{ "uniprot_canonical_ac": "C7G034-1", "uniprot_ac": "C7G034", "uniprot_id": "C7G034_DICDI", "mass": { "chemical_mass": 425074.0, "monoisotopic_mass": 425074.0 }, "refseq": { "ac": "XP_002649137", "name": "hypothetical protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002649137" }, "gene_names": [ { "name": "DDB_G0285063", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/C7G034", "id": "C7G034" } ], "protein_names": [ { "name": "HECT-type E3 ubiquitin transferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "C7G034" }, { "name": "2.3.2.26", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "C7G034" }, { "name": "hypothetical protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002649137", "id": "XP_002649137" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/C7G034", "locus": {} } ], "crossref": [ { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0285063", "url": "http://dictybase.org/gene/DDB_G0285063", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8624873", "url": "https://www.ncbi.nlm.nih.gov/gene/8624873", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0285063", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0285063", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AESPQIN", "url": "https://omabrowser.org/oma/group/AESPQIN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00632", "url": "http://pfam.xfam.org/family/PF00632", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06012", "url": "http://pfam.xfam.org/family/PF06012", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06025", "url": "http://pfam.xfam.org/family/PF06025", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14377", "url": "http://pfam.xfam.org/family/PF14377", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1169408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8948751", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9013406", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013406", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9013420", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013420", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_002649137", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002649137", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C7G034-1", "url": "https://www.uniprot.org/uniprot/C7G034-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGKLSKVYKIITEEKNFIETLVHCPEEQLKNILLKFKEWPFGKTDDFNHWVDVLERFDSIIGKIVTKYHPTPSSSGKSTNPISSAASSSTSSSSSSASSSNTTLSTSSSSNTSPPCILNVDNNPDFPNDKEFIILIIKFTRSLLRNCINSNLFNSSDELNSLFTFPDYDILIELFKFFNVLFSKKKFVKDNSSFIQTIIPKLSIISSGFNEDHLHPLSLCKEDTKIPESLNSFNFEFYKSKSKTTVNTKSTTTTTTTTTTPSSTSPPTSNININSKSIFFEKITVSTIEESGKVIIRLFDIDKINATPYEIASKLIQDYGIPEEDQYFVHFRIGLLKGLPNYEYRKKYMQLRLVATNTLYHQSLINFASNSTNYNFGGTQDTEYLGELMELLKNYTIVPEPILVASIYTMAALASTTPTSSLTLLLQRSFSSGFFSSVIRKCVAVITGTSQDPLITESFINAMFYFVFKLSNKALLHENIVFQSLLPLIKNHTTNIYHLRFQINALQIIQSLFLVKLNNIELFSEQGYLQDLIASISEEVDFIINYKKPEETKDDLVVENTYFSKKSSSSTNISDESKKKKPLVHSGSSSNILNKKEDKDLLQLTTNTNTITTSTTEQQLIDSTTKKEYKFDENILNDEFYLKLLYHKSTLLLGLMNCLLPISGTAVIPRALLNQIVDSPIHQVLKSIFSHYESFIPAIIADCFIIPTNLIQNEPTCFTAINNTGLIDMIFDFILNKEIPHEILYIIPETLNAFCLNSAFKTKVSESGLIRKFLKTLVNPKNVNSLNIRTLNSIGNGLDELVRHHPELKIPTIKEIISLLDDVIAMTPPKEPKSSPSSSTAALEKSTHNQMFLLINKFITLFFSNGEHDKIFIQEGGLEKLLDIYTSSQFICKDLMIFKSLSIDNTPTVLRSIIKVLNNHFTTLDVLCEWRTSRIIRDWVPEELACRDDIQSTIDVIKSLVLILTSLVRENPPDIPLPVLDEWSKEDGLSVYSSLCALQKAFYWEFSCGENSVFCLPNPLNKPSSSSSSSTTTTTTTNESPTNKHISSSSSSSSSSTTSSTNNNNETSNNENTTTTTTTTTTTTTTATTTTTVTQPPLDLNLFLNSSLLTNLEDLSRYFFETINSLNKRDGLNYETKTELLTKNISKNLVGWIQWKPEESDPCAKTQYYVYISKVLTNNSTLLFPQLINGLYDVGYFDTFFGILSDLTDRYIECIPNGNLDAFKYSQPLTQCGSLLRQAIFQLTSSKSMNGGTLPSLKSISEKIIPNLVFNLQNYWNHPQLSDLPYAKNLLDCVHDVFLKYDGVAQQQTQQQQDPSKKSSIQSPPSRPTFVPNENSINTLMDMGFIREHIETAMQSLQSNNVDNITDWMLSNPYIPEDEEKKAKEKAEKAEKAEKERLEKEKAEKEKQNSITSLLNGLRPTLFDRTLSILLNVKGHSSNELDSIFKMFHFIIKDGNISETKEIIANRLIQEVQTHLVEEKLKFFSFKTKSLFFIIQKLNESPEISGLFVEKGLLALVIKVISNLLKDHLVRNDDSIQISVTPLDSSTTTTTTTTTSTNDDKISTSTTPSKRPKSPTTTSESILIYLNGLLSITYDLSKKQLIKPTNNFDFEAEEKKLQKQQEEEQDRCSPTDTTLIDICLGLLKPSPSIIDGSLLKLISELTKNYAIANYFMKNQGMLLLQAKNTKSSMLKENTIYVINIFKQLLDDNKTVYNTMQSNIRHTINNKGVSKGIPTKTLLGLLSKDVSKNPITFLKACSEICRIHTNSNSVYLSAQANEIFEKNVSSCELKDFPHFQQLSNFLIKSLLIKDETPISTTSSISTTTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTTNNTPTPAQLSKELRKSSSLKSITSVAAALAADQQLQDKTSNILSKANILRLLEELLIQYPLFQQTILNYQGVNLVQYVFEHFLPCTSLTAEEKASGELFNATHQAASRFLVSLCSTEDGREKVFSAIAEHLKLSIAEYSSQNVANKKIPYNKMVSISNLVSLLLNFPPHSLSSEFNQLMINNDMINILLELLNLVDVGSSRASQMINSLLQTIGHLTKFSSLPKPTTEEDSTRTNMFQLPYQAYDGFFRATRDFQTNATSFNGGGPPGTIEFDSEFENDMHHSNSIGVGSRRLDFSSDSEDEVIEMDEDDEDDDEDDDDEDDSDGEDGEDIEMVIENGMDGQIDDAIINDEQDSDDEEEEVENTNDSDGSSSSSEDDQNDVDDDDDDDDDDDDDDEEDDDSNNEDNLQRGRQFAQIDHINHIQHQNHHHHPQQQQHHQQQQHHLINHFRGAHQNFNPMMEQAFLGGDRRLAMPQGGSDANLRNWIGENVERNLSNILVALGQNEGRIEDLIRSDPGQLTRNLERFEQMIMNFDLRSNARLRLGRDGNLYSFDFNRLKNDTDESVAYAQSFELILIKILTTITKEEEAAQKAKEKAEKEKLKEELRAKEKAEKEKLKELKRQQKEKEEKERAEKVEITTTETKIDSITDSIAATTTTSPTTNDVSTTSTPTTPKTVTNSPTITAAVNDPLPIEPLTIEPLVTSPPIQQSSTEVNTPLPTTTSNESTNKSTNESTTTTTSNESTSESTNESTTTTNNNENAPLEESGTSTSSITETTNLPPTTTTTTTPPPATTTTTTSPTVESEASSSTTTSSTTTSSTTTTTTSTNPPTTQAPPAPINVDLGIDPTFLAALPAELRAEVLSTQLTSIHQSNTGDGPITINPEFLSALPLEIQNEVLEQERIISERRASQAARNVARVSVNPTDLVQDMDNASFLATLPPDLREEVLMSQPEAFLQTLPPELHAEAVRLRETHPPRFEFRSSIPDSFNRIPSPRRILKEVAKPKKVNQAGSLVKKENLLALIKILHFDQSINRQQLNSILVQICTFSDNREELLCYILQILTGYQSIVSQQPQRKTAESDKFSPITDPCHPLMRFRMFRSFEVTNHPPLLVVKRLLDILQSLTTGNSLTVNWMLTPQPIVPSTQSQNSHGKEKDDGSGSTSPSLEKACPLWKLCDALNDKNIFSKSLLLERLISILLLIVDSTSTEKPKIPLIPSQQVESLINTLLAGNPKIGSLLVTIAVSCDENRQIILDQLNTNAKRLTKDVINNLESMKQIFNDTDVSPQNYLPSSTKENNFLRVLQTIQSILNPKKPDPIIEQQQQQQQQQQQQQQQQQQQQQQQQSPSSTAANSITSPAASTTTPITESATTETTPSTTTPSTSNTTPTTTTTTTTTNTKKEQPSMTLGEYFSNNHELDILWGSIKSFLTLFSLEKEEKEPITKLKLTSKKKAGSNPMNSLLLPLVEIYFLVNSPTSEMLSSTMIPSSPSLAGLKLSSSVGNGLSASTSNGNLAGTPPIMDYNTSRFFEFVEQNKHLINDLVRQDNSLLSESLAVLIKTPRFLDFDNKRTYFRNYFQSKKERSSTIRLKVRRNHIFEDSYNQLRMRPAEELKGKLNIQFSGEEGLDAGGLLREWYLVLSREMFNPGYALFKQSASDNVTFQPNPESYINPDHLSYFKFIGRIIGKALYDGLMLDAFFTRSFYKHMLGLTINVSDMEAIDPTYHKNLLWILDNDITNVMELTFSTEIDIFDSMKVIELKPNGANIPVTEDNKLEYVRLVASVRMTNSIKDQINSFLEGFHELIPKSLIGIFNEMELELLISGLPEIDIDDLRANTEYSGYSSDSQQILWFWNTVSNFSNEEKASLLQFVTGTSKVPLEGFKALGGMGGPQKFQIHRIRGNAHRLPTAHTCFNQLDIPEYESQEQLKKLLKIAIGEASEGFGFV", "length": 3792, "header": "tr|C7G034-1|C7G034_DICDI Isoform 1 of HECT-type E3 ubiquitin transferase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=C7G034-1" }, "isoforms": [ { "isoform_ac": "C7G034-1", "url": "", "sequence": { "sequence": "MKGKLSKVYKIITEEKNFIETLVHCPEEQLKNILLKFKEWPFGKTDDFNHWVDVLERFDSIIGKIVTKYHPTPSSSGKSTNPISSAASSSTSSSSSSASSSNTTLSTSSSSNTSPPCILNVDNNPDFPNDKEFIILIIKFTRSLLRNCINSNLFNSSDELNSLFTFPDYDILIELFKFFNVLFSKKKFVKDNSSFIQTIIPKLSIISSGFNEDHLHPLSLCKEDTKIPESLNSFNFEFYKSKSKTTVNTKSTTTTTTTTTTPSSTSPPTSNININSKSIFFEKITVSTIEESGKVIIRLFDIDKINATPYEIASKLIQDYGIPEEDQYFVHFRIGLLKGLPNYEYRKKYMQLRLVATNTLYHQSLINFASNSTNYNFGGTQDTEYLGELMELLKNYTIVPEPILVASIYTMAALASTTPTSSLTLLLQRSFSSGFFSSVIRKCVAVITGTSQDPLITESFINAMFYFVFKLSNKALLHENIVFQSLLPLIKNHTTNIYHLRFQINALQIIQSLFLVKLNNIELFSEQGYLQDLIASISEEVDFIINYKKPEETKDDLVVENTYFSKKSSSSTNISDESKKKKPLVHSGSSSNILNKKEDKDLLQLTTNTNTITTSTTEQQLIDSTTKKEYKFDENILNDEFYLKLLYHKSTLLLGLMNCLLPISGTAVIPRALLNQIVDSPIHQVLKSIFSHYESFIPAIIADCFIIPTNLIQNEPTCFTAINNTGLIDMIFDFILNKEIPHEILYIIPETLNAFCLNSAFKTKVSESGLIRKFLKTLVNPKNVNSLNIRTLNSIGNGLDELVRHHPELKIPTIKEIISLLDDVIAMTPPKEPKSSPSSSTAALEKSTHNQMFLLINKFITLFFSNGEHDKIFIQEGGLEKLLDIYTSSQFICKDLMIFKSLSIDNTPTVLRSIIKVLNNHFTTLDVLCEWRTSRIIRDWVPEELACRDDIQSTIDVIKSLVLILTSLVRENPPDIPLPVLDEWSKEDGLSVYSSLCALQKAFYWEFSCGENSVFCLPNPLNKPSSSSSSSTTTTTTTNESPTNKHISSSSSSSSSSTTSSTNNNNETSNNENTTTTTTTTTTTTTTATTTTTVTQPPLDLNLFLNSSLLTNLEDLSRYFFETINSLNKRDGLNYETKTELLTKNISKNLVGWIQWKPEESDPCAKTQYYVYISKVLTNNSTLLFPQLINGLYDVGYFDTFFGILSDLTDRYIECIPNGNLDAFKYSQPLTQCGSLLRQAIFQLTSSKSMNGGTLPSLKSISEKIIPNLVFNLQNYWNHPQLSDLPYAKNLLDCVHDVFLKYDGVAQQQTQQQQDPSKKSSIQSPPSRPTFVPNENSINTLMDMGFIREHIETAMQSLQSNNVDNITDWMLSNPYIPEDEEKKAKEKAEKAEKAEKERLEKEKAEKEKQNSITSLLNGLRPTLFDRTLSILLNVKGHSSNELDSIFKMFHFIIKDGNISETKEIIANRLIQEVQTHLVEEKLKFFSFKTKSLFFIIQKLNESPEISGLFVEKGLLALVIKVISNLLKDHLVRNDDSIQISVTPLDSSTTTTTTTTTSTNDDKISTSTTPSKRPKSPTTTSESILIYLNGLLSITYDLSKKQLIKPTNNFDFEAEEKKLQKQQEEEQDRCSPTDTTLIDICLGLLKPSPSIIDGSLLKLISELTKNYAIANYFMKNQGMLLLQAKNTKSSMLKENTIYVINIFKQLLDDNKTVYNTMQSNIRHTINNKGVSKGIPTKTLLGLLSKDVSKNPITFLKACSEICRIHTNSNSVYLSAQANEIFEKNVSSCELKDFPHFQQLSNFLIKSLLIKDETPISTTSSISTTTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTTNNTPTPAQLSKELRKSSSLKSITSVAAALAADQQLQDKTSNILSKANILRLLEELLIQYPLFQQTILNYQGVNLVQYVFEHFLPCTSLTAEEKASGELFNATHQAASRFLVSLCSTEDGREKVFSAIAEHLKLSIAEYSSQNVANKKIPYNKMVSISNLVSLLLNFPPHSLSSEFNQLMINNDMINILLELLNLVDVGSSRASQMINSLLQTIGHLTKFSSLPKPTTEEDSTRTNMFQLPYQAYDGFFRATRDFQTNATSFNGGGPPGTIEFDSEFENDMHHSNSIGVGSRRLDFSSDSEDEVIEMDEDDEDDDEDDDDEDDSDGEDGEDIEMVIENGMDGQIDDAIINDEQDSDDEEEEVENTNDSDGSSSSSEDDQNDVDDDDDDDDDDDDDDEEDDDSNNEDNLQRGRQFAQIDHINHIQHQNHHHHPQQQQHHQQQQHHLINHFRGAHQNFNPMMEQAFLGGDRRLAMPQGGSDANLRNWIGENVERNLSNILVALGQNEGRIEDLIRSDPGQLTRNLERFEQMIMNFDLRSNARLRLGRDGNLYSFDFNRLKNDTDESVAYAQSFELILIKILTTITKEEEAAQKAKEKAEKEKLKEELRAKEKAEKEKLKELKRQQKEKEEKERAEKVEITTTETKIDSITDSIAATTTTSPTTNDVSTTSTPTTPKTVTNSPTITAAVNDPLPIEPLTIEPLVTSPPIQQSSTEVNTPLPTTTSNESTNKSTNESTTTTTSNESTSESTNESTTTTNNNENAPLEESGTSTSSITETTNLPPTTTTTTTPPPATTTTTTSPTVESEASSSTTTSSTTTSSTTTTTTSTNPPTTQAPPAPINVDLGIDPTFLAALPAELRAEVLSTQLTSIHQSNTGDGPITINPEFLSALPLEIQNEVLEQERIISERRASQAARNVARVSVNPTDLVQDMDNASFLATLPPDLREEVLMSQPEAFLQTLPPELHAEAVRLRETHPPRFEFRSSIPDSFNRIPSPRRILKEVAKPKKVNQAGSLVKKENLLALIKILHFDQSINRQQLNSILVQICTFSDNREELLCYILQILTGYQSIVSQQPQRKTAESDKFSPITDPCHPLMRFRMFRSFEVTNHPPLLVVKRLLDILQSLTTGNSLTVNWMLTPQPIVPSTQSQNSHGKEKDDGSGSTSPSLEKACPLWKLCDALNDKNIFSKSLLLERLISILLLIVDSTSTEKPKIPLIPSQQVESLINTLLAGNPKIGSLLVTIAVSCDENRQIILDQLNTNAKRLTKDVINNLESMKQIFNDTDVSPQNYLPSSTKENNFLRVLQTIQSILNPKKPDPIIEQQQQQQQQQQQQQQQQQQQQQQQQSPSSTAANSITSPAASTTTPITESATTETTPSTTTPSTSNTTPTTTTTTTTTNTKKEQPSMTLGEYFSNNHELDILWGSIKSFLTLFSLEKEEKEPITKLKLTSKKKAGSNPMNSLLLPLVEIYFLVNSPTSEMLSSTMIPSSPSLAGLKLSSSVGNGLSASTSNGNLAGTPPIMDYNTSRFFEFVEQNKHLINDLVRQDNSLLSESLAVLIKTPRFLDFDNKRTYFRNYFQSKKERSSTIRLKVRRNHIFEDSYNQLRMRPAEELKGKLNIQFSGEEGLDAGGLLREWYLVLSREMFNPGYALFKQSASDNVTFQPNPESYINPDHLSYFKFIGRIIGKALYDGLMLDAFFTRSFYKHMLGLTINVSDMEAIDPTYHKNLLWILDNDITNVMELTFSTEIDIFDSMKVIELKPNGANIPVTEDNKLEYVRLVASVRMTNSIKDQINSFLEGFHELIPKSLIGIFNEMELELLISGLPEIDIDDLRANTEYSGYSSDSQQILWFWNTVSNFSNEEKASLLQFVTGTSKVPLEGFKALGGMGGPQKFQIHRIRGNAHRLPTAHTCFNQLDIPEYESQEQLKKLLKIAIGEASEGFGFV", "length": 3792, "header": "tr|C7G034-1|C7G034_DICDI Isoform 1 of HECT-type E3 ubiquitin transferase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=C7G034-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0285063", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0285063", "resource": "KEGG Pathway" }, { "id": "R-DDI-1169408", "name": "ISG15 antiviral mechanism", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" }, { "id": "R-DDI-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-DDI-8948751", "name": "Regulation of PTEN stability and activity", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-DDI-9013406", "name": "RHOQ GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-DDI-9013420", "name": "RHOU GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013420", "resource": "Reactome", "description": "RHOU GTPase cycle" }, { "id": "R-DDI-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "C7G034", "url": "https://www.uniprot.org/uniprot/C7G034" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1066, "end_pos": 1068, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1073, "end_pos": 1075, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1106, "end_pos": 1108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1145, "end_pos": 1147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1179, "end_pos": 1181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1180, "end_pos": 1182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1365, "end_pos": 1367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1457, "end_pos": 1459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1500, "end_pos": 1502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1709, "end_pos": 1711, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1783, "end_pos": 1785, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1853, "end_pos": 1855, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1856, "end_pos": 1858, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1955, "end_pos": 1957, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2112, "end_pos": 2114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2220, "end_pos": 2222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2347, "end_pos": 2349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2413, "end_pos": 2415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2577, "end_pos": 2579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2581, "end_pos": 2583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2585, "end_pos": 2587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2594, "end_pos": 2596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2602, "end_pos": 2604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2785, "end_pos": 2787, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3131, "end_pos": 3133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3235, "end_pos": 3237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3373, "end_pos": 3375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3507, "end_pos": 3509, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3561, "end_pos": 3563, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3705, "end_pos": 3707, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 395, "end_pos": 397, "annotation": "n_glycosylation_sequon" }, { "start_pos": 492, "end_pos": 494, "annotation": "n_glycosylation_sequon" }, { "start_pos": 573, "end_pos": 575, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54QF1-1", "C7G034-1" ], "evidence": [ { "id": "R-DDI-1169399", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1169399" } ] }, { "id": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DN5-1", "Q54QV7-1", "C7G034-1", "Q54I82-1", "Q54QS3-1", "Q54RF5-1", "Q54UQ2-1", "Q54V35-1", "Q54V83-1", "Q54VI4-1", "Q55E06-1", "Q55FF3-1", "Q5V9E9-1", "Q86A67-1", "Q86IJ1-1", "Q86AU1-1", "O77229-1", "P0CT31-1", "P15112-1", "P22887-1", "P34093-1", "Q00766-1", "Q54DD0-1", "Q54DK3-1", "Q54LY5-1", "Q54MA9-1", "Q54NE6-1", "Q54QQ0-1", "Q54QR2-1", "Q555L5-1", "Q556G3-1", "Q55EK9-1", "Q6TMK4-1", "Q75JR2-1" ], "evidence": [ { "id": "R-DDI-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798748" } ] }, { "id": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DN5-1", "Q54QV7-1", "Q54R55-1", "C7G034-1", "Q54GE1-1", "Q54I82-1", "Q54QD9-1", "Q54QS3-1", "Q54RF5-1", "Q54UQ2-1", "Q54V35-1", "Q54V83-1", "Q54VI4-1", "Q54Y06-1", "Q54YA0-1", "Q55E06-1", "Q55FF3-1", "Q5V9E9-1", "Q86A67-1", "Q86IJ1-1", "Q94503-1", "Q55GA9-1", "Q86AU1-1", "O76856-1", "O77229-1", "P04989-1", "P0CT31-1", "P15112-1", "P22887-1", "P34093-1", "P42525-1", "P52922-1", "P54639-1", "P54640-1", "Q00766-1", "Q23894-1", "Q23919-1", "Q54B14-1", "Q54DD0-1", "Q54DK3-1", "Q54MA9-1", "Q54NE6-1", "Q54QQ0-1", "Q54QR2-1", "Q555L5-1", "Q556G3-1", "Q75JR2-1", "Q8MUF9-1", "Q94504-1" ], "evidence": [ { "id": "R-DDI-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6800434" } ] }, { "id": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54QF1-1", "C7G034-1", "Q54JL7-1", "Q8T9S7-1" ], "evidence": [ { "id": "R-DDI-6807134", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6807134" } ] }, { "id": "R-DDI-9018746", "name": "RHOQ binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54QF1-1", "C7G034-1", "P36411-1", "Q55D99-1", "Q55DD4-1", "Q55GV3-1", "Q869N2-1" ], "evidence": [ { "id": "R-DDI-9018746", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9018746" } ] }, { "id": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54QF1-1", "Q553T4-1", "C7G034-1", "Q55D99-1", "Q55DD4-1", "Q55GV3-1", "Q869N2-1" ], "evidence": [ { "id": "R-DDI-9018766", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9018766" } ] }, { "id": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DN5-1", "Q54FX4-1", "Q54GG5-1", "Q54IL3-1", "Q54KP2-1", "Q54LZ6-1", "Q54QF1-1", "Q54QS0-1", "Q54TM9-1", "Q54VW9-1", "Q54VX1-1", "Q54XG4-1", "Q55DC5-1", "Q54N05-1", "Q54VG3-1", "C7G034-1", "Q54I43-1", "Q54LP7-1", "Q54QG5-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q555H8-1", "Q55EY8-1", "Q86K32-1", "Q55CM4-1", "Q75JE1-1", "Q75JS0-1", "Q8T2Q2-1", "Q54HT1-1", "Q557E7-1", "Q557I6-1", "Q55C16-1", "Q6T486-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983140" } ] }, { "id": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DN5-1", "Q54GG5-1", "Q54IL3-1", "Q54KP2-1", "Q54LZ6-1", "Q54QF1-1", "Q54QS0-1", "Q54TM9-1", "Q54VX1-1", "Q54XG4-1", "Q55DC5-1", "Q54N05-1", "C7G034-1", "Q54QG5-1", "Q555H8-1", "Q55CM4-1", "Q75JS0-1", "Q8T2Q2-1", "Q54HT1-1", "Q557E7-1", "Q557I6-1", "Q6T486-1" ], "evidence": [ { "id": "R-DDI-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983147" } ] }, { "id": "R-DDI-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DN5-1", "Q54FX4-1", "Q54GG5-1", "Q54IL3-1", "Q54KP2-1", "Q54LZ6-1", "Q54QF1-1", "Q54QS0-1", "Q54TM9-1", "Q54VW9-1", "Q54VX1-1", "Q54XG4-1", "Q55DC5-1", "Q54N05-1", "Q54VG3-1", "C7G034-1", "Q54I43-1", "Q54LP7-1", "Q54QG5-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q555H8-1", "Q55EY8-1", "Q86K32-1", "Q55CM4-1", "Q75JE1-1", "Q75JS0-1", "Q8T2Q2-1", "Q54HT1-1", "Q557E7-1", "Q557I6-1", "Q55C16-1", "Q6T486-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983156" } ] }, { "id": "R-DDI-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DN5-1", "Q54FX4-1", "Q54GG5-1", "Q54IL3-1", "Q54KP2-1", "Q54LZ6-1", "Q54QF1-1", "Q54QS0-1", "Q54TM9-1", "Q54VW9-1", "Q54VX1-1", "Q54XG4-1", "Q55DC5-1", "Q54N05-1", "Q54VG3-1", "C7G034-1", "Q54I43-1", "Q54LP7-1", "Q54QG5-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q555H8-1", "Q55EY8-1", "Q86K32-1", "Q55CM4-1", "Q75JE1-1", "Q75JS0-1", "Q8T2Q2-1", "Q54HT1-1", "Q557E7-1", "Q557I6-1", "Q55C16-1", "Q6T486-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "C7G034", "gene_name": "", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "C7G034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C7G034" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "C7G034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C7G034" } ] } ] }, { "uniprot_ac": "O76856", "gene_name": "ctsD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "O76856", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76856" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "O76856", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76856" } ] } ] }, { "uniprot_ac": "O77229", "gene_name": "catA", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "O77229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O77229" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "O77229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O77229" } ] } ] }, { "uniprot_ac": "P04989", "gene_name": "cprB", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "P04989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04989" } ] } ] }, { "uniprot_ac": "P0CT31", "gene_name": "eef1a1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P0CT31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CT31" } ] } ] }, { "uniprot_ac": "P15112", "gene_name": "efbA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P15112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15112" } ] } ] }, { "uniprot_ac": "P22887", "gene_name": "ndkC-1", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P22887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22887" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P22887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22887" } ] } ] }, { "uniprot_ac": "P34093", "gene_name": "ndkM", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P34093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34093" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P34093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34093" } ] } ] }, { "uniprot_ac": "P36411", "gene_name": "rab7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P36411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36411" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P36411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36411" } ] } ] }, { "uniprot_ac": "P42525", "gene_name": "erkA", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42525" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P42525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42525" } ] } ] }, { "uniprot_ac": "P52922", "gene_name": "lkhA", "activity": [ { "ec_number": "3.4.11.-", "activity": "", "evidence": [ { "id": "P52922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52922" } ] }, { "ec_number": "3.3.2.10", "activity": "an epoxide + H2O = an ethanediol.", "evidence": [ { "id": "P52922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52922" } ] } ] }, { "uniprot_ac": "P54639", "gene_name": "cprD", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "P54639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54639" } ] } ] }, { "uniprot_ac": "P54640", "gene_name": "cprE", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "P54640", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54640" } ] } ] }, { "uniprot_ac": "Q00766", "gene_name": "glpV", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q00766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00766" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q00766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00766" } ] } ] }, { "uniprot_ac": "Q23894", "gene_name": "cprC", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q23894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23894" } ] } ] }, { "uniprot_ac": "Q23919", "gene_name": "pgmA", "activity": [ { "ec_number": "5.4.2.2", "activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.", "evidence": [ { "id": "Q23919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23919" } ] }, { "ec_number": "5.4.2.2", "activity": "", "evidence": [ { "id": "Q23919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23919" } ] } ] }, { "uniprot_ac": "Q54B14", "gene_name": "qpct", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "Q54B14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B14" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "Q54B14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B14" } ] } ] }, { "uniprot_ac": "Q54DD0", "gene_name": "amdA", "activity": [ { "ec_number": "3.5.4.6", "activity": "AMP + H(+) + H2O = IMP + NH4(+).", "evidence": [ { "id": "Q54DD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DD0" } ] }, { "ec_number": "3.5.4.6", "activity": "", "evidence": [ { "id": "Q54DD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DD0" } ] } ] }, { "uniprot_ac": "Q54DK3", "gene_name": "cdc7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54DK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DK3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54DK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DK3" } ] } ] }, { "uniprot_ac": "Q54DN5", "gene_name": "", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q54DN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "Q54DN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ] } ] }, { "uniprot_ac": "Q54FX4", "gene_name": "", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54FX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54FX4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54FX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54FX4" } ] } ] }, { "uniprot_ac": "Q54GE1", "gene_name": "glb1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "Q54GE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GE1" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "Q54GE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GE1" } ] } ] }, { "uniprot_ac": "Q54GG5", "gene_name": "ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54GG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GG5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q54GG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GG5" } ] } ] }, { "uniprot_ac": "Q54HT1", "gene_name": "tirA", "activity": [ { "ec_number": "3.2.2.6", "activity": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide.", "evidence": [ { "id": "Q54HT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HT1" } ] }, { "ec_number": "3.2.2.6", "activity": "", "evidence": [ { "id": "Q54HT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HT1" } ] } ] }, { "uniprot_ac": "Q54I43", "gene_name": "ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54I43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I43" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54I43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I43" } ] } ] }, { "uniprot_ac": "Q54I82", "gene_name": "cda", "activity": [ { "ec_number": "3.5.4.5", "activity": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+).", "evidence": [ { "id": "Q54I82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I82" } ] }, { "ec_number": "3.5.4.5", "activity": "", "evidence": [ { "id": "Q54I82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I82" } ] } ] }, { "uniprot_ac": "Q54IL3", "gene_name": "", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q54IL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IL3" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q54IL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IL3" } ] } ] }, { "uniprot_ac": "Q54JL7", "gene_name": "cnrN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "Q54JL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JL7" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "Q54JL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JL7" } ] } ] }, { "uniprot_ac": "Q54KP2", "gene_name": "", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54KP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KP2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q54KP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KP2" } ] } ] }, { "uniprot_ac": "Q54LP7", "gene_name": "ube2j2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54LP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LP7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54LP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LP7" } ] } ] }, { "uniprot_ac": "Q54LY5", "gene_name": "ku80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q54LY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LY5" } ] } ] }, { "uniprot_ac": "Q54LZ6", "gene_name": "", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q54LZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LZ6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q54LZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LZ6" } ] } ] }, { "uniprot_ac": "Q54MA9", "gene_name": "ku70", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q54MA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MA9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q54MA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MA9" } ] } ] }, { "uniprot_ac": "Q54N05", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54N05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N05" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54N05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N05" } ] } ] }, { "uniprot_ac": "Q54NE6", "gene_name": "gpmA", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q54NE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NE6" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q54NE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NE6" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "Q54NE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NE6" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q54NE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NE6" } ] } ] }, { "uniprot_ac": "Q54QD9", "gene_name": "ctsB", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "Q54QD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QD9" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "Q54QD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QD9" } ] } ] }, { "uniprot_ac": "Q54QF1", "gene_name": "", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54QF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QF1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q54QF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QF1" } ] } ] }, { "uniprot_ac": "Q54QG5", "gene_name": "", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q54QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QG5" } ] } ] }, { "uniprot_ac": "Q54QQ0", "gene_name": "impdh", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "Q54QQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QQ0" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q54QQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QQ0" } ] } ] }, { "uniprot_ac": "Q54QR2", "gene_name": "psmB7", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q54QR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QR2" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q54QR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QR2" } ] } ] }, { "uniprot_ac": "Q54QS0", "gene_name": "", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q54QS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QS0" } ] } ] }, { "uniprot_ac": "Q54QS3", "gene_name": "ddx3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q54QS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q54QS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QS3" } ] } ] }, { "uniprot_ac": "Q54QV7", "gene_name": "gsta5", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "Q54QV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV7" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q54QV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV7" } ] } ] }, { "uniprot_ac": "Q54R55", "gene_name": "ctsZ", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "Q54R55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R55" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "Q54R55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R55" } ] } ] }, { "uniprot_ac": "Q54RF5", "gene_name": "pyk", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "Q54RF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RF5" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "Q54RF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RF5" } ] } ] }, { "uniprot_ac": "Q54TI6", "gene_name": "ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q54TI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TI6" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q54TI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TI6" } ] } ] }, { "uniprot_ac": "Q54TM9", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54TM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TM9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54TM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TM9" } ] } ] }, { "uniprot_ac": "Q54UQ2", "gene_name": "pgmB", "activity": [ { "ec_number": "5.4.2.2", "activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.", "evidence": [ { "id": "Q54UQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54UQ2" } ] }, { "ec_number": "5.4.2.2", "activity": "", "evidence": [ { "id": "Q54UQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54UQ2" } ] } ] }, { "uniprot_ac": "Q54V35", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54V35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54V35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54V35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54V35" } ] } ] }, { "uniprot_ac": "Q54V83", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54V83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54V83" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54V83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54V83" } ] } ] }, { "uniprot_ac": "Q54VG3", "gene_name": "", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54VG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VG3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54VG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VG3" } ] } ] }, { "uniprot_ac": "Q54VI4", "gene_name": "gsta3", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "Q54VI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VI4" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q54VI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VI4" } ] } ] }, { "uniprot_ac": "Q54VW9", "gene_name": "", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54VW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VW9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54VW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VW9" } ] } ] }, { "uniprot_ac": "Q54VX1", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54VX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VX1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54VX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VX1" } ] } ] }, { "uniprot_ac": "Q54XG4", "gene_name": "", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q54XG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XG4" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q54XG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XG4" } ] } ] }, { "uniprot_ac": "Q54XS6", "gene_name": "ube2c", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54XS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XS6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54XS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XS6" } ] } ] }, { "uniprot_ac": "Q54Y06", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54Y06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Y06" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q54Y06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Y06" } ] } ] }, { "uniprot_ac": "Q54YA0", "gene_name": "acly", "activity": [ { "ec_number": "2.3.3.8", "activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.", "evidence": [ { "id": "Q54YA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54YA0" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q54YA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54YA0" } ] } ] }, { "uniprot_ac": "Q553F3", "gene_name": "ubc2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q553F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553F3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q553F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553F3" } ] } ] }, { "uniprot_ac": "Q553T4", "gene_name": "", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q553T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553T4" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q553T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553T4" } ] } ] }, { "uniprot_ac": "Q555H8", "gene_name": "rnf160", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q555H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q555H8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q555H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q555H8" } ] } ] }, { "uniprot_ac": "Q555L5", "gene_name": "prdx4", "activity": [ { "ec_number": "1.11.1.24", "activity": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O.", "evidence": [ { "id": "Q555L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q555L5" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "Q555L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q555L5" } ] } ] }, { "uniprot_ac": "Q556G3", "gene_name": "gsta2-2", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "Q556G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q556G3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q556G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q556G3" } ] } ] }, { "uniprot_ac": "Q557E7", "gene_name": "cblA-2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q557E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557E7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q557E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557E7" } ] } ] }, { "uniprot_ac": "Q557I6", "gene_name": "mip1-2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q557I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557I6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q557I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557I6" } ] } ] }, { "uniprot_ac": "Q55C16", "gene_name": "uba1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q55C16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55C16" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q55C16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55C16" } ] } ] }, { "uniprot_ac": "Q55CM4", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q55CM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q55CM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CM4" } ] } ] }, { "uniprot_ac": "Q55D99", "gene_name": "pakA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55D99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55D99" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55D99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55D99" } ] } ] }, { "uniprot_ac": "Q55DC5", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q55DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DC5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q55DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DC5" } ] } ] }, { "uniprot_ac": "Q55DD4", "gene_name": "pakD", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55DD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DD4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55DD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DD4" } ] } ] }, { "uniprot_ac": "Q55E06", "gene_name": "alad", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen.", "evidence": [ { "id": "Q55E06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55E06" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "Q55E06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55E06" } ] } ] }, { "uniprot_ac": "Q55EK9", "gene_name": "pykA", "activity": [ { "ec_number": "2.7.1.35", "activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q55EK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EK9" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q55EK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EK9" } ] } ] }, { "uniprot_ac": "Q55EY8", "gene_name": "ube2w", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q55EY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EY8" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q55EY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EY8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q55EY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EY8" } ] } ] }, { "uniprot_ac": "Q55FF3", "gene_name": "gsta1", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "Q55FF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FF3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q55FF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FF3" } ] } ] }, { "uniprot_ac": "Q55GA9", 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