{ "uniprot_canonical_ac": "O00186-1", "uniprot_ac": "O00186", "uniprot_id": "STXB3_HUMAN", "mass": { "chemical_mass": 67764.0, "monoisotopic_mass": 67764.0 }, "refseq": { "ac": "NP_009200", "name": "syntaxin-binding protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" }, "gene_names": [ { "name": "STXBP3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00186", "id": "O00186" }, { "name": "MUNC18-3; MUNC18C; PSP; UNC-18C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200", "id": "NP_009200" }, { "name": "STXBP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200", "id": "NP_009200" } ], "protein_names": [ { "name": "Syntaxin-binding protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00186" }, { "name": "PSP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00186" }, { "name": "Platelet Sec1 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00186" }, { "name": "Protein unc-18 homolog 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00186" }, { "name": "Protein unc-18 homolog C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00186" }, { "name": "Unc-18C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00186" }, { "name": "Unc18-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00186" }, { "name": "syntaxin 4 binding protein; unc18-3; platelet Sec1 protein; protein unc-18 homolog 3; protein unc-18 homolog C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200", "id": "NP_009200" }, { "name": "syntaxin-binding protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200", "id": "NP_009200" } ], "function": [ { "annotation": "Data suggest MUNC18C is required for STX4-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 fragment binds to MUNC18C and inhibits interactions of STX4 with synaptosome-associated protein 23 (SNAP23) and vesicle-associated membrane protein 2 (VAMP2). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 = syntaxin 4)", "evidence": [ { "database": "RefSeq", "id": "NP_009200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" }, { "database": "PubMed", "id": "28798239", "url": "https://glygen.org/publication/PubMed/28798239" } ] }, { "annotation": "PP2B-Aalpha-Munc18c complex supports agonist-induced VWF secretion by HUVECs.", "evidence": [ { "database": "RefSeq", "id": "NP_009200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" }, { "database": "PubMed", "id": "28294518", "url": "https://glygen.org/publication/PubMed/28294518" } ] }, { "annotation": "Pancreatic acini from Munc18c-depleted mice (Munc18c(+/-)) and human pancreas (lenti-Munc18c-shRNA-treated) exhibit normal apical exocytosis of zymogen granules (ZGs) in response to physiologic stimulation with the intestinal hormone cholecystokinin (CCK-8).", "evidence": [ { "database": "RefSeq", "id": "NP_009200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" }, { "database": "PubMed", "id": "29284677", "url": "https://glygen.org/publication/PubMed/29284677" } ] }, { "annotation": "Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.", "evidence": [ { "database": "UniProtKB", "id": "O00186", "url": "https://www.uniprot.org/uniprot/O00186#function" } ] }, { "annotation": "Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.", "evidence": [ { "database": "RefSeq", "id": "NP_009200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" }, { "database": "PubMed", "id": "33891011", "url": "https://glygen.org/publication/PubMed/33891011" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O00186", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00186" } ], "glycoeffect": [], "start_pos": 240, "end_pos": 240, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "1", "chr_pos": "108779319", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R240", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix uteri cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": 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"disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "86.59", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116266", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116266" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "91.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116266", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116266" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00186", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00186" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00186" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O00186", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00186" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": 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"10194441", "url": "https://glygen.org/publication/PubMed/10194441" } ] }, { "title": "Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Chung SH, Polgar J, Reed GL", "evidence": [ { "database": "Reactome", "id": "R-HSA-114516", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114516" } ], "reference": [ { "type": "PubMed", "id": "10856305", "url": "https://glygen.org/publication/PubMed/10856305" } ] }, { "title": "Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.", "journal": "Diabetes", "date": "2005", "authors": "Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "15919790", "url": "https://glygen.org/publication/PubMed/15919790" } ] }, { "title": "AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.", "journal": "The Biochemical journal", "date": "2005", "authors": "Miinea CP, Sano H, Kane S, Sano E, Fukuda M, Peranen J, Lane WS, Lienhard GE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "15971998", "url": "https://glygen.org/publication/PubMed/15971998" } ] }, { "title": "A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Ramm G, Larance M, Guilhaus M, James DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "16880201", "url": "https://glygen.org/publication/PubMed/16880201" } ] }, { "title": "Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle.", "journal": "Diabetes", "date": "2007", "authors": "Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "17369524", "url": "https://glygen.org/publication/PubMed/17369524" } ] }, { "title": "Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes.", "journal": "Endocrinology", "date": "2008", "authors": "Umahara M, Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Shimizu H, Pessin JE, Mori M", "evidence": [ { "database": "iPTMnet", "id": "O00186", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00186" } ], 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Motamedchaboki K, Chen Y, Czech MP, Mann M, Kruger M, Jiang ZY", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "21907143", "url": "https://glygen.org/publication/PubMed/21907143" } ] }, { "title": "Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B.", "journal": "Cell communication and signaling : CCS", "date": "2013", "authors": "Bakke J, Bettaieb A, Nagata N, Matsuo K, Haj FG", "evidence": [ { "database": "iPTMnet", "id": "O00186", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00186" } ], "reference": [ { "type": "PubMed", "id": "23937695", "url": "https://glygen.org/publication/PubMed/23937695" } ] }, { "title": "Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets.", "journal": "The Journal of biological 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matrix invasion of tumor cells.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Brasher MI, Martynowicz DM, Grafinger OR, Hucik A, Shanks-Skinner E, Uniacke J, Coppolino MG", "evidence": [ { "database": "RefSeq", "id": "NP_009200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" } ], "reference": [ { "type": "PubMed", "id": "28798239", "url": "https://glygen.org/publication/PubMed/28798239" } ] }, { "title": "Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis.", "journal": "The Journal of biological chemistry", "date": "2018", "authors": "Dolai S, Liang T, Orabi AI, Xie L, Holmyard D, Javed TA, Fernandez NA, Xie H, Cattral MS, Thurmond DC, Thorn P, Gaisano HY", "evidence": [ { "database": "RefSeq", "id": "NP_009200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009200" } ], "reference": [ { "type": "PubMed", "id": "29284677", "url": "https://glygen.org/publication/PubMed/29284677" } ] 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