{ "uniprot_canonical_ac": "F8WCM5-1", "uniprot_ac": "F8WCM5", "uniprot_id": "INSR2_HUMAN", "mass": { "chemical_mass": 21537.0, "monoisotopic_mass": 21537.0 }, "refseq": { "ac": "NP_001035835", "name": "insulin, isoform 2 precursor", "summary": "This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" }, "gene_names": [ { "name": "INS-IGF2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/F8WCM5", "id": "F8WCM5" }, { "name": "INS-IGF2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835", "id": "NP_001035835" }, { "name": "INSIGF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835", "id": "NP_001035835" } ], "protein_names": [ { "name": "Insulin, isoform 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "F8WCM5" }, { "name": "INS-IGF2 readthrough transcript protein; insulin- insulin-like growth factor 2 read-through product", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835", "id": "NP_001035835" }, { "name": "INS-IGF2 readthrough transcript protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "F8WCM5" }, { "name": "insulin, isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835", "id": "NP_001035835" } ], "function": [ { "annotation": "GWAS of five gynecologic diseases and cross-trait analysis in Japanese.", "evidence": [ { "database": "RefSeq", "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" }, { "database": "PubMed", "id": "31488892", "url": "https://glygen.org/publication/PubMed/31488892" } ] }, { "annotation": "High INS-IGF2 expression is associated with Lung Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" }, { "database": "PubMed", "id": "30803359", "url": "https://glygen.org/publication/PubMed/30803359" } ] }, { "annotation": "Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" }, { "database": "PubMed", "id": "34267199", "url": "https://glygen.org/publication/PubMed/34267199" } ] }, { "annotation": "Periconception maternal smoking and low education are associated with dna methylation on INSIGF in the very young child.", "evidence": [ { "database": "RefSeq", "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" }, { "database": "PubMed", "id": "25102259", "url": "https://glygen.org/publication/PubMed/25102259" } ] }, { "annotation": "This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" } ] }, { "annotation": "We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 x 10(-94) Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835" }, { "database": "PubMed", "id": "25102180", "url": "https://glygen.org/publication/PubMed/25102180" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "18.51", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "16.41", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "17.43", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "26.99", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "16.34", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "32.86", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.62", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "14.41", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "14.63", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "F8WCM5", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/F8WCM5" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "F8WCM5", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/F8WCM5" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "F8WCM5", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/F8WCM5" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "F8WCM5", "url": "https://www.uniprot.org/uniprot/F8WCM5" } ], "common_name": "Human" } ], "gene": [ { "name": "INS-IGF2", "url": "https://www.uniprot.org/uniprot/F8WCM5", "locus": { "chromosome": "11", "start_pos": 2132538, "end_pos": 2161209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000129965", "url": "https://www.ensembl.org/id/ENSG00000129965" } ] } } ], "crossref": [ { "id": "ENSG00000129965", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000129965", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04367", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04367", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "INS-IGF2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=INS-IGF2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "723961", "url": "https://www.ncbi.nlm.nih.gov/gene/723961", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "33527", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33527", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "F8WCM5", "url": "https://www.ebi.ac.uk/intact/interactors/id:F8WCM5*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR004825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:723961", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:723961", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NX_F8WCM5", "url": "https://www.nextprot.org/entry/NX_F8WCM5", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "4213741at2759", "url": "http://www.orthodb.org/?query=4213741at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11454:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11454:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7YQ3", "url": "https://www.rcsb.org/structure/7YQ3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7YQ4", "url": "https://www.rcsb.org/structure/7YQ4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7YQ5", "url": "https://www.rcsb.org/structure/7YQ5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8GUY", "url": "https://www.rcsb.org/structure/8GUY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00049", "url": "http://pfam.xfam.org/family/PF00049", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "F8WCM5", "url": "https://pharos.nih.gov/targets/F8WCM5", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_F8WCM5", "url": "http://purl.obolibrary.org/obo/PR_F8WCM5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001035835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035835", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F8WCM5", "url": "https://www.uniprot.org/uniprot/F8WCM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WCM5-1", "url": "https://www.uniprot.org/uniprot/F8WCM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQASALSLSSSTSTWPEGLDATARAPPALVVTANIGQAGGSSSRQFRQRALGTSDSPVLFIHCPGAAGTAQGLEYRGRRVTTELVWEEVDSSPQPQGSESLPAQPPAQPAPQPEPQQAREPSPEVSCCGLWPRRPQRSQN", "length": 200, "header": "sp|F8WCM5-1|INSR2_HUMAN Isoform 1 of Insulin, isoform 2 OS=Homo sapiens OX=9606 GN=INS-IGF2 PE=1 SV=1 CANONICAL=F8WCM5-1" }, "isoforms": [ { "isoform_ac": "F8WCM5-1", "url": "", "sequence": { "sequence": "MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQASALSLSSSTSTWPEGLDATARAPPALVVTANIGQAGGSSSRQFRQRALGTSDSPVLFIHCPGAAGTAQGLEYRGRRVTTELVWEEVDSSPQPQGSESLPAQPPAQPAPQPEPQQAREPSPEVSCCGLWPRRPQRSQN", "length": 200, "header": "sp|F8WCM5-1|INSR2_HUMAN Isoform 1 of Insulin, isoform 2 OS=Homo sapiens OX=9606 GN=INS-IGF2 PE=1 SV=1 CANONICAL=F8WCM5-1" }, "locus": { "chromosome": "11", "start_pos": 2160971, "end_pos": 2147615, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000356578.8", "url": "https://www.ensembl.org/id/ENST00000356578.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000348986.4", "url": "https://www.ensembl.org/id/ENSP00000348986.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.", "journal": "Hum. Mol. Genet.", "date": "2006", "authors": "Monk D, Sanches R, Arnaud P, Apostolidou S, Hills F A, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Const\u00e2ncia M, Moore G E", "evidence": [ { "database": "UniProtKB", "id": "F8WCM5", "url": "https://www.uniprot.org/uniprot/F8WCM5" } ], "reference": [ { "type": "PubMed", "id": "16531418", "url": "https://glygen.org/publication/PubMed/16531418" } ] }, { "title": "Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.", "journal": "PLoS genetics", "date": "2014", "authors": "Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P, Langefeld CD, Keene KL, Freedman BI, Mychaleckyj JC, Nayak U, Raffel LJ, Goodarzi MO, Chen YD, Taylor HA Jr, Correa A, Sims M, Couper D, 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