{
"uniprot_canonical_ac": "O00154-1",
"uniprot_ac": "O00154",
"uniprot_id": "BACH_HUMAN",
"mass": {
"chemical_mass": 41796.0,
"monoisotopic_mass": 41796.0
},
"refseq": {
"ac": "NP_009205",
"name": "cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa",
"summary": "This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
"gene_names": [
{
"name": "ACOT7",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O00154",
"id": "O00154"
},
{
"name": "ACH1; ACT; BACH; CTE-II; hBACH; LACH; LACH1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205",
"id": "NP_009205"
},
{
"name": "ACOT7",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205",
"id": "NP_009205"
},
{
"name": "BACH",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O00154",
"id": "O00154"
}
],
"protein_names": [
{
"name": "Cytosolic acyl coenzyme A thioester hydrolase",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O00154"
},
{
"name": "3.1.2.2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "Acyl-CoA thioesterase 7",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "BACH",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "Brain acyl-CoA hydrolase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "CTE-IIa",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "CTE-II",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "Long chain acyl-CoA thioester hydrolase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
},
{
"name": "cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205",
"id": "NP_009205"
},
{
"name": "cytosolic acyl coenzyme A thioester hydrolase; brain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; acyl-CoA thioesterase, long chain; acyl-CoA thioesterase 2; CTE-IIa",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205",
"id": "NP_009205"
},
{
"name": "hBACH",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O00154"
}
],
"function": [
{
"annotation": "Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "35215835",
"url": "https://glygen.org/publication/PubMed/35215835"
}
]
},
{
"annotation": "BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "15592755",
"url": "https://glygen.org/publication/PubMed/15592755"
}
]
},
{
"annotation": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051).",
"evidence": [
{
"database": "UniProtKB",
"id": "O00154",
"url": "https://www.uniprot.org/uniprot/O00154#function"
},
{
"database": "PubMed",
"id": "10578051",
"url": "https://glygen.org/publication/PubMed/10578051"
}
]
},
{
"annotation": "NMRAL2P activation suppresses ACOT7 expression in gastric cancer.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "32469171",
"url": "https://glygen.org/publication/PubMed/32469171"
}
]
},
{
"annotation": "PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "28518146",
"url": "https://glygen.org/publication/PubMed/28518146"
}
]
},
{
"annotation": "Patients in high ACOT7 group had a significant lower EFS and OS, while patients in high versus low expression levels of other types of ACOT showed no significant difference on the outcome",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "31640082",
"url": "https://glygen.org/publication/PubMed/31640082"
}
]
},
{
"annotation": "The human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "12435388",
"url": "https://glygen.org/publication/PubMed/12435388"
}
]
},
{
"annotation": "This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
}
]
},
{
"annotation": "WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_009205",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_009205"
},
{
"database": "PubMed",
"id": "28472401",
"url": "https://glygen.org/publication/PubMed/28472401"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "rs1336516746",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1336516746"
},
{
"id": "rs1336516746",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1336516746"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 143,
"end_pos": 143,
"sequence_org": "M",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVM->NVT).",
"chr_id": "1",
"chr_pos": "6327349",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "M143",
"keywords": [
"ebi",
"germline"
]
}
],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "91.28",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "83.1",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "80.42",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "66.6",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "86.52",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "89.44",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "80.79",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "79.36",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "75.21",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "65.25",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "78.41",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "82.26",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "81.13",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000097021",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000097021"
}
]
}
],
"expression_disease": [
{
"significant": "No",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
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}
],
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{
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},
"synonyms": [
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},
{
"id": "DOID:10534",
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{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"name": "stomach cancer",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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},
{
"id": "MONDO:0001056",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
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},
{
"id": "DOID:11054",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
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},
{
"id": "MONDO:0001187",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
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},
"synonyms": [
{
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
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"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
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"name": "neoplasm of uterus",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
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"evidence": [
{
"database": "BioXpress",
"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
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"name": "esophageal cancer",
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},
"synonyms": [
{
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"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "Ca middle third oesophagus",
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},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
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"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
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"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
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"name": "malignant tumor of the esophagus",
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},
{
"id": "MONDO:0007576",
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"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
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"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
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"id": "O00154",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00154"
}
],
"disease": [
{
"disease_id": "DOID:9256",
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
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},
"synonyms": [
{
"id": "MONDO:0005575",
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"name": "colorectal cancer",
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},
{
"id": "MONDO:0005575",
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"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"name": "colorectum cancer",
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},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
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"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566R0-1",
"O88267-1",
"O55171-1",
"Q8VHK0-1",
"Q64559-2",
"P13437-1",
"P08635-1",
"P49753-1",
"O14734-1",
"Q86TX2-1",
"Q8N9L9-1",
"O00154-1",
"Q5T1C6-1",
"P42765-1",
"Q9NPJ3-1",
"Q9NV23-1",
"Q9QYR7-1",
"P58137-1",
"O55137-1",
"Q6Q2Z6-1",
"Q9QYR9-1",
"Q91V12-1",
"Q8BWT1-1",
"Q3UUI3-1",
"Q8R197-1",
"Q9CQR4-1"
],
"evidence": [
{
"id": "40059",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/40059"
}
]
},
{
"id": "40119",
"name": "",
"equation": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566R0-1",
"O88267-1",
"O55171-1",
"Q63276-1",
"Q8VHK0-1",
"Q64559-2",
"P13437-1",
"P08635-1",
"P49753-1",
"O14734-1",
"Q86TX2-1",
"Q8N9L9-1",
"Q8WXI4-1",
"O00154-1",
"Q14032-1",
"Q8N1Q8-1",
"Q5T1C6-1",
"P42765-1",
"Q9NPJ3-1",
"Q9NV23-1",
"Q68D91-1",
"Q8VHQ9-1",
"Q9CQJ0-1",
"Q9QYR7-1",
"P58137-1",
"O55137-1",
"Q6Q2Z6-1",
"Q9QYR9-1",
"Q91V12-1",
"Q91X34-1",
"Q8BWT1-1",
"Q3UUI3-1",
"Q8BL86-1",
"Q8R197-1",
"Q9CQR4-1"
],
"evidence": [
{
"id": "40119",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/40119"
}
]
},
{
"id": "40139",
"name": "",
"equation": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566R0-1",
"O88267-1",
"O55171-1",
"Q8VHK0-1",
"Q64559-2",
"P49753-1",
"O14734-1",
"Q86TX2-1",
"Q8N9L9-1",
"O00154-1",
"Q8N1Q8-1",
"Q5T1C6-1",
"Q9NPJ3-1",
"Q9CQJ0-1",
"Q9QYR7-1",
"P58137-1",
"O55137-1",
"Q6Q2Z6-1",
"Q9QYR9-1",
"Q91V12-1",
"Q3UUI3-1",
"Q9CQR4-1"
],
"evidence": [
{
"id": "40139",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/40139"
}
]
},
{
"id": "R-HSA-5690043",
"name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA",
"equation": "",
"summary": "The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health. Free fatty acids can act as detergents to disrupt membranes so their generation is normally tightly regulated to states where they will be rapidly consumed or sequestered. Acyl-coenzyme A thioesterases (ACOTs) hydrolyse the thioester bond in medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFA-CoA, LCFA-CoA) to their free fatty acids (MCFA, LCFA) (Cohen 2013, Hunt et al. 2012, Kirkby et al. 2010). ACOTs that function in the cytosol are ACOT1 (Hunt et al. 2005), ACOT11 (Adams et al. 2001), ACOT12 trimer (Swarbrick et al. 2014), ACOT13 tetramer (Cao et al. 2009, Cheng et al. 2006), ACOT7 hexamer (Hunt et al. 2005b) and ACOT7L dimer (Jiang et al. 2006).
Recent mouse studies reveals a key regulatory role for PCTP in lipid and glucose metabolism. Phosphatidylcholine transfer protein (PCTP aka STARD2) is a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain superfamily, a functionally diverse group of proteins that share a unique structural motif for binding lipids. PCTP appears to limit access of fatty acids to mitochondria by binding to (Ersoy et al. 2013) and stimulating the activity of acyl-coenzyme A thioesterase 13 (ACOT13, aka Acyl-CoA thioesterase 13, THEM2), an enzyme that catalyses the hydrolysis of acyl-CoAs to their free fatty acids (Kawano et al. 2014). Ultimately, insulin signaling is downregulated (Kang et al. 2010).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q86TX2-1",
"Q9NPJ3-1",
"Q8WXI4-1",
"Q8WYK0-1",
"O00154-1",
"Q6ZUV0-1"
],
"evidence": [
{
"id": "R-HSA-5690043",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5690043"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "O00154",
"gene_name": "ACOT7",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "O00154",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00154"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "O00154",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00154"
}
]
}
]
},
{
"uniprot_ac": "O14734",
"gene_name": "ACOT8",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.27",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.11",
"activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.5",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.5",
"activity": "",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
},
{
"ec_number": "3.1.2.11",
"activity": "",
"evidence": [
{
"id": "O14734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14734"
}
]
}
]
},
{
"uniprot_ac": "O55137",
"gene_name": "Acot1",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "O55137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55137"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "O55137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55137"
}
]
}
]
},
{
"uniprot_ac": "O55171",
"gene_name": "Acot2",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "O55171",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55171"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "O55171",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55171"
}
]
}
]
},
{
"uniprot_ac": "O60733",
"gene_name": "PLA2G6",
"activity": [
{
"ec_number": "3.1.1.4",
"activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).",
"evidence": [
{
"id": "O60733",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60733"
}
]
},
{
"ec_number": "3.1.1.4",
"activity": "",
"evidence": [
{
"id": "O60733",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60733"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "O60733",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60733"
}
]
},
{
"ec_number": "3.1.1.5",
"activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.",
"evidence": [
{
"id": "O60733",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60733"
}
]
}
]
},
{
"uniprot_ac": "O88267",
"gene_name": "Acot1",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "O88267",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88267"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "O88267",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88267"
}
]
}
]
},
{
"uniprot_ac": "P08635",
"gene_name": "Olah",
"activity": [
{
"ec_number": "3.1.2.14",
"activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].",
"evidence": [
{
"id": "P08635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08635"
}
]
},
{
"ec_number": "3.1.2.14",
"activity": "",
"evidence": [
{
"id": "P08635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08635"
}
]
}
]
},
{
"uniprot_ac": "P13437",
"gene_name": "Acaa2",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "P13437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13437"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P13437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13437"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "P13437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13437"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.",
"evidence": [
{
"id": "P13437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13437"
}
]
},
{
"ec_number": "2.3.1.9",
"activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.",
"evidence": [
{
"id": "P13437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13437"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "",
"evidence": [
{
"id": "P13437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13437"
}
]
}
]
},
{
"uniprot_ac": "P41903",
"gene_name": "TES1",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P41903",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41903"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "P41903",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41903"
}
]
}
]
},
{
"uniprot_ac": "P42765",
"gene_name": "ACAA2",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "P42765",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42765"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P42765",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42765"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "P42765",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42765"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.",
"evidence": [
{
"id": "P42765",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42765"
}
]
},
{
"ec_number": "2.3.1.9",
"activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.",
"evidence": [
{
"id": "P42765",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42765"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "",
"evidence": [
{
"id": "P42765",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42765"
}
]
}
]
},
{
"uniprot_ac": "P49753",
"gene_name": "ACOT2",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P49753",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49753"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "P49753",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49753"
}
]
}
]
},
{
"uniprot_ac": "P58137",
"gene_name": "Acot8",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.27",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.11",
"activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.5",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.11",
"activity": "",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.5",
"activity": "",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "",
"evidence": [
{
"id": "P58137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58137"
}
]
}
]
},
{
"uniprot_ac": "P80250",
"gene_name": "",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P80250",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P80250"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "P80250",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P80250"
}
]
}
]
},
{
"uniprot_ac": "P97570",
"gene_name": "Pla2g6",
"activity": [
{
"ec_number": "3.1.1.4",
"activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).",
"evidence": [
{
"id": "P97570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97570"
}
]
},
{
"ec_number": "3.1.1.4",
"activity": "",
"evidence": [
{
"id": "P97570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97570"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P97570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97570"
}
]
},
{
"ec_number": "3.1.1.5",
"activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.",
"evidence": [
{
"id": "P97570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97570"
}
]
}
]
},
{
"uniprot_ac": "P97819",
"gene_name": "Pla2g6",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "P97819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97819"
}
]
},
{
"ec_number": "3.1.1.4",
"activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).",
"evidence": [
{
"id": "P97819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97819"
}
]
},
{
"ec_number": "3.1.1.5",
"activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.",
"evidence": [
{
"id": "P97819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97819"
}
]
},
{
"ec_number": "3.1.1.4",
"activity": "",
"evidence": [
{
"id": "P97819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97819"
}
]
}
]
},
{
"uniprot_ac": "Q14032",
"gene_name": "BAAT",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q14032",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14032"
}
]
},
{
"ec_number": "3.1.2.27",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "Q14032",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14032"
}
]
},
{
"ec_number": "2.3.1.65",
"activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).",
"evidence": [
{
"id": "Q14032",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14032"
}
]
},
{
"ec_number": "2.3.1.65",
"activity": "",
"evidence": [
{
"id": "Q14032",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14032"
}
]
}
]
},
{
"uniprot_ac": "Q3UUI3",
"gene_name": "Them4",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q3UUI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UUI3"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q3UUI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UUI3"
}
]
}
]
},
{
"uniprot_ac": "Q566R0",
"gene_name": "Them4",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q566R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566R0"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q566R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566R0"
}
]
}
]
},
{
"uniprot_ac": "Q5T1C6",
"gene_name": "THEM4",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q5T1C6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T1C6"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q5T1C6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T1C6"
}
]
}
]
},
{
"uniprot_ac": "Q63276",
"gene_name": "Baat",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q63276",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63276"
}
]
},
{
"ec_number": "3.1.2.27",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "Q63276",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63276"
}
]
},
{
"ec_number": "2.3.1.65",
"activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).",
"evidence": [
{
"id": "Q63276",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63276"
}
]
},
{
"ec_number": "2.3.1.65",
"activity": "",
"evidence": [
{
"id": "Q63276",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63276"
}
]
}
]
},
{
"uniprot_ac": "Q64559",
"gene_name": "Acot7",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q64559",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64559"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q64559",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64559"
}
]
}
]
},
{
"uniprot_ac": "Q68D91",
"gene_name": "MBLAC2",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q68D91",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q68D91"
}
]
},
{
"ec_number": "3.5.2.6",
"activity": "a beta-lactam + H2O = a substituted beta-amino acid.",
"evidence": [
{
"id": "Q68D91",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q68D91"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q68D91",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q68D91"
}
]
}
]
},
{
"uniprot_ac": "Q6Q2Z6",
"gene_name": "Acot5",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q6Q2Z6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q2Z6"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q6Q2Z6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q2Z6"
}
]
}
]
},
{
"uniprot_ac": "Q6ZUV0",
"gene_name": "ACOT7L",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q6ZUV0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZUV0"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q6ZUV0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZUV0"
}
]
}
]
},
{
"uniprot_ac": "Q86TX2",
"gene_name": "ACOT1",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "Q86TX2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86TX2"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q86TX2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86TX2"
}
]
}
]
},
{
"uniprot_ac": "Q8BL86",
"gene_name": "Mblac2",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8BL86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BL86"
}
]
},
{
"ec_number": "3.5.2.6",
"activity": "a beta-lactam + H2O = a substituted beta-amino acid.",
"evidence": [
{
"id": "Q8BL86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BL86"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q8BL86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BL86"
}
]
}
]
},
{
"uniprot_ac": "Q8BWT1",
"gene_name": "Acaa2",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "Q8BWT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWT1"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8BWT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWT1"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "Q8BWT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWT1"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.",
"evidence": [
{
"id": "Q8BWT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWT1"
}
]
},
{
"ec_number": "2.3.1.9",
"activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.",
"evidence": [
{
"id": "Q8BWT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWT1"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "",
"evidence": [
{
"id": "Q8BWT1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWT1"
}
]
}
]
},
{
"uniprot_ac": "Q8N1Q8",
"gene_name": "THEM5",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8N1Q8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N1Q8"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q8N1Q8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N1Q8"
}
]
}
]
},
{
"uniprot_ac": "Q8N9L9",
"gene_name": "ACOT4",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8N9L9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N9L9"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.",
"evidence": [
{
"id": "Q8N9L9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N9L9"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "",
"evidence": [
{
"id": "Q8N9L9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N9L9"
}
]
}
]
},
{
"uniprot_ac": "Q8R197",
"gene_name": "Olah",
"activity": [
{
"ec_number": "3.1.2.14",
"activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].",
"evidence": [
{
"id": "Q8R197",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R197"
}
]
},
{
"ec_number": "3.1.2.14",
"activity": "",
"evidence": [
{
"id": "Q8R197",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R197"
}
]
}
]
},
{
"uniprot_ac": "Q8VHK0",
"gene_name": "Acot8",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.27",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.11",
"activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.5",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.11",
"activity": "",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.5",
"activity": "",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.3",
"activity": "",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "",
"evidence": [
{
"id": "Q8VHK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK0"
}
]
}
]
},
{
"uniprot_ac": "Q8VHQ9",
"gene_name": "Acot11",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "Q8VHQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHQ9"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8VHQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHQ9"
}
]
}
]
},
{
"uniprot_ac": "Q8WXI4",
"gene_name": "ACOT11",
"activity": [
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "Q8WXI4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WXI4"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q8WXI4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WXI4"
}
]
}
]
},
{
"uniprot_ac": "Q8WYK0",
"gene_name": "ACOT12",
"activity": [
{
"ec_number": "3.1.2.1",
"activity": "acetyl-CoA + H2O = acetate + CoA + H(+).",
"evidence": [
{
"id": "Q8WYK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WYK0"
}
]
},
{
"ec_number": "3.1.2.1",
"activity": "",
"evidence": [
{
"id": "Q8WYK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WYK0"
}
]
}
]
},
{
"uniprot_ac": "Q91V12",
"gene_name": "Acot7",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q91V12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91V12"
}
]
},
{
"ec_number": "3.1.2.2",
"activity": "",
"evidence": [
{
"id": "Q91V12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91V12"
}
]
}
]
},
{
"uniprot_ac": "Q91X34",
"gene_name": "Baat",
"activity": [
{
"ec_number": "3.1.2.2",
"activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.",
"evidence": [
{
"id": "Q91X34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91X34"
}
]
},
{
"ec_number": "3.1.2.27",
"activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).",
"evidence": [
{
"id": "Q91X34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91X34"
}
]
},
{
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