{ "uniprot_canonical_ac": "O00214-1", "uniprot_ac": "O00214", "uniprot_id": "LEG8_HUMAN", "mass": { "chemical_mass": 35808.0, "monoisotopic_mass": 35808.0 }, "refseq": { "ac": "NP_006490", "name": "galectin-8 isoform a", "summary": "This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" }, "gene_names": [ { "name": "LGALS8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00214", "id": "O00214" }, { "name": "Gal-8; PCTA-1; PCTA1; Po66-CBP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490", "id": "NP_006490" }, { "name": "LGALS8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490", "id": "NP_006490" } ], "protein_names": [ { "name": "Galectin-8", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00214" }, { "name": "Gal-8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00214" }, { "name": "PCTA-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00214" }, { "name": "Po66 carbohydrate binding protein; prostate carcinoma tumor antigen 1; galectin-8g; po66 carbohydrate-binding protein; lectin, galactoside-binding, soluble, 8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490", "id": "NP_006490" }, { "name": "Po66 carbohydrate-binding protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00214" }, { "name": "Po66-CBP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00214" }, { "name": "Prostate carcinoma tumor antigen 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00214" }, { "name": "galectin-8 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490", "id": "NP_006490" } ], "function": [ { "annotation": "Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214#function" }, { "database": "PubMed", "id": "28077878", "url": "https://glygen.org/publication/PubMed/28077878" }, { "database": "PubMed", "id": "22246324", "url": "https://glygen.org/publication/PubMed/22246324" }, { "database": "PubMed", "id": "21288902", "url": "https://glygen.org/publication/PubMed/21288902" } ] }, { "annotation": "CircHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" }, { "database": "PubMed", "id": "34526098", "url": "https://glygen.org/publication/PubMed/34526098" } ] }, { "annotation": "Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" }, { "database": "PubMed", "id": "37352334", "url": "https://glygen.org/publication/PubMed/37352334" } ] }, { "annotation": "Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" }, { "database": "PubMed", "id": "34225486", "url": "https://glygen.org/publication/PubMed/34225486" } ] }, { "annotation": "Galectin-8 and -9 as prognostic factors for cervical cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" }, { "database": "PubMed", "id": "35377045", "url": "https://glygen.org/publication/PubMed/35377045" } ] }, { "annotation": "Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" }, { "database": "PubMed", "id": "34613662", "url": "https://glygen.org/publication/PubMed/34613662" } ] }, { "annotation": "This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O00214", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00214" } ], "glycoeffect": [], "start_pos": 233, "end_pos": 233, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "1", "chr_pos": "236544809", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R233", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 190, "end_pos": 190, "sequence_org": "R", "sequence_mut": "H", "comment": "Does not affect localization to cytoplasmic vesicles in case of infection by S.typhimurium.", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" }, { "database": "PubMed", "id": "22246324", "url": "https://glygen.org/publication/PubMed/22246324" } ] }, { "start_pos": 69, "end_pos": 69, "sequence_org": "R", "sequence_mut": "H", "comment": "Abolishes localization to cytoplasmic vesicles in case of infection by S.typhimurium.", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" }, { "database": "PubMed", "id": "22246324", "url": "https://glygen.org/publication/PubMed/22246324" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "88.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "88.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "68.67", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "93.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "95.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "79.16", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "93.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.59", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "84.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.17", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "94.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "94.94", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116977", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116977" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00214", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00214" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00214", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00214" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00214" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"https://www.ensembl.org/id/ENSP00000434860.1" } ] } }, { "isoform_ac": "E9PNC2-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRWICRMAAA", "length": 53, "header": "tr|E9PNC2-1|LEG8_HUMAN Computationally mapped isoform of Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236538910, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442397.6", "url": "https://www.ensembl.org/id/ENST00000442397.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000413278.2", "url": "https://www.ensembl.org/id/ENSP00000413278.2" } ] } }, { "isoform_ac": "E9PPL1-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDA", "length": 43, "header": "tr|E9PPL1-1|E9PPL1_HUMAN Computationally mapped isoform of Galectin 8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236537580, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000529489.5", "url": "https://www.ensembl.org/id/ENST00000529489.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000437007.1", "url": "https://www.ensembl.org/id/ENSP00000437007.1" } ] } }, { "isoform_ac": "E9PPM4-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPIPGGSAEWQQHETSSRCGLSFQSSFQKGRLHCLQYFDK", "length": 53, "header": "tr|E9PPM4-1|LEG8_HUMAN Computationally mapped isoform of Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236538992, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434231.6", "url": "https://www.ensembl.org/id/ENST00000434231.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000407428.2", "url": "https://www.ensembl.org/id/ENSP00000407428.2" } ] } }, { "isoform_ac": "E9PRN3-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQDLQSTQ", "length": 121, "header": "tr|E9PRN3-1|LEG8_HUMAN Computationally mapped isoform of Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236541671, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430527.6", "url": "https://www.ensembl.org/id/ENST00000430527.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000398630.2", "url": "https://www.ensembl.org/id/ENSP00000398630.2" } ] } }, { "isoform_ac": "F6V2D4-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVPKSGTPQLPSNRGGDISKIAPRTVYTKSKDSTVNHTLTCTKIPPMNYVSKRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW", "length": 300, "header": "tr|F6V2D4-1|F6V2D4_HUMAN Computationally mapped isoform of Galectin OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236548158, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416919.6", "url": "https://www.ensembl.org/id/ENST00000416919.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000410843.2", "url": "https://www.ensembl.org/id/ENSP00000410843.2" } ] } }, { "isoform_ac": "H7BXD8-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRL", "length": 175, "header": "tr|H7BXD8-1|LEG8_HUMAN Computationally mapped isoform of Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236544813, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000238181.11", "url": "https://www.ensembl.org/id/ENST00000238181.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000238181.7", "url": "https://www.ensembl.org/id/ENSP00000238181.7" } ] } }, { "isoform_ac": "O00214-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW", "length": 317, "header": "sp|O00214-1|LEG8_HUMAN Isoform 1 of Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=4 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236548158, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000341872.10", "url": "https://www.ensembl.org/id/ENST00000341872.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000342139.6", "url": "https://www.ensembl.org/id/ENSP00000342139.6" } ] } }, { "isoform_ac": "O00214-2", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLPSNRGGDISKIAPRTVYTKSKDSTVNHTLTCTKIPPMNYVSKRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW", "length": 359, "header": "sp|O00214-2|LEG8_HUMAN Isoform 2 of Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=4 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236548158, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000450372.6", "url": "https://www.ensembl.org/id/ENST00000450372.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000408657.2", "url": "https://www.ensembl.org/id/ENSP00000408657.2" } ] } }, { "isoform_ac": "Q5T3P9-1", "url": "", "sequence": { "sequence": "MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLPSNRGGDISKIAPRTVYTKSKDSTV", "length": 208, "header": "tr|Q5T3P9-1|Q5T3P9_HUMAN Computationally mapped isoform of Galectin OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=1 CANONICAL=O00214-1" }, "locus": { "chromosome": "1", "start_pos": 236542989, "end_pos": 236526071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000406509.7", "url": "https://www.ensembl.org/id/ENST00000406509.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000385999.3", "url": "https://www.ensembl.org/id/ENSP00000385999.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene.", "journal": "Oncogene", "date": "2000", "authors": "Gopalkrishnan R V, Roberts T, Tuli S, Kang D, Christiansen K A, Fisher P B", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "reference": [ { "type": "PubMed", "id": "10980616", "url": "https://glygen.org/publication/PubMed/10980616" } ] }, { "title": "Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.", "journal": "Exp. Cell Res.", "date": "2009", "authors": "Cueni Leah N, Detmar Michael", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "reference": [ { "type": "PubMed", "id": "19268462", "url": "https://glygen.org/publication/PubMed/19268462" } ] }, { "title": "Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "reference": [ { "type": "PubMed", "id": "21288902", "url": "https://glygen.org/publication/PubMed/21288902" } ] }, { "title": "Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.", "journal": "Nature", "date": "2012", "authors": "Thurston TL, Wandel MP, von Muhlinen N, Foeglein A, Randow F", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "reference": [ { "type": "PubMed", "id": "22246324", "url": "https://glygen.org/publication/PubMed/22246324" } ] }, { "title": "PLA2G16 represents a switch between entry and clearance of Picornaviridae.", "journal": "Nature", "date": "2017", "authors": "Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "reference": [ { "type": "PubMed", "id": "28077878", "url": "https://glygen.org/publication/PubMed/28077878" } ] }, { "title": "Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.", "journal": "mBio", "date": "2021", "authors": "Bell SL, Lopez KL, Cox JS, Patrick KL, Watson RO", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" } ], "reference": [ { "type": "PubMed", "id": "34225486", "url": "https://glygen.org/publication/PubMed/34225486" } ] }, { "title": "circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2021", "authors": "Xu YP, Dong ZN, Wang SW, Zheng YM, Zhang C, Zhou YQ, Zhao YJ, Zhao Y, Wang F, Peng R, Tang MC, Bai DS, Huang XY, Guo CY", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" } ], "reference": [ { "type": "PubMed", "id": "34526098", "url": "https://glygen.org/publication/PubMed/34526098" } ] }, { "title": "Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.", "journal": "ChemMedChem", "date": "2022", "authors": "Girardi B, Manna M, Van Klaveren S, Tomasic T, Jakopin Z, Leffler H, Nilsson UJ, Ricklin D, Mravljak J, Schwardt O, Anderluh M", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" } ], "reference": [ { "type": "PubMed", "id": "34613662", "url": "https://glygen.org/publication/PubMed/34613662" } ] }, { "title": "Galectin-8 and -9 as prognostic factors for cervical cancer.", "journal": "Archives of gynecology and obstetrics", "date": "2022", "authors": "Beyer S, Wehrmann M, Meister S, Kolben TM, Trillsch F, Burges A, Czogalla B, Schmoeckel E, Mahner S, Jeschke U, Kolben T", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" } ], "reference": [ { "type": "PubMed", "id": "35377045", "url": "https://glygen.org/publication/PubMed/35377045" } ] }, { "title": "Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.", "journal": "PLoS pathogens", "date": "2023-06", "authors": "Morrison Huntly M, Craft Julia, Rivera-Lugo Rafael, Johnson Jeffery R, Golovkine Guillaume R, Bell Samantha L, Dodd Claire E, Van Dis Erik, Beatty Wandy L, Margolis Shally R, Repasy Teresa, Shaker Isaac, Lee Angus Y, Vance Russell E, Stanley Sarah A, Watson Robert O, Krogan Nevan J, Portnoy Daniel A, Penn Bennett H, Cox Jeffery S", "evidence": [ { "database": "RefSeq", "id": "NP_006490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006490" } ], "reference": [ { "type": "PubMed", "id": "37352334", "url": "https://glygen.org/publication/PubMed/37352334" } ] }, { "title": "Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1996", "authors": "Su Z Z, Lin J, Shen R, Fisher P E, Goldstein N I, Fisher P B", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "reference": [ { "type": "PubMed", "id": "8692978", "url": "https://glygen.org/publication/PubMed/8692978" } ] } ], "pathway": [ { "id": "hsa:3964", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3964", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q62665-1", "protein_name": "Galectin-8", "gene_name": "Lgals8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSLSNLQNIIYNPTIPYVSTITEQLKPGSLIVIRGHVPKDSERFQVDFQHGNSLKPRADVAFHFNPRFKRSNCIVCNTLTNEKWGWEEITHDMPFRKEKSFEIVIMVLKNKFHVAVNGKHILLYAHRINPEKIDTLGIFGKVNIHSIGFRFSSDLQSMETSTLGLTQISKENIQKSGKLHLSLPFEARLNASMGPGRTVVVKGEVNTNATSFNVDLVAGRSRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITCFPFSSGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKDLSSIDTLAVDGDIRLLDVRSW", "length": 316 }, "evidence": [ { "id": "45920276", "url": "http://www.informatics.jax.org/homology/45920276", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JL15-1", "protein_name": "Galectin-8", "gene_name": "Lgals8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSLNNLQNIIYNPIIPYVGTITEQLKPGSLIVIRGHVPKDSERFQVDFQLGNSLKPRADVAFHFNPRFKRSSCIVCNTLTQEKWGWEEITYDMPFRKEKSFEIVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSIGFRFSSDLQSMETSALGLTQINRENIQKPGKLQLSLPFEARLNASMGPGRTVVIKGEVNTNARSFNVDLVAGKTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITCFPFSSGMYFEMIIYCDVREFKVAINGVHSLEYKHRFKDLSSIDTLSVDGDIRLLDVRSW", "length": 316 }, "evidence": [ { "id": "45920276", "url": "http://www.informatics.jax.org/homology/45920276", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "xenophagy", "id": "GO:0098792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098792", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" }, { "name": "lymphatic endothelial cell migration", "id": "GO:1904977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904977", "evidence": [ { "database": "UniProtKB", "id": "O00214", "url": "https://www.uniprot.org/uniprot/O00214" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 233 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 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