGWAGSCFWQWSFCPPACVGCIEEEAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 85, "header": "sp|O00453-3|LST1_HUMAN Isoform 3 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": {} }, { "isoform_ac": "O00453-4", "url": "", "sequence": { "sequence": "MTQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 53, "header": "sp|O00453-4|LST1_HUMAN Isoform 4 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": {} }, { "isoform_ac": "O00453-5", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRGPGLLRAGTPLCISAEAASAQQ", "length": 59, "header": "sp|O00453-5|LST1_HUMAN Isoform 5 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2844405, "end_pos": 2843121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000400250.5", "url": "https://www.ensembl.org/id/ENST00000400250.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000383109.1", "url": "https://www.ensembl.org/id/ENSP00000383109.1" } ] } }, { "isoform_ac": "O00453-6", "url": "", "sequence": { "sequence": "MLSRNDVKRLERSWRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT", "length": 51, "header": "sp|O00453-6|LST1_HUMAN Isoform 6 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_DBB_CTG1", "start_pos": 2836410, "end_pos": 2835035, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000423871.5", "url": "https://www.ensembl.org/id/ENST00000423871.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000400069.1", "url": "https://www.ensembl.org/id/ENSP00000400069.1" } ] } }, { "isoform_ac": "O00453-7", "url": "", "sequence": { "sequence": "MLSRNDVKRLERSWHLSVLVPGPGLLRAGTPLCISAEAASAQQ", "length": 43, "header": "sp|O00453-7|LST1_HUMAN Isoform 7 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": {} }, { "isoform_ac": "O00453-8", "url": "", "sequence": { "sequence": "MLSRNDAPSVLVPGPGLLRAGTPLCISAEAASAQQ", "length": 35, "header": "sp|O00453-8|LST1_HUMAN Isoform 8 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "6", "start_pos": 31588582, "end_pos": 31587300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376092.7", "url": "https://www.ensembl.org/id/ENST00000376092.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000365260.3", "url": "https://www.ensembl.org/id/ENSP00000365260.3" } ] } }, { "isoform_ac": "O00453-9", "url": "", "sequence": { "sequence": "MLSRNDEAASAQQ", "length": 13, "header": "sp|O00453-9|LST1_HUMAN Isoform 9 of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=2 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 2893623, "end_pos": 2892341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000413426.5", "url": "https://www.ensembl.org/id/ENST00000413426.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000408876.1", "url": "https://www.ensembl.org/id/ENSP00000408876.1" } ] } }, { "isoform_ac": "Q2HNT4-1", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRREAASAQQ", "length": 44, "header": "tr|Q2HNT4-1|LST1_HUMAN Computationally mapped isoform of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "6", "start_pos": 31588582, "end_pos": 31587300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000396101.7", "url": "https://www.ensembl.org/id/ENST00000396101.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000379408.3", "url": "https://www.ensembl.org/id/ENSP00000379408.3" } ] } }, { "isoform_ac": "Q5HYT5-1", "url": "", "sequence": { "sequence": "MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHR", "length": 36, "header": "tr|Q5HYT5-1|Q5HYT5_HUMAN Computationally mapped isoform of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=4 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_SSTO_CTG1", "start_pos": 2887010, "end_pos": 2886581, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000433520.5", "url": "https://www.ensembl.org/id/ENST00000433520.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000402235.1", "url": "https://www.ensembl.org/id/ENSP00000402235.1" } ] } }, { "isoform_ac": "Q5STB1-1", "url": "", "sequence": { "sequence": "MLSRNDGPGLLRAGTPLCISAEAASAQQ", "length": 28, "header": "tr|Q5STB1-1|LST1_HUMAN Computationally mapped isoform of Leukocyte-specific transcript 1 protein OS=Homo sapiens OX=9606 GN=LST1 PE=1 SV=1 CANONICAL=O00453-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2844405, "end_pos": 2843121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000400253.5", "url": "https://www.ensembl.org/id/ENST00000400253.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000383112.1", "url": "https://www.ensembl.org/id/ENSP00000383112.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": 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"date": "2000-03-15", "authors": "Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss E H, Zwierzina H", "evidence": [ { "database": "UniProtKB", "id": "O00453", "url": "https://www.uniprot.org/uniprot/O00453" } ], "reference": [ { "type": "PubMed", "id": "10706707", "url": "https://glygen.org/publication/PubMed/10706707" } ] }, { "title": "Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells.", "journal": "Experimental cell research", "date": "2001", "authors": "Raghunathan A, Sivakamasundari R, Wolenski J, Poddar R, Weissman SM", "evidence": [ { "database": "UniProtKB", "id": "O00453", "url": "https://www.uniprot.org/uniprot/O00453" } ], "reference": [ { "type": "PubMed", "id": "11478849", "url": "https://glygen.org/publication/PubMed/11478849" } ] }, { "title": "Analysis of the gene-dense major histocompatibility complex class III 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