{ "uniprot_canonical_ac": "A8MW95-1", "uniprot_ac": "A8MW95", "uniprot_id": "BECN2_HUMAN", "mass": { "chemical_mass": 48153.0, "monoisotopic_mass": 48153.0 }, "refseq": { "ac": "NP_001277622", "name": "beclin-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, "gene_names": [ { "name": "BECN2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A8MW95", "id": "A8MW95" }, { "name": "BECN1L1; BECN1P1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622", "id": "NP_001277622" }, { "name": "BECN1L1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8MW95", "id": "A8MW95" }, { "name": "BECN1P1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8MW95", "id": "A8MW95" }, { "name": "BECN2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622", "id": "NP_001277622" } ], "protein_names": [ { "name": "Beclin-2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A8MW95" }, { "name": "Beclin-1 autophagy-related pseudogene 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A8MW95" }, { "name": "Beclin-1-like protein 1; beclin-1 autophagy-related pseudogene 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622", "id": "NP_001277622" }, { "name": "Beclin-1-like protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A8MW95" }, { "name": "beclin-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622", "id": "NP_001277622" } ], "function": [ { "annotation": "Beclin 2 negatively regulates innate immune signaling and tumor development.", "evidence": [ { "database": "RefSeq", "id": "NP_001277622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, { "database": "PubMed", "id": "32865519", "url": "https://glygen.org/publication/PubMed/32865519" } ] }, { "annotation": "Both transfected and endogenous beclin 2 coimmunoprecipitated with vGPCR. Beclin 2 overexpression decreased HA-vGPCR steady-state levels. It regulates vGPCR levels by a lysosomal degradation pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_001277622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, { "database": "PubMed", "id": "26929373", "url": "https://glygen.org/publication/PubMed/26929373" } ] }, { "annotation": "Distinct patterns of Beclin 1 and Beclin 2 were associated with aggressive clinical outcomes. Beclin 1 overexpression, as well as Beclin 2 overexpression and depletion, contributed to tumor growth. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001277622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, { "database": "PubMed", "id": "26506105", "url": "https://glygen.org/publication/PubMed/26506105" } ] }, { "annotation": "Further data showed that reactive oxygen species-c-Jun activation by HBx resulted in the release of beclin-1 from its association with beclin-2 to form a complex with VPS34, thus enhancing autophagosome formation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001277622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, { "database": "PubMed", "id": "28515304", "url": "https://glygen.org/publication/PubMed/28515304" } ] }, { "annotation": "Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95#function" }, { "database": "PubMed", "id": "23954414", "url": "https://glygen.org/publication/PubMed/23954414" } ] }, { "annotation": "Polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer.", "evidence": [ { "database": "RefSeq", "id": "NP_001277622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "annotation": "Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2]", "evidence": [ { "database": "RefSeq", "id": "NP_001277622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277622" }, { "database": "PubMed", "id": "23954414", "url": "https://glygen.org/publication/PubMed/23954414" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 173, "end_pos": 173, "sequence_org": "E", "sequence_mut": "L", "comment": "Decreases homodimerization. Decreases interaction with ATG14.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 187, "end_pos": 187, "sequence_org": "N", "sequence_mut": "L", "comment": "Increases strongly homodimerization. Decreases interaction with ATG14.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 190, "end_pos": 190, "sequence_org": "A", "sequence_mut": "L", "comment": "Decreases interaction with ATG14. Increases slightly homodimerization; when associated with L-215.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 197, "end_pos": 197, "sequence_org": "A", "sequence_mut": "L", "comment": "Decreases interaction with ATG14. Probably strongly increases homodimerization; when associated with L-208.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 208, "end_pos": 208, "sequence_org": "E", "sequence_mut": "L", "comment": "Decreases interaction with ATG14. Probably strongly increases homodimerization; when associated with L-197.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 211, "end_pos": 211, "sequence_org": "H", "sequence_mut": "L", "comment": "Increases homodimerization. Decreases interaction with ATG14.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 215, "end_pos": 215, "sequence_org": "Y", "sequence_mut": "L", "comment": "Decreases interaction with ATG14. Increases slightly homodimerization; when associated with L-190.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 222, "end_pos": 222, "sequence_org": "Q", "sequence_mut": "L", "comment": "Decreases homodimerization. Decreases interaction with ATG14.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 243, "end_pos": 243, "sequence_org": "R", "sequence_mut": "L", "comment": "Decreases homodimerization. Decreases interaction with ATG14.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "28218432", "url": "https://glygen.org/publication/PubMed/28218432" } ] }, { "start_pos": 80, "end_pos": 80, "sequence_org": "I", "sequence_mut": "S", "comment": "Abolishes interaction with GPRASP1/GASP1 and ability to degrade G-protein coupled receptor. Does not affect function in autophagy.", "evidence": [ { "database": "UniProtKB", "id": "A8MW95", "url": "https://www.uniprot.org/uniprot/A8MW95" }, { "database": "PubMed", "id": "23954414", "url": "https://glygen.org/publication/PubMed/23954414" } ] } ], "expression_tissue": [], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A8MW95", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MW95" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", 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