{ "uniprot_canonical_ac": "B0G0Y8-1", "uniprot_ac": "B0G0Y8", "uniprot_id": "PDE3_DICDI", "mass": { "chemical_mass": 53121.0, "monoisotopic_mass": 53121.0 }, "refseq": { "ac": "XP_001732951", "name": "cGMP-specific phosphodiesterase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001732951" }, "gene_names": [ { "name": "pde3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B0G0Y8", "id": "B0G0Y8" }, { "name": "DDB_G0268634", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B0G0Y8", "id": "B0G0Y8" }, { "name": "pde3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001732951", "id": "XP_001732951" } ], "protein_names": [ { "name": "cGMP-specific 3',5'-cGMP phosphodiesterase 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B0G0Y8" }, { "name": "3.1.4.35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G0Y8" }, { "name": "DdPDE3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G0Y8" }, { "name": "Phosphodiesterase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G0Y8" }, { "name": "cGMP-specific phosphodiesterase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001732951", "id": "XP_001732951" } ], "function": [ { "annotation": "Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP.", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8#function" }, { "database": "PubMed", "id": "11171061", "url": "https://glygen.org/publication/PubMed/11171061" }, { "database": "PubMed", "id": "12429832", "url": "https://glygen.org/publication/PubMed/12429832" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "pde3", "url": "https://www.uniprot.org/uniprot/B0G0Y8", "locus": {} } ], "crossref": [ { "id": "DDB_G0268634", "url": "http://dictybase.org/gene/DDB_G0268634", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8616668", "url": "https://www.ncbi.nlm.nih.gov/gene/8616668", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0268634", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0268634", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WANALME", "url": "https://omabrowser.org/oma/group/WANALME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11347", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11347", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11347:SF198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11347:SF198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00233", "url": "http://pfam.xfam.org/family/PF00233", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B0G0Y8", "url": "http://purl.obolibrary.org/obo/PR_B0G0Y8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-111957", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-111957", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-165160", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-165160", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-180024", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-180024", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-418457", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-418457", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-418555", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_001732951", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001732951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16957", "url": "https://www.rhea-db.org/rhea/16957", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0G0Y8-1", "url": "https://www.uniprot.org/uniprot/B0G0Y8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPQQNIMKQLQQMQSSPYPSSSPSSTTVSQNNDNLNHNVHSLNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSINEKNKINDNNNRGNSDDGNNNNSNNNSNNNNSNNNNRDDEEEEGDDEDNNNNNNSNNNKIRGYNDNNDINDIFSINFSSWSKSKDNLIENGVLIFEESGLYKELNLSKSSILNFLSIVASSYRNNPFHSFNHAIAVTQTIFLILLKTNLFNILSPIEKLSIIIASICHDLDHPALSNRFQINMKSSIAVLYNNKSVLENHHLSICLGILESKIGNELLSTLTVEEKKQFFRRVKILILATDMENHFTYKKQFDDIISTFSWDNSEHRDLLLIMFLKSADISNELRSFDISNKWANALMEEFFNQSDLEKLNNLPLTPFMEREKVVLHLTQVSFIEKFLLPSYQSLQNLLPSLEDFVQRIIENKEIWSNNGSSSSTTSSSPN", "length": 466, "header": "sp|B0G0Y8-1|PDE3_DICDI Isoform 1 of cGMP-specific 3',5'-cGMP phosphodiesterase 3 OS=Dictyostelium discoideum OX=44689 GN=pde3 PE=1 SV=1 CANONICAL=B0G0Y8-1" }, "isoforms": [ { "isoform_ac": "B0G0Y8-1", "url": "", "sequence": { "sequence": "MAPQQNIMKQLQQMQSSPYPSSSPSSTTVSQNNDNLNHNVHSLNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSINEKNKINDNNNRGNSDDGNNNNSNNNSNNNNSNNNNRDDEEEEGDDEDNNNNNNSNNNKIRGYNDNNDINDIFSINFSSWSKSKDNLIENGVLIFEESGLYKELNLSKSSILNFLSIVASSYRNNPFHSFNHAIAVTQTIFLILLKTNLFNILSPIEKLSIIIASICHDLDHPALSNRFQINMKSSIAVLYNNKSVLENHHLSICLGILESKIGNELLSTLTVEEKKQFFRRVKILILATDMENHFTYKKQFDDIISTFSWDNSEHRDLLLIMFLKSADISNELRSFDISNKWANALMEEFFNQSDLEKLNNLPLTPFMEREKVVLHLTQVSFIEKFLLPSYQSLQNLLPSLEDFVQRIIENKEIWSNNGSSSSTTSSSPN", "length": 466, "header": "sp|B0G0Y8-1|PDE3_DICDI Isoform 1 of cGMP-specific 3',5'-cGMP phosphodiesterase 3 OS=Dictyostelium discoideum OX=44689 GN=pde3 PE=1 SV=1 CANONICAL=B0G0Y8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium.", "journal": "The Biochemical journal", "date": "2001-02-01", "authors": "Kuwayama H, Snippe H, Derks M, Roelofs J, Van Haastert P J", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "reference": [ { "type": "PubMed", "id": "11171061", "url": "https://glygen.org/publication/PubMed/11171061" } ] }, { "title": "Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in dictyostelium.", "journal": "Molecular biology of the cell", "date": "2002-11", "authors": "Bosgraaf Leonard, Russcher Henk, Snippe Helena, Bader Sonya, Wind Joyce, Van Haastert Peter J M", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "reference": [ { "type": "PubMed", "id": "12429832", "url": "https://glygen.org/publication/PubMed/12429832" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes.", "journal": "Bioinformatics", "date": "2005", "authors": "Booth Ezgi O, Van Driessche Nancy, Zhuchenko Olga, Kuspa Adam, Shaulsky Gad", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "reference": [ { "type": "PubMed", "id": "16234315", "url": "https://glygen.org/publication/PubMed/16234315" } ] }, { "title": "Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP.", "journal": "Biochem. J.", "date": "2007", "authors": "Bader Sonya, Kortholt Arjan, Van Haastert Peter J M", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "reference": [ { "type": "PubMed", "id": "17040207", "url": "https://glygen.org/publication/PubMed/17040207" } ] } ], "pathway": [ { "id": "ddi:DDB_G0268634", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0268634", "resource": "KEGG Pathway" }, { "id": "R-DDI-111957", "name": "Cam-PDE 1 activation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-111957", "resource": "Reactome", "description": "Cam-PDE 1 activation" }, { "id": "R-DDI-165160", "name": "PDE3B signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-165160", "resource": "Reactome", "description": "PDE3B signalling" }, { "id": "R-DDI-180024", "name": "DARPP-32 events", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-180024", "resource": "Reactome", "description": "DARPP-32 events" }, { "id": "R-DDI-418457", "name": "cGMP effects", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-418457", "resource": "Reactome", "description": "cGMP effects" }, { "id": "R-DDI-418555", "name": "G alpha (s) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" }, { "name": "cGMP binding", "id": "GO:0030553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030553", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" }, { "name": "3',5'-cyclic-GMP phosphodiesterase activity", "id": "GO:0047555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047555", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" }, { "name": "3',5'-cyclic-nucleotide phosphodiesterase activity", "id": "GO:0004114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004114", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cGMP-mediated signaling", "id": "GO:0019934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019934", "evidence": [ { "database": "UniProtKB", "id": "B0G0Y8", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16957", "name": "", "equation": "3',5'-cyclic GMP + H2O = GMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VID6-1", "P61250-1", "O54735-1", "Q8QZV1-1", "M0R4R9-1", "Q9QYJ6-1", "Q63421-1", "A0A8I6A416-1", "Q01066-1", "Q62865-1", "Q01062-1", "Q63085-1", "P18545-1", "Q13956-1", "O76083-1", "P51160-1", "P16499-1", "Q9HCR9-1", "O76074-1", "P35913-1", "Q9Y233-3", "Q14123-1", "O00408-1", "Q13370-1", "P54750-1", "Q01064-1", "Q14432-1", "Q01065-1", "P09174-1", "P61249-1", "Q91ZQ1-1", "P27664-1", "P23440-1", "Q8CG03-1", "O70628-1", "P0C1Q2-1", "Q8CA95-1", "Q61481-4", "Q61409-1", "Q9Z0X4-1", "Q922S4-1", "Q64338-3", "B0G0Y8-1", "P12019-1", "Q54HY0-1", "Q8MLZ3-1", "Q8MM62-1", "B7YZV4-1", "Q9I7S6-1", "Q9VFI9-1", "Q9VJ79-1" ], "evidence": [ { "id": "16957", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16957" } ] }, { "id": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-111955", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-111955" } ] }, { "id": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-111956", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-111956" } ] }, { "id": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-111962", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-111962" } ] }, { "id": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-162425", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-162425" } ] }, { "id": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-418456", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-418456" } ] }, { "id": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-418553", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-418553" } ] }, { "id": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-9629675", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9629675" } ] }, { "id": "R-DDI-9629679", "name": "PDE3A inhibitors bind PDE3A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-9629679", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9629679" } ] }, { "id": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-9644869", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9644869" } ] }, { "id": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-9705507", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9705507" } ] }, { "id": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-9708261", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9708261" } ] }, { "id": "R-DDI-9708275", "name": "PDE4A binds PDE4A inhibitors", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B0G0Y8-1", "Q23917-1", "Q86H13-1" ], "evidence": [ { "id": "R-DDI-9708275", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9708275" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6A416", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A8I6A416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A416" } ] } ] }, { "uniprot_ac": "B0G0Y8", "gene_name": "pde3", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "B0G0Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "B0G0Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ] } ] }, { "uniprot_ac": "B7YZV4", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] } ] }, { "uniprot_ac": "M0R4R9", "gene_name": "Pde6g", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "M0R4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4R9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "M0R4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4R9" } ] } ] }, { "uniprot_ac": "O00408", "gene_name": "PDE2A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] } ] }, { "uniprot_ac": "O54735", "gene_name": "Pde5a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] } ] }, { "uniprot_ac": "O70628", "gene_name": "Pde9a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] } ] }, { "uniprot_ac": "O76074", "gene_name": "PDE5A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] } ] }, { "uniprot_ac": "O76083", "gene_name": "PDE9A", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O76083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76083" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O76083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76083" } ] } ] }, { "uniprot_ac": "P09174", "gene_name": "Pde6g", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P09174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09174" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P09174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09174" } ] } ] }, { "uniprot_ac": "P0C1Q2", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] } ] }, { "uniprot_ac": "P12019", "gene_name": "pdsA", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] } ] }, { "uniprot_ac": "P16499", "gene_name": "PDE6A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] } ] }, { "uniprot_ac": "P18545", "gene_name": "PDE6G", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P18545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18545" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P18545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18545" } ] } ] }, { "uniprot_ac": "P23440", "gene_name": "Pde6b", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P23440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23440" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P23440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23440" } ] } ] }, { "uniprot_ac": "P27664", "gene_name": "Pde6a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] } ] }, { "uniprot_ac": "P35913", "gene_name": "PDE6B", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P35913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35913" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P35913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35913" } ] } ] }, { "uniprot_ac": "P51160", "gene_name": "PDE6C", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P51160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51160" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P51160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51160" } ] } ] }, { "uniprot_ac": "P54750", "gene_name": "PDE1A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] } ] }, { "uniprot_ac": "P61249", "gene_name": "Pde6h", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P61249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61249" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P61249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61249" } ] } ] }, { "uniprot_ac": "P61250", "gene_name": "Pde6h", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P61250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61250" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P61250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61250" } ] } ] }, { "uniprot_ac": "Q01062", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] } ] }, { "uniprot_ac": "Q01064", "gene_name": "PDE1B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] } ] }, { "uniprot_ac": "Q01065", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] } ] }, { "uniprot_ac": "Q01066", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] } ] }, { "uniprot_ac": "Q13370", "gene_name": "PDE3B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] } ] }, { "uniprot_ac": "Q13956", "gene_name": "PDE6H", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + 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