{ "uniprot_canonical_ac": "C9JRZ8-1", "uniprot_ac": "C9JRZ8", "uniprot_id": "AK1BF_HUMAN", "mass": { "chemical_mass": 36537.0, "monoisotopic_mass": 36537.0 }, "refseq": { "ac": "NP_001074007", "name": "aldo-keto reductase family 1 member B15 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, "gene_names": [ { "name": "AKR1B15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/C9JRZ8", "id": "C9JRZ8" }, { "name": "AK1R1B7; AKR1B10L; AKR1R1B7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007", "id": "NP_001074007" }, { "name": "AKR1B15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007", "id": "NP_001074007" } ], "protein_names": [ { "name": "Aldo-keto reductase family 1 member B15", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "C9JRZ8" }, { "name": "1.1.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "1.1.1.216", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "1.1.1.300", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "1.1.1.54", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "1.1.1.64", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "Estradiol 17-beta-dehydrogenase AKR1B15", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "Farnesol dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "Testosterone 17beta-dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C9JRZ8" }, { "name": "aldo-keto reductase family 1 member B15 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007", "id": "NP_001074007" }, { "name": "putative aldo-keto reductase family 1 member B15; estradiol 17-beta-dehydrogenase AKR1B15; farnesol dehydrogenase; testosterone 17beta-dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007", "id": "NP_001074007" } ], "function": [ { "annotation": "AKR1B15 and Akr1b16 genes are expressed as functional proteins in human and murine tissues", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, { "database": "PubMed", "id": "21276782", "url": "https://glygen.org/publication/PubMed/21276782" } ] }, { "annotation": "AKR1B15.2 localizes to the cytosol and displays no enzymatic activity with the substrates tested.", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, { "database": "PubMed", "id": "25577493", "url": "https://glygen.org/publication/PubMed/25577493" } ] }, { "annotation": "Amino acid substitutions clustered in loops A and C result in a smaller more hydrophobic and more rigid active site in AKR1B15 compared with the AKR1B10 pocket, consistent with distinct substrate specificity and narrower inhibitor selectivity for AKR1B15. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, { "database": "PubMed", "id": "26222439", "url": "https://glygen.org/publication/PubMed/26222439" } ] }, { "annotation": "Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8#function" }, { "database": "PubMed", "id": "21276782", "url": "https://glygen.org/publication/PubMed/21276782" }, { "database": "PubMed", "id": "26222439", "url": "https://glygen.org/publication/PubMed/26222439" }, { "database": "PubMed", "id": "25577493", "url": "https://glygen.org/publication/PubMed/25577493" } ] }, { "annotation": "Human sperm possess an aldo-keto reductase on their membrane surface and are thus enzymatically protected against reactive aldehyde species both in the male and female reproductive tract", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, { "database": "PubMed", "id": "22970857", "url": "https://glygen.org/publication/PubMed/22970857" } ] }, { "annotation": "No oxidoreductase activity observed with the tested substrates.", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8#function" }, { "database": "PubMed", "id": "25577493", "url": "https://glygen.org/publication/PubMed/25577493" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, { "database": "PubMed", "id": "20877624", "url": "https://glygen.org/publication/PubMed/20877624" } ] }, { "annotation": "Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" }, { "database": "PubMed", "id": "22277967", "url": "https://glygen.org/publication/PubMed/22277967" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "41.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "61.52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "52.65", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "61.86", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "75.3", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "56.13", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "43.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "44.92", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "59.33", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000227471", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000227471" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "C9JRZ8", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/C9JRZ8" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", 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"MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "C9JRZ8", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/C9JRZ8" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "C9JRZ8", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/C9JRZ8" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSHLEDFPFDAEY", "length": 316, "header": "sp|C9JRZ8-1|AK1BF_HUMAN Isoform 1 of Aldo-keto reductase family 1 member B15 OS=Homo sapiens OX=9606 GN=AKR1B15 PE=1 SV=2 CANONICAL=C9JRZ8-1" }, "locus": { "chromosome": "7", "start_pos": 134579546, "end_pos": 134565481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000652743.1", "url": "https://www.ensembl.org/id/ENST00000652743.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000498877.1", "url": "https://www.ensembl.org/id/ENSP00000498877.1" } ] } }, { "isoform_ac": "C9JRZ8-2", "url": "", "sequence": { "sequence": "MVLQMEPQVNSTNNFHQGPLDQPVGPLTGLKSSLLKDTTSAGPLLRPYPASLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSHLEDFPFDAEY", "length": 344, "header": "sp|C9JRZ8-2|AK1BF_HUMAN Isoform 2 of Aldo-keto reductase family 1 member B15 OS=Homo sapiens OX=9606 GN=AKR1B15 PE=1 SV=2 CANONICAL=C9JRZ8-1" }, "locus": { "chromosome": "7", "start_pos": 134579546, "end_pos": 134564620, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000457545.7", "url": "https://www.ensembl.org/id/ENST00000457545.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000389289.1", "url": "https://www.ensembl.org/id/ENSP00000389289.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2002", "authors": "Cohen MH, Johnson JR, Li N, Chen G, Pazdur R", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "11895893", "url": "https://glygen.org/publication/PubMed/11895893" } ] }, { "title": "An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane.", "journal": "Cancer", "date": "2002", "authors": "Buzdar AU, Robertson JF, Eiermann W, Nabholtz JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "12404296", "url": "https://glygen.org/publication/PubMed/12404296" } ] }, { "title": "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.", "journal": "Endocrinology", "date": "2003", "authors": "Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "12697717", "url": "https://glygen.org/publication/PubMed/12697717" } ] }, { "title": "HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines.", "journal": "Journal of drug targeting", "date": "2005", "authors": "Greco F, Vicent MJ, Penning NA, Nicholson RI, Duncan R", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "16332571", "url": "https://glygen.org/publication/PubMed/16332571" } ] }, { "title": "Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.", "journal": "The Biochemical journal", "date": "2007", "authors": "Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "17067289", "url": "https://glygen.org/publication/PubMed/17067289" } ] }, { "title": "Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.", "journal": "Journal of medicinal chemistry", "date": "1991", "authors": "Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "1825337", "url": "https://glygen.org/publication/PubMed/1825337" } ] }, { "title": "Integrated view on 17beta-hydroxysteroid dehydrogenases.", "journal": "Molecular and cellular endocrinology", "date": "2009", "authors": "Moeller G, Adamski J", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "19027824", "url": "https://glygen.org/publication/PubMed/19027824" } ] }, { "title": "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.", "journal": "PloS one", "date": "2010", "authors": "Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" } ], "reference": [ { "type": "PubMed", "id": "20877624", "url": "https://glygen.org/publication/PubMed/20877624" } ] }, { "title": "Functional expression of novel human and murine AKR1B genes.", "journal": "Chemico-biological interactions", "date": "2011", "authors": "Salabei JK, Li XP, Petrash JM, Bhatnagar A, Barski OA", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" }, { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" } ], "reference": [ { "type": "PubMed", "id": "21276782", "url": "https://glygen.org/publication/PubMed/21276782" } ] }, { "title": "Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.", "journal": "The Journal of steroid biochemistry and molecular biology", "date": "1990", "authors": "Bhatnagar AS, Hausler A, Schieweck K, Lang M, Bowman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": 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Christodoulou J, Fletcher JM, Bruno DL, Goldblatt J, Dimauro S, Thorburn DR, Mootha VK", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" } ], "reference": [ { "type": "PubMed", "id": "22277967", "url": "https://glygen.org/publication/PubMed/22277967" } ] }, { "title": "17beta-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer.", "journal": "PloS one", "date": "2012", "authors": "Sivik T, Gunnarsson C, Fornander T, Nordenskjold B, Skoog L, Stal O, Jansson A", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "22792371", "url": "https://glygen.org/publication/PubMed/22792371" } ] }, { "title": "Identification of a role for a mouse sperm surface aldo-keto reductase (AKR1B7) and its human analogue in the detoxification of the reactive aldehyde, acrolein.", "journal": "Andrologia", "date": "2013", "authors": "Jagoe WN, Howe K, O'Brien SC, Carroll J", "evidence": [ { "database": "RefSeq", "id": "NP_001074007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074007" } ], "reference": [ { "type": "PubMed", "id": "22970857", "url": "https://glygen.org/publication/PubMed/22970857" } ] }, { "title": "Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Weber S, Salabei JK, Moller G, Kremmer E, Bhatnagar A, Adamski J, Barski OA", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" }, { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" }, { "database": "RefSeq", "id": "NP_001074007", "url": 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Enzyme and Its Murine Ortholog.", "journal": "PloS one", "date": "2015", "authors": "Gargano EM, Allegretta G, Perspicace E, Carotti A, Van Koppen C, Frotscher M, Marchais-Oberwinkler S, Hartmann RW", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "26230928", "url": "https://glygen.org/publication/PubMed/26230928" } ] }, { "title": "Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo.", "journal": "Steroids", "date": "1981", "authors": "Brodie AM, Garrett WM, Hendrickson JR, Tsai-Morris CH, Marcotte PA, Robinson CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "7336466", "url": "https://glygen.org/publication/PubMed/7336466" } ] }, { "title": "Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis.", "journal": "Endocrine reviews", "date": "1994", "authors": "Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": "PubMed", "id": "8076586", "url": "https://glygen.org/publication/PubMed/8076586" } ] }, { "title": "Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S", "evidence": [ { "database": "Reactome", "id": "R-HSA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-193144" } ], "reference": [ { "type": 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{ "sequence": "MAAFVKLSTKAKMPIVGLGTWKSPPDKVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWPTFFEKSLVKKAFQKTLLDLKLDYLDLYLIHWPQGFQSGNVFLPTDDKGNVLTSKYTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRPSAKPEDPVLLEIPKIKEIASKHKKTAAQVLIRFHIERNVAVIPKSVTPSRIQENIQVFDFQLSEEDMAAILSFNRNWRACGLFAASRNEDFPFHSEY", "length": 316 }, "evidence": [ { "id": "45919720", "url": "http://www.informatics.jax.org/homology/45919720", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "alditol:NADP+ 1-oxidoreductase activity", "id": "GO:0004032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "id": "GO:0004303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004303", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "testosterone 17-beta-dehydrogenase (NADP+) activity", "id": "GO:0047045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047045", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "NADP-retinol dehydrogenase activity", "id": "GO:0052650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052650", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "allyl-alcohol dehydrogenase activity", "id": "GO:0047655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047655", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" }, { "name": "farnesol dehydrogenase activity", "id": "GO:0047886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047886", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "estrogen biosynthetic process", "id": "GO:0006703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006703", "evidence": [ { "database": "UniProtKB", "id": "C9JRZ8", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12168", "name": "", "equation": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51635-1", "P07943-1", "C9JRZ8-1", "O60218-1", "P14550-1", "P15121-1", "P45376-1", "Q9JII6-1", "P00330-1" ], "evidence": [ { "id": "12168", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12168" } ] }, { "id": "14697", "name": "", "equation": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZF77-1", "C9JRZ8-1" ], "evidence": [ { "id": "14697", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14697" } ] }, { "id": "14981", "name": "", "equation": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54939-1", "C9JRZ8-1", "P42330-1", "P37058-1", "P17516-1", "Q04828-1", "P14061-1", "Q96LJ7-1", "P70385-1", "P51656-1", "Q99L04-1" ], "evidence": [ { "id": "14981", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14981" } ] }, { "id": "24616", "name": "", "equation": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7R8-1", "Q62904-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O54939-1", "C9JRZ8-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "P56937-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q5T2L2-1", "P37058-1", "P51656-1", "O70503-1", "O88736-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "P70385-1" ], "evidence": [ { "id": "24616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24616" } ] }, { "id": "25033", "name": "", "equation": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q80ZF7-1", "P07943-1", "D4A8D2-1", "Q8VID1-1", "A0A8I6AEH6-1", "Q6AXX5-1", "D3ZEP9-1", "A0A8I6ASF1-1", "A0A8I6A068-1", "C9JRZ8-1", "O60218-1", "P15121-1", "O75911-1", "Q9NYR8-1", "Q96NR8-1", "Q9HBH5-1", "Q8TC12-1", "Q8IZV5-1", "Q8NBN7-1", "Q9Y394-1", "Q8VCH7-1", "P45376-1", "O88876-1", "Q8CEE7-1", "Q9ERI6-1", "Q8BYK4-1", "Q9QYF1-1", "D3Z6W3-1", "Q99LB2-1", "Q9CXR1-1", "Q9W3K9-1", "Q9VKB8-1" ], "evidence": [ { "id": "25033", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25033" } ] }, { "id": "35607", "name": "", "equation": "acetoin + NADP(+) = diacetyl + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "C9JRZ8-1" ], "evidence": [ { "id": "35607", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35607" } ] }, { "id": "42120", "name": "", "equation": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54939-1", "C9JRZ8-1", "Q04828-1", "P37058-1", "P70385-1" ], "evidence": [ { "id": "42120", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42120" } ] }, { "id": "42156", "name": "", "equation": "androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54939-1", "C9JRZ8-1", "Q04828-1", "P42330-1", "P37058-1", "P70385-1" ], "evidence": [ { "id": "42156", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42156" } ] }, { "id": "46628", "name": "", "equation": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54939-1", "C9JRZ8-1", "P37058-1", "P70385-1" ], "evidence": [ { "id": "46628", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46628" } ] }, { "id": "50616", "name": "", "equation": "NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97584-1", "C9JRZ8-1", "Q14914-1", "Q91YR9-1" ], "evidence": [ { "id": "50616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50616" } ] }, { "id": "54916", "name": "", "equation": "9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07943-1", "A0A8I6AEH6-1", "Q6AXX5-1", "D3ZEP9-1", "A0A8I6ASF1-1", "A0A8I6A068-1", "C9JRZ8-1", "O60218-1", "P15121-1", "Q96NR8-1", "Q9HBH5-1", "Q8TC12-1", "P42330-1", "P45376-1", "Q9ERI6-1", "Q8BYK4-1", "Q9QYF1-1" ], "evidence": [ { "id": "54916", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54916" } ] }, { "id": "58416", "name": "", "equation": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "C9JRZ8-1", "O60218-1" ], "evidence": [ { "id": "58416", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/58416" } ] }, { "id": "58424", "name": "", "equation": "(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07943-1", "A0A8I6AEH6-1", "A0A8I6ASF1-1", "A0A8I6A068-1", "C9JRZ8-1", "O60218-1", "P15121-1", "P45376-1" ], "evidence": [ { "id": "58424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/58424" } ] }, { "id": "R-HSA-5696822", "name": "AKR1B15 reduces EST17b to E1", "equation": "", "summary": "The aldo-keto reductases (AKRs) are multifunctional enzymes that catalyse the reduction of biogenic and xenobiotic aldehydes and ketones as well as the synthesis and metabolism of sex hormones. The newest identified member, Aldo-keto reductase family 1 member B15 (AKR1B15) is able to catalyse the reduction of 17beta-sex hormones such as 17beta-estradiol (EST17b) to estrone (E1). Two isoforms of AKR1B15 exist in different subcellular locations; isoform 2 is cytosolic (like most AKRs) whereas isoform 1 co-localises with the mitochondria (Weber et al. 2015).", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-5696835" ], "output_participant_list": [ "R-ALL-5696848" ], "enzyme_list": [ "C9JRZ8-1" ], "evidence": [ { "id": "R-HSA-5696822", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5696822" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5696835", "participant_name": "EST17b [mitochondrial matrix]", "crossref": [ { "id": "C00951", "database": "COMPOUND", "url": "" }, { "id": "16469", "database": "ChEBI", "url": "" }, { "id": "8143549", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000151", "database": "HMDB Metabolite", "url": "" }, { "id": "000013520815", "database": "ZINC", "url": "" }, { "id": "1013", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "16469", "database": "ChEBI", "url": "" }, { "id": "HMDB0000151", "database": "HMDB Metabolite", "url": "" }, { "id": "1013", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8143549", "database": "PubChem Substance", "url": "" }, { "id": "C00951", "database": "COMPOUND", "url": "" }, { "id": "000013520815", "database": "ZINC", "url": "" }, { "id": "16469", "database": "ChEBI", "url": "" }, { "id": "HMDB0000151", "database": "HMDB Metabolite", "url": "" }, { "id": "1013", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8143549", "database": "PubChem Substance", "url": "" }, { "id": "C00951", "database": "COMPOUND", "url": "" }, { "id": "000013520815", "database": "ZINC", "url": "" }, { "id": "C00951", "database": "COMPOUND", "url": "" }, { "id": "16469", "database": "ChEBI", "url": "" }, { "id": "8143549", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000151", "database": "HMDB Metabolite", "url": "" }, { "id": "000013520815", "database": "ZINC", "url": "" }, { "id": "1013", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8143549", "database": "PubChem Substance", "url": "" }, { "id": "000013520815", "database": "ZINC", "url": "" }, { "id": "C00951", "database": "COMPOUND", "url": "" }, { "id": "16469", "database": "ChEBI", "url": "" }, { "id": "1013", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000151", "database": "HMDB Metabolite", "url": "" }, { "id": "8143549", "database": "PubChem Substance", "url": "" }, { "id": "000013520815", "database": "ZINC", "url": "" }, { "id": "C00951", "database": "COMPOUND", "url": "" }, { "id": "16469", "database": "ChEBI", "url": "" }, { "id": "1013", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000151", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-5696848", "participant_name": "E1 [mitochondrial matrix]", "crossref": [ { "id": "HMDB0000145", "database": "HMDB Metabolite", "url": "" }, { "id": "8144215", "database": "PubChem Substance", "url": "" }, { "id": "C00468", "database": "COMPOUND", "url": "" }, { "id": "2818", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "17263", "database": "ChEBI", "url": "" }, { "id": "000013509425", "database": "ZINC", "url": "" }, { "id": "C00468", "database": "COMPOUND", "url": "" }, { "id": "17263", "database": "ChEBI", "url": "" }, { "id": "HMDB0000145", "database": "HMDB Metabolite", "url": "" }, { "id": "000013509425", "database": "ZINC", "url": "" }, { "id": "8144215", "database": "PubChem Substance", "url": "" }, { "id": "2818", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00468", "database": "COMPOUND", "url": "" }, { "id": "17263", "database": "ChEBI", "url": "" }, { "id": "HMDB0000145", "database": "HMDB Metabolite", "url": "" }, { "id": "000013509425", "database": "ZINC", "url": "" }, { "id": "8144215", "database": "PubChem Substance", "url": "" }, { "id": "2818", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000013509425", "database": "ZINC", "url": "" }, { "id": "17263", "database": "ChEBI", "url": "" }, { "id": "2818", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00468", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000145", "database": "HMDB Metabolite", "url": "" }, { "id": "8144215", "database": "PubChem Substance", "url": "" }, { "id": "C00468", "database": "COMPOUND", "url": "" }, { "id": "17263", "database": "ChEBI", "url": "" }, { "id": "HMDB0000145", "database": "HMDB Metabolite", "url": "" }, { "id": "000013509425", "database": "ZINC", "url": "" }, { "id": "8144215", "database": "PubChem Substance", "url": "" }, { "id": "2818", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00468", "database": "COMPOUND", "url": "" }, { "id": "17263", "database": "ChEBI", "url": "" }, { "id": "HMDB0000145", "database": "HMDB Metabolite", "url": "" }, { "id": "000013509425", "database": "ZINC", "url": "" }, { "id": "8144215", "database": "PubChem Substance", "url": "" }, { "id": "2818", "database": "Guide to Pharmacology - Ligands", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6A068", "gene_name": "Akr1b1-ps2", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "A0A8I6A068", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A068" } ] }, { "ec_number": "1.1.1.21", "activity": "an alditol + NADP(+) = an aldose + H(+) + NADPH.", "evidence": [ { "id": "A0A8I6A068", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A068" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0A8I6A068", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A068" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "A0A8I6A068", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A068" } ] } ] }, { "uniprot_ac": "A0A8I6AEH6", "gene_name": "AC127963.2", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "A0A8I6AEH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AEH6" } ] }, { "ec_number": "1.1.1.21", "activity": "an alditol + NADP(+) = an aldose + H(+) + NADPH.", "evidence": [ { "id": "A0A8I6AEH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AEH6" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0A8I6AEH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AEH6" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "A0A8I6AEH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AEH6" } ] } ] }, { "uniprot_ac": "A0A8I6ASF1", "gene_name": "Akr1b1-ps1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "A0A8I6ASF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ASF1" } ] }, { "ec_number": "1.1.1.21", "activity": "an alditol + NADP(+) = an aldose + H(+) + NADPH.", "evidence": [ { "id": "A0A8I6ASF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ASF1" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "A0A8I6ASF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ASF1" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0A8I6ASF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ASF1" } ] } ] }, { "uniprot_ac": "C9JRZ8", "gene_name": "AKR1B15", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.216", "activity": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] } ] }, { "uniprot_ac": "D3Z6W3", "gene_name": "Rdh8", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "D3Z6W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z6W3" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "D3Z6W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z6W3" } ] } ] }, { "uniprot_ac": "D3ZEP9", "gene_name": "Rdh12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "D3ZEP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEP9" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "D3ZEP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEP9" } ] } ] }, { "uniprot_ac": "D3ZF77", "gene_name": "Akr1c15", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "D3ZF77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZF77" } ] }, { "ec_number": "1.1.1.216", "activity": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH.", "evidence": [ { "id": "D3ZF77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZF77" } ] }, { "ec_number": "1.1.1.216", "activity": "", "evidence": [ { "id": "D3ZF77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZF77" } ] } ] }, { "uniprot_ac": "D4A8D2", "gene_name": "Rdh8", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "D4A8D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8D2" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "D4A8D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8D2" } ] } ] }, { "uniprot_ac": "O14756", "gene_name": "HSD17B6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] } ] }, { "uniprot_ac": "O54753", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] } ] }, { "uniprot_ac": "O54939", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] } ] }, { "uniprot_ac": "O60218", "gene_name": "AKR1B10", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "O60218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60218" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "O60218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60218" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "O60218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60218" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "O60218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60218" } ] } ] }, { "uniprot_ac": "O70503", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] } ] }, { "uniprot_ac": "O75911", "gene_name": "DHRS3", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "O75911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75911" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "O75911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75911" } ] } ] }, { "uniprot_ac": "O88736", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] } ] }, { "uniprot_ac": "O88876", "gene_name": "Dhrs3", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "O88876", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88876" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "O88876", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88876" } ] } ] }, { "uniprot_ac": "P00330", "gene_name": "ADH1", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P00330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00330" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "P00330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00330" } ] }, { "ec_number": "1.1.1.78", "activity": "(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH.", "evidence": [ { "id": "P00330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00330" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P00330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00330" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P00330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00330" } ] }, { "ec_number": "1.1.1.78", "activity": "", "evidence": [ { "id": "P00330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00330" } ] } ] }, { "uniprot_ac": "P07943", "gene_name": "Akr1b1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.21", "activity": "an alditol + NADP(+) = an aldose + H(+) + NADPH.", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH.", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P07943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07943" } ] } ] }, { "uniprot_ac": "P14061", "gene_name": "HSD17B1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] } ] }, { "uniprot_ac": "P14550", "gene_name": "AKR1A1", "activity": [ { "ec_number": "1.1.1.2", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.19", "activity": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH.", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.20", "activity": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH.", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH.", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.2", "activity": "", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P14550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14550" } ] } ] }, { "uniprot_ac": "P15121", "gene_name": "AKR1B1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.21", "activity": "an alditol + NADP(+) = an aldose + H(+) + NADPH.", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH.", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "P15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15121" } ] } ] }, { "uniprot_ac": "P17516", "gene_name": "AKR1C4", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.225", "activity": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] } ] }, { "uniprot_ac": "P37058", "gene_name": "HSD17B3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] } ] }, { "uniprot_ac": "P42330", "gene_name": "AKR1C3", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.188", "activity": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] } ] }, { "uniprot_ac": "P45376", "gene_name": "Akr1b1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.21", "activity": "an alditol + NADP(+) = an aldose + H(+) + NADPH.", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH.", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P45376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45376" } ] } ] }, { "uniprot_ac": "P51635", "gene_name": "Akr1a1", "activity": [ { "ec_number": "1.1.1.2", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.19", "activity": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH.", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.20", "activity": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH.", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH.", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.2", "activity": "", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.20", "activity": "", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] }, { "ec_number": "1.1.1.19", "activity": "", "evidence": [ { "id": "P51635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51635" } ] } ] }, { "uniprot_ac": "P51656", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] } ] }, { "uniprot_ac": "P51657", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] } ] }, { "uniprot_ac": "P52895", "gene_name": "AKR1C2", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] } ] }, { "uniprot_ac": "P56937", "gene_name": "HSD17B7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] } ] }, { "uniprot_ac": "P70385", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] } ] }, { "uniprot_ac": "P97584", "gene_name": "Ptgr1", "activity": [ { "ec_number": "1.3.1.74", "activity": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH.", "evidence": [ { "id": "P97584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97584" } ] }, { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH.", "evidence": [ { "id": "P97584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97584" } ] }, { "ec_number": "1.3.1.74", "activity": "", "evidence": [ { "id": "P97584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97584" } ] }, { "ec_number": "1.3.1.48", "activity": "", "evidence": [ { "id": "P97584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97584" } ] } ] }, { "uniprot_ac": "Q04828", "gene_name": "AKR1C1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.149", "activity": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] } ] }, { "uniprot_ac": "Q14914", "gene_name": "PTGR1", "activity": [ { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH.", "evidence": [ { "id": "Q14914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14914" } ] }, { "ec_number": "1.3.1.48", "activity": "", "evidence": [ { "id": "Q14914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14914" } ] }, { "ec_number": "1.3.1.74", "activity": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH.", "evidence": [ { "id": "Q14914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14914" } ] }, { "ec_number": "1.3.1.74", "activity": "", "evidence": [ { "id": "Q14914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14914" } ] } ] }, { "uniprot_ac": "Q3U0B3", "gene_name": "Dhrs11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] } ] }, { "uniprot_ac": "Q53GQ0", "gene_name": "HSD17B12", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] } ] }, { "uniprot_ac": "Q5T2L2", "gene_name": "AKR1C8", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5T2L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T2L2" } ] } ] }, { "uniprot_ac": "Q62904", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] } ] }, { "uniprot_ac": "Q6AXX5", "gene_name": "Rdh11", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q6AXX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXX5" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q6AXX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXX5" } ] } ] }, { "uniprot_ac": "Q6AYS8", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] } ] }, { "uniprot_ac": "Q6P7R8", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] } ] }, { "uniprot_ac": "Q6UWP2", "gene_name": "DHRS11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] } ] }, { "uniprot_ac": "Q80ZF7", "gene_name": "Rdh10", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q80ZF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZF7" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q80ZF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZF7" } ] } ] }, { "uniprot_ac": "Q8BYK4", "gene_name": "Rdh12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8BYK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYK4" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8BYK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYK4" } ] } ] }, { "uniprot_ac": "Q8CEE7", "gene_name": "Rdh13", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8CEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CEE7" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8CEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CEE7" } ] } ] }, { "uniprot_ac": "Q8IZV5", "gene_name": "RDH10", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8IZV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IZV5" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8IZV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IZV5" } ] } ] }, { "uniprot_ac": "Q8NBN7", "gene_name": "RDH13", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8NBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBN7" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8NBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBN7" } ] } ] }, { "uniprot_ac": "Q8NBQ5", "gene_name": "HSD17B11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] } ] }, { "uniprot_ac": "Q8TC12", "gene_name": "RDH11", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8TC12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC12" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8TC12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC12" } ] } ] }, { "uniprot_ac": "Q8VCH7", "gene_name": "Rdh10", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8VCH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH7" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8VCH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH7" } ] } ] }, { "uniprot_ac": "Q8VID1", "gene_name": "Dhrs4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] } ] }, { "uniprot_ac": "Q91YR9", "gene_name": "Ptgr1", "activity": [ { "ec_number": "1.3.1.74", "activity": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH.", "evidence": [ { "id": "Q91YR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YR9" } ] }, { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH.", "evidence": [ { "id": "Q91YR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YR9" } ] } ] }, { "uniprot_ac": "Q96LJ7", "gene_name": "DHRS1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q96LJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LJ7" } ] } ] }, { "uniprot_ac": "Q96NR8", "gene_name": "RDH12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q96NR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96NR8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q96NR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96NR8" } ] } ] }, { "uniprot_ac": "Q99L04", "gene_name": "Dhrs1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q99L04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99L04" } ] } ] }, { "uniprot_ac": "Q99LB2", "gene_name": "Dhrs4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q99LB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LB2" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "Q99LB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LB2" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q99LB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LB2" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q99LB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LB2" } ] } ] }, { "uniprot_ac": "Q9CXR1", "gene_name": "Dhrs7", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q9CXR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CXR1" } ] } ] }, { "uniprot_ac": "Q9EQ06", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9EQ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQ06" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q9EQ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQ06" } ] } ] }, { "uniprot_ac": "Q9ERI6", "gene_name": "Rdh14", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q9ERI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERI6" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q9ERI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERI6" } ] } ] }, { "uniprot_ac": "Q9HBH5", "gene_name": "RDH14", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q9HBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBH5" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q9HBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBH5" } ] } ] }, { "uniprot_ac": "Q9JII6", "gene_name": "Akr1a1", "activity": [ { 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