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"url": "", "id": "B0G107" } ], "function": [ { "annotation": "Has deoxynucleoside triphosphate (dNTPase) activity.", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107#function" }, { "database": "UniProtKB", "id": "Q9Y3Z3", "url": "https://www.uniprot.org/uniprot/Q9Y3Z3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/B0G107", "locus": {} } ], "crossref": [ { "id": "cd00077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0272484", "url": "http://dictybase.org/gene/DDB_G0272484", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8618486", "url": "https://www.ncbi.nlm.nih.gov/gene/8618486", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0272484", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0272484", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NDQVHGY", "url": "https://omabrowser.org/oma/group/NDQVHGY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11373", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11373", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11373:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11373:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01966", "url": "http://pfam.xfam.org/family/PF01966", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19276", "url": "http://pfam.xfam.org/family/PF19276", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B0G107", "url": "http://purl.obolibrary.org/obo/PR_B0G107", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-8956319", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8956319", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_001732970", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001732970", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "46148", "url": "https://www.rhea-db.org/rhea/46148", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0G107-1", "url": "https://www.uniprot.org/uniprot/B0G107-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNTFKYVNEDVSGTEGEESDYDPSEFIRGYHESPRSPRLIDYEMGRGLMGNFKGLGINKVRQSNEYDNDTDYSSRKSSKIINDVIHGHMEVPDYIMDFIDTEQFQRLRDLKQVGTTSFVFPCASHSRFEHSIGVSHLAGKYIDRIKVTQPELEITEREQKFVRIAGLCHDLGHGPFSHAFESWVDQLGGSKRFHHEDMSIKMLNWIIDDHGLDEYDSDDIKFISSLIQGKHRPKERAFIYDIVANNRNSVDVDKFDYLSRDSYYLGRSTVCDFQRLMEFSKVIDDQICFLSKEIYNLYELFHTRYSLHKLVYTHKVGKSIEFMIADAFTEADQFLKISDQLEDPKEFINLSDSLLRRIETSKEPELEKSRKIIKNIRNRNLYKFVDEIIVSTDKIRWSADSLAEDIAKVGNGILESDIIVQNLKLNYAFKDKDPVQSTRFYTRYDSTQSFTIKKEETSHLIPNQFQEERIRIFCRSKEKCEQVQTAFRKLLKNHNLSPNPSFTVSPARNIKKI", "length": 514, "header": "sp|B0G107-1|SAMH1_DICDI Isoform 1 of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=B0G107-1" }, "isoforms": [ { "isoform_ac": "B0G107-1", "url": "", "sequence": { "sequence": "MNNTFKYVNEDVSGTEGEESDYDPSEFIRGYHESPRSPRLIDYEMGRGLMGNFKGLGINKVRQSNEYDNDTDYSSRKSSKIINDVIHGHMEVPDYIMDFIDTEQFQRLRDLKQVGTTSFVFPCASHSRFEHSIGVSHLAGKYIDRIKVTQPELEITEREQKFVRIAGLCHDLGHGPFSHAFESWVDQLGGSKRFHHEDMSIKMLNWIIDDHGLDEYDSDDIKFISSLIQGKHRPKERAFIYDIVANNRNSVDVDKFDYLSRDSYYLGRSTVCDFQRLMEFSKVIDDQICFLSKEIYNLYELFHTRYSLHKLVYTHKVGKSIEFMIADAFTEADQFLKISDQLEDPKEFINLSDSLLRRIETSKEPELEKSRKIIKNIRNRNLYKFVDEIIVSTDKIRWSADSLAEDIAKVGNGILESDIIVQNLKLNYAFKDKDPVQSTRFYTRYDSTQSFTIKKEETSHLIPNQFQEERIRIFCRSKEKCEQVQTAFRKLLKNHNLSPNPSFTVSPARNIKKI", "length": 514, "header": "sp|B0G107-1|SAMH1_DICDI Isoform 1 of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=B0G107-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gl\u00f6ckner Gernot, Eichinger Ludwig, Szafranski Karol, Pachebat Justin A, Bankier Alan T, Dear Paul H, Lehmann R\u00fcdiger, Baumgart Cornelia, Parra Gen\u00eds, Abril Josep F, Guig\u00f3 Roderic, Kumpf Kai, Tunggal Budi, Cox Edward, Quail Michael A, Platzer Matthias, Rosenthal Andr\u00e9, Noegel Angelika A,", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0272484", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0272484", "resource": "KEGG Pathway" }, { "id": "R-DDI-8956319", "name": "Nucleotide catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8956319", "resource": "Reactome", "description": "Nucleotide catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" }, { "name": "dGTPase activity", "id": "GO:0008832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008832", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" }, { "name": "deoxynucleoside triphosphate hydrolase activity", "id": "GO:0106375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106375", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" }, { "name": "dGTP catabolic process", "id": "GO:0006203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006203", "evidence": [ { "database": "UniProtKB", "id": "B0G107", "url": "https://www.uniprot.org/uniprot/B0G107" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "46148", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Y3Z3-1", "Q60710-1", "B0G107-1" ], "evidence": [ { "id": "46148", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46148" } ] }, { "id": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-8866574" ], "output_participant_list": [ "R-ALL-8866567", "R-ALL-8866608" ], "enzyme_list": [ "B0G107-1" ], "evidence": [ { "id": "R-DDI-8866601", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8866601" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-8866567", "participant_name": "PPPi [nucleoplasm]", "crossref": [ { "id": "18036", "database": "ChEBI", "url": "" }, { "id": "000006827739", "database": "ZINC", "url": "" }, { "id": "C03279", "database": "COMPOUND", "url": "" }, { "id": "C03279", "database": "COMPOUND", "url": "" }, { "id": "18036", "database": "ChEBI", "url": "" }, { "id": "000006827739", "database": "ZINC", "url": "" }, { "id": "18036", "database": "ChEBI", "url": "" }, { "id": "000006827739", "database": "ZINC", "url": "" }, { "id": "C03279", "database": "COMPOUND", "url": "" }, { 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"reaction_enzymes": [ { "uniprot_ac": "B0G107", "gene_name": "", "activity": [ { "ec_number": "3.1.5.-", "activity": "", "evidence": [ { "id": "B0G107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G107" } ] } ] }, { "uniprot_ac": "Q60710", "gene_name": "Samhd1", "activity": [ { "ec_number": "3.1.5.-", "activity": "", "evidence": [ { "id": "Q60710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60710" } ] } ] }, { "uniprot_ac": "Q9Y3Z3", "gene_name": "SAMHD1", "activity": [ { "ec_number": "3.1.5.-", "activity": "", "evidence": [ { "id": "Q9Y3Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y3Z3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 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