{ "uniprot_canonical_ac": "G9CGD6-1", "uniprot_ac": "G9CGD6", "uniprot_id": "CNIPF_HUMAN", "mass": { "chemical_mass": 100365.0, "monoisotopic_mass": 100365.0 }, "refseq": {}, "gene_names": [ { "name": "IPCEF1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/G9CGD6", "id": "G9CGD6" } ], "protein_names": [ { "name": "CNK3/IPCEF1 fusion protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "G9CGD6" } ], "function": [ { "annotation": "Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration.", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6#function" }, { "database": "PubMed", "id": "22085542", "url": "https://glygen.org/publication/PubMed/22085542" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" } ], "common_name": "Human" } ], "gene": [ { "name": "IPCEF1", "url": "https://www.uniprot.org/uniprot/G9CGD6", "locus": { "chromosome": "6", "start_pos": 154154496, "end_pos": 154356803, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000074706", "url": "https://www.ensembl.org/id/ENSG00000074706" } ] } } ], "crossref": [ { "id": "cd01260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09511", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09511", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "G9CGD6", "url": "https://www.ebi.ac.uk/intact/interactors/id:G9CGD6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NX_G9CGD6", "url": "https://www.nextprot.org/entry/NX_G9CGD6", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "ACHPKVM", "url": "https://omabrowser.org/oma/group/ACHPKVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "http://pfam.xfam.org/family/PF00169", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "http://pfam.xfam.org/family/PF00536", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "http://pfam.xfam.org/family/PF00595", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06663", "url": "http://pfam.xfam.org/family/PF06663", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10534", "url": "http://pfam.xfam.org/family/PF10534", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "G9CGD6", "url": "https://pharos.nih.gov/targets/G9CGD6", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G9CGD6-1", "url": "https://www.uniprot.org/uniprot/G9CGD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G9CGD6-2", "url": "https://www.uniprot.org/uniprot/G9CGD6-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G9CGD6-3", "url": "https://www.uniprot.org/uniprot/G9CGD6-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKAFVSTKMTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI", "length": 899, "header": "sp|G9CGD6-1|CNIPF_HUMAN Isoform 1 of CNK3/IPCEF1 fusion protein OS=Homo sapiens OX=9606 GN=IPCEF1 PE=1 SV=1 CANONICAL=G9CGD6-1" }, "isoforms": [ { "isoform_ac": "G9CGD6-1", "url": "", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKAFVSTKMTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI", "length": 899, "header": "sp|G9CGD6-1|CNIPF_HUMAN Isoform 1 of CNK3/IPCEF1 fusion protein OS=Homo sapiens OX=9606 GN=IPCEF1 PE=1 SV=1 CANONICAL=G9CGD6-1" }, "locus": {} }, { "isoform_ac": "G9CGD6-2", "url": "", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKAFVSTKMTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI", "length": 900, "header": "sp|G9CGD6-2|CNIPF_HUMAN Isoform 2 of CNK3/IPCEF1 fusion protein OS=Homo sapiens OX=9606 GN=IPCEF1 PE=1 SV=1 CANONICAL=G9CGD6-1" }, "locus": {} }, { "isoform_ac": "G9CGD6-3", "url": "", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKAFVSTKMTSYMAIDGSALAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI", "length": 830, "header": "sp|G9CGD6-3|CNIPF_HUMAN Isoform 3 of CNK3/IPCEF1 fusion protein OS=Homo sapiens OX=9606 GN=IPCEF1 PE=1 SV=1 CANONICAL=G9CGD6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 383, "end_pos": 383, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "G9CGD6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/G9CGD6" } ], "site_lbl": "Ser383" }, { "start_pos": 873, "end_pos": 873, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "G9CGD6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/G9CGD6" } ], "site_lbl": "Ser873" } ], "glycation": [], "keywords": [], "publication": [ { "title": "CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.", "journal": "Experimental cell research", "date": "2012", "authors": "Attar MA, Salem JC, Pursel HS, Santy LC", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" } ], "reference": [ { "type": "PubMed", "id": "22085542", "url": "https://glygen.org/publication/PubMed/22085542" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" }, { "database": "iPTMnet", "id": "G9CGD6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/G9CGD6" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" }, { "database": "iPTMnet", "id": "G9CGD6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/G9CGD6" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" } ], "pmid": "" }, { "name": "positive regulation of cellular response to hepatocyte growth factor stimulus", "id": "GO:2001114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001114", "evidence": [ { "database": "UniProtKB", "id": "G9CGD6", "url": "https://www.uniprot.org/uniprot/G9CGD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 825, "end_pos": 827, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 383, 873 ], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 825, "end_pos": 827 } ] }, 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