{ "uniprot_canonical_ac": "A8MX19-1", "uniprot_ac": "A8MX19", "uniprot_id": "F90AC_HUMAN", "mass": { "chemical_mass": 49786.0, "monoisotopic_mass": 49786.0 }, "refseq": {}, "gene_names": [ { "name": "FAM90A12", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A8MX19", "id": "A8MX19" }, { "name": "FAM90A12P", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8MX19", "id": "A8MX19" } ], "protein_names": [ { "name": "Protein FAM90A12", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A8MX19" }, { "name": "Protein FAM90A12P", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A8MX19" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "A8MX19", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MX19" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "A8MX19", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MX19" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "A8MX19", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MX19" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": 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"Protein Classification" ] }, { "id": "PF15288", "url": "http://pfam.xfam.org/family/PF15288", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A8MX19", "url": "https://pharos.nih.gov/targets/A8MX19", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "A8MX19", "url": "https://www.uniprot.org/uniprot/A8MX19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8MX19-1", "url": "https://www.uniprot.org/uniprot/A8MX19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMARRDPKSWAKRLVRAQTLQKQRRAPVGPRAPPPDEEDPRLKCKNCGAFGHTARSTRCPMKCWKAALVPATLGKKEGKENLKPWKPRAEANPGPLNKDKGEKEERPRQQDPQRKALLHMFSGKPPEKPLPNGKGSTESSDYLRVASGPMPVHTSSKRPRLDPILADRSATAMSGRGSVLASLSPLRKASLSSSSSLGPKERQTGAAADMPQPAVRHEGREPLLVVKPTHSRPEGGCREVPQAASKTHGLPQAARPQAQDKRPAVTSLPCPPAATHSLGLGSNLSFGPGAKRPAQAPIQACLNFPKKPRLGPFQIPESAIQGGELGAPENLQPPPAATELGPSTSPQMGRRTPAQVPSVDRQPPHSRPCLPTAQACTMSHHSAASHDGAQPLRVLFRRLENGRWSSSLLAAPSFHSPEKPGAFLAQSPHVSEKSEAPCVRVPPSVLYEDLQVSSSSEDSDSDLE", "length": 464, "header": "sp|A8MX19-1|F90AC_HUMAN Isoform 1 of Protein FAM90A12 OS=Homo sapiens OX=9606 GN=FAM90A12 PE=1 SV=1 CANONICAL=A8MX19-1" }, "isoforms": [ { "isoform_ac": "A8MX19-1", "url": "", "sequence": { "sequence": "MMARRDPKSWAKRLVRAQTLQKQRRAPVGPRAPPPDEEDPRLKCKNCGAFGHTARSTRCPMKCWKAALVPATLGKKEGKENLKPWKPRAEANPGPLNKDKGEKEERPRQQDPQRKALLHMFSGKPPEKPLPNGKGSTESSDYLRVASGPMPVHTSSKRPRLDPILADRSATAMSGRGSVLASLSPLRKASLSSSSSLGPKERQTGAAADMPQPAVRHEGREPLLVVKPTHSRPEGGCREVPQAASKTHGLPQAARPQAQDKRPAVTSLPCPPAATHSLGLGSNLSFGPGAKRPAQAPIQACLNFPKKPRLGPFQIPESAIQGGELGAPENLQPPPAATELGPSTSPQMGRRTPAQVPSVDRQPPHSRPCLPTAQACTMSHHSAASHDGAQPLRVLFRRLENGRWSSSLLAAPSFHSPEKPGAFLAQSPHVSEKSEAPCVRVPPSVLYEDLQVSSSSEDSDSDLE", "length": 464, "header": "sp|A8MX19-1|F90AC_HUMAN Isoform 1 of Protein FAM90A12 OS=Homo sapiens OX=9606 GN=FAM90A12 PE=1 SV=1 CANONICAL=A8MX19-1" }, "locus": { "chromosome": "8", "start_pos": 8030646, "end_pos": 8027639, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000519497.2", "url": "https://www.ensembl.org/id/ENST00000519497.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000514268.1", "url": "https://www.ensembl.org/id/ENSP00000514268.1" } ] } } ], "glycosylation": [], 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