{ "uniprot_canonical_ac": "O00327-2", "uniprot_ac": "O00327", "uniprot_id": "BMAL1_HUMAN", "mass": { "chemical_mass": 68762.0, "monoisotopic_mass": 68762.0 }, "refseq": { "ac": "NP_001025443", "name": "basic helix-loop-helix ARNT-like protein 1 isoform a", "summary": "The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" }, "gene_names": [ { "name": "BMAL1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00327", "id": "O00327" }, { "name": "ARNTL; ARNTL1; bHLHe5; BMAL1c; JAP3; MOP3; PASD3; TIC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443", "id": "NP_001025443" }, { "name": "ARNTL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00327", "id": "O00327" }, { "name": "BHLHE5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00327", "id": "O00327" }, { "name": "BMAL1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443", "id": "NP_001025443" }, { "name": "MOP3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00327", "id": "O00327" }, { "name": "PASD3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00327", "id": "O00327" } ], "protein_names": [ { "name": "Basic helix-loop-helix ARNT-like protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00327" }, { "name": "Aryl hydrocarbon receptor nuclear translocator-like protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "Basic-helix-loop-helix-PAS protein MOP3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "Brain and muscle ARNT-like 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "Class E basic helix-loop-helix protein 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "Member of PAS protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "PAS domain-containing protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "aryl hydrocarbon receptor nuclear translocator-like protein 1; member of PAS superfamily 3; basic helix-loop-helix family member e5; PAS domain containing 3; ARNT-like protein 1, brain and muscle; aryl hydrocarbon receptor nuclear translocator like; bHLH-PAS protein JAP3; basic-helix-loop-helix-PAS orphan MOP3; member of PAS protein 3; brain and muscle ARNT-like 1; PAS domain-containing protein 3; testis tissue sperm-binding protein Li 50e; basic-helix-loop-helix-PAS protein MOP3; class E basic helix-loop-helix protein 5; basic helix-loop-helix ARNT-like protein 1; mutant basic helix-loop-helix ARNT-like protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443", "id": "NP_001025443" }, { "name": "bHLH-PAS protein JAP3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "bHLHe5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00327" }, { "name": "basic helix-loop-helix ARNT-like protein 1 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443", "id": "NP_001025443" } ], "function": [ { "annotation": "(Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327#function" }, { "database": "PubMed", "id": "34545347", "url": "https://glygen.org/publication/PubMed/34545347" } ] }, { "annotation": "Artificial induction of circadian rhythm by combining exogenous BMAL1 expression and polycomb repressive complex 2 inhibition in human induced pluripotent stem cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" }, { "database": "PubMed", "id": "37421441", "url": "https://glygen.org/publication/PubMed/37421441" } ] }, { "annotation": "Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" }, { "database": "PubMed", "id": "37667322", "url": "https://glygen.org/publication/PubMed/37667322" } ] }, { "annotation": "New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" }, { "database": "PubMed", "id": "37660646", "url": "https://glygen.org/publication/PubMed/37660646" } ] }, { "annotation": "Role of Bmal1 and Gut Microbiota in Alzheimer's Disease and Parkinson's Disease Pathophysiology: The Probable Effect of Melatonin on Their Association. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" }, { "database": "PubMed", "id": "37823531", "url": "https://glygen.org/publication/PubMed/37823531" } ] }, { "annotation": "The clock gene Bmal1 controls inflammatory mediators in rheumatoid arthritis fibroblast-like synoviocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" }, { "database": "PubMed", "id": "38043198", "url": "https://glygen.org/publication/PubMed/38043198" } ] }, { "annotation": "The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021].", "evidence": [ { "database": "RefSeq", "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443" } ] }, { "annotation": "Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repressBMAL1 transcription, respectively.BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327#function" }, { "database": "PubMed", "id": "24005054", "url": "https://glygen.org/publication/PubMed/24005054" }, { "database": "PubMed", "id": "23955654", "url": "https://glygen.org/publication/PubMed/23955654" }, { "database": "PubMed", "id": "11441146", "url": "https://glygen.org/publication/PubMed/11441146" }, { "database": "PubMed", "id": "18587630", "url": "https://glygen.org/publication/PubMed/18587630" }, { "database": "UniProtKB", "id": "Q9WTL8", "url": "https://www.uniprot.org/uniprot/Q9WTL8#function" }, { "database": "PubMed", "id": "28985504", "url": "https://glygen.org/publication/PubMed/28985504" }, { "database": "PubMed", "id": "23785138", "url": "https://glygen.org/publication/PubMed/23785138" }, { "database": "PubMed", "id": "12738229", "url": "https://glygen.org/publication/PubMed/12738229" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1408943124", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1408943124" }, { "id": "rs1408943124", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1408943124#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 105, "end_pos": 105, "sequence_org": "M", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAM->NAT).", "chr_id": "11", "chr_pos": "13358526", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "M105", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs759348002", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759348002" }, { "id": "rs759348002", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759348002" }, { "id": "rs759348002", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs759348002" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 304, "end_pos": 304, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NEP->NES).", "chr_id": "11", "chr_pos": "13372252", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P304", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1266346151", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1266346151" }, { "id": "rs1266346151", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1266346151" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 398, "end_pos": 398, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIT->NIT).", "chr_id": "11", "chr_pos": "13375631", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K398", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 10, "end_pos": 10, "sequence_org": "S", "sequence_mut": "A", "comment": "Enhanced PER1 reporter activity by CLOCK-BMAL1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 10, "end_pos": 10, "sequence_org": "S", "sequence_mut": "E", "comment": "Enhanced PER1 reporter activity by CLOCK-BMAL1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 10, "end_pos": 10, "sequence_org": "S", "sequence_mut": "L", "comment": "2-2.5-fold increase in CLOCK-BMAL1 transcriptional activity in the absence of CRY1. No change in repression activity in the presence of CRY1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 125, "end_pos": 125, "sequence_org": "L", "sequence_mut": "H", "comment": "Impaired CLOCK binding.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "23229515", "url": "https://glygen.org/publication/PubMed/23229515" } ] }, { "start_pos": 611, "end_pos": 611, "sequence_org": "A", "sequence_mut": "S", "comment": "Increased desensitization to CRY1, in the presence of CLOCK. Approximately 2-fold increase in CLOCK-BMAL1 transcriptional activity in the absence of CRY1; when associated with E-407.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 611, "end_pos": 611, "sequence_org": "A", "sequence_mut": "T", "comment": "Increased desensitization to CRY1, in the presence of CLOCK. Approximately 2-fold increase in CLOCK-BMAL1 transcriptional activity in the absence of CRY1; when associated with E-407.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 612, "end_pos": 612, "sequence_org": "G", "sequence_mut": "E", "comment": "Increased desensitization to CRY1, in the presence of CLOCK. Approximately 2-fold increase in CLOCK-BMAL1 transcriptional activity in the absence of CRY1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 78, "end_pos": 78, "sequence_org": "S", "sequence_mut": "E", "comment": "Phosphomimetic mutant which severely impairs DNA binding and CLOCK-BMAL1 transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "23229515", "url": "https://glygen.org/publication/PubMed/23229515" } ] }, { "start_pos": 88, "end_pos": 88, "sequence_org": "M", "sequence_mut": "F", "comment": "No effect on CLOCK binding.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "23229515", "url": "https://glygen.org/publication/PubMed/23229515" } ] }, { "start_pos": 90, "end_pos": 90, "sequence_org": "S", "sequence_mut": "E", "comment": "Phosphomimetic mutant with no effect on DNA binding or CLOCK-BMAL1 transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "23229515", "url": "https://glygen.org/publication/PubMed/23229515" } ] }, { "start_pos": 9, "end_pos": 9, "sequence_org": "S", "sequence_mut": "A", "comment": "Enhanced PER1 reporter activity by CLOCK-BMAL1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 9, "end_pos": 9, "sequence_org": "S", "sequence_mut": "E", "comment": "Enhanced PER1 reporter activity by CLOCK-BMAL1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] }, { "start_pos": 9, "end_pos": 9, "sequence_org": "S", "sequence_mut": "F", "comment": "2-2.5-fold increase in CLOCK-BMAL1 transcriptional activity in the absence of CRY1. No change in repression activity in the presence of CRY1.", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "16474406", "url": "https://glygen.org/publication/PubMed/16474406" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "80.57", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "75.67", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "80.45", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "84.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "94.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "85.3", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "83.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "80.74", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "89.5", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000133794", "url": 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00327", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00327" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00327" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" } ], "common_name": "Human" } ], "gene": [ { "name": "BMAL1", "url": "https://www.uniprot.org/uniprot/O00327", "locus": { "chromosome": "11", "start_pos": 13387266, "end_pos": 13276652, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000133794", "url": "https://www.ensembl.org/id/ENSG00000133794" } ] } } ], "crossref": [ { "id": "ENSG00000133794", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133794", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11438", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11438", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "BMAL1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMAL1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "406", "url": "https://www.ncbi.nlm.nih.gov/gene/406", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "701", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=701", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O00327", "url": "https://www.ebi.ac.uk/intact/interactors/id:O00327*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:406", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:406", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "602550", "url": "http://www.omim.org/entry/602550", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O00327", "url": "https://www.nextprot.org/entry/NX_O00327", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O00327", "url": "https://oglcnac.org/atlas/detail/O00327", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O00327", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00327", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "YHHEDIP", "url": "https://omabrowser.org/oma/group/YHHEDIP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23042", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23042", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23042:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23042:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "4H10", "url": "https://www.rcsb.org/structure/4H10", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00010", "url": "http://pfam.xfam.org/family/PF00010", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00989", "url": "http://pfam.xfam.org/family/PF00989", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14598", "url": "http://pfam.xfam.org/family/PF14598", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O00327", "url": "https://pharos.nih.gov/targets/O00327", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O00327", "url": "http://purl.obolibrary.org/obo/PR_O00327", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1368108", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1368108", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9707616", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9768919", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9768919", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001025443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025443", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-1", "url": "https://www.uniprot.org/uniprot/O00327-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-2", "url": "https://www.uniprot.org/uniprot/O00327-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-3", "url": "https://www.uniprot.org/uniprot/O00327-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-4", "url": "https://www.uniprot.org/uniprot/O00327-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-5", "url": "https://www.uniprot.org/uniprot/O00327-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-6", "url": "https://www.uniprot.org/uniprot/O00327-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-7", "url": "https://www.uniprot.org/uniprot/O00327-7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-8", "url": "https://www.uniprot.org/uniprot/O00327-8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00327-9", "url": "https://www.uniprot.org/uniprot/O00327-9", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 626, "header": "sp|O00327-2|BMAL1_HUMAN Isoform 2 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "isoforms": [ { "isoform_ac": "O00327-1", "url": "", "sequence": { "sequence": "MINIESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 583, "header": "sp|O00327-1|BMAL1_HUMAN Isoform 1 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": {} }, { "isoform_ac": "O00327-2", "url": "", "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 626, "header": "sp|O00327-2|BMAL1_HUMAN Isoform 2 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": { "chromosome": "11", "start_pos": 13386753, "end_pos": 13354309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000403290.6", "url": "https://www.ensembl.org/id/ENST00000403290.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000384517.1", "url": "https://www.ensembl.org/id/ENSP00000384517.1" } ] } }, { "isoform_ac": "O00327-3", "url": "", "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKR", "length": 224, "header": "sp|O00327-3|BMAL1_HUMAN Isoform 3 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": {} }, { "isoform_ac": "O00327-4", "url": "", "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 508, "header": "sp|O00327-4|BMAL1_HUMAN Isoform 4 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": {} }, { "isoform_ac": "O00327-5", "url": "", "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKAFCTIHSTGYFGIFTTRTSRHIVL", "length": 301, "header": "sp|O00327-5|BMAL1_HUMAN Isoform 5 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": {} }, { "isoform_ac": "O00327-6", "url": "", "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLSRVDTGHLGQVERCTVLSRPNSRFLIAGMFTEPTSWKAGTQPSHSSQHPPTAWTACCPLEKVAQRGPTPLFQGFQGEPGLGQEK", "length": 526, "header": "sp|O00327-6|BMAL1_HUMAN Isoform 6 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": {} }, { "isoform_ac": "O00327-7", "url": "", "sequence": { "sequence": "MSKEAVSLWALTVSLQPPVPLCVCREMTGSGRRKQQCVTLPFISRELCFYLLLFPPPRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 624, "header": "sp|O00327-7|BMAL1_HUMAN Isoform 7 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": { "chromosome": "11", "start_pos": 13386753, "end_pos": 13356882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000403482.7", "url": "https://www.ensembl.org/id/ENST00000403482.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000385897.3", "url": "https://www.ensembl.org/id/ENSP00000385897.3" } ] } }, { "isoform_ac": "O00327-8", "url": "", "sequence": { "sequence": "MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 625, "header": "sp|O00327-8|BMAL1_HUMAN Isoform 8 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": { "chromosome": "11", "start_pos": 13386753, "end_pos": 13354309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000389707.8", "url": "https://www.ensembl.org/id/ENST00000389707.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000374357.4", "url": "https://www.ensembl.org/id/ENSP00000374357.4" } ] } }, { "isoform_ac": "O00327-9", "url": "", "sequence": { "sequence": "MINIESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL", "length": 582, "header": "sp|O00327-9|BMAL1_HUMAN Isoform 9 of Basic helix-loop-helix ARNT-like protein 1 OS=Homo sapiens OX=9606 GN=BMAL1 PE=1 SV=2 CANONICAL=O00327-2" }, "locus": { "chromosome": "11", "start_pos": 13386753, "end_pos": 13355286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000401424.6", "url": "https://www.ensembl.org/id/ENST00000401424.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000385915.2", "url": "https://www.ensembl.org/id/ENSP00000385915.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 418, "start_aa": "Ser", "end_pos": 418, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser418", "evidence": [ { "id": "O00327", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00327" }, { "id": "23395176", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23395176" }, { "id": "O00327", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00327" } ] } ], "phosphorylation": [ { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "P49841-1", "kinase_gene_name": "GSK3B", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00327", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00327" }, { "database": "PubMed", "id": "20049328", "url": "https://glygen.org/publication/PubMed/20049328" } ], "site_lbl": "Ser17" }, { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by GSK3-beta", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "iPTMnet", "id": "O00327", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00327" }, { "database": "PubMed", "id": "20049328", "url": "https://glygen.org/publication/PubMed/20049328" } ], "site_lbl": "Ser17" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "P49841-1", "kinase_gene_name": "GSK3B", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00327", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00327" }, { "database": "PubMed", "id": "20049328", "url": "https://glygen.org/publication/PubMed/20049328" } ], "site_lbl": "Thr21" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by GSK3-beta", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "iPTMnet", "id": "O00327", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00327" }, { "database": "PubMed", "id": "20049328", "url": "https://glygen.org/publication/PubMed/20049328" } ], "site_lbl": "Thr21" }, { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "PubMed", "id": "23229515", "url": "https://glygen.org/publication/PubMed/23229515" }, { "database": "iPTMnet", "id": "O00327", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00327" }, { "database": "PubMed", "id": "27153104", "url": "https://glygen.org/publication/PubMed/27153104" } ], "site_lbl": "Ser78" }, { "start_pos": 90, "end_pos": 90, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "iPTMnet", "id": "O00327", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00327" }, { "database": "PubMed", "id": "19330005", "url": "https://glygen.org/publication/PubMed/19330005" }, { "database": "PubMed", "id": "24312621", "url": "https://glygen.org/publication/PubMed/24312621" }, { "database": "PubMed", "id": "26562092", "url": "https://glygen.org/publication/PubMed/26562092" } ], "site_lbl": "Ser90" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei.", "journal": "Genomics", "date": "1999", "authors": "Steeves TD, King DP, Zhao Y, Sangoram AM, Du F, Bowcock AM, Moore RY, Takahashi JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "10198158", "url": "https://glygen.org/publication/PubMed/10198158" } ] }, { "title": "Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation.", "journal": "Biochimica et biophysica acta", "date": "1999", "authors": "Miller YI, Shaklai N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9707616" } ], "reference": [ { "type": "PubMed", "id": "10381560", "url": "https://glygen.org/publication/PubMed/10381560" } ] }, { "title": "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Griffin EA Jr, Staknis D, Weitz CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "10531061", "url": "https://glygen.org/publication/PubMed/10531061" } ] }, { "title": "The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Cheema SK, Agellon LB", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "10777541", "url": "https://glygen.org/publication/PubMed/10777541" } ] }, { "title": "Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon.", "journal": "Neuroreport", "date": "2000", "authors": "Keesler GA, Camacho F, Guo Y, Virshup D, Mondadori C, Yao Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "10790862", "url": "https://glygen.org/publication/PubMed/10790862" } ] }, { "title": "CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-1368108", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1368108" } ], "reference": [ { "type": "PubMed", "id": "11018023", "url": "https://glygen.org/publication/PubMed/11018023" } ] }, { "title": "Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, Yoshida E, Suardita K, Matsuda Y, Kato Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1368108", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1368108" } ], "reference": [ { "type": "PubMed", "id": "11162494", "url": "https://glygen.org/publication/PubMed/11162494" } ] }, { "title": "Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.", "journal": "FEBS letters", "date": "2001", "authors": "Camacho F, Cilio M, Guo Y, Virshup DM, Patel K, Khorkova O, Styren S, Morse B, Yao Z, Keesler GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "11165242", "url": "https://glygen.org/publication/PubMed/11165242" } ] }, { "title": "An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.", "journal": "Science (New York, N.Y.)", "date": "2001", "authors": "Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptacek LJ, Fu YH", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "11232563", "url": "https://glygen.org/publication/PubMed/11232563" } ] }, { "title": "Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes.", "journal": "Journal of molecular endocrinology", "date": "2001", "authors": "Ognjanovic S, Bao S, Yamamoto SY, Garibay-Tupas J, Samal B, Bryant-Greenwood GD", "evidence": [ { "database": "Reactome", "id": "R-HSA-1368108", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1368108" } ], "reference": [ { "type": "PubMed", "id": "11241162", "url": "https://glygen.org/publication/PubMed/11241162" } ] }, { "title": "Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes.", "journal": "Biochimica et biophysica acta", "date": "2001", "authors": "Roberts AG, Elder GH", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "11267664", "url": "https://glygen.org/publication/PubMed/11267664" } ] }, { "title": "Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.", "journal": "The EMBO journal", "date": "2001", "authors": "Ogawa K, Sun J, Taketani S, Nakajima O, Nishitani C, Sassa S, Hayashi N, Yamamoto M, Shibahara S, Fujita H, Igarashi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9707616" } ], "reference": [ { "type": "PubMed", "id": "11387216", "url": "https://glygen.org/publication/PubMed/11387216" } ] }, { "title": "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.", "journal": "Science (New York, N.Y.)", "date": "2001", "authors": "Rutter J, Reick M, Wu LC, McKnight SL", "evidence": [ { "database": "UniProtKB", "id": "O00327", "url": "https://www.uniprot.org/uniprot/O00327" }, { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "11441146", "url": "https://glygen.org/publication/PubMed/11441146" } ] }, { "title": "NPAS2: an analog of clock operative in the mammalian forebrain.", "journal": "Science (New York, N.Y.)", "date": "2001", "authors": "Reick M, Garcia JA, Dudley C, McKnight SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400253" } ], "reference": [ { "type": "PubMed", "id": "11441147", "url": "https://glygen.org/publication/PubMed/11441147" } ] }, { "title": "Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "12118000", "url": "https://glygen.org/publication/PubMed/12118000" } ] }, { "title": "Pro-oxidant and cytotoxic effects of circulating heme.", "journal": "Blood", "date": "2002", "authors": "Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW, Balla G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9707616" } ], "reference": [ { "type": "PubMed", "id": "12130498", "url": "https://glygen.org/publication/PubMed/12130498" } ] }, { "title": "Circadian Transcription. Thinking outside the E-Box.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Munoz E, Brewer M, Baler R", "evidence": [ { "database": "Reactome", "id": "R-HSA-1368108", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1368108" } ], "reference": [ { "type": "PubMed", "id": "12130638", "url": "https://glygen.org/publication/PubMed/12130638" } ] }, { "title": "Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.", "journal": "Journal of lipid research", "date": "2002", "authors": "Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "12177166", "url": "https://glygen.org/publication/PubMed/12177166" } ] }, { "title": "Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene.", "journal": "The EMBO journal", "date": "2002", "authors": "Sun J, Hoshino H, Takaku K, Nakajima O, Muto A, Suzuki H, Tashiro S, Takahashi S, Shibahara S, Alam J, Taketo MM, Yamamoto M, Igarashi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9707616" } ], "reference": [ { "type": "PubMed", "id": "12356737", "url": "https://glygen.org/publication/PubMed/12356737" } ] }, { "title": "Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Raspe E, Mautino G, Duval C, Fontaine C, Duez H, Barbier O, Monte D, Fruchart J, Fruchart JC, Staels B", "evidence": [ { "database": "Reactome", "id": "R-HSA-400253", "url": 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