{ "uniprot_canonical_ac": "O00408-1", "uniprot_ac": "O00408", "uniprot_id": "PDE2A_HUMAN", "mass": { "chemical_mass": 105717.0, "monoisotopic_mass": 105717.0 }, "refseq": { "ac": "NP_001137311", "name": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, "gene_names": [ { "name": "PDE2A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00408", "id": "O00408" }, { "name": "CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311", "id": "NP_001137311" }, { "name": "PDE2A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311", "id": "NP_001137311" } ], "protein_names": [ { "name": "cGMP-dependent 3',5'-cyclic phosphodiesterase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00408" }, { "name": "3.1.4.17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00408" }, { "name": "CGS-PDE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00408" }, { "name": "Cyclic GMP-stimulated phosphodiesterase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00408" }, { "name": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311", "id": "NP_001137311" }, { "name": "cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; cGMP-stimulated phosphodiesterase 2; phosphodiesterase 2A, cGMP-stimulated", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311", "id": "NP_001137311" }, { "name": "cGSPDE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00408" } ], "function": [ { "annotation": "Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia.", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, { "database": "PubMed", "id": "32467598", "url": "https://glygen.org/publication/PubMed/32467598" } ] }, { "annotation": "Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets.", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, { "database": "PubMed", "id": "12038792", "url": "https://glygen.org/publication/PubMed/12038792" } ] }, { "annotation": "Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, { "database": "PubMed", "id": "36611861", "url": "https://glygen.org/publication/PubMed/36611861" } ] }, { "annotation": "MiR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/beta-catenin signaling. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, { "database": "PubMed", "id": "34512162", "url": "https://glygen.org/publication/PubMed/34512162" } ] }, { "annotation": "Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, { "database": "PubMed", "id": "33112806", "url": "https://glygen.org/publication/PubMed/33112806" } ] }, { "annotation": "Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" }, { "database": "PubMed", "id": "33087821", "url": "https://glygen.org/publication/PubMed/33087821" } ] }, { "annotation": "Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408#function" }, { "database": "UniProtKB", "id": "Q922S4", "url": "https://www.uniprot.org/uniprot/Q922S4#function" }, { "database": "PubMed", "id": "28463107", "url": "https://glygen.org/publication/PubMed/28463107" } ] }, { "annotation": "cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9210593, PubMed:29392776, PubMed:15938621). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027).", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408#function" }, { "database": "PubMed", "id": "24705027", "url": "https://glygen.org/publication/PubMed/24705027" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" }, { "database": "PubMed", "id": "29392776", "url": "https://glygen.org/publication/PubMed/29392776" }, { "database": "PubMed", "id": "9210593", "url": "https://glygen.org/publication/PubMed/9210593" } ] } ], "disease": [ { "disease_id": "MONDO:0030900", "recommended_name": { "id": "MONDO:0030900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030900", "name": "intellectual developmental disorder with paroxysmal dyskinesia or seizures", "description": "" }, "synonyms": [ { "id": "MONDO:0030900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030900", "name": "IDDPADS", "description": "" }, { "id": "MIM:619150", "resource": "MIM", "url": "https://www.omim.org/entry/619150", "name": "Intellectual developmental disorder with paroxysmal dyskinesia or seizures", "description": "Intellectual developmental disorder with paroxysmal dyskinesia or seizures" } ], "evidence": [ { "id": "619150", "database": "MIM", "url": "https://www.omim.org/entry/619150" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 811, "end_pos": 811, "sequence_org": "D", "sequence_mut": "A", "comment": "Decreased 3',5'-cyclic-AMP phosphodiesterase activity. No effect on 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 812, "end_pos": 812, "sequence_org": "Q", "sequence_mut": "I", "comment": "No effect on 3',5'-cyclic-AMP phosphodiesterase activity. Decreased 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 812, "end_pos": 812, "sequence_org": "Q", "sequence_mut": "P", "comment": "Loss of 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 819, "end_pos": 819, "sequence_org": "T", "sequence_mut": "Y", "comment": "Loss of 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 826, "end_pos": 826, "sequence_org": "I", "sequence_mut": "V", "comment": "Decreased 3',5'-cyclic-AMP phosphodiesterase activity. Increased 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 827, "end_pos": 827, "sequence_org": "Y", "sequence_mut": "A", "comment": "Decreased 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 827, "end_pos": 827, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of 3',5'-cyclic-AMP phosphodiesterase activity. Decreased 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 827, "end_pos": 827, "sequence_org": "Y", "sequence_mut": "M", "comment": "Loss of 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 827, "end_pos": 827, "sequence_org": "Y", "sequence_mut": "V", "comment": "Loss of 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 847, "end_pos": 847, "sequence_org": "M", "sequence_mut": "L", "comment": "Decreased 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 858, "end_pos": 858, "sequence_org": "L", "sequence_mut": "M", "comment": "Decreased 3',5'-cyclic-AMP phosphodiesterase activity. Decreased 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 858, "end_pos": 858, "sequence_org": "L", "sequence_mut": "S", "comment": "Loss of 3',5'-cyclic-AMP phosphodiesterase activity. Decreased 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "start_pos": 907, "end_pos": 907, "sequence_org": "L", "sequence_mut": "A", "comment": "Decreased 3',5'-cyclic-AMP phosphodiesterase activity. Loss of 3',5'-cyclic-GMP phosphodiesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" }, { "database": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "83.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "68.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "80.65", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "57.72", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "92.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "84.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "75.22", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "83.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "89.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "76.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "84.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "89.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186642", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186642" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00408", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00408" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00408", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00408" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O00408", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00408" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"sequence": "MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 941, "header": "sp|O00408-1|PDE2A_HUMAN Isoform 1 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "isoforms": [ { "isoform_ac": "C9JPD5-1", "url": "", "sequence": { "sequence": "MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKT", "length": 197, "header": "tr|C9JPD5-1|C9JPD5_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=8 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72581935, "end_pos": 72578912, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420501.5", "url": "https://www.ensembl.org/id/ENST00000420501.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000388997.1", "url": "https://www.ensembl.org/id/ENSP00000388997.1" } ] } }, { "isoform_ac": "E9PEF1-1", "url": "", "sequence": { "sequence": "MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 826, "header": "tr|E9PEF1-1|PDE2A_HUMAN Computationally mapped isoform of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=2 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72674207, "end_pos": 72577387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000418754.6", "url": "https://www.ensembl.org/id/ENST00000418754.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000410310.2", "url": "https://www.ensembl.org/id/ENSP00000410310.2" } ] } }, { "isoform_ac": "F5GXX2-1", "url": "", "sequence": { "sequence": "MMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFD", "length": 178, "header": "tr|F5GXX2-1|F5GXX2_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72583458, "end_pos": 72579549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000542223.1", "url": "https://www.ensembl.org/id/ENST00000542223.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000440834.1", "url": "https://www.ensembl.org/id/ENSP00000440834.1" } ] } }, { "isoform_ac": "F5H130-1", "url": "", "sequence": { "sequence": "MRRQPAASLDPLAKEPGPPGSRDDRLEDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVH", "length": 144, "header": "tr|F5H130-1|F5H130_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642272, "end_pos": 72591351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000538749.5", "url": "https://www.ensembl.org/id/ENST00000538749.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000439683.1", "url": "https://www.ensembl.org/id/ENSP00000439683.1" } ] } }, { "isoform_ac": "F5H143-1", "url": "", "sequence": { "sequence": "MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQETVYTYLLDGRLSSPRSGWAAMGWASQTCQGSPWPGWWLHWLLIPKCWSCR", "length": 92, "header": "tr|F5H143-1|F5H143_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=4 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642376, "end_pos": 72596634, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000543750.5", "url": "https://www.ensembl.org/id/ENST00000543750.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000438008.1", "url": "https://www.ensembl.org/id/ENSP00000438008.1" } ] } }, { "isoform_ac": "F5H1D7-1", "url": "", "sequence": { "sequence": "MSYILKMPGTCLPGEGTTYELPPSSLHPSSAPVTSGGTCPALLTEAGWEAPIMAFTEAASAVGPSWTHSGASRSSSSRTSRRRRRSHAPTAC", "length": 92, "header": "tr|F5H1D7-1|F5H1D7_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=4 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72658055, "end_pos": 72642256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000536458.1", "url": "https://www.ensembl.org/id/ENST00000536458.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000445750.1", "url": "https://www.ensembl.org/id/ENSP00000445750.1" } ] } }, { "isoform_ac": "F5H2R8-1", "url": "", "sequence": { "sequence": "MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQPAWTPLQRSQDPQGVETTDWRTPC", "length": 65, "header": "tr|F5H2R8-1|F5H2R8_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=4 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642376, "end_pos": 72608742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000539367.5", "url": "https://www.ensembl.org/id/ENST00000539367.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000445443.1", "url": "https://www.ensembl.org/id/ENSP00000445443.1" } ] } }, { "isoform_ac": "F5H2V7-1", "url": "", "sequence": { "sequence": "MGQACGHSILCRSQQYPAARPAEPQPGPPCKGARTPRE", "length": 38, "header": "tr|F5H2V7-1|F5H2V7_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=4 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72674207, "end_pos": 72631097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000535701.1", "url": "https://www.ensembl.org/id/ENST00000535701.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000439302.1", "url": "https://www.ensembl.org/id/ENSP00000439302.1" } ] } }, { "isoform_ac": "F5H2Z0-1", "url": "", "sequence": { "sequence": "MGQACGHSILCRSQQYPAARPAEPSLQLPEHCFHTCDLI", "length": 39, "header": "tr|F5H2Z0-1|F5H2Z0_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=4 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72674207, "end_pos": 72668381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000546038.1", "url": "https://www.ensembl.org/id/ENST00000546038.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000438295.1", "url": "https://www.ensembl.org/id/ENSP00000438295.1" } ] } }, { "isoform_ac": "F5H3Z7-1", "url": "", "sequence": { "sequence": "MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVRCTVAS", "length": 106, "header": "tr|F5H3Z7-1|PDE2A_HUMAN Computationally mapped isoform of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642376, "end_pos": 72591341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000536308.5", "url": "https://www.ensembl.org/id/ENST00000536308.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000438559.1", "url": "https://www.ensembl.org/id/ENSP00000438559.1" } ] } }, { "isoform_ac": "F5H5P8-1", "url": "", "sequence": { "sequence": "MRRQPAASLDPLAKEPGPPGSRDDRLEDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKV", "length": 86, "header": "tr|F5H5P8-1|F5H5P8_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=8 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642272, "end_pos": 72605140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000542969.2", "url": "https://www.ensembl.org/id/ENST00000542969.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000443232.1", "url": "https://www.ensembl.org/id/ENSP00000443232.1" } ] } }, { "isoform_ac": "H0YFL1-1", "url": "", "sequence": { "sequence": "PGLDRSRGRGRAELGGEVGGLGDPGSRRRARRGAERRLRDPDTEVRRGPLSDRRLALAGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQ", "length": 336, "header": "tr|H0YFL1-1|PDE2A_HUMAN Computationally mapped isoform of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72590419, "end_pos": 72584552, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000475807.6", "url": "https://www.ensembl.org/id/ENST00000475807.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000439077.1", "url": "https://www.ensembl.org/id/ENSP00000439077.1" } ] } }, { "isoform_ac": "H0YG13-1", "url": "", "sequence": { "sequence": "XSAVTPSPCLSLSQLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDV", "length": 172, "header": "tr|H0YG13-1|H0YG13_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72590021, "end_pos": 72585426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000538299.1", "url": "https://www.ensembl.org/id/ENST00000538299.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000441322.1", "url": "https://www.ensembl.org/id/ENSP00000441322.1" } ] } }, { "isoform_ac": "H0YGL2-1", "url": "", "sequence": { "sequence": "XLWLVASGGRHSAFPVSHPKGVGLACLPSTVASTGGCHWETGRAWEFRELRPAWTPLQRSQDPQGVETTDWRTPC", "length": 75, "header": "tr|H0YGL2-1|PDE2A_HUMAN Computationally mapped isoform of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72636130, "end_pos": 72608740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000537631.5", "url": "https://www.ensembl.org/id/ENST00000537631.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000443737.1", "url": "https://www.ensembl.org/id/ENSP00000443737.1" } ] } }, { "isoform_ac": "H7C009-1", "url": "", "sequence": { "sequence": "FPTASSVPEHKGVGFHAWDVRNLRKLRGQVPAGSLPPTDPSLHRWFLAPLPSPEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEG", "length": 327, "header": "tr|H7C009-1|H7C009_HUMAN Computationally mapped isoform of Phosphodiesterase 2A OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72584473, "end_pos": 72579282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000441209.6", "url": "https://www.ensembl.org/id/ENST00000441209.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000392457.2", "url": "https://www.ensembl.org/id/ENSP00000392457.2" } ] } }, { "isoform_ac": "O00408-1", "url": "", "sequence": { "sequence": "MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 941, "header": "sp|O00408-1|PDE2A_HUMAN Isoform 1 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72674207, "end_pos": 72577387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000334456.10", "url": "https://www.ensembl.org/id/ENST00000334456.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000334910.5", "url": "https://www.ensembl.org/id/ENSP00000334910.5" } ] } }, { "isoform_ac": "O00408-2", "url": "", "sequence": { "sequence": "MRRQPAASLDPLAKEPGPPGSRDDRLEDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 920, "header": "sp|O00408-2|PDE2A_HUMAN Isoform 2 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642272, "end_pos": 72577387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000444035.6", "url": "https://www.ensembl.org/id/ENST00000444035.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000411657.3", "url": "https://www.ensembl.org/id/ENSP00000411657.3" } ] } }, { "isoform_ac": "O00408-3", "url": "", "sequence": { "sequence": "MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 934, "header": "sp|O00408-3|PDE2A_HUMAN Isoform 3 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642376, "end_pos": 72577387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000544570.5", "url": "https://www.ensembl.org/id/ENST00000544570.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000442256.1", "url": "https://www.ensembl.org/id/ENSP00000442256.1" } ] } }, { "isoform_ac": "O00408-4", "url": "", "sequence": { "sequence": "MKKQRIQEGKSLAHRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 932, "header": "sp|O00408-4|PDE2A_HUMAN Isoform 4 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72668341, "end_pos": 72577387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000540345.5", "url": "https://www.ensembl.org/id/ENST00000540345.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000446399.1", "url": "https://www.ensembl.org/id/ENSP00000446399.1" } ] } }, { "isoform_ac": "O00408-5", "url": "", "sequence": { "sequence": "MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVRFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE", "length": 685, "header": "sp|O00408-5|PDE2A_HUMAN Isoform 5 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": { "chromosome": "11", "start_pos": 72642376, "end_pos": 72577387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376450.7", "url": "https://www.ensembl.org/id/ENST00000376450.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000365633.3", "url": "https://www.ensembl.org/id/ENSP00000365633.3" } ] } }, { "isoform_ac": "O00408-6", "url": "", "sequence": { "sequence": "MRRQPAASLDPLAKEPGPPGSRDDRLEDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFPLRTTTILMVGLGPGGYRGPRKKLPEGQLSALQRGALGRSRMGLMGRRDPRTGRQAQV", "length": 786, "header": "sp|O00408-6|PDE2A_HUMAN Isoform 6 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1 CANONICAL=O00408-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O00408", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00408" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Src tyrosine kinase is a novel direct effector of G proteins.", "journal": "Cell", "date": "2000", "authors": "Ma YC, Huang J, Ali S, Lowry W, Huang XY", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "11007482", "url": "https://glygen.org/publication/PubMed/11007482" } ] }, { "title": "Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman HA, Koch WJ, Luttrell LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12036966", "url": "https://glygen.org/publication/PubMed/12036966" } ] }, { "title": "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases.", "journal": "Thrombosis and haemostasis", "date": "2002", "authors": "Manns JM, Brenna KJ, Colman RW, Sheth SB", "evidence": [ { "database": "RefSeq", "id": "NP_001137311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137311" } ], "reference": [ { "type": "PubMed", "id": "12038792", "url": "https://glygen.org/publication/PubMed/12038792" } ] }, { "title": "Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Dessauer CW, Chen-Goodspeed M, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12058044", "url": "https://glygen.org/publication/PubMed/12058044" } ] }, { "title": "Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.", "journal": "Biochemical pharmacology", "date": "2002", "authors": "Wenzel-Seifert K, Liu HY, Seifert R", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12106601", "url": "https://glygen.org/publication/PubMed/12106601" } ] }, { "title": "The pharmacology of cilostazol.", "journal": "Diabetes, obesity & metabolism", "date": "2002", "authors": "Schror K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12180353", "url": "https://glygen.org/publication/PubMed/12180353" } ] }, { "title": "Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.", "journal": "European journal of pharmacology", "date": "2003", "authors": "Zhang JY, Nawoschik S, Kowal D, Smith D, Spangler T, Ochalski R, Schechter L, Dunlop J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12860470", "url": "https://glygen.org/publication/PubMed/12860470" } ] }, { "title": "Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles.", "journal": "The Journal of biological chemistry", "date": "1958", "authors": "SUTHERLAND EW, RALL TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "13549488", "url": "https://glygen.org/publication/PubMed/13549488" } ] }, { "title": "Insights into G protein structure, function, and regulation.", "journal": "Endocrine reviews", "date": "2003", "authors": "Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "14671004", "url": "https://glygen.org/publication/PubMed/14671004" } ] }, { "title": "Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "1517224", "url": "https://glygen.org/publication/PubMed/1517224" } ] }, { "title": "Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients.", "journal": "Lung", "date": "2004", "authors": "Beeh KM, Beier J, Lerch C, Schulz AK, Buhl R", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "15765929", "url": "https://glygen.org/publication/PubMed/15765929" } ] }, { "title": "Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system.", "journal": "Frontiers in bioscience : a journal and virtual library", "date": "2005", "authors": "Maurice DH", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "15769620", "url": "https://glygen.org/publication/PubMed/15769620" } ] }, { "title": "Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.", "journal": "Biochemistry", "date": "2005", "authors": "Iffland A, Kohls D, Low S, Luan J, Zhang Y, Kothe M, Cao Q, Kamath AV, Ding YH, Ellenberger T", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "reference": [ { "type": "PubMed", "id": "15938621", "url": "https://glygen.org/publication/PubMed/15938621" } ] }, { "title": "The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.", "journal": "International journal of biological sciences", "date": "2005", "authors": "Siderovski DP, Willard FS", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "15951850", "url": "https://glygen.org/publication/PubMed/15951850" } ] }, { "title": "Preferential inhibition of human phosphodiesterase 4 by ibudilast.", "journal": "Life sciences", "date": "2006", "authors": "Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, Natsumeda Y, Noguchi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16313925", "url": "https://glygen.org/publication/PubMed/16313925" } ] }, { "title": "G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Violin JD, Ren XR, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16687412", "url": "https://glygen.org/publication/PubMed/16687412" } ] }, { "title": "Structural basis of function in heterotrimeric G proteins.", "journal": "Quarterly reviews of biophysics", "date": "2006", "authors": "Oldham WM, Hamm HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16923326", "url": "https://glygen.org/publication/PubMed/16923326" } ] }, { "title": "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.", "journal": "Blood", "date": "2007", "authors": "Antl M, von Bruhl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418457", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418457" } ], "reference": [ { "type": "PubMed", "id": "16990611", "url": "https://glygen.org/publication/PubMed/16990611" } ] }, { "title": "Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.", "journal": "Current medicinal chemistry", "date": "2006", "authors": "Huang Z, Mancini JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "17168849", "url": "https://glygen.org/publication/PubMed/17168849" } ] }, { "title": "PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast.", "journal": "International journal of chronic obstructive pulmonary disease", "date": "2007", "authors": "Boswell-Smith V, Spina D", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "18044684", "url": "https://glygen.org/publication/PubMed/18044684" } ] }, { "title": "Dissociation of heterotrimeric g proteins in cells.", "journal": "Science signaling", "date": "2008", "authors": "Lambert NA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "18577758", "url": "https://glygen.org/publication/PubMed/18577758" } ] }, { "title": "The efficacy and safety of cilomilast in COPD.", "journal": "Drugs", "date": "2008", "authors": "Rennard S, Knobil K, Rabe KF, Morris A, Schachter N, Locantore N, Canonica WG, Zhu Y, Barnhart F", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19105585", "url": "https://glygen.org/publication/PubMed/19105585" } ] }, { "title": "Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.", "journal": "J. 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"https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "negative regulation of vascular permeability", "id": "GO:0043116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043116", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cAMP-mediated signaling", "id": "GO:0019933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019933", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "ventricular septum development", "id": "GO:0003281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "aorta development", "id": "GO:0035904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035904", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to granulocyte macrophage colony-stimulating factor stimulus", "id": "GO:0097011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097011", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cGMP-mediated signaling", "id": "GO:0019934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019934", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "negative regulation of cAMP-mediated signaling", "id": "GO:0043951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043951", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "regulation of mitochondrion organization", "id": "GO:0010821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010821", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "positive regulation of vascular permeability", "id": "GO:0043117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043117", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "monocyte differentiation", "id": "GO:0030224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030224", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to macrophage colony-stimulating factor stimulus", "id": "GO:0036006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036006", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cGMP catabolic process", "id": "GO:0046069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046069", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "regulation of cGMP-mediated signaling", "id": "GO:0010752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010752", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to cGMP", "id": "GO:0071321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071321", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "negative regulation of cGMP-mediated signaling", "id": "GO:0010754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010754", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cellular response to 2,3,7,8-tetrachlorodibenzodioxine", "id": "GO:1904613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904613", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "O00408", "url": "https://www.uniprot.org/uniprot/O00408" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" }, { "start_pos": 910, "end_pos": 912, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14653", "name": "", "equation": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62865-1", "Q01062-1", "Q63085-1", "Q01066-1", "Q9QYJ6-1", "Q63421-1", "A0A8I6A416-1", "O00408-1", "Q13370-1", "P54750-1", "Q14432-1", "Q9Y233-3", "Q01064-1", "Q14123-1", "Q9Z0X4-1", "Q01065-1", "Q61481-4", "Q61409-1", "Q8CA95-1", "Q922S4-1", "Q64338-3", "P22434-1", "B7YZV4-1" ], "evidence": [ { "id": "14653", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14653" } ] }, { "id": "16957", "name": "", "equation": "3',5'-cyclic GMP + H2O = GMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VID6-1", "P61250-1", "O54735-1", "Q8QZV1-1", "M0R4R9-1", "Q9QYJ6-1", "Q63421-1", "A0A8I6A416-1", "Q01066-1", "Q62865-1", "Q01062-1", "Q63085-1", "P18545-1", "Q13956-1", "O76083-1", "P51160-1", "P16499-1", "Q9HCR9-1", "O76074-1", "P35913-1", "Q9Y233-3", "Q14123-1", "O00408-1", "Q13370-1", "P54750-1", "Q01064-1", "Q14432-1", "Q01065-1", "P09174-1", "P61249-1", "Q91ZQ1-1", "P27664-1", "P23440-1", "Q8CG03-1", "O70628-1", "P0C1Q2-1", "Q8CA95-1", "Q61481-4", "Q61409-1", "Q9Z0X4-1", "Q922S4-1", "Q64338-3", "B0G0Y8-1", "P12019-1", "Q54HY0-1", "Q8MLZ3-1", "Q8MM62-1", "B7YZV4-1", "Q9I7S6-1", "Q9VFI9-1", "Q9VJ79-1" ], "evidence": [ { "id": "16957", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16957" } ] }, { "id": "25277", "name": "", "equation": "3',5'-cyclic AMP + H2O = AMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VID6-1", "O08593-1", "P14644-1", "Q63421-1", "P54748-1", "P14270-5", "P14646-3", "Q9QYJ6-1", "A0A8I6A416-1", "Q01066-1", "Q62865-1", "Q01062-1", "Q924C3-1", "Q63085-1", "Q07343-1", "Q08499-1", "O60658-1", "O95263-1", "Q08493-1", "Q13946-1", "Q9NP56-1", "Q9HCR9-1", "P27815-1", "Q14123-1", "Q9Y233-3", "O00408-1", "Q13370-1", "P22413-1", "P54750-1", "Q01064-1", "Q14432-1", "Q01063-1", "Q01065-1", "E9Q4S1-1", "Q9QXQ1-1", "O88502-1", "O89084-1", "P0C1Q2-1", "P70453-1", "Q3UEI1-1", "Q64338-3", "Q8CA95-1", "B1AWC9-1", "Q61481-4", "Q61409-1", "Q9Z0X4-1", "P06802-1", "Q922S4-1", "P06776-1", "P12019-1", "Q23917-1", "Q54HY0-1", "Q86H13-1", "Q8MM62-1", "Q9W4T4-1", "Q6NNF2-1", "B7YZV4-1", "Q9VJ79-1" ], "evidence": [ { "id": "25277", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25277" } ] }, { "id": "R-HSA-418456", "name": "cGMP is degraded by PDEs", "equation": "", "summary": "Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O76074-1", "O00408-1", "O76083-1", "P54750-1", "Q01064-1", "Q9Y233-3", "Q9HCR9-1" ], "evidence": [ { "id": "R-HSA-418456", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418456" } ] }, { "id": "R-HSA-418553", "name": "cAMP degradation by Phosphodiesterases", "equation": "", "summary": "Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27815-1", "Q13946-1", "O00408-1", "Q08499-1", "Q9NP56-1", "O60658-1", "O95263-1", "P54750-1", "Q01064-1", "Q08493-1", "Q9Y233-3", "Q9HCR9-1" ], "evidence": [ { "id": "R-HSA-418553", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418553" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6A416", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A8I6A416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A416" } ] } ] }, { "uniprot_ac": "B0G0Y8", "gene_name": "pde3", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "B0G0Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "B0G0Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ] } ] }, { "uniprot_ac": "B1AWC9", "gene_name": "Pde4b", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "B1AWC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWC9" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "B1AWC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWC9" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "B1AWC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWC9" } ] } ] }, { "uniprot_ac": "B7YZV4", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] } ] }, { "uniprot_ac": "E9Q4S1", "gene_name": "Pde8b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "E9Q4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q4S1" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "E9Q4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q4S1" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "E9Q4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q4S1" } ] } ] }, { "uniprot_ac": "M0R4R9", "gene_name": "Pde6g", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "M0R4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4R9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "M0R4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4R9" } ] } ] }, { "uniprot_ac": "O00408", "gene_name": "PDE2A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] } ] }, { "uniprot_ac": "O08593", "gene_name": "Pde7a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O08593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08593" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O08593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08593" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O08593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08593" } ] } ] }, { "uniprot_ac": "O54735", "gene_name": "Pde5a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] } ] }, { "uniprot_ac": "O60658", "gene_name": "PDE8A", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O60658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60658" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O60658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60658" } ] } ] }, { "uniprot_ac": "O70628", "gene_name": "Pde9a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] } ] }, { "uniprot_ac": "O76074", "gene_name": "PDE5A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] } ] }, { "uniprot_ac": "O76083", "gene_name": "PDE9A", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O76083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76083" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O76083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76083" } ] } ] }, { "uniprot_ac": "O88502", "gene_name": "Pde8a", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O88502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88502" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O88502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88502" } ] } ] }, { "uniprot_ac": "O89084", "gene_name": "Pde4a", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O89084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89084" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O89084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89084" } ] } ] }, { "uniprot_ac": "O95263", "gene_name": "PDE8B", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O95263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95263" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O95263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95263" } ] } ] }, { "uniprot_ac": "P06776", "gene_name": "PDE2", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P06776", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06776" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P06776", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06776" } ] } ] }, { "uniprot_ac": "P06802", "gene_name": "Enpp1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P06802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06802" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "P06802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06802" } ] } ] }, { "uniprot_ac": "P09174", "gene_name": "Pde6g", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P09174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09174" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P09174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09174" } ] } ] }, { "uniprot_ac": "P0C1Q2", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] } ] }, { "uniprot_ac": "P12019", "gene_name": "pdsA", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] } ] }, { "uniprot_ac": "P14270", "gene_name": "Pde4d", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P14270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14270" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P14270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14270" } ] } ] }, { "uniprot_ac": "P14644", "gene_name": "Pde4c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P14644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14644" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P14644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14644" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P14644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14644" } ] } ] }, { "uniprot_ac": "P14646", "gene_name": "Pde4b", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14646" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14646" } ] } ] }, { "uniprot_ac": "P16499", "gene_name": "PDE6A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] } ] }, { "uniprot_ac": "P18545", "gene_name": "PDE6G", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P18545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18545" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P18545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18545" } ] } ] }, { "uniprot_ac": "P22413", "gene_name": "ENPP1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P22413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22413" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "P22413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22413" } ] } ] }, { "uniprot_ac": "P22434", "gene_name": "PDE1", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "P22434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22434" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "P22434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22434" } ] } ] }, { "uniprot_ac": "P23440", "gene_name": "Pde6b", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P23440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23440" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P23440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23440" } ] } ] }, { "uniprot_ac": "P27664", "gene_name": "Pde6a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] } ] }, { "uniprot_ac": "P27815", "gene_name": "PDE4A", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P27815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27815" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P27815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27815" } ] } ] }, { "uniprot_ac": "P35913", "gene_name": "PDE6B", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P35913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35913" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P35913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35913" } ] } ] }, { "uniprot_ac": "P51160", "gene_name": "PDE6C", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P51160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51160" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P51160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51160" } ] } ] }, { "uniprot_ac": "P54748", "gene_name": "Pde4a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54748" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54748" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54748" } ] } ] }, { "uniprot_ac": "P54750", "gene_name": "PDE1A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] } ] }, { "uniprot_ac": "P61249", "gene_name": "Pde6h", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P61249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61249" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P61249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61249" } ] } ] }, { "uniprot_ac": "P61250", "gene_name": "Pde6h", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P61250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61250" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P61250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61250" } ] } ] }, { "uniprot_ac": "P70453", "gene_name": "Pde7a", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P70453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70453" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P70453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70453" } ] } ] }, { "uniprot_ac": "Q01062", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] } ] }, { "uniprot_ac": "Q01063", "gene_name": "Pde4d", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01063" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q01063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01063" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q01063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01063" } ] } ] }, { "uniprot_ac": "Q01064", "gene_name": "PDE1B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] } ] }, { "uniprot_ac": "Q01065", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] } ] }, { "uniprot_ac": "Q01066", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] } ] }, { "uniprot_ac": "Q07343", "gene_name": "PDE4B", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q07343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07343" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q07343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07343" } ] } ] }, { "uniprot_ac": "Q08493", "gene_name": "PDE4C", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q08493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08493" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q08493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08493" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q08493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08493" } ] } ] }, { "uniprot_ac": "Q08499", "gene_name": "PDE4D", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q08499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08499" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q08499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08499" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q08499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08499" } ] } ] }, { "uniprot_ac": "Q13370", "gene_name": "PDE3B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] } ] }, { "uniprot_ac": "Q13946", "gene_name": "PDE7A", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q13946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13946" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q13946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13946" } ] } ] }, { "uniprot_ac": "Q13956", "gene_name": "PDE6H", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q13956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13956" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q13956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13956" } ] } ] }, { "uniprot_ac": "Q14123", "gene_name": "PDE1C", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] } ] }, { "uniprot_ac": "Q14432", "gene_name": "PDE3A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q14432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14432" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q14432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14432" } ] } ] }, { "uniprot_ac": "Q23917", "gene_name": "regA", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q23917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23917" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q23917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23917" } ] } ] }, { "uniprot_ac": "Q3UEI1", "gene_name": "Pde4c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3UEI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UEI1" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q3UEI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UEI1" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q3UEI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UEI1" } ] } ] }, { "uniprot_ac": "Q54HY0", "gene_name": "pde7", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] } ] }, { "uniprot_ac": "Q61409", "gene_name": "Pde3b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] } ] }, { "uniprot_ac": "Q61481", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q61481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61481" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q61481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61481" } ] } ] }, { "uniprot_ac": "Q62865", "gene_name": "Pde3a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q62865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62865" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q62865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62865" } ] } ] }, { "uniprot_ac": "Q63085", "gene_name": "Pde3b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] } ] }, { "uniprot_ac": "Q63421", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] } ] }, { "uniprot_ac": "Q64338", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q64338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64338" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q64338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64338" } ] } ] }, { "uniprot_ac": "Q6NNF2", "gene_name": "Pde8", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q6NNF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NNF2" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q6NNF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NNF2" } ] } ] }, { "uniprot_ac": "Q86H13", "gene_name": "Pde4", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q86H13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86H13" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q86H13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86H13" } ] } ] }, { "uniprot_ac": "Q8CA95", "gene_name": "Pde10a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] } ] }, { "uniprot_ac": "Q8CG03", "gene_name": "Pde5a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8CG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CG03" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8CG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CG03" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8CG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CG03" } ] } ] }, { "uniprot_ac": "Q8MLZ3", "gene_name": "pdeD", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8MLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MLZ3" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8MLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MLZ3" } ] } ] }, { "uniprot_ac": "Q8MM62", "gene_name": "pdeE", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] } ] }, { "uniprot_ac": "Q8QZV1", "gene_name": "Pde9a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8QZV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV1" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8QZV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV1" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8QZV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV1" } ] } ] }, { "uniprot_ac": "Q8VID6", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] } ] }, { "uniprot_ac": "Q91ZQ1", "gene_name": "Pde6c", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q91ZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZQ1" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q91ZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZQ1" } ] } ] }, { "uniprot_ac": "Q922S4", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] } ] }, { "uniprot_ac": "Q924C3", "gene_name": "Enpp1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "Q924C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924C3" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "Q924C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924C3" } ] } ] }, { "uniprot_ac": "Q9HCR9", "gene_name": "PDE11A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] } ] }, { "uniprot_ac": "Q9I7S6", "gene_name": "Pde9", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9I7S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S6" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9I7S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S6" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9I7S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S6" } ] } ] }, { "uniprot_ac": "Q9NP56", "gene_name": "PDE7B", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9NP56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP56" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9NP56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP56" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9NP56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP56" } ] } ] }, { "uniprot_ac": "Q9QXQ1", "gene_name": "Pde7b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9QXQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXQ1" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9QXQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXQ1" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9QXQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXQ1" } ] } ] }, { "uniprot_ac": "Q9QYJ6", "gene_name": "Pde10a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] } ] }, { "uniprot_ac": "Q9VFI9", "gene_name": "Pde6", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9VFI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFI9" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9VFI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFI9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9VFI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFI9" } ] } ] }, { "uniprot_ac": "Q9VJ79", "gene_name": "Pde11", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] } ] }, { "uniprot_ac": "Q9W4T4", "gene_name": "dnc", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9W4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W4T4" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9W4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W4T4" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9W4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W4T4" } ] } ] }, { "uniprot_ac": "Q9Y233", "gene_name": "PDE10A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9Y233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y233" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9Y233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y233" } ] } ] }, { "uniprot_ac": "Q9Z0X4", "gene_name": "Pde3a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9Z0X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0X4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9Z0X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0X4" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 423, "end_pos": 425 }, { "start_pos": 704, "end_pos": 706 }, { "start_pos": 910, 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