{ "uniprot_canonical_ac": "O00418-1", "uniprot_ac": "O00418", "uniprot_id": "EF2K_HUMAN", "mass": { "chemical_mass": 82144.0, "monoisotopic_mass": 82144.0 }, "refseq": { "ac": "NP_037434", "name": "eukaryotic elongation factor 2 kinase", "summary": "This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" }, "gene_names": [ { "name": "EEF2K", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00418", "id": "O00418" }, { "name": "CaMKIII; eEF-2K; HSU93850", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434", "id": "NP_037434" }, { "name": "EEF2K", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434", "id": "NP_037434" } ], "protein_names": [ { "name": "Eukaryotic elongation factor 2 kinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00418" }, { "name": "2.7.11.20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00418" }, { "name": "Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00418" }, { "name": "calmodulin-dependent protein kinase III; elongation factor-2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; eEF-2 kinase; eukaroytic elongation factor 2 kinase; alternative protein EEF2K", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434", "id": "NP_037434" }, { "name": "eEF-2 kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00418" }, { "name": "eEF-2K", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00418" }, { "name": "eukaryotic elongation factor 2 kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434", "id": "NP_037434" } ], "function": [ { "annotation": "EEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" }, { "database": "PubMed", "id": "34352439", "url": "https://glygen.org/publication/PubMed/34352439" } ] }, { "annotation": "EEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" }, { "database": "PubMed", "id": "35347072", "url": "https://glygen.org/publication/PubMed/35347072" } ] }, { "annotation": "MiRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" }, { "database": "PubMed", "id": "35718922", "url": "https://glygen.org/publication/PubMed/35718922" } ] }, { "annotation": "Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" }, { "database": "PubMed", "id": "34796967", "url": "https://glygen.org/publication/PubMed/34796967" } ] }, { "annotation": "Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" }, { "database": "PubMed", "id": "37172726", "url": "https://glygen.org/publication/PubMed/37172726" } ] }, { "annotation": "This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" } ] }, { "annotation": "Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418#function" }, { "database": "PubMed", "id": "9144159", "url": "https://glygen.org/publication/PubMed/9144159" }, { "database": "PubMed", "id": "14709557", "url": "https://glygen.org/publication/PubMed/14709557" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O00418", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00418" } ], "glycoeffect": [], "start_pos": 303, "end_pos": 303, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "16", "chr_pos": "22257648", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R303", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 348, "end_pos": 348, "sequence_org": "T", "sequence_mut": "A", "comment": "Decreased kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "22216903", "url": "https://glygen.org/publication/PubMed/22216903" } ] }, { "start_pos": 366, "end_pos": 366, "sequence_org": "S", "sequence_mut": "A", "comment": "Abrogates phosphorylation by RPS6KB1.", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "11500364", "url": "https://glygen.org/publication/PubMed/11500364" }, { "database": "PubMed", "id": "22216903", "url": "https://glygen.org/publication/PubMed/22216903" } ] }, { "start_pos": 366, "end_pos": 366, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "11500364", "url": "https://glygen.org/publication/PubMed/11500364" }, { "database": "PubMed", "id": "22216903", "url": "https://glygen.org/publication/PubMed/22216903" } ] }, { "start_pos": 78, "end_pos": 78, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "22216903", "url": "https://glygen.org/publication/PubMed/22216903" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "73.1", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000103319", "url": 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"evidence": [ { "database": "BioXpress", "id": "O00418", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00418" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", 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"https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O00418", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00418" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00418" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00418" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00418", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00418" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O00418", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00418" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "common_name": "Human" } ], "gene": [ { "name": "EEF2K", "url": "https://www.uniprot.org/uniprot/O00418", "locus": { "chromosome": "HG926_PATCH", "start_pos": 816312, "end_pos": 898761, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000284161", "url": "https://www.ensembl.org/id/ENSG00000284161" } ] } } ], "crossref": [ { "id": "ENSG00000103319", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000103319", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O00418", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00418", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "2.7.11.20", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.20&UniProtAcc=O00418", "database": 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"categories": [ "3D Structure" ] }, { "id": "5KS5", "url": "https://www.rcsb.org/structure/5KS5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6NX4", "url": "https://www.rcsb.org/structure/6NX4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7SHQ", "url": "https://www.rcsb.org/structure/7SHQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8FNY", "url": "https://www.rcsb.org/structure/8FNY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8FO6", "url": "https://www.rcsb.org/structure/8FO6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8GM4", "url": "https://www.rcsb.org/structure/8GM4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8GM5", "url": "https://www.rcsb.org/structure/8GM5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF02816", "url": "http://pfam.xfam.org/family/PF02816", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O00418", "url": "https://pharos.nih.gov/targets/O00418", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O00418", "url": "http://purl.obolibrary.org/obo/PR_O00418", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21436", "url": "https://www.rhea-db.org/rhea/21436", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "H3BRH4", "url": "https://www.uniprot.org/uniprot/H3BRH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BRH4-1", "url": "https://www.uniprot.org/uniprot/H3BRH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00418-1", "url": "https://www.uniprot.org/uniprot/O00418-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE", "length": 725, "header": "sp|O00418-1|EF2K_HUMAN Isoform 1 of Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2 CANONICAL=O00418-1" }, "isoforms": [ { "isoform_ac": "H3BRH4-1", "url": "", "sequence": { "sequence": "MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLRE", "length": 412, "header": "tr|H3BRH4-1|H3BRH4_HUMAN Computationally mapped isoform of Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=1 CANONICAL=O00418-1" }, "locus": { "chromosome": "16", "start_pos": 22258700, "end_pos": 22225730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000568269.5", "url": "https://www.ensembl.org/id/ENST00000568269.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000456243.1", "url": "https://www.ensembl.org/id/ENSP00000456243.1" } ] } }, { "isoform_ac": "O00418-1", "url": "", "sequence": { "sequence": "MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE", "length": 725, "header": "sp|O00418-1|EF2K_HUMAN Isoform 1 of Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2 CANONICAL=O00418-1" }, "locus": { "chromosome": "16", "start_pos": 22283993, "end_pos": 22225730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000263026.10", "url": "https://www.ensembl.org/id/ENST00000263026.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000263026.5", "url": "https://www.ensembl.org/id/ENSP00000263026.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O00418", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00418" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" } ] } ], "phosphorylation": [ { "start_pos": 135, "end_pos": 135, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" }, { "database": "PubMed", "id": "17287340", "url": "https://glygen.org/publication/PubMed/17287340" }, { "database": "phospho.ELM", "id": "O00418", "url": "http://phospho.elm.eu.org/byAccession/O00418.html" } ], "site_lbl": "Ser135" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "15144186", "url": "https://glygen.org/publication/PubMed/15144186" }, { "database": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" }, { "database": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" }, { "database": "phospho.ELM", "id": "O00418", "url": "http://phospho.elm.eu.org/byAccession/O00418.html" } ], "site_lbl": "Ser18" }, { "start_pos": 243, "end_pos": 243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "site_lbl": "Ser243" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Ser27" }, { "start_pos": 31, "end_pos": 31, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Ser31" }, { "start_pos": 345, 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Petrov AN, Ryazanov AG", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "reference": [ { "type": "PubMed", "id": "11015200", "url": "https://glygen.org/publication/PubMed/11015200" } ] }, { "title": "Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.", "journal": "The Biochemical journal", "date": "2001", "authors": "Diggle TA, Subkhankulova T, Lilley KS, Shikotra N, Willis AE, Redpath NT", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "11171059", "url": "https://glygen.org/publication/PubMed/11171059" } ] }, { "title": "A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.", "journal": "The EMBO journal", "date": "2001", "authors": "Knebel A, Morrice N, Cohen P", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "11500363", "url": "https://glygen.org/publication/PubMed/11500363" } ] }, { "title": "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.", "journal": "The EMBO journal", "date": "2001", "authors": "Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "11500364", "url": "https://glygen.org/publication/PubMed/11500364" } ] }, { "title": "Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.", "journal": "Cell", "date": "2002", "authors": "Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "12150926", "url": "https://glygen.org/publication/PubMed/12150926" } ] }, { "title": "Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.", "journal": "The Biochemical journal", "date": "2002", "authors": "Knebel A, Haydon CE, Morrice N, Cohen P", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "12171600", "url": "https://glygen.org/publication/PubMed/12171600" } ] }, { "title": "Sirolimus: its discovery, biological properties, and mechanism of action.", "journal": "Transplantation proceedings", "date": "2003", "authors": "Sehgal SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "12742462", "url": "https://glygen.org/publication/PubMed/12742462" } ] }, { "title": "mTOR-mediated regulation of translation factors by amino acids.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Proud CG", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "14684180", "url": "https://glygen.org/publication/PubMed/14684180" } ] }, { "title": "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Browne GJ, Finn SG, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "14709557", "url": "https://glygen.org/publication/PubMed/14709557" } ] }, { "title": "A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Browne GJ, Proud CG", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "15024086", "url": "https://glygen.org/publication/PubMed/15024086" } ] }, { "title": "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.", "journal": "Analytical chemistry", "date": "2004", "authors": "Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "15144186", "url": "https://glygen.org/publication/PubMed/15144186" } ] }, { "title": "Upstream and downstream of mTOR.", "journal": "Genes & development", "date": "2004", "authors": "Hay N, Sonenberg N", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "15314020", "url": "https://glygen.org/publication/PubMed/15314020" } ] }, { "title": "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Ali SM, Sabatini DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "15809305", "url": "https://glygen.org/publication/PubMed/15809305" } ] }, { "title": "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.", "journal": "Nature biotechnology", "date": "2006", "authors": "Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.", "journal": "Cell", "date": "1991", "authors": "Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "1715244", "url": "https://glygen.org/publication/PubMed/1715244" } ] }, { "title": "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Molina H, Horn DM, Tang N, Mathivanan S, Pandey A", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "17287340", "url": "https://glygen.org/publication/PubMed/17287340" } ] }, { "title": "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Sugiyama N, Masuda T, Shinoda K, Nakamura A, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" } ] }, { "title": "Patterns of somatic mutation in human cancer genomes.", "journal": "Nature", "date": "2007", "authors": "Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "reference": [ { "type": "PubMed", "id": "17344846", "url": "https://glygen.org/publication/PubMed/17344846" } ] }, { "title": "cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.", "journal": "The EMBO journal", "date": "2008", "authors": "Smith EM, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "18337751", "url": "https://glygen.org/publication/PubMed/18337751" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": 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J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway.", "journal": "The American journal of pathology", "date": "2010", "authors": "Khan AA, Dace DS, Ryazanov AG, Kelly J, Apte RS", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "20472894", "url": "https://glygen.org/publication/PubMed/20472894" } ] }, { "title": "TGFbeta enforces activation of eukaryotic elongation factor-2 (eEF2) via inactivation of eEF2 kinase by p90 ribosomal S6 kinase (p90Rsk) to induce mesangial cell hypertrophy.", "journal": "FEBS letters", "date": "2010", "authors": "Das F, Ghosh-Choudhury N, Kasinath BS, Choudhury GG", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "20837011", "url": "https://glygen.org/publication/PubMed/20837011" } ] }, { "title": "The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.", "journal": "Cellular signalling", "date": "2011", "authors": "Perraud AL, Zhao X, Ryazanov AG, Schmitz C", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", 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"evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "22115317", "url": "https://glygen.org/publication/PubMed/22115317" } ] }, { "title": "Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase.", "journal": "The Biochemical journal", "date": "2012", "authors": "Pyr Dit Ruys S, Wang X, Smith EM, Herinckx G, Hussain N, Rider MH, Vertommen D, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "22216903", "url": "https://glygen.org/publication/PubMed/22216903" } ] }, { "title": "Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "reference": [ { "type": "PubMed", "id": "22223895", "url": "https://glygen.org/publication/PubMed/22223895" } ] }, { "title": "Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.", "journal": "Biochemistry", "date": "2012", "authors": "Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "22329831", "url": "https://glygen.org/publication/PubMed/22329831" } ] }, { "title": "Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.", "journal": "Science signaling", "date": "2012", "authors": "Kruiswijk F, Yuniati L, Magliozzi R, Low TY, Lim R, Bolder R, Mohammed S, Proud CG, Heck AJ, Pagano M, Guardavaccaro D", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "22669845", "url": "https://glygen.org/publication/PubMed/22669845" } ] }, { "title": "Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Huber-Keener KJ, Evans BR, Ren X, Cheng Y, Zhang Y, Hait WN, Yang JM", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "22749997", "url": "https://glygen.org/publication/PubMed/22749997" } ] }, { "title": "Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.", "journal": "Autophagy", "date": "2013", "authors": "Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "23182879", "url": "https://glygen.org/publication/PubMed/23182879" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00418", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00418" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity.", "journal": "The Biochemical journal", "date": "2015", "authors": "Wang X, Xie J, da Mota SR, Moore CE, Proud CG", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "25670349", "url": "https://glygen.org/publication/PubMed/25670349" } ] }, { "title": "Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Tavares CDJ, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "27956550", "url": "https://glygen.org/publication/PubMed/27956550" } ] }, { "title": "The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2.", "journal": "Cell communication and signaling : CCS", "date": "2020-02-13", "authors": "Xiao Min, Xie Jianling, Wu Yu, Wang Genzhu, Qi Xin, Liu Zailiang, Wang Yuying, Wang Xuemin, Hoque Ashfaqul, Oakhill Jon, Proud Christopher G, Li Jing", "evidence": [ { "database": "iPTMnet", "id": "O00418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00418" } ], "reference": [ { "type": "PubMed", "id": "32054489", "url": "https://glygen.org/publication/PubMed/32054489" } ] }, { "title": "eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.", "journal": "Pathology, research and practice", "date": "2021", "authors": "Jiang M, Qi L, Jin K, Li L, Wu Y, Song D, Gan J, Huang M, Li Y, Song C", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" } ], "reference": [ { "type": "PubMed", "id": "34352439", "url": "https://glygen.org/publication/PubMed/34352439" } ] }, { "title": "Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease.", "journal": "Journal of neurochemistry", "date": "2023-07", "authors": "Ma Tao", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" } ], "reference": [ { "type": "PubMed", "id": "34796967", "url": "https://glygen.org/publication/PubMed/34796967" } ] }, { "title": "eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.", "journal": "Journal for immunotherapy of cancer", "date": "2022", "authors": "Chen X, Wang K, Jiang S, Sun H, Che X, Zhang M, He J, Wen Y, Liao M, Li X, Zhou X, Song J, Ren X, Yi W, Yang J, Chen X, Yin M, Cheng Y", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" } ], "reference": [ { "type": "PubMed", "id": "35347072", "url": "https://glygen.org/publication/PubMed/35347072" } ] }, { "title": "miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.", "journal": "Anti-cancer agents in medicinal chemistry", "date": "2022", "authors": "Gurbuz N, Kahraman N, Sonmez HE, Mokhlis HA, Kosar PA, Ozpolat B", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" } ], "reference": [ { "type": "PubMed", "id": "35718922", "url": "https://glygen.org/publication/PubMed/35718922" } ] }, { "title": "Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.", "journal": "The Journal of biological chemistry", "date": "2023-06", "authors": "Piserchio Andrea, Isiorho Eta A, Dalby Kevin N, Ghose Ranajeet", "evidence": [ { "database": "RefSeq", "id": "NP_037434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037434" } ], "reference": [ { "type": "PubMed", "id": "37172726", "url": "https://glygen.org/publication/PubMed/37172726" } ] }, { "title": "Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Ryazanov AG, Ward MD, Mendola CE, Pavur KS, Dorovkov MV, Wiedmann M, Erdjument-Bromage H, Tempst P, Parmer TG, Prostko CR, Germino FJ, Hait WN", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "reference": [ { "type": "PubMed", "id": "9144159", "url": "https://glygen.org/publication/PubMed/9144159" } ] }, { "title": "Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.", "journal": "Clinical biochemistry", "date": "1998", "authors": "Sehgal SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "9721431", "url": "https://glygen.org/publication/PubMed/9721431" } ] } ], "pathway": [ { "id": "hsa:29904", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:29904", "resource": "KEGG Pathway" }, { "id": "R-HSA-166208", "name": "mTORC1-mediated signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208", "resource": "Reactome", "description": "mTORC1-mediated signalling" } ], "orthologs": [ { "uniprot_canonical_ac": "O08796-1", "protein_name": "Eukaryotic elongation factor 2 kinase", "gene_name": "Eef2k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADEDLIFCLEGVDGGRCSRAGHNADSDTDSDDDEGYFICPITDDHMSNQNVSSKVQSYYSNLTKTECGSTGSPASSFHFKEAWKHAIEKAKHMPDPWAEFHLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRSVYFEDVQLQMEAKLWGEDYNRHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRICQSMGLTPFDLSPREQDAVNQSTRLLQSAKTILRGTEEKCGSPRIRTLSSSRPPLLLRLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFGDLDNMGPRDHDRMDNHRDSENSGDSGYPSEKRSDLDDPEPREHGHSNGNRRHESDEDSLGSSGRVCVETWNLLNPSRLHLPRPSAVALEVQRLNALDLGRKIGKSVLGKVHLAMVRYHEGGRFCEKDEEWDRESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSPDRCQDWSEALHWYNTALETTDCDEGGEYDGIQDEPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE", "length": 724 }, "evidence": [ { "id": "45924143", "url": "http://www.informatics.jax.org/homology/45924143", "database": "MGI" }, { "id": "O00418", "url": "https://omabrowser.org/oma/group/O00418/", "database": "OMA" } ], "common_name": "Mouse" }, { 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"id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "elongation factor-2 kinase activity", "id": "GO:0004686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004686", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "translation factor activity, RNA binding", "id": "GO:0008135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008135", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "cellular response to anoxia", "id": "GO:0071454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071454", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "cellular response to brain-derived neurotrophic factor stimulus", "id": "GO:1990416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990416", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "response to prolactin", "id": "GO:1990637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990637", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "response to ischemia", "id": "GO:0002931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002931", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "regulation of protein autophosphorylation", "id": "GO:0031952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031952", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "positive regulation of endocytosis", "id": "GO:0045807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045807", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "positive regulation of dendritic spine morphogenesis", "id": "GO:0061003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061003", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "translational elongation", "id": "GO:0006414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006414", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "regulation of translation at postsynapse", "id": "GO:0140245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140245", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "myosin II filament disassembly", "id": "GO:0031037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031037", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.", "evidence": [ { "database": "UniProtKB", "id": "O00418", "url": "https://www.uniprot.org/uniprot/O00418" }, { "database": "PubMed", "id": "11500363", "url": "https://glygen.org/publication/PubMed/11500363" }, { "database": "PubMed", "id": "18337751", "url": "https://glygen.org/publication/PubMed/18337751" }, { "database": "PubMed", "id": "11015200", "url": "https://glygen.org/publication/PubMed/11015200" }, { "database": "PubMed", "id": "11500364", "url": "https://glygen.org/publication/PubMed/11500364" }, { "database": "PubMed", "id": "21112387", "url": "https://glygen.org/publication/PubMed/21112387" }, { "database": "PubMed", "id": "22216903", "url": "https://glygen.org/publication/PubMed/22216903" }, { "database": "PubMed", "id": "14709557", "url": "https://glygen.org/publication/PubMed/14709557" } ] } ], 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