{ "uniprot_canonical_ac": "O00151-1", "uniprot_ac": "O00151", "uniprot_id": "PDLI1_HUMAN", "mass": { "chemical_mass": 36072.0, "monoisotopic_mass": 36072.0 }, "refseq": { "ac": "NP_066272", "name": "PDZ and LIM domain protein 1", "summary": "This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, "gene_names": [ { "name": "PDLIM1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00151", "id": "O00151" }, { "name": "CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272", "id": "NP_066272" }, { "name": "CLIM1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00151", "id": "O00151" }, { "name": "CLP36", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00151", "id": "O00151" }, { "name": "PDLIM1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272", "id": "NP_066272" } ], "protein_names": [ { "name": "PDZ and LIM domain protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00151" }, { "name": "C-terminal LIM domain protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00151" }, { "name": "Elfin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00151" }, { "name": "LIM domain protein CLP-36", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00151" }, { "name": "PDZ and LIM domain protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272", "id": "NP_066272" }, { "name": "carboxyl terminal LIM domain protein 1; epididymis secretory protein Li 112; elfin; LIM domain protein CLP-36", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272", "id": "NP_066272" } ], "function": [ { "annotation": "CLP-36 contains a PDZ- and LIM domain, is widely expressed, interacts with actinin-1, actinin-2 and actinin-4, and localizes to actin stress fibers. The gene (7 exons) is localised to contig NT_008878.2 on chromosome 10.", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, { "database": "PubMed", "id": "11110697", "url": "https://glygen.org/publication/PubMed/11110697" } ] }, { "annotation": "Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151#function" }, { "database": "UniProtKB", "id": "P52944", "url": "https://www.uniprot.org/uniprot/P52944#function" }, { "database": "PubMed", "id": "10861853", "url": "https://glygen.org/publication/PubMed/10861853" } ] }, { "annotation": "Distribution of PDLIM1 at actin-rich structures generated by invasive and adherent bacterial pathogens.", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, { "database": "PubMed", "id": "33022122", "url": "https://glygen.org/publication/PubMed/33022122" } ] }, { "annotation": "Enigma protein shown to interact with alpha actinin 2 by yeast two-hybrid screening and immunochemistry (co-localization at myocardial Z-disks).", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, { "database": "PubMed", "id": "10861853", "url": "https://glygen.org/publication/PubMed/10861853" } ] }, { "annotation": "Hyperprogression on immunotherapy with complete response to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case report.", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, { "database": "PubMed", "id": "33181636", "url": "https://glygen.org/publication/PubMed/33181636" } ] }, { "annotation": "MicroRNA-370-3p inhibits cell proliferation and induces chronic myelogenous leukaemia cell apoptosis by suppressing PDLIM1/Wnt/beta-catenin signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, { "database": "PubMed", "id": "31986893", "url": "https://glygen.org/publication/PubMed/31986893" } ] }, { "annotation": "PDLIM1 interacts with HK2 to promote gastric cancer progression through enhancing the Warburg effect via Wnt/beta-catenin signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" }, { "database": "PubMed", "id": "37930472", "url": "https://glygen.org/publication/PubMed/37930472" } ] }, { "annotation": "This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs945497385", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs945497385" }, { "id": "rs945497385", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs945497385" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 123, "end_pos": 123, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRS->NRR); o-glyco-site-loss (S->R).", "chr_id": "10", "chr_pos": "95264028", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S123", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1163951608", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1163951608" }, { "id": "rs1163951608", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1163951608#frequency_tab" }, { "id": "rs1163951608", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1163951608" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 108, "end_pos": 108, "sequence_org": "S", "sequence_mut": "C", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->C).", "chr_id": "10", "chr_pos": "95268788", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S108", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O00151", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00151" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 108, "end_pos": 108, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->F).", "chr_id": "10", "chr_pos": "95268788", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S108", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs756605593", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756605593" }, { "id": "rs756605593", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756605593" }, { "id": "rs756605593", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756605593" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 128, "end_pos": 128, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "10", "chr_pos": "95264014", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T128", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1589513400", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1589513400" }, { "id": "rs1589513400", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1589513400" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 128, "end_pos": 128, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "10", "chr_pos": "95264015", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T128", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs199561336", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199561336" }, { "id": "rs199561336", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs199561336" }, { "id": "rs199561336", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199561336" }, { "id": "rs199561336", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199561336" }, { "id": "rs199561336", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs199561336#frequency_tab" }, { "id": "rs199561336", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs199561336" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 130, "end_pos": 130, "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->L).", "chr_id": "10", "chr_pos": "95264008", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "S130", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O00151", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00151" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 130, "end_pos": 130, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "W", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->W).", "chr_id": "10", "chr_pos": "95264008", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "S130", "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": 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"malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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Cell. Biochem.", "date": "1999", "authors": "Kotaka M, Ngai S M, Garcia-Barcelo M, Tsui S K, Fung K P, Lee C Y, Waye M M", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" } ], "reference": [ { "type": "PubMed", "id": "10022510", "url": "https://glygen.org/publication/PubMed/10022510" } ] }, { "title": "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Vallenius T, Luukko K, M\u00e4kel\u00e4 T P", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" } ], "reference": [ { "type": "PubMed", "id": "10753915", "url": "https://glygen.org/publication/PubMed/10753915" } ] }, { "title": "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2.", "journal": "Journal of cellular biochemistry", "date": "2000", "authors": "Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li Hy, Ng EK, Schaper J, Tsui SK, Fung Kp, Lee Cy, Waye MM", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" }, { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" } ], "reference": [ { "type": "PubMed", "id": "10861853", "url": "https://glygen.org/publication/PubMed/10861853" } ] }, { "title": "Human CLP-36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.", "journal": "Blood", "date": "2000", "authors": "Bauer K, Kratzer M, Otte M, de Quintana KL, Hagmann J, Arnold GJ, Eckerskorn C, Lottspeich F, Siess W", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" }, { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" } ], "reference": [ { "type": "PubMed", "id": "11110697", "url": "https://glygen.org/publication/PubMed/11110697" } ] }, { "title": "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.", "journal": "Nat. Biotechnol.", "date": "2003", "authors": "Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" } ], "reference": [ { "type": "PubMed", "id": "12665801", "url": "https://glygen.org/publication/PubMed/12665801" } ] }, { "title": "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.", "journal": "Analytical chemistry", "date": "2004", "authors": "Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" }, { "database": "iPTMnet", "id": "O00151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00151" } ], "reference": [ { "type": "PubMed", "id": "15144186", "url": 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"https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer.", "journal": "Analytical chemistry", "date": "2010", "authors": "Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "O00151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00151" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": 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of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" }, { "database": "iPTMnet", "id": "O00151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00151" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "O00151", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O00151", "url": "https://www.uniprot.org/uniprot/O00151" }, { "database": "iPTMnet", "id": "O00151", "url": 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"Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" }, { "database": "O-GlcNAc Atlas", "id": "O00151", "url": "https://oglcnac.org/atlas/detail/O00151" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" }, { "database": "O-GlcNAc Atlas", "id": "O00151", "url": "https://oglcnac.org/atlas/detail/O00151" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.", "journal": "Journal of the American Chemical Society", "date": "2019", "authors": "Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O00151", "url": "https://oglcnac.org/atlas/detail/O00151" } ], "reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" 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"https://www.oglcnac.mcw.edu/search/?query_protein=O00151" }, { "database": "O-GlcNAc Atlas", "id": "O00151", "url": "https://oglcnac.org/atlas/detail/O00151" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "Distribution of PDLIM1 at actin-rich structures generated by invasive and adherent bacterial pathogens.", "journal": "Anatomical record (Hoboken, N.J. : 2007)", "date": "2021", "authors": "Dhanda AS, Yang D, Kooner A, Guttman JA", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" } ], "reference": [ { "type": "PubMed", "id": "33022122", "url": "https://glygen.org/publication/PubMed/33022122" } ] }, { "title": "Hyperprogression on immunotherapy with complete response to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case report.", "journal": "Medicine", "date": "2020", "authors": "Fricke J, Mambetsariev I, Pharaon R, Subbiah S, Rajurkar S, Salgia R", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" } ], "reference": [ { "type": "PubMed", "id": "33181636", "url": "https://glygen.org/publication/PubMed/33181636" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00151" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "PDLIM1 interacts with HK2 to promote gastric cancer progression through enhancing the Warburg effect via Wnt/\u03b2-catenin signaling.", "journal": "Cell and tissue research", "date": "2024-01", "authors": "Lei Yunpeng, He Lirui, Li Yue, Hou Jianing, Zhang Haoran, Li Guan", "evidence": [ { "database": "RefSeq", "id": "NP_066272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066272" } ], "reference": [ { "type": "PubMed", "id": "37930472", "url": "https://glygen.org/publication/PubMed/37930472" } ] } ], 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