{ "uniprot_canonical_ac": "B0M0P8-1", "uniprot_ac": "B0M0P8", "uniprot_id": "GEFL_DICDI", "mass": { "chemical_mass": 262822.0, "monoisotopic_mass": 262822.0 }, "refseq": { "ac": "XP_643190", "name": "Ras guanine nucleotide exchange factor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643190" }, "gene_names": [ { "name": "gefL", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B0M0P8", "id": "B0M0P8" }, { "name": "DDB_G0276371", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B0M0P8", "id": "B0M0P8" }, { "name": "gefL", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643190", "id": "XP_643190" }, { "name": "rasGEFL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B0M0P8", "id": "B0M0P8" } ], "protein_names": [ { "name": "Ras guanine nucleotide exchange factor L", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B0M0P8" }, { "name": "Ras guanine nucleotide exchange factor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643190", "id": "XP_643190" }, { "name": "RasGEF domain-containing protein L", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0M0P8" } ], "function": [ { "annotation": "Promotes the exchange of Ras-bound GDP by GTP.", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "gefL", "url": "https://www.uniprot.org/uniprot/B0M0P8", "locus": {} } ], "crossref": [ { "id": "cd00155", "url": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0276371", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0276371", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113:SF346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00617", "url": "http://pfam.xfam.org/family/PF00617", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00618", "url": "http://pfam.xfam.org/family/PF00618", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06371", "url": "http://pfam.xfam.org/family/PF06371", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12799", "url": "http://pfam.xfam.org/family/PF12799", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B0M0P8", "url": "http://purl.obolibrary.org/obo/PR_B0M0P8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-193648", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-193648", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_643190", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643190", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0M0P8-1", "url": "https://www.uniprot.org/uniprot/B0M0P8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSMSSGGINKLFEGSLSKDGKTSRIEHQKIKQSGCPLLIKLMKDNGHITNVIIKSCRLKVLPGEISSLGGHLKKLHIEDNKIQEIPNLEQLEQLEELILPNNDIAKFQVSISKLTTLRLLDLSGNQLGTIPVRLFSLVSMRELYLDENQFSNFPSHLCELQKLTTLGFSNNLLKSIPTQIGQMIGLKKLILSGNQMESIPMEISNLKSLTHLDCSSNILSSIPNELGNKLSQLSFLFLQHNKLRSIPDEIGQCQSLVSLRLNNNSITLLPQSIGELENLQELYLQENRLNTLPSELGNCCSLKKLYLEFNKLIALPDRFKRLHCLNVLSLHDNLLDDLPNFLSLEFSQHLIRFTIHNNPFLRENGIDVIDSLQFLNSHLLSIQNFINNHDQQNDNSNNNNNNNNTTTTTTTTTTTTTTSTTNNNNTLFTDSYLSSASSSSFLNKSPSGLSLVGSFNGTIKKSISNSSNMNGSGSNGVGHGSGLTPKLNFKSLITSRDFSSDSDSDTDSTSSFSTYSSSTINTKRASISPRTSLTLSNSASNDSVSAVANGNGNNNNNNNNNNNNNNNSNNNNSGLVNSISSFSLSSGQINYYNISRARRGTHGNDQPHQTISPSTSTEKLQQTVSTPRQQSFFISVLNRRKSSLNNSQNGNNSNNNSNNNNNNSNNNISSLSSSNFANSLYNPLMSSSPTSSPSSSYSNLHSSFNGTSTPPFSSPSQSSPLSNSINGIHCNYSNNNNNNNNSNNNNNNNNNNNINNNNNNSNNNNNINTNGNNNSFNGIIMGSPIYKSFQSLYETLLDDLDYSKKRREELLNLSVEEKWIFLQRIKPDCTNSLVSNGVYQLQHQISSNDLKTLISSPPKLNSSQQLLSSSSSSSSLSSSSTSATHSLQNKSLPSISVCPKSPRTHMKVLSASSLFTLEDITKLRQQLVSKPVSWVINFAESTGIVSILSMITTYSQNLINNVNKDQPQSQPQPQPQPQPRPQPQQPQPQQPQPQQLLPLLSQLQPQQQQQQQQQTQQPQPQLQAQTKSDDHFIINECLGCIKLLVELEMQSLLLNDTAEIIFPLILSSQVSTKRMTFEVLELICKIFSLGSTIVLESIKNYSKKINEPLTKVFSHITSPLDSEYPADLKVSCMSLINHLIGSNHLSLEARIETRSKFLSNDILLIIKNLRIDGEGIETSSWKQLELEMKQFESMMVQDDNQTSNAEANELVSNELSQSIDNNNNNNNNNNNNSSTNLVNNNNNNNINSNCNSIINGGNSSDSLINNSVGTGVGSIMGVGSFMGVNEIEYDSPRKEFDELKSSNNNNSNSNSVNNFINNITEPIMPLTPTEGKLVVIVSMQQTRQQAQLQQQLQQQLEEEDDDEVPLSSSVATTASTTANTTLIEPNHLPIQTREVIVSVQRKSQAGDVIRSLLASNSNLKELGEWGLFVNDSNSNNNNNNNNNNNNKLSTNVIGRFLKDDEYIFDQMTTSSTSGSLSSDDGATPRLMTRSIPRFKEYRLKMIPWKVRVSLEKVKEMGLVLNANNTANGQFNESKFIAEAPMDPTMTCTGLVYHLIKKYLPNVNDRYCLEADDFGLYLDTNAGGLMWGGGTGGGYWLEPLEKLHDYEIFKDPKSTVALKLRPKGVKLKFADGTYEIFRLDLMSPTEKIFQEISEKVIDSNNNINLSYYGIFVDRQQGGANGNGISDSPILVSQSSSTSLIEESKKQRKPEWLEKGLPLYHYKINSRCCLRFALRPSNITLLIDISLFKSFQQQQQQQQQQQQQSTSSSSSSSSSSSVSSNNNSTNNSNNLIGSLNNSINTISELDESIDDNGLSSSSSDKEDQISTPSTSNLLSKFQQVDESISNLKFQLPQPIQSKQIIVQLPLHLPLGEALETDENWIETGIEREKCSFHFDSFDGILMNQTQPLNTQNFTEKNRICVLMADELEINSEQTNHNKTNIWDEPFDSSTIICDPDNPGQIRAATLNKLLEQATNNIEKDRELMNILLMTYMSFATSDILLDKLVERYNVPEHEKEQKSVVQLHTIVFLKNWLEQQAPQAASGGGLEEKFLVRLSEFVDKQISLDGYTKIVPQLKKWIDSALKEKRAYAMPEAARPNQLTTKLPSLTSSLLDDELFVAQQLTLREYETFKRIQAVEFLGQAWGKPKLQYKAPNLLKMIERFNKISTGVSTAILSQPKIKTRVKLICRFIKIAQHCRDLNNYHLLTAFMAGIRNSNVVRLRLSWAKVPKKHLHILEDLEKIMSMEGSFKEFRTKMAETIPPCIPYLGVYLKDLTFIEEGNPDSINSLINWGKKKLIYNIISIIQRCQQVSYDFGNQNQSQVAQKSDLVLNYFDSLPIALDELLYKISLNLEPRSNFNN", "length": 2356, "header": "sp|B0M0P8-1|GEFL_DICDI Isoform 1 of Ras guanine nucleotide exchange factor L OS=Dictyostelium discoideum OX=44689 GN=gefL PE=2 SV=1 CANONICAL=B0M0P8-1" }, "isoforms": [ { "isoform_ac": "B0M0P8-1", "url": "", "sequence": { "sequence": "MKSMSSGGINKLFEGSLSKDGKTSRIEHQKIKQSGCPLLIKLMKDNGHITNVIIKSCRLKVLPGEISSLGGHLKKLHIEDNKIQEIPNLEQLEQLEELILPNNDIAKFQVSISKLTTLRLLDLSGNQLGTIPVRLFSLVSMRELYLDENQFSNFPSHLCELQKLTTLGFSNNLLKSIPTQIGQMIGLKKLILSGNQMESIPMEISNLKSLTHLDCSSNILSSIPNELGNKLSQLSFLFLQHNKLRSIPDEIGQCQSLVSLRLNNNSITLLPQSIGELENLQELYLQENRLNTLPSELGNCCSLKKLYLEFNKLIALPDRFKRLHCLNVLSLHDNLLDDLPNFLSLEFSQHLIRFTIHNNPFLRENGIDVIDSLQFLNSHLLSIQNFINNHDQQNDNSNNNNNNNNTTTTTTTTTTTTTTSTTNNNNTLFTDSYLSSASSSSFLNKSPSGLSLVGSFNGTIKKSISNSSNMNGSGSNGVGHGSGLTPKLNFKSLITSRDFSSDSDSDTDSTSSFSTYSSSTINTKRASISPRTSLTLSNSASNDSVSAVANGNGNNNNNNNNNNNNNNNSNNNNSGLVNSISSFSLSSGQINYYNISRARRGTHGNDQPHQTISPSTSTEKLQQTVSTPRQQSFFISVLNRRKSSLNNSQNGNNSNNNSNNNNNNSNNNISSLSSSNFANSLYNPLMSSSPTSSPSSSYSNLHSSFNGTSTPPFSSPSQSSPLSNSINGIHCNYSNNNNNNNNSNNNNNNNNNNNINNNNNNSNNNNNINTNGNNNSFNGIIMGSPIYKSFQSLYETLLDDLDYSKKRREELLNLSVEEKWIFLQRIKPDCTNSLVSNGVYQLQHQISSNDLKTLISSPPKLNSSQQLLSSSSSSSSLSSSSTSATHSLQNKSLPSISVCPKSPRTHMKVLSASSLFTLEDITKLRQQLVSKPVSWVINFAESTGIVSILSMITTYSQNLINNVNKDQPQSQPQPQPQPQPRPQPQQPQPQQPQPQQLLPLLSQLQPQQQQQQQQQTQQPQPQLQAQTKSDDHFIINECLGCIKLLVELEMQSLLLNDTAEIIFPLILSSQVSTKRMTFEVLELICKIFSLGSTIVLESIKNYSKKINEPLTKVFSHITSPLDSEYPADLKVSCMSLINHLIGSNHLSLEARIETRSKFLSNDILLIIKNLRIDGEGIETSSWKQLELEMKQFESMMVQDDNQTSNAEANELVSNELSQSIDNNNNNNNNNNNNSSTNLVNNNNNNNINSNCNSIINGGNSSDSLINNSVGTGVGSIMGVGSFMGVNEIEYDSPRKEFDELKSSNNNNSNSNSVNNFINNITEPIMPLTPTEGKLVVIVSMQQTRQQAQLQQQLQQQLEEEDDDEVPLSSSVATTASTTANTTLIEPNHLPIQTREVIVSVQRKSQAGDVIRSLLASNSNLKELGEWGLFVNDSNSNNNNNNNNNNNNKLSTNVIGRFLKDDEYIFDQMTTSSTSGSLSSDDGATPRLMTRSIPRFKEYRLKMIPWKVRVSLEKVKEMGLVLNANNTANGQFNESKFIAEAPMDPTMTCTGLVYHLIKKYLPNVNDRYCLEADDFGLYLDTNAGGLMWGGGTGGGYWLEPLEKLHDYEIFKDPKSTVALKLRPKGVKLKFADGTYEIFRLDLMSPTEKIFQEISEKVIDSNNNINLSYYGIFVDRQQGGANGNGISDSPILVSQSSSTSLIEESKKQRKPEWLEKGLPLYHYKINSRCCLRFALRPSNITLLIDISLFKSFQQQQQQQQQQQQQSTSSSSSSSSSSSVSSNNNSTNNSNNLIGSLNNSINTISELDESIDDNGLSSSSSDKEDQISTPSTSNLLSKFQQVDESISNLKFQLPQPIQSKQIIVQLPLHLPLGEALETDENWIETGIEREKCSFHFDSFDGILMNQTQPLNTQNFTEKNRICVLMADELEINSEQTNHNKTNIWDEPFDSSTIICDPDNPGQIRAATLNKLLEQATNNIEKDRELMNILLMTYMSFATSDILLDKLVERYNVPEHEKEQKSVVQLHTIVFLKNWLEQQAPQAASGGGLEEKFLVRLSEFVDKQISLDGYTKIVPQLKKWIDSALKEKRAYAMPEAARPNQLTTKLPSLTSSLLDDELFVAQQLTLREYETFKRIQAVEFLGQAWGKPKLQYKAPNLLKMIERFNKISTGVSTAILSQPKIKTRVKLICRFIKIAQHCRDLNNYHLLTAFMAGIRNSNVVRLRLSWAKVPKKHLHILEDLEKIMSMEGSFKEFRTKMAETIPPCIPYLGVYLKDLTFIEEGNPDSINSLINWGKKKLIYNIISIIQRCQQVSYDFGNQNQSQVAQKSDLVLNYFDSLPIALDELLYKISLNLEPRSNFNN", "length": 2356, "header": "sp|B0M0P8-1|GEFL_DICDI Isoform 1 of Ras guanine nucleotide exchange factor L OS=Dictyostelium discoideum OX=44689 GN=gefL PE=2 SV=1 CANONICAL=B0M0P8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gl\u00f6ckner Gernot, Eichinger Ludwig, Szafranski Karol, Pachebat Justin A, Bankier Alan T, Dear Paul H, Lehmann R\u00fcdiger, Baumgart Cornelia, Parra Gen\u00eds, Abril Josep F, Guig\u00f3 Roderic, Kumpf Kai, Tunggal Budi, Cox Edward, Quail Michael A, Platzer Matthias, Rosenthal Andr\u00e9, Noegel Angelika A,", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles.", "journal": "Genome Biol.", "date": "2005", "authors": "Wilkins Andrew, Szafranski Karol, Fraser Derek J, Bakthavatsalam Deenadayalan, M\u00fcller Rolf, Fisher Paul R, Gl\u00f6ckner Gernot, Eichinger Ludwig, Noegel Angelika A, Insall Robert H", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "reference": [ { "type": "PubMed", "id": "16086850", "url": "https://glygen.org/publication/PubMed/16086850" } ] } ], "pathway": [ { "id": "ddi:DDB_G0276371", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0276371", "resource": "KEGG Pathway" }, { "id": "R-DDI-193648", "name": "NRAGE signals death through JNK", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-193648", "resource": "Reactome", "description": "NRAGE signals death through JNK" }, { "id": "R-DDI-9013148", "name": "CDC42 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-DDI-9013149", "name": "RAC1 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013149", "resource": "Reactome", "description": "RAC1 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "B0M0P8", "url": "https://www.uniprot.org/uniprot/B0M0P8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": 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