{
    "uniprot_canonical_ac": "B7ZC32-1",
    "uniprot_ac": "B7ZC32",
    "uniprot_id": "KIF28_HUMAN",
    "mass": {
        "chemical_mass": 108254.0,
        "monoisotopic_mass": 108254.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "KIF28P",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/B7ZC32",
            "id": "B7ZC32"
        },
        {
            "name": "KLP6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/B7ZC32",
            "id": "B7ZC32"
        }
    ],
    "protein_names": [
        {
            "name": "Kinesin-like protein KIF28P",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "B7ZC32"
        },
        {
            "name": "Kinesin-like protein 6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "B7ZC32"
        }
    ],
    "function": [
        {
            "annotation": "Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B7ZC32",
                    "url": "https://www.uniprot.org/uniprot/B7ZC32#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Prostate cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:10283",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:10283",
                    "recommended_name": {
                        "id": "DOID:10283",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10283",
                        "name": "prostate cancer",
                        "description": "A male reproductive organ cancer that is located_in the prostate."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "NGP - new growth of prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "malignant tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, type 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "HPC9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "EHBP1 familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "familial prostate cancer caused by mutation in EHBP1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, type 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "HPC12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, type 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "HPC5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, type 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, susceptibility to, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "HPC3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, type 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, susceptibility to, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "HPC4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, on chromosome 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "MSMB familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "familial prostate cancer caused by mutation in MSMB",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, type 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "HPC13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, type 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "HPC8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "predisposing for prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, type 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "HPC6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "HPC10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate carcinoma",
                            "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, hereditary",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "HPC7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer aggressiveness",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "RNASEL familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "familial prostate cancer caused by mutation in RNASEL",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, type 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "HPC1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "Prca1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "HPC11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "HPC14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "HPC15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "HPCX1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer susceptibility, X-linked",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "HPCX2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MIM:611868",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611868",
                            "name": "Prostate cancer, hereditary, 12",
                            "description": "Prostate cancer, hereditary, 12"
                        },
                        {
                            "id": "MIM:611928",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611928",
                            "name": "Prostate cancer, hereditary, 13",
                            "description": "Prostate cancer, hereditary, 13"
                        },
                        {
                            "id": "MIM:176807",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/176807",
                            "name": "Prostate cancer",
                            "description": "Prostate cancer"
                        },
                        {
                            "id": "MIM:601518",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/601518",
                            "name": "Prostate cancer, hereditary, 1",
                            "description": "Prostate cancer, hereditary, 1"
                        },
                        {
                            "id": "MIM:611955",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611955",
                            "name": "Prostate cancer, hereditary, 11",
                            "description": "Prostate cancer, hereditary, 11"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Stomach cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:10534",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:10534",
                    "recommended_name": {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "stomach cancer",
                        "description": "A gastrointestinal system cancer that is located_in the stomach."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10534",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "name": "gastric cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10534",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "name": "gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the stomach."
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "Ca lesser curvature - stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "cancer of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer risk after h. pylori infection",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant stomach neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of greater curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of greater curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "stomach cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "Ca body - stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "ca greater curvature of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer, intestinal",
                            "description": ""
                        },
                        {
                            "id": "MIM:613659",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/613659",
                            "name": "Gastric cancer",
                            "description": "Gastric cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Urinary bladder cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:11054",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Head and neck cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:11934",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck tumours",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head/neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "tumor of head and neck",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Lung cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1324",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Breast cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1612",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast cancer",
                        "description": "A thoracic cancer that originates in the mammary gland."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant tumor of the breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "down",
            "name": "Thyroid cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1781",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1781",
                    "recommended_name": {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid cancer",
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid gland cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "Thyroid gland neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant tumour of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid neoplasm",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "down",
            "name": "Kidney cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:263",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:263",
                    "recommended_name": {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "kidney cancer",
                        "description": "A urinary system cancer that is located_in the kidney."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant neoplasm of kidney except pelvis",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant tumour of kidney",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "renal cancer",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Liver cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:3571",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:3571",
                    "recommended_name": {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "liver cancer",
                        "description": "A hepatobiliary system cancer that is located_in the liver."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Ca liver - primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Resectable malignant neoplasm of Liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant hepato-biliary neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant tumor of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "non-resectable primary hepatic malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary liver cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "resectable malignant neoplasm of the liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, not specified as primary or secondary",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "down",
            "name": "Uterine cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:363",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:363",
                    "recommended_name": {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterine cancer",
                        "description": "A female reproductive organ cancer that is located_in the uterus."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "CA - cancer of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "Tumour of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterus neoplasm",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "down",
            "name": "Esophageal cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:5041",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:5041",
                    "recommended_name": {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "esophageal cancer",
                        "description": "A gastrointestinal system cancer that is located_in the esophagus."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "Ca lower third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "Ca middle third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "esophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of lower third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of middle third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of upper third esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of Distal Third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of Proximal Third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of abdominal esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of the middle Third of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the esophagus."
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "cancer of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "cancer of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal carcinoma, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal squamous cell carcinoma, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophagus neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophagus tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant oesophagus neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant oesophagus tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "oesophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca lower third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca lower third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca middle third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca middle third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of distal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of lower third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of lower third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of middle third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of middle third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of proximal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of upper third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of upper third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of abdominal esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of the middle third of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of abdominal oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of distal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of proximal third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of the middle third of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Aerodigestive tract cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Escc, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal squamous cell carcinoma, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "gastric cardia adenocarcinoma, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MIM:133239",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/133239",
                            "name": "Esophageal cancer",
                            "description": "Esophageal cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Colorectal cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:9256",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "B7ZC32",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/B7ZC32"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:9256",
                    "recommended_name": {
                        "id": "DOID:9256",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:9256",
                        "name": "colorectal cancer",
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectal cancer",
                            "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "cancer of colorectum",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "cancer of large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "cancer of large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "cancer of the large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colon cancer, advanced, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colon cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectal cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectal cancer with chromosomal instability, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectal cancer, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectal cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colorectum cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant colorectal neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant colorectal tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant colorectal tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant colorectum neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant large bowel neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant large bowel tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant large bowel tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant large intestine neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant large intestine tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant large intestine tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant neoplasm of colorectum",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant neoplasm of large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant neoplasm of large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant neoplasm of the large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant neoplasm of the large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumor of large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumor of large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumor of the large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumor of the large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumour of large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumour of large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumour of the large bowel",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "malignant tumour of the large intestine",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "CRC",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colon cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0005575",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                            "name": "large intestine cancer",
                            "description": ""
                        },
                        {
                            "id": "MIM:114500",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114500",
                            "name": "Colorectal cancer",
                            "description": "Colorectal cancer"
                        }
                    ]
                }
            ]
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B7ZC32",
                    "url": "https://www.uniprot.org/uniprot/B7ZC32"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "KIF28P",
            "url": "https://www.uniprot.org/uniprot/B7ZC32",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "cd22709",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22709",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "KIF28P",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIF28P",
            "database": "GeneCards",
            "categories": [
                "Gene Annotation",
                "Organism-specific"
            ]
        },
        {
            "id": "2836",
            "url": "https://glyconnect.expasy.org/browser/proteins/2836",
            "database": "GlyConnect",
            "categories": [
                "Glycoproteomics",
                "Glycan"
            ]
        },
        {
            "id": "49205",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=49205",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "B7ZC32",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:B7ZC32*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000253",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000253",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001752",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008984",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR022140",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR022140",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027640",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027640",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036961",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NX_B7ZC32",
            "url": "https://www.nextprot.org/entry/NX_B7ZC32",
            "database": "neXtProt",
            "categories": [
                "Protein",
                "Organism-specific"
            ]
        },
        {
            "id": "PTHR24115",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24115",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24115:SF344",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24115:SF344",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00225",
            "url": "http://pfam.xfam.org/family/PF00225",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00498",
            "url": "http://pfam.xfam.org/family/PF00498",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12423",
            "url": "http://pfam.xfam.org/family/PF12423",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "B7ZC32",
            "url": "https://pharos.nih.gov/targets/B7ZC32",
            "database": "PHAROS",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "PR_B7ZC32",
            "url": "http://purl.obolibrary.org/obo/PR_B7ZC32",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-HSA-6811434",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-HSA-983189",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "B7ZC32",
            "url": "https://www.uniprot.org/uniprot/B7ZC32",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B7ZC32-1",
            "url": "https://www.uniprot.org/uniprot/B7ZC32-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPTQSVDSVKAVRVRPFSQREKNSGSKCVISMHSRTTTTTQDPKNPEHVKTFTFDLAYWSHNGFQRDKDGVLISADPSRKFAGQRDVFHDLGRGILDSAWQGYNATLLAYGQTGSGKSYSMIGFGCKQGIIPTVCEELFRAIENQGRNQEHQVMFSMLEIYKEIIRDLLSRTKKPGGLRIREDQQLGFYVEGLKSVPCENYAQIERLMEQGTKIRTTASTNMNASSSRSHLVITIQFKQVFLDRDLTKQSSINLVDLARSERQKSSGSEGDRLREGSCVNLSLTNLGSVISVLADAAMGKKVLHIPYRDSVLTKLLQSALGGNSRTALVAAVSPADICYEETLSTLRYAERERKIRNRAVANTWTLMRKSRAENSKLLPMMTFPHLLNLSEDPQLTRVLKYFIQAGTQPAPCPRPALSPPHPALRISDKHASFTNADGKVTVTPHSKCKVAVNGVPITTRTKLQHLDRLILGSNSTYLYVGFPSEWGSEDLSRFDYDFFQLERAAAEGASADKLGAADGGDGKAGPSVLAAFQDYIKLMPLVSEANQMSEEPKKGLNMELKVKNLASSDSRGYDLQKEVLVKVTHHGSHEVWIWSKAKFINRKFLMQELYQRFLDGDHGPVARDDDPFWDPVEVVRLGSAHIWLQSLAYCMKLEEQVEFLNCDGLEEAVLHTCIAPCSPTGQTHGEEDVVIDPLELLGKRMDFQIHIVRCLGVNWMKEDAKRGTQIGYRIYDLPNTIYTKPVWKSVNPQIEETVQFAALTASQEFLNYLRTNALIVDLWGLQEGCTELSCSQLGLMVTGEGHILVDTKKISTVKDISQAASNQIPELYLKLLKLEQETEPLRNINRALREENVLLKASLAKTASGQAPKPSNTLKISGMTAQLPSAGEMSQMCTQQAGSDRELAKALKVFYQSMNTARGQLFRLRRHQPPEVDQMLRPFIHQRSQMFKDLGDLRESSLWTLKMTLLL",
        "length": 967,
        "header": "sp|B7ZC32-1|KIF28_HUMAN Isoform 1 of Kinesin-like protein KIF28P  OS=Homo sapiens OX=9606 GN=KIF28P PE=3 SV=2 CANONICAL=B7ZC32-1"
    },
    "isoforms": [
        {
            "isoform_ac": "B7ZC32-1",
            "url": "",
            "sequence": {
                "sequence": "MPTQSVDSVKAVRVRPFSQREKNSGSKCVISMHSRTTTTTQDPKNPEHVKTFTFDLAYWSHNGFQRDKDGVLISADPSRKFAGQRDVFHDLGRGILDSAWQGYNATLLAYGQTGSGKSYSMIGFGCKQGIIPTVCEELFRAIENQGRNQEHQVMFSMLEIYKEIIRDLLSRTKKPGGLRIREDQQLGFYVEGLKSVPCENYAQIERLMEQGTKIRTTASTNMNASSSRSHLVITIQFKQVFLDRDLTKQSSINLVDLARSERQKSSGSEGDRLREGSCVNLSLTNLGSVISVLADAAMGKKVLHIPYRDSVLTKLLQSALGGNSRTALVAAVSPADICYEETLSTLRYAERERKIRNRAVANTWTLMRKSRAENSKLLPMMTFPHLLNLSEDPQLTRVLKYFIQAGTQPAPCPRPALSPPHPALRISDKHASFTNADGKVTVTPHSKCKVAVNGVPITTRTKLQHLDRLILGSNSTYLYVGFPSEWGSEDLSRFDYDFFQLERAAAEGASADKLGAADGGDGKAGPSVLAAFQDYIKLMPLVSEANQMSEEPKKGLNMELKVKNLASSDSRGYDLQKEVLVKVTHHGSHEVWIWSKAKFINRKFLMQELYQRFLDGDHGPVARDDDPFWDPVEVVRLGSAHIWLQSLAYCMKLEEQVEFLNCDGLEEAVLHTCIAPCSPTGQTHGEEDVVIDPLELLGKRMDFQIHIVRCLGVNWMKEDAKRGTQIGYRIYDLPNTIYTKPVWKSVNPQIEETVQFAALTASQEFLNYLRTNALIVDLWGLQEGCTELSCSQLGLMVTGEGHILVDTKKISTVKDISQAASNQIPELYLKLLKLEQETEPLRNINRALREENVLLKASLAKTASGQAPKPSNTLKISGMTAQLPSAGEMSQMCTQQAGSDRELAKALKVFYQSMNTARGQLFRLRRHQPPEVDQMLRPFIHQRSQMFKDLGDLRESSLWTLKMTLLL",
                "length": 967,
                "header": "sp|B7ZC32-1|KIF28_HUMAN Isoform 1 of Kinesin-like protein KIF28P  OS=Homo sapiens OX=9606 GN=KIF28P PE=3 SV=2 CANONICAL=B7ZC32-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G11911BT",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 280,
            "start_aa": "Asn",
            "end_pos": 280,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn280",
            "evidence": [
                {
                    "id": "2836",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2836"
                },
                {
                    "id": "29992770",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29992770"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors.",
            "journal": "Cell",
            "date": "1999",
            "authors": "Bremser M, Nickel W, Schweikert M, Ravazzola M, Amherdt M, Hughes CA, Sollner TH, Rothman JE, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10052452",
                    "url": "https://glygen.org/publication/PubMed/10052452"
                }
            ]
        },
        {
            "title": "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23.",
            "journal": "The Journal of biological chemistry",
            "date": "1999",
            "authors": "Zhao L, Helms JB, Brunner J, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10318838",
                    "url": "https://glygen.org/publication/PubMed/10318838"
                }
            ]
        },
        {
            "title": "NSF N-terminal domain crystal structure: models of NSF function.",
            "journal": "Molecular cell",
            "date": "1999",
            "authors": "Yu RC, Jahn R, Brunger AT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10445031",
                    "url": "https://glygen.org/publication/PubMed/10445031"
                }
            ]
        },
        {
            "title": "An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion.",
            "journal": "Nature cell biology",
            "date": "1999",
            "authors": "Muller JM, Rabouille C, Newman R, Shorter J, Freemont P, Schiavo G, Warren G, Shima DT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10559959",
                    "url": "https://glygen.org/publication/PubMed/10559959"
                }
            ]
        },
        {
            "title": "Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex.",
            "journal": "Cell",
            "date": "2000",
            "authors": "Goldberg J",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10761932",
                    "url": "https://glygen.org/publication/PubMed/10761932"
                }
            ]
        },
        {
            "title": "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.",
            "journal": "The EMBO journal",
            "date": "2000",
            "authors": "Eugster A, Frigerio G, Dale M, Duden R",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10921873",
                    "url": "https://glygen.org/publication/PubMed/10921873"
                }
            ]
        },
        {
            "title": "Functional characterization of novel human ARFGAP3.",
            "journal": "FEBS letters",
            "date": "2001",
            "authors": "Liu X, Zhang C, Xing G, Chen Q, He F",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11172815",
                    "url": "https://glygen.org/publication/PubMed/11172815"
                }
            ]
        },
        {
            "title": "The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmic reticulum retrieval in yeast.",
            "journal": "The Journal of biological chemistry",
            "date": "2001",
            "authors": "Andag U, Neumann T, Schmitt HD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11493604",
                    "url": "https://glygen.org/publication/PubMed/11493604"
                }
            ]
        },
        {
            "title": "Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain.",
            "journal": "The Journal of biological chemistry",
            "date": "2002",
            "authors": "Wang H, Kazanietz MG",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11689559",
                    "url": "https://glygen.org/publication/PubMed/11689559"
                }
            ]
        },
        {
            "title": "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET.",
            "journal": "Developmental cell",
            "date": "2001",
            "authors": "Majoul I, Straub M, Hell SW, Duden R, Soling HD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11703931",
                    "url": "https://glygen.org/publication/PubMed/11703931"
                }
            ]
        },
        {
            "title": "Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23.",
            "journal": "The EMBO journal",
            "date": "2001",
            "authors": "Gommel DU, Memon AR, Heiss A, Lottspeich F, Pfannstiel J, Lechner J, Reinhard C, Helms JB, Nickel W, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11726511",
                    "url": "https://glygen.org/publication/PubMed/11726511"
                }
            ]
        },
        {
            "title": "Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit.",
            "journal": "Molecular biology of the cell",
            "date": "2001",
            "authors": "Reilly BA, Kraynack BA, VanRheenen SM, Waters MG",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11739780",
                    "url": "https://glygen.org/publication/PubMed/11739780"
                }
            ]
        },
        {
            "title": "Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1.",
            "journal": "The Journal of cell biology",
            "date": "2001",
            "authors": "Lanoix J, Ouwendijk J, Stark A, Szafer E, Cassel D, Dejgaard K, Weiss M, Nilsson T",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11748249",
                    "url": "https://glygen.org/publication/PubMed/11748249"
                }
            ]
        },
        {
            "title": "Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.",
            "journal": "Developmental cell",
            "date": "2002",
            "authors": "Mishima M, Kaitna S, Glotzer M",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11782313",
                    "url": "https://glygen.org/publication/PubMed/11782313"
                }
            ]
        },
        {
            "title": "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2002",
            "authors": "Kawamoto K, Yoshida Y, Tamaki H, Torii S, Shinotsuka C, Yamashina S, Nakayama K",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12047556",
                    "url": "https://glygen.org/publication/PubMed/12047556"
                }
            ]
        },
        {
            "title": "Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.",
            "journal": "The Journal of cell biology",
            "date": "2002",
            "authors": "Muller JM, Shorter J, Newman R, Deinhardt K, Sagiv Y, Elazar Z, Warren G, Shima DT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12070132",
                    "url": "https://glygen.org/publication/PubMed/12070132"
                }
            ]
        },
        {
            "title": "Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.",
            "journal": "Nature structural biology",
            "date": "2002",
            "authors": "Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12368902",
                    "url": "https://glygen.org/publication/PubMed/12368902"
                }
            ]
        },
        {
            "title": "A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles.",
            "journal": "Nature",
            "date": "1992",
            "authors": "Nislow C, Lombillo VA, Kuriyama R, McIntosh JR",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1406973",
                    "url": "https://glygen.org/publication/PubMed/1406973"
                }
            ]
        },
        {
            "title": "Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat.",
            "journal": "The Journal of biological chemistry",
            "date": "2003",
            "authors": "Andag U, Schmitt HD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14504276",
                    "url": "https://glygen.org/publication/PubMed/14504276"
                }
            ]
        },
        {
            "title": "Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature.",
            "journal": "Nature",
            "date": "2003",
            "authors": "Bigay J, Gounon P, Robineau S, Antonny B",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14654841",
                    "url": "https://glygen.org/publication/PubMed/14654841"
                }
            ]
        },
        {
            "title": "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.",
            "journal": "The EMBO journal",
            "date": "2004",
            "authors": "Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15029241",
                    "url": "https://glygen.org/publication/PubMed/15029241"
                }
            ]
        },
        {
            "title": "Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor.",
            "journal": "Journal of structural biology",
            "date": "2004",
            "authors": "Whiteheart SW, Matveeva EA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15037235",
                    "url": "https://glygen.org/publication/PubMed/15037235"
                }
            ]
        },
        {
            "title": "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.",
            "journal": "The EMBO journal",
            "date": "2004",
            "authors": "Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, Tani K, Yamamoto A, Tagaya M",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15272311",
                    "url": "https://glygen.org/publication/PubMed/15272311"
                }
            ]
        },
        {
            "title": "Human chromokinesin KIF4A functions in chromosome condensation and segregation.",
            "journal": "The Journal of cell biology",
            "date": "2004",
            "authors": "Mazumdar M, Sundareshan S, Misteli T",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15326200",
                    "url": "https://glygen.org/publication/PubMed/15326200"
                }
            ]
        },
        {
            "title": "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi.",
            "journal": "Molecular biology of the cell",
            "date": "2005",
            "authors": "Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15616190",
                    "url": "https://glygen.org/publication/PubMed/15616190"
                }
            ]
        },
        {
            "title": "Live imaging of bidirectional traffic from the ERGIC.",
            "journal": "Journal of cell science",
            "date": "2005",
            "authors": "Ben-Tekaya H, Miura K, Pepperkok R, Hauri HP",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15632110",
                    "url": "https://glygen.org/publication/PubMed/15632110"
                }
            ]
        },
        {
            "title": "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2005",
            "authors": "Szul T, Garcia-Mata R, Brandon E, Shestopal S, Alvarez C, Sztul E",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15813748",
                    "url": "https://glygen.org/publication/PubMed/15813748"
                }
            ]
        },
        {
            "title": "Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic.",
            "journal": "Molecular biology of the cell",
            "date": "2005",
            "authors": "Volpicelli-Daley LA, Li Y, Zhang CJ, Kahn RA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16030262",
                    "url": "https://glygen.org/publication/PubMed/16030262"
                }
            ]
        },
        {
            "title": "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.",
            "journal": "The Journal of cell biology",
            "date": "1992",
            "authors": "Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1607388",
                    "url": "https://glygen.org/publication/PubMed/1607388"
                }
            ]
        },
        {
            "title": "Kinesin-2 is a motor for late endosomes and lysosomes.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2005",
            "authors": "Brown CL, Maier KC, Stauber T, Ginkel LM, Wordeman L, Vernos I, Schroer TA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16262723",
                    "url": "https://glygen.org/publication/PubMed/16262723"
                }
            ]
        },
        {
            "title": "ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "1992",
            "authors": "Donaldson JG, Cassel D, Kahn RA, Klausner RD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1631136",
                    "url": "https://glygen.org/publication/PubMed/1631136"
                }
            ]
        },
        {
            "title": "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.",
            "journal": "Molecular biology of the cell",
            "date": "2006",
            "authors": "Arasaki K, Taniguchi M, Tani K, Tagaya M",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16571679",
                    "url": "https://glygen.org/publication/PubMed/16571679"
                }
            ]
        },
        {
            "title": "ARF proteins: roles in membrane traffic and beyond.",
            "journal": "Nature reviews. Molecular cell biology",
            "date": "2006",
            "authors": "D'Souza-Schorey C, Chavrier P",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16633337",
                    "url": "https://glygen.org/publication/PubMed/16633337"
                }
            ]
        },
        {
            "title": "ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein.",
            "journal": "Cell",
            "date": "1991",
            "authors": "Serafini T, Orci L, Amherdt M, Brunner M, Kahn RA, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1680566",
                    "url": "https://glygen.org/publication/PubMed/1680566"
                }
            ]
        },
        {
            "title": "SNAREs--engines for membrane fusion.",
            "journal": "Nature reviews. Molecular cell biology",
            "date": "2006",
            "authors": "Jahn R, Scheller RH",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16912714",
                    "url": "https://glygen.org/publication/PubMed/16912714"
                }
            ]
        },
        {
            "title": "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic.",
            "journal": "Journal of cell science",
            "date": "2006",
            "authors": "Zhao X, Claude A, Chun J, Shields DJ, Presley JF, Melancon P",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16926190",
                    "url": "https://glygen.org/publication/PubMed/16926190"
                }
            ]
        },
        {
            "title": "Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins.",
            "journal": "Molecular and cellular biology",
            "date": "2006",
            "authors": "Bethune J, Kol M, Hoffmann J, Reckmann I, Brugger B, Wieland F",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16940185",
                    "url": "https://glygen.org/publication/PubMed/16940185"
                }
            ]
        },
        {
            "title": "A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex.",
            "journal": "Current biology : CB",
            "date": "2006",
            "authors": "Stauber T, Simpson JC, Pepperkok R, Vernos I",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17113389",
                    "url": "https://glygen.org/publication/PubMed/17113389"
                }
            ]
        },
        {
            "title": "Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature.",
            "journal": "Biochemistry",
            "date": "2007",
            "authors": "Mesmin B, Drin G, Levi S, Rawet M, Cassel D, Bigay J, Antonny B",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17253781",
                    "url": "https://glygen.org/publication/PubMed/17253781"
                }
            ]
        },
        {
            "title": "The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression.",
            "journal": "Current biology : CB",
            "date": "2007",
            "authors": "Mayr MI, Hummer S, Bormann J, Gruner T, Adio S, Woehlke G, Mayer TU",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17346968",
                    "url": "https://glygen.org/publication/PubMed/17346968"
                }
            ]
        },
        {
            "title": "Differential localization of coatomer complex isoforms within the Golgi apparatus.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2007",
            "authors": "Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Sollner T, Brugger B, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17360540",
                    "url": "https://glygen.org/publication/PubMed/17360540"
                }
            ]
        },
        {
            "title": "Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association.",
            "journal": "Molecular biology of the cell",
            "date": "2007",
            "authors": "Monetta P, Slavin I, Romero N, Alvarez C",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17429068",
                    "url": "https://glygen.org/publication/PubMed/17429068"
                }
            ]
        },
        {
            "title": "Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2007",
            "authors": "Sun Z, Anderl F, Frohlich K, Zhao L, Hanke S, Brugger B, Wieland F, Bethune J",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17451557",
                    "url": "https://glygen.org/publication/PubMed/17451557"
                }
            ]
        },
        {
            "title": "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.",
            "journal": "Molecular biology of the cell",
            "date": "2007",
            "authors": "Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17538014",
                    "url": "https://glygen.org/publication/PubMed/17538014"
                }
            ]
        },
        {
            "title": "Two human ARFGAPs associated with COP-I-coated vesicles.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2007",
            "authors": "Frigerio G, Grimsey N, Dale M, Majoul I, Duden R",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17760859",
                    "url": "https://glygen.org/publication/PubMed/17760859"
                }
            ]
        },
        {
            "title": "Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane.",
            "journal": "The Biochemical journal",
            "date": "2008",
            "authors": "Takida S, Maeda Y, Kinoshita T",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17927562",
                    "url": "https://glygen.org/publication/PubMed/17927562"
                }
            ]
        },
        {
            "title": "Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.",
            "journal": "Journal of cell science",
            "date": "2007",
            "authors": "Szul T, Grabski R, Lyons S, Morohashi Y, Shestopal S, Lowe M, Sztul E",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17956946",
                    "url": "https://glygen.org/publication/PubMed/17956946"
                }
            ]
        },
        {
            "title": "A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2008",
            "authors": "Langer JD, Roth CM, Bethune J, Stoops EH, Brugger B, Herten DP, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18182008",
                    "url": "https://glygen.org/publication/PubMed/18182008"
                }
            ]
        },
        {
            "title": "The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.",
            "journal": "Molecular biology of the cell",
            "date": "2008",
            "authors": "Mitrovic S, Ben-Tekaya H, Koegler E, Gruenberg J, Hauri HP",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18287528",
                    "url": "https://glygen.org/publication/PubMed/18287528"
                }
            ]
        },
        {
            "title": "Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E.",
            "journal": "Molecular cell",
            "date": "2008",
            "authors": "Espeut J, Gaussen A, Bieling P, Morin V, Prieto S, Fesquet D, Surrey T, Abrieu A",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18342609",
                    "url": "https://glygen.org/publication/PubMed/18342609"
                }
            ]
        },
        {
            "title": "Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1.",
            "journal": "Molecular biology of the cell",
            "date": "2008",
            "authors": "Chun J, Shapovalova Z, Dejgaard SY, Presley JF, Melancon P",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18524849",
                    "url": "https://glygen.org/publication/PubMed/18524849"
                }
            ]
        },
        {
            "title": "Consensus nomenclature for the human ArfGAP domain-containing proteins.",
            "journal": "The Journal of cell biology",
            "date": "2008",
            "authors": "Kahn RA, Bruford E, Inoue H, Logsdon JM Jr, Nie Z, Premont RT, Randazzo PA, Satake M, Theibert AB, Zapp ML, Cassel D",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18809720",
                    "url": "https://glygen.org/publication/PubMed/18809720"
                }
            ]
        },
        {
            "title": "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles.",
            "journal": "Nature",
            "date": "1991",
            "authors": "Waters MG, Serafini T, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1898986",
                    "url": "https://glygen.org/publication/PubMed/1898986"
                }
            ]
        },
        {
            "title": "Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.",
            "journal": "The Journal of cell biology",
            "date": "2008",
            "authors": "Weimer C, Beck R, Eckert P, Reckmann I, Moelleken J, Brugger B, Wieland F",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19015319",
                    "url": "https://glygen.org/publication/PubMed/19015319"
                }
            ]
        },
        {
            "title": "Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.",
            "journal": "Molecular biology of the cell",
            "date": "2009",
            "authors": "Kliouchnikov L, Bigay J, Mesmin B, Parnis A, Rawet M, Goldfeder N, Antonny B, Cassel D",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19109418",
                    "url": "https://glygen.org/publication/PubMed/19109418"
                }
            ]
        },
        {
            "title": "Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules.",
            "journal": "Molecular biology of the cell",
            "date": "2009",
            "authors": "Cai S, Weaver LN, Ems-McClung SC, Walczak CE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19116309",
                    "url": "https://glygen.org/publication/PubMed/19116309"
                }
            ]
        },
        {
            "title": "Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.",
            "journal": "Nature structural &amp; molecular biology",
            "date": "2009",
            "authors": "Tripathi A, Ren Y, Jeffrey PD, Hughson FM",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19151722",
                    "url": "https://glygen.org/publication/PubMed/19151722"
                }
            ]
        },
        {
            "title": "Membrane fusion: grappling with SNARE and SM proteins.",
            "journal": "Science (New York, N.Y.)",
            "date": "2009",
            "authors": "Sudhof TC, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19164740",
                    "url": "https://glygen.org/publication/PubMed/19164740"
                }
            ]
        },
        {
            "title": "Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition.",
            "journal": "PLoS biology",
            "date": "2009",
            "authors": "Hammond JW, Cai D, Blasius TL, Li Z, Jiang Y, Jih GT, Meyhofer E, Verhey KJ",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19338388",
                    "url": "https://glygen.org/publication/PubMed/19338388"
                }
            ]
        },
        {
            "title": "Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.",
            "journal": "Molecular biology of the cell",
            "date": "2009",
            "authors": "Aoki T, Ichimura S, Itoh A, Kuramoto M, Shinkawa T, Isobe T, Tagaya M",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19369418",
                    "url": "https://glygen.org/publication/PubMed/19369418"
                }
            ]
        },
        {
            "title": "Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein.",
            "journal": "Science (New York, N.Y.)",
            "date": "1991",
            "authors": "Donaldson JG, Kahn RA, Lippincott-Schwartz J, Klausner RD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1957170",
                    "url": "https://glygen.org/publication/PubMed/1957170"
                }
            ]
        },
        {
            "title": "The COPI system: molecular mechanisms and function.",
            "journal": "FEBS letters",
            "date": "2009",
            "authors": "Beck R, Rawet M, Wieland FT, Cassel D",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19631211",
                    "url": "https://glygen.org/publication/PubMed/19631211"
                }
            ]
        },
        {
            "title": "A link between ER tethering and COP-I vesicle uncoating.",
            "journal": "Developmental cell",
            "date": "2009",
            "authors": "Zink S, Wenzel D, Wurm CA, Schmitt HD",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19758564",
                    "url": "https://glygen.org/publication/PubMed/19758564"
                }
            ]
        },
        {
            "title": "A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.",
            "journal": "Cell",
            "date": "2009",
            "authors": "Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, Hughson FM",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20005805",
                    "url": "https://glygen.org/publication/PubMed/20005805"
                }
            ]
        },
        {
            "title": "Regulation of ER-Golgi intermediate compartment tubulation and mobility by COPI coats, motor proteins and microtubules.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2010",
            "authors": "Tomas M, Martinez-Alonso E, Ballesta J, Martinez-Menarguez JA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20136777",
                    "url": "https://glygen.org/publication/PubMed/20136777"
                }
            ]
        },
        {
            "title": "Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors.",
            "journal": "Molecular biology of the cell",
            "date": "2010",
            "authors": "Manolea F, Chun J, Chen DW, Clarke I, Summerfeldt N, Dacks JB, Melancon P",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20357002",
                    "url": "https://glygen.org/publication/PubMed/20357002"
                }
            ]
        },
        {
            "title": "Selective export of human GPI-anchored proteins from the endoplasmic reticulum.",
            "journal": "Journal of cell science",
            "date": "2010",
            "authors": "Bonnon C, Wendeler MW, Paccaud JP, Hauri HP",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20427317",
                    "url": "https://glygen.org/publication/PubMed/20427317"
                }
            ]
        },
        {
            "title": "Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.",
            "journal": "Structure (London, England : 1993)",
            "date": "2010",
            "authors": "Civril F, Wehenkel A, Giorgi FM, Santaguida S, Di Fonzo A, Grigorean G, Ciccarelli FD, Musacchio A",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20462495",
                    "url": "https://glygen.org/publication/PubMed/20462495"
                }
            ]
        },
        {
            "title": "Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2010",
            "authors": "Hsia KC, Hoelz A",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20534429",
                    "url": "https://glygen.org/publication/PubMed/20534429"
                }
            ]
        },
        {
            "title": "Models for the functions of Arf GAPs.",
            "journal": "Seminars in cell &amp; developmental biology",
            "date": "2011",
            "authors": "East MP, Kahn RA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20637885",
                    "url": "https://glygen.org/publication/PubMed/20637885"
                }
            ]
        },
        {
            "title": "Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.",
            "journal": "Journal of neurochemistry",
            "date": "2011",
            "authors": "Luo W, Wang Y, Reiser G",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21219331",
                    "url": "https://glygen.org/publication/PubMed/21219331"
                }
            ]
        },
        {
            "title": "Evidence that the head of kinesin is sufficient for force generation and motility in vitro.",
            "journal": "Science (New York, N.Y.)",
            "date": "1990",
            "authors": "Yang JT, Saxton WM, Stewart RJ, Raff EC, Goldstein LS",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2142332",
                    "url": "https://glygen.org/publication/PubMed/2142332"
                }
            ]
        },
        {
            "title": "The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation.",
            "journal": "The Journal of biological chemistry",
            "date": "2011",
            "authors": "Meiringer CT, Rethmeier R, Auffarth K, Wilson J, Perz A, Barlowe C, Schmitt HD, Ungermann C",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21550981",
                    "url": "https://glygen.org/publication/PubMed/21550981"
                }
            ]
        },
        {
            "title": "Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF).",
            "journal": "Biochimica et biophysica acta",
            "date": "2012",
            "authors": "Zhao C, Smith EC, Whiteheart SW",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21689688",
                    "url": "https://glygen.org/publication/PubMed/21689688"
                }
            ]
        },
        {
            "title": "COPI budding within the Golgi stack.",
            "journal": "Cold Spring Harbor perspectives in biology",
            "date": "2011",
            "authors": "Popoff V, Adolf F, Brugger B, Wieland F",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21844168",
                    "url": "https://glygen.org/publication/PubMed/21844168"
                }
            ]
        },
        {
            "title": "COPII and COPI traffic at the ER-Golgi interface.",
            "journal": "Physiology (Bethesda, Md.)",
            "date": "2011",
            "authors": "Szul T, Sztul E",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22013193",
                    "url": "https://glygen.org/publication/PubMed/22013193"
                }
            ]
        },
        {
            "title": "p24 proteins are required for secretion of Wnt ligands.",
            "journal": "EMBO reports",
            "date": "2011",
            "authors": "Buechling T, Chaudhary V, Spirohn K, Weiss M, Boutros M",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22094269",
                    "url": "https://glygen.org/publication/PubMed/22094269"
                }
            ]
        },
        {
            "title": "A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes.",
            "journal": "Cell",
            "date": "2012",
            "authors": "Yu X, Breitman M, Goldberg J",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22304919",
                    "url": "https://glygen.org/publication/PubMed/22304919"
                }
            ]
        },
        {
            "title": "Secretory protein biogenesis and traffic in the early secretory pathway.",
            "journal": "Genetics",
            "date": "2013",
            "authors": "Barlowe CK, Miller EA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23396477",
                    "url": "https://glygen.org/publication/PubMed/23396477"
                }
            ]
        },
        {
            "title": "Isolation of a 45-kDa fragment from the kinesin heavy chain with enhanced ATPase and microtubule-binding activities.",
            "journal": "The Journal of biological chemistry",
            "date": "1989",
            "authors": "Kuznetsov SA, Vaisberg YA, Rothwell SW, Murphy DB, Gelfand VI",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2521221",
                    "url": "https://glygen.org/publication/PubMed/2521221"
                }
            ]
        },
        {
            "title": "A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses.",
            "journal": "Cell",
            "date": "1989",
            "authors": "Yang JT, Laymon RA, Goldstein LS",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2522352",
                    "url": "https://glygen.org/publication/PubMed/2522352"
                }
            ]
        },
        {
            "title": "Moonlighting functions of the NRZ (mammalian Dsl1) complex.",
            "journal": "Frontiers in cell and developmental biology",
            "date": "2014",
            "authors": "Tagaya M, Arasaki K, Inoue H, Kimura H",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25364732",
                    "url": "https://glygen.org/publication/PubMed/25364732"
                }
            ]
        },
        {
            "title": "Diverse roles for the p24 family of proteins in eukaryotic cells.",
            "journal": "Biomolecular concepts",
            "date": "2012",
            "authors": "Schuiki I, Volchuk A",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25436559",
                    "url": "https://glygen.org/publication/PubMed/25436559"
                }
            ]
        },
        {
            "title": "Three alphaSNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF).",
            "journal": "The Journal of biological chemistry",
            "date": "2015",
            "authors": "Shah N, Colbert KN, Enos MD, Herschlag D, Weis WI",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25492864",
                    "url": "https://glygen.org/publication/PubMed/25492864"
                }
            ]
        },
        {
            "title": "Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N-Glycopeptides Found in Serum.",
            "journal": "Proteomics. Clinical applications",
            "date": "2018",
            "authors": "Saraswat M, Makitie A, Tohmola T, Dickinson A, Saraswat S, Joenvaara S, Renkonen S",
            "evidence": [
                {
                    "database": "GlyConnect",
                    "id": "2836",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2836"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29992770",
                    "url": "https://glygen.org/publication/PubMed/29992770"
                }
            ]
        },
        {
            "title": "The quaternary structure of bovine brain kinesin.",
            "journal": "The EMBO journal",
            "date": "1988",
            "authors": "Kuznetsov SA, Vaisberg EA, Shanina NA, Magretova NN, Chernyak VY, Gelfand VI",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "3130248",
                    "url": "https://glygen.org/publication/PubMed/3130248"
                }
            ]
        },
        {
            "title": "Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide.",
            "journal": "Biochemistry",
            "date": "1988",
            "authors": "Bloom GS, Wagner MC, Pfister KK, Brady ST",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "3134048",
                    "url": "https://glygen.org/publication/PubMed/3134048"
                }
            ]
        },
        {
            "title": "KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria.",
            "journal": "Cell",
            "date": "1994",
            "authors": "Nangaku M, Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, Hirokawa N",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7528108",
                    "url": "https://glygen.org/publication/PubMed/7528108"
                }
            ]
        },
        {
            "title": "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.",
            "journal": "Cell",
            "date": "1995",
            "authors": "Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7539720",
                    "url": "https://glygen.org/publication/PubMed/7539720"
                }
            ]
        },
        {
            "title": "Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.",
            "journal": "The Journal of cell biology",
            "date": "1995",
            "authors": "Wordeman L, Mitchison TJ",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7822426",
                    "url": "https://glygen.org/publication/PubMed/7822426"
                }
            ]
        },
        {
            "title": "Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic.",
            "journal": "The Journal of cell biology",
            "date": "1995",
            "authors": "Lippincott-Schwartz J, Cole NB, Marotta A, Conrad PA, Bloom GS",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7844144",
                    "url": "https://glygen.org/publication/PubMed/7844144"
                }
            ]
        },
        {
            "title": "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.",
            "journal": "The Journal of cell biology",
            "date": "1994",
            "authors": "Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7929562",
                    "url": "https://glygen.org/publication/PubMed/7929562"
                }
            ]
        },
        {
            "title": "Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.",
            "journal": "Cell",
            "date": "1994",
            "authors": "Letourneur F, Gaynor EC, Hennecke S, Demolliere C, Duden R, Emr SD, Riezman H, Cosson P",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8001155",
                    "url": "https://glygen.org/publication/PubMed/8001155"
                }
            ]
        },
        {
            "title": "Coatomer interaction with di-lysine endoplasmic reticulum retention motifs.",
            "journal": "Science (New York, N.Y.)",
            "date": "1994",
            "authors": "Cosson P, Letourneur F",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8128252",
                    "url": "https://glygen.org/publication/PubMed/8128252"
                }
            ]
        },
        {
            "title": "En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles.",
            "journal": "The Journal of cell biology",
            "date": "1994",
            "authors": "Hara-Kuge S, Kuge O, Orci L, Amherdt M, Ravazzola M, Wieland FT, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8132710",
                    "url": "https://glygen.org/publication/PubMed/8132710"
                }
            ]
        },
        {
            "title": "A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion.",
            "journal": "Cell",
            "date": "1993",
            "authors": "Sollner T, Bennett MK, Whiteheart SW, Scheller RH, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8221884",
                    "url": "https://glygen.org/publication/PubMed/8221884"
                }
            ]
        },
        {
            "title": "Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.",
            "journal": "The Journal of cell biology",
            "date": "1993",
            "authors": "Tanigawa G, Orci L, Amherdt M, Ravazzola M, Helms JB, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8253837",
                    "url": "https://glygen.org/publication/PubMed/8253837"
                }
            ]
        },
        {
            "title": "Binding of coatomer to Golgi membranes requires ADP-ribosylation factor.",
            "journal": "The Journal of biological chemistry",
            "date": "1993",
            "authors": "Palmer DJ, Helms JB, Beckers CJ, Orci L, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8505331",
                    "url": "https://glygen.org/publication/PubMed/8505331"
                }
            ]
        },
        {
            "title": "Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.",
            "journal": "Cell",
            "date": "1995",
            "authors": "Blangy A, Lane HA, d'Herin P, Harper M, Kress M, Nigg EA",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8548803",
                    "url": "https://glygen.org/publication/PubMed/8548803"
                }
            ]
        },
        {
            "title": "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.",
            "journal": "The EMBO journal",
            "date": "1996",
            "authors": "Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8599929",
                    "url": "https://glygen.org/publication/PubMed/8599929"
                }
            ]
        },
        {
            "title": "Direct observation of single kinesin molecules moving along microtubules.",
            "journal": "Nature",
            "date": "1996",
            "authors": "Vale RD, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-983189",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8602245",
                    "url": "https://glygen.org/publication/PubMed/8602245"
                }
            ]
        },
        {
            "title": "Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles.",
            "journal": "Cell",
            "date": "1996",
            "authors": "Mayer A, Wickner W, Haas A",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8620540",
                    "url": "https://glygen.org/publication/PubMed/8620540"
                }
            ]
        },
        {
            "title": "Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "1997",
            "authors": "Zhao L, Helms JB, Brugger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9114004",
                    "url": "https://glygen.org/publication/PubMed/9114004"
                }
            ]
        },
        {
            "title": "Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "1997",
            "authors": "Otto H, Hanson PI, Jahn R",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9177194",
                    "url": "https://glygen.org/publication/PubMed/9177194"
                }
            ]
        },
        {
            "title": "Bidirectional transport by distinct populations of COPI-coated vesicles.",
            "journal": "Cell",
            "date": "1997",
            "authors": "Orci L, Stamnes M, Ravazzola M, Amherdt M, Perrelet A, Sollner TH, Rothman JE",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9244307",
                    "url": "https://glygen.org/publication/PubMed/9244307"
                }
            ]
        },
        {
            "title": "ER-to-Golgi transport visualized in living cells.",
            "journal": "Nature",
            "date": "1997",
            "authors": "Presley JF, Cole NB, Schroer TA, Hirschberg K, Zaal KJ, Lippincott-Schwartz J",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9288971",
                    "url": "https://glygen.org/publication/PubMed/9288971"
                }
            ]
        },
        {
            "title": "The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1.",
            "journal": "The EMBO journal",
            "date": "1997",
            "authors": "Aoe T, Cukierman E, Lee A, Cassel D, Peters PJ, Hsu VW",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9405360",
                    "url": "https://glygen.org/publication/PubMed/9405360"
                }
            ]
        },
        {
            "title": "A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "1998",
            "authors": "Harter C, Wieland FT",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9751720",
                    "url": "https://glygen.org/publication/PubMed/9751720"
                }
            ]
        },
        {
            "title": "Receptor-induced polymerization of coatomer.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "1999",
            "authors": "Reinhard C, Harter C, Bremser M, Brugger B, Sohn K, Helms JB, Wieland F",
            "evidence": [
                {
                    "database": "Reactome",
                    "id": "R-HSA-6811434",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9990005",
                    "url": "https://glygen.org/publication/PubMed/9990005"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "R-HSA-6811434",
            "name": "COPI-dependent Golgi-to-ER retrograde traffic",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811434",
            "resource": "Reactome",
            "description": "COPI-dependent Golgi-to-ER retrograde traffic"
        },
        {
            "id": "R-HSA-983189",
            "name": "Kinesins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983189",
            "resource": "Reactome",
            "description": "Kinesins"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule binding",
                        "id": "GO:0008017",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP hydrolysis activity",
                        "id": "GO:0016887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule motor activity",
                        "id": "GO:0003777",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "microtubule",
                        "id": "GO:0005874",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial membrane",
                        "id": "GO:0031966",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "kinesin complex",
                        "id": "GO:0005871",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "microtubule-based movement",
                        "id": "GO:0007018",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrion organization",
                        "id": "GO:0007005",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "organelle transport along microtubule",
                        "id": "GO:0072384",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072384",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoskeleton-dependent intracellular transport",
                        "id": "GO:0030705",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030705",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B7ZC32",
                                "url": "https://www.uniprot.org/uniprot/B7ZC32"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 104,
            "end_pos": 106,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 223,
            "end_pos": 225,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 280,
            "end_pos": 282,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 388,
            "end_pos": 390,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 474,
            "end_pos": 476,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
    "sequence_features": {
        "n_linked_sites": [
            280
        ],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 104,
                "end_pos": 106
            },
            {
                "start_pos": 223,
                "end_pos": 225
            },
            {
                "start_pos": 280,
                "end_pos": 282
            },
            {
                "start_pos": 388,
                "end_pos": 390
            },
            {
                "start_pos": 474,
                "end_pos": 476
            }
        ]
    },
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                },
                {
                    "field": "n_linked_glycans",
                    "count": 1
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 1
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": [
                "glytoucan_ac",
                "type",
                "subtype",
                "site_category",
                "site_seq",
                "relation",
                "comment",
                "start_pos",
                "start_aa",
                "end_pos",
                "end_aa",
                "residue",
                "site_lbl"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                },
                {
                    "field": "n_linked_glycans",
                    "count": 1
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 1
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": [
                "glytoucan_ac",
                "type",
                "subtype",
                "site_category",
                "site_seq",
                "relation",
                "comment",
                "start_pos",
                "start_aa",
                "end_pos",
                "end_aa",
                "residue",
                "site_lbl"
            ]
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 109
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}
