{ "uniprot_canonical_ac": "A8MTJ3-1", "uniprot_ac": "A8MTJ3", "uniprot_id": "GNAT3_HUMAN", "mass": { "chemical_mass": 40357.0, "monoisotopic_mass": 40357.0 }, "refseq": { "ac": "NP_001095856", "name": "guanine nucleotide-binding protein G(t) subunit alpha-3", "summary": "Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" }, "gene_names": [ { "name": "GNAT3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A8MTJ3", "id": "A8MTJ3" }, { "name": "GDCA; HG1E", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856", "id": "NP_001095856" }, { "name": "GNAT3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856", "id": "NP_001095856" } ], "protein_names": [ { "name": "Guanine nucleotide-binding protein G(t) subunit alpha-3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A8MTJ3" }, { "name": "Gustducin alpha-3 chain", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A8MTJ3" }, { "name": "guanine nucleotide-binding protein G(t) subunit alpha-3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856", "id": "NP_001095856" }, { "name": "gustducin alpha-3 chain; gustducin, alpha polypeptide; gustatory G protein; guanine nucleotide binding protein, alpha transducing 3; heterotrimeric guanine nucleotide-binding protein 1E", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856", "id": "NP_001095856" } ], "function": [ { "annotation": "Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" }, { "database": "PubMed", "id": "34860335", "url": "https://glygen.org/publication/PubMed/34860335" } ] }, { "annotation": "Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3#function" }, { "database": "PubMed", "id": "17724330", "url": "https://glygen.org/publication/PubMed/17724330" }, { "database": "PubMed", "id": "11917125", "url": "https://glygen.org/publication/PubMed/11917125" } ] }, { "annotation": "Intestinal alteration of alpha-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission.", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" }, { "database": "PubMed", "id": "34338041", "url": "https://glygen.org/publication/PubMed/34338041" } ] }, { "annotation": "Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" }, { "database": "PubMed", "id": "32138214", "url": "https://glygen.org/publication/PubMed/32138214" } ] }, { "annotation": "Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" } ] }, { "annotation": "Worldwide diversity, association potential, and natural selection in the superimposed taste genes, CD36 and GNAT3.", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" }, { "database": "PubMed", "id": "34972209", "url": "https://glygen.org/publication/PubMed/34972209" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "A8MTJ3", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A8MTJ3" } ], "glycoeffect": [], "start_pos": 129, "end_pos": 129, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "7", "chr_pos": "80478916", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R129", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", 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"malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "A8MTJ3", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MTJ3" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "A8MTJ3", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MTJ3" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "A8MTJ3", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A8MTJ3" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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directionality modulated by PTEN.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Gu J, Tamura M, Pankov R, Danen EH, Takino T, Matsumoto K, Yamada KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "10427092", "url": "https://glygen.org/publication/PubMed/10427092" } ] }, { "title": "Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.", "journal": "Molecular pharmacology", "date": "1999", "authors": "Linden J, Thai T, Figler H, Jin X, Robeva AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "10496952", "url": "https://glygen.org/publication/PubMed/10496952" } ] }, { "title": "Cooperative effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for phosphatidylinositol 3-kinase activity.", "journal": "Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research", "date": "2000", "authors": "Qiao H, Saulnier R, Patryzkat A, Rahimi N, Raptis L, Rossiter J, Tremblay E, Elliott B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "10714768", "url": "https://glygen.org/publication/PubMed/10714768" } ] }, { "title": "Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Kahlert S, Nuedling S, van Eickels M, Vetter H, Meyer R, Grohe C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": 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"PubMed", "id": "10806474", "url": "https://glygen.org/publication/PubMed/10806474" } ] }, { "title": "Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "10954748", "url": "https://glygen.org/publication/PubMed/10954748" } ] }, { "title": "Src tyrosine kinase is a novel direct effector of G proteins.", "journal": "Cell", "date": "2000", "authors": "Ma YC, Huang J, Ali S, Lowry W, Huang XY", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "11007482", "url": "https://glygen.org/publication/PubMed/11007482" } ] }, { "title": "Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.", "journal": "Nature", "date": "2000", "authors": "Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, Liao JK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11029009", "url": "https://glygen.org/publication/PubMed/11029009" } ] }, { "title": "Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells.", "journal": "Circulation research", "date": "2000", "authors": "Haynes MP, Sinha D, Russell KS, Collinge M, Fulton D, Morales-Ruiz M, Sessa WC, Bender JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11029403", "url": "https://glygen.org/publication/PubMed/11029403" } ] }, { "title": "Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2000", "authors": "Filardo EJ, Quinn JA, Bland KI, Frackelton AR Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11043579", "url": "https://glygen.org/publication/PubMed/11043579" } ] }, { "title": "Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Hisamoto K, Ohmichi M, Kurachi H, Hayakawa J, Kanda Y, Nishio Y, Adachi K, Tasaka K, Miyoshi E, Fujiwara N, Taniguchi N, Murata Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11044445", "url": "https://glygen.org/publication/PubMed/11044445" } ] }, { "title": "Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells.", "journal": "IUBMB life", "date": "2000", "authors": "Kim JH, Kim JH, Song WK, Kim JH, Chun JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11185956", "url": "https://glygen.org/publication/PubMed/11185956" } ] }, { "title": "Identification of the platelet ADP receptor targeted by antithrombotic drugs.", "journal": "Nature", "date": "2001", "authors": "Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB", "evidence": [ { "database": "Reactome", "id": "R-HSA-392170", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392170" } ], "reference": [ { "type": "PubMed", "id": "11196645", "url": "https://glygen.org/publication/PubMed/11196645" } ] }, { "title": "G(z) signaling: emerging divergence from G(i) signaling.", "journal": "Oncogene", "date": "2001", "authors": "Ho MK, Wong YH", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "11313909", "url": "https://glygen.org/publication/PubMed/11313909" } ] }, { "title": "Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i).", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Wyckoff MH, Chambliss KL, Mineo C, Yuhanna IS, Mendelsohn ME, Mumby SM, Shaul PW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11369763", "url": "https://glygen.org/publication/PubMed/11369763" } ] }, { "title": "A human cellular model for studying the regulation of glucagon-like peptide-1 secretion.", "journal": "Endocrinology", "date": "2001", "authors": "Reimer RA, Darimont C, Gremlich S, Nicolas-Metral V, Ruegg UT, Mace K", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "11564718", "url": "https://glygen.org/publication/PubMed/11564718" } ] }, { "title": "PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells.", "journal": "The EMBO journal", "date": "2001", "authors": "Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, Fiorentino R, Varricchio L, Barone MV, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11689445", "url": "https://glygen.org/publication/PubMed/11689445" } ] }, { "title": "Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2002", "authors": "Filardo EJ, Quinn JA, Frackelton AR Jr, Bland KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "11773440", "url": "https://glygen.org/publication/PubMed/11773440" } ] }, { "title": "ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2002", "authors": "Razandi M, Oh P, Pedram A, Schnitzer J, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11773442", "url": "https://glygen.org/publication/PubMed/11773442" } ] }, { "title": "Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2002", "authors": "Song RX, McPherson RA, Adam L, Bao Y, Shupnik M, Kumar R, Santen RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11773443", "url": "https://glygen.org/publication/PubMed/11773443" } ] }, { "title": "CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling.", "journal": "Genes & development", "date": "2002", "authors": "Yu WH, Woessner JF Jr, McNeish JD, Stamenkovic I", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "11825873", "url": "https://glygen.org/publication/PubMed/11825873" } ] }, { "title": "Human receptors for sweet and umami taste.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3" }, { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "11917125", "url": 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Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman HA, Koch WJ, Luttrell LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12036966", "url": "https://glygen.org/publication/PubMed/12036966" } ] }, { "title": "Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Sato K, Nagao T, Kakumoto M, Kimoto M, Otsuki T, Iwasaki T, Tokmakov AA, Owada K, Fukami Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12048194", "url": "https://glygen.org/publication/PubMed/12048194" } ] }, { "title": "Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Dessauer CW, Chen-Goodspeed M, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12058044", "url": "https://glygen.org/publication/PubMed/12058044" } ] }, { "title": "Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.", "journal": "Biochemical pharmacology", "date": "2002", "authors": "Wenzel-Seifert K, Liu HY, Seifert R", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12106601", "url": "https://glygen.org/publication/PubMed/12106601" } ] }, { "title": "Regulators of G-protein signalling as new central nervous system drug targets.", "journal": "Nature reviews. Drug discovery", "date": "2002", "authors": "Neubig RR, Siderovski DP", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "12120503", "url": "https://glygen.org/publication/PubMed/12120503" } ] }, { "title": "The pharmacology of cilostazol.", "journal": "Diabetes, obesity & metabolism", "date": "2002", "authors": "Schror K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12180353", "url": "https://glygen.org/publication/PubMed/12180353" } ] }, { "title": "Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells.", "journal": "Molecular biology of the cell", "date": "2002", "authors": "Marino M, Acconcia F, Bresciani F, Weisz A, Trentalance A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12388769", "url": "https://glygen.org/publication/PubMed/12388769" } ] }, { "title": "Proximal events in signaling by plasma membrane estrogen receptors.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Razandi M, Pedram A, Park ST, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12421825", "url": "https://glygen.org/publication/PubMed/12421825" } ] }, { "title": "Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12431978", "url": "https://glygen.org/publication/PubMed/12431978" } ] }, { "title": "Nongenomic actions of steroid hormones.", "journal": "Nature reviews. Molecular cell biology", "date": "2003", "authors": "Losel R, Wehling M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12511868", "url": "https://glygen.org/publication/PubMed/12511868" } ] }, { "title": "Role of leptin in the regulation of glucagon-like peptide-1 secretion.", "journal": "Diabetes", "date": "2003", "authors": "Anini Y, Brubaker PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "12540594", "url": "https://glygen.org/publication/PubMed/12540594" } ] }, { "title": "Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.", "journal": "Blood", "date": "2003", "authors": "Ding Z, Kim S, Dorsam RT, Jin J, Kunapuli SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-392170", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392170" } ], "reference": [ { "type": "PubMed", "id": "12560222", "url": "https://glygen.org/publication/PubMed/12560222" } ] }, { "title": "Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Razandi M, Alton G, Pedram A, Ghonshani S, Webb P, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12588983", "url": "https://glygen.org/publication/PubMed/12588983" } ] }, { "title": "Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment.", "journal": "Protein expression and purification", "date": "2003", "authors": "Bonic A, Mackin RB", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "12651102", "url": "https://glygen.org/publication/PubMed/12651102" } ] }, { "title": "Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Li L, Haynes MP, Bender JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12682286", "url": "https://glygen.org/publication/PubMed/12682286" } ] }, { "title": "Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells.", "journal": "Molecular biology of the cell", "date": "2003", "authors": "Marino M, Acconcia F, Trentalance A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12808053", "url": "https://glygen.org/publication/PubMed/12808053" } ] }, { "title": "Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells.", "journal": "Endocrinology", "date": "2003", "authors": "Anini Y, Brubaker PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "12810581", "url": "https://glygen.org/publication/PubMed/12810581" } ] }, { "title": "Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.", "journal": "European journal of pharmacology", "date": "2003", "authors": "Zhang JY, Nawoschik S, Kowal D, Smith D, Spangler T, Ochalski R, Schechter L, Dunlop J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12860470", "url": "https://glygen.org/publication/PubMed/12860470" } ] }, { "title": "Sphingosine kinase transmits estrogen signaling in human breast cancer cells.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2003", "authors": "Sukocheva OA, Wang L, Albanese N, Pitson SM, Vadas MA, Xia P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "12881510", "url": "https://glygen.org/publication/PubMed/12881510" } ] }, { "title": "Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Ahmed CM, Ware DH, Lee SC, Patten CD, Ferrer-Montiel AV, Schinder AF, McPherson JD, Wagner-McPherson CB, Wasmuth JJ, Evans GA, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "1325650", "url": "https://glygen.org/publication/PubMed/1325650" } ] }, { "title": "Molecular cloning and expression of an adenosine A2b receptor from human brain.", "journal": "Biochemical and biophysical research communications", "date": "1992", "authors": "Pierce KD, Furlong TJ, Selbie LA, Shine J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "1325798", "url": "https://glygen.org/publication/PubMed/1325798" } ] }, { "title": "Gz-mediated hormonal inhibition of cyclic AMP accumulation.", "journal": "Science (New York, N.Y.)", "date": "1992", "authors": "Wong YH, Conklin BR, Bourne HR", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "1347957", "url": "https://glygen.org/publication/PubMed/1347957" } ] }, { "title": "Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles.", "journal": "The Journal of biological chemistry", "date": "1958", "authors": "SUTHERLAND EW, RALL TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "13549488", "url": "https://glygen.org/publication/PubMed/13549488" } ] }, { "title": "Purification and functional reconstitution of the human P2Y12 receptor.", "journal": "Molecular pharmacology", "date": "2003", "authors": "Bodor ET, Waldo GL, Hooks SB, Corbitt J, Boyer JL, Harden TK", "evidence": [ { "database": "Reactome", "id": "R-HSA-392170", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392170" } ], "reference": [ { "type": "PubMed", "id": "14573771", "url": "https://glygen.org/publication/PubMed/14573771" } ] }, { "title": "TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "14634208", "url": "https://glygen.org/publication/PubMed/14634208" } ] }, { "title": "Insights into G protein structure, function, and regulation.", "journal": "Endocrine reviews", "date": "2003", "authors": "Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "14671004", "url": "https://glygen.org/publication/PubMed/14671004" } ] }, { "title": "17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression.", "journal": "The Journal of investigative dermatology", "date": "2003", "authors": "Kanda N, Watanabe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "14675202", "url": "https://glygen.org/publication/PubMed/14675202" } ] }, { "title": "Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.", "journal": "Canadian journal of physiology and pharmacology", "date": "2003", "authors": "Brubaker PL, Anini Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "14719035", "url": "https://glygen.org/publication/PubMed/14719035" } ] }, { "title": "Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.", "journal": "Biological chemistry", "date": "2003", "authors": "Bar J, Weber A, Hoffmann T, Stork J, Wermann M, Wagner L, Aust S, Gerhartz B, Demuth HU", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "14719797", "url": "https://glygen.org/publication/PubMed/14719797" } ] }, { "title": "The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "14764897", "url": "https://glygen.org/publication/PubMed/14764897" } ] }, { "title": "Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man.", "journal": "European journal of clinical investigation", "date": "1992", "authors": "Eissele R, Goke R, Willemer S, Harthus HP, Vermeer H, Arnold R, Goke B", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "1499644", "url": "https://glygen.org/publication/PubMed/1499644" } ] }, { "title": "S-palmitoylation modulates human estrogen receptor-alpha functions.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Acconcia F, Ascenzi P, Fabozzi G, Visca P, Marino M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15033483", "url": "https://glygen.org/publication/PubMed/15033483" } ] }, { "title": "Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.", "journal": "Circulation research", "date": "2004", "authors": "Tanimoto T, Lungu AO, Berk BC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15044318", "url": "https://glygen.org/publication/PubMed/15044318" } ] }, { "title": "The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, Pezzi V, Montanaro D, Musti AM, Picard D, Ando S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15090535", "url": "https://glygen.org/publication/PubMed/15090535" } ] }, { "title": "Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2004", "authors": "Ahren B, Landin-Olsson M, Jansson PA, Svensson M, Holmes D, Schweizer A", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "15126524", "url": "https://glygen.org/publication/PubMed/15126524" } ] }, { "title": "Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "1517224", "url": "https://glygen.org/publication/PubMed/1517224" } ] }, { "title": "Plasma membrane estrogen receptors exist and functions as dimers.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2004", "authors": "Razandi M, Pedram A, Merchenthaler I, Greene GL, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15231873", "url": "https://glygen.org/publication/PubMed/15231873" } ] }, { "title": "17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression.", "journal": "The Journal of investigative dermatology", "date": "2004", "authors": "Kanda N, Watanabe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "15245432", "url": "https://glygen.org/publication/PubMed/15245432" } ] }, { "title": "Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Castoria G, Migliaccio A, Di Domenico M, Lombardi M, de Falco A, Varricchio L, Bilancio A, Barone MV, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15314172", "url": "https://glygen.org/publication/PubMed/15314172" } ] }, { "title": "Different functional roles of T1R subunits in the heteromeric taste receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "15353592", "url": "https://glygen.org/publication/PubMed/15353592" } ] }, { "title": "Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2004", "authors": "Cummins TR, Dib-Hajj SD, Waxman SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "15385606", "url": "https://glygen.org/publication/PubMed/15385606" } ] }, { "title": "Nitric Oxide as a Unique Bioactive Signaling Messenger in Physiology and Pathophysiology.", "journal": "Journal of biomedicine & biotechnology", "date": "2004", "authors": "Tuteja N, Chandra M, Tuteja R, Misra MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15467163", "url": "https://glygen.org/publication/PubMed/15467163" } ] }, { "title": "Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol.", "journal": "Molecular biology of the cell", "date": "2005", "authors": "Acconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, Visca P, Marino M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15496458", "url": "https://glygen.org/publication/PubMed/15496458" } ] }, { "title": "Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.", "journal": "Endocrinology", "date": "2005", "authors": "Thomas P, Pang Y, Filardo EJ, Dong J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "15539556", "url": "https://glygen.org/publication/PubMed/15539556" } ] }, { "title": "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15569929", "url": "https://glygen.org/publication/PubMed/15569929" } ] }, { "title": "Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders.", "journal": "Clinical science (London, England : 1979)", "date": "2005", "authors": "Gorrell MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "15584901", "url": "https://glygen.org/publication/PubMed/15584901" } ] }, { "title": "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.", "journal": "Nature medicine", "date": "2005", "authors": "Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "15619630", "url": "https://glygen.org/publication/PubMed/15619630" } ] }, { "title": "Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005", "authors": "Thelemann A, Petti F, Griffin G, Iwata K, Hunt T, Settinari T, Fenyo D, Gibson N, Haley JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15657067", "url": "https://glygen.org/publication/PubMed/15657067" } ] }, { "title": "Integration of the extranuclear and nuclear actions of estrogen.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2005", "authors": "Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15705661", "url": "https://glygen.org/publication/PubMed/15705661" } ] }, { "title": "A transmembrane intracellular estrogen receptor mediates rapid cell signaling.", "journal": "Science (New York, N.Y.)", "date": "2005", "authors": "Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "15705806", "url": "https://glygen.org/publication/PubMed/15705806" } ] }, { "title": "Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli.", "journal": "Chemical senses", "date": "2005", "authors": "San Gabriel A, Uneyama H, Yoshie S, Torii K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "15738140", "url": "https://glygen.org/publication/PubMed/15738140" } ] }, { "title": "Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients.", "journal": "Lung", "date": "2004", "authors": "Beeh KM, Beier J, Lerch C, Schulz AK, Buhl R", "evidence": [ { 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"https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "15951850", "url": "https://glygen.org/publication/PubMed/15951850" } ] }, { "title": "Rapid, estrogen receptor-mediated signaling: why is the endothelium so special?", "journal": "Science's STKE : signal transduction knowledge environment", "date": "2005", "authors": "Kim KH, Bender JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "15956360", "url": "https://glygen.org/publication/PubMed/15956360" } ] }, { "title": "Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2006", "authors": "Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K, Egan JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "16219666", "url": "https://glygen.org/publication/PubMed/16219666" } ] }, { "title": "The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2006", "authors": "Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Ando S, Maggiolini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "16239258", "url": "https://glygen.org/publication/PubMed/16239258" } ] }, { "title": "S-palmitoylation modulates estrogen receptor alpha localization and functions.", "journal": "Steroids", "date": "2006", "authors": "Marino M, Ascenzi P, Acconcia F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "16274718", "url": "https://glygen.org/publication/PubMed/16274718" } ] }, { "title": "Preferential inhibition of human phosphodiesterase 4 by ibudilast.", "journal": "Life sciences", "date": "2006", "authors": "Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, Natsumeda Y, Noguchi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16313925", "url": "https://glygen.org/publication/PubMed/16313925" } ] }, { "title": "Multiple Gi protein subtypes regulate a single effector mechanism.", "journal": "Molecular pharmacology", "date": "1991", "authors": "Gerhardt MA, Neubig RR", "evidence": [ { "database": "Reactome", "id": "R-HSA-170670", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170670" } ], "reference": [ { "type": "PubMed", "id": "1658606", "url": "https://glygen.org/publication/PubMed/1658606" } ] }, { "title": "The vertebrate phototransduction cascade: amplification and termination mechanisms.", "journal": "Reviews of physiology, biochemistry and pharmacology", "date": "2005", "authors": "Chen CK", "evidence": [ { "database": "Reactome", "id": "R-HSA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594" } ], "reference": [ { "type": "PubMed", "id": "16634148", "url": "https://glygen.org/publication/PubMed/16634148" } ] }, { "title": "Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA, Xia P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "16636149", "url": "https://glygen.org/publication/PubMed/16636149" } ] }, { "title": "Nature of functional estrogen receptors at the plasma membrane.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2006", "authors": "Pedram A, Razandi M, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "16645038", "url": "https://glygen.org/publication/PubMed/16645038" } ] }, { "title": "G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Violin JD, Ren XR, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16687412", "url": "https://glygen.org/publication/PubMed/16687412" } ] }, { "title": "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.", "journal": "Am. J. Physiol.", "date": "2006", "authors": "Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3" }, { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "16728727", "url": "https://glygen.org/publication/PubMed/16728727" } ] }, { "title": "17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.", "journal": "Molecular pharmacology", "date": "2006", "authors": "Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, Ando S, Maggiolini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "16835357", "url": "https://glygen.org/publication/PubMed/16835357" } ] }, { "title": "Structural basis of function in heterotrimeric G proteins.", "journal": "Quarterly reviews of biophysics", "date": "2006", "authors": "Oldham WM, Hamm HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "16923326", "url": "https://glygen.org/publication/PubMed/16923326" } ] }, { "title": "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.", "journal": "J. Comp. Physiol. A", "date": "2007", "authors": "Fehr Johanna, Meyer Dorke, Widmayer Patricia, Borth Heike Claudia, Ackermann Frauke, Wilhelm Beate, Gudermann Thomas, Boekhoff Ingrid", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3" } ], "reference": [ { "type": "PubMed", "id": "17021831", "url": "https://glygen.org/publication/PubMed/17021831" } ] }, { "title": "Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.", "journal": "Annual review of physiology", "date": "2007", "authors": "Lange CA, Gioeli D, Hammes SR, Marker PC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "17037979", "url": "https://glygen.org/publication/PubMed/17037979" } ] }, { "title": "Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases.", "journal": "The Journal of endocrinology", "date": "2006", "authors": "Reimer RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "17065399", "url": "https://glygen.org/publication/PubMed/17065399" } ] }, { "title": "An SCN9A channelopathy causes congenital inability to experience pain.", "journal": "Nature", "date": "2006", "authors": "Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, McHale DP, Wood JN, Gribble FM, Woods CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "17167479", "url": "https://glygen.org/publication/PubMed/17167479" } ] }, { "title": "Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.", "journal": "Current medicinal chemistry", "date": "2006", "authors": "Huang Z, Mancini JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "17168849", "url": "https://glygen.org/publication/PubMed/17168849" } ] }, { "title": "Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.", "journal": "Journal of neurochemistry", "date": "2006", "authors": "Clark MJ, Traynor JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-170670", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170670" } ], "reference": [ { "type": "PubMed", "id": "17230639", "url": "https://glygen.org/publication/PubMed/17230639" } ] }, { "title": "Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.", "journal": "Endocrinology", "date": "2007", "authors": "Filardo E, Quinn J, Pang Y, Graeber C, Shaw S, Dong J, Thomas P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "17379646", "url": "https://glygen.org/publication/PubMed/17379646" } ] }, { "title": "Steroid hormone rapid signaling: the pivotal role of S-palmitoylation.", "journal": "IUBMB life", "date": "2006", "authors": "Marino M, Ascenzi P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "17424910", "url": "https://glygen.org/publication/PubMed/17424910" } ] }, { "title": "The G-protein coupling properties of the human sweet and amino acid taste receptors.", "journal": "Developmental neurobiology", "date": "2007", "authors": "Sainz E, Cavenagh MM, LopezJimenez ND, Gutierrez JC, Battey JF, Northup JK, Sullivan SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "17506496", "url": "https://glygen.org/publication/PubMed/17506496" } ] }, { "title": "Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.", "journal": "Endocrinology", "date": "2007", "authors": "Song RX, Zhang Z, Chen Y, Bao Y, Santen RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "17525128", "url": "https://glygen.org/publication/PubMed/17525128" } ] }, { "title": "A conserved mechanism for steroid receptor translocation to the plasma membrane.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "17535799", "url": "https://glygen.org/publication/PubMed/17535799" } ] }, { "title": "GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.", "journal": "Molecular and cellular endocrinology", "date": "2007", "authors": "Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R, Knauf C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "17681422", "url": "https://glygen.org/publication/PubMed/17681422" } ] }, { "title": "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-09-18", "authors": "Jang Hyeung-Jin, Kokrashvili Zaza, Theodorakis Michael J, Carlson Olga D, Kim Byung-Joon, Zhou Jie, Kim Hyeon Ho, Xu Xiangru, Chan Sic L, Juhaszova Magdalena, Bernier Michel, Mosinger Bedrich, Margolskee Robert F, Egan Josephine M", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3" } ], "reference": [ { "type": "PubMed", "id": "17724330", "url": "https://glygen.org/publication/PubMed/17724330" } ] }, { "title": "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Margolskee Robert F, Dyer Jane, Kokrashvili Zaza, Salmon Kieron S H, Ilegems Erwin, Daly Kristian, Maillet Emeline L, Ninomiya Yuzo, Mosinger Bedrich, Shirazi-Beechey Soraya P", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3" } ], "reference": [ { "type": "PubMed", "id": "17724332", "url": "https://glygen.org/publication/PubMed/17724332" } ] }, { "title": "Extranuclear steroid receptors: nature and actions.", "journal": "Endocrine reviews", "date": "2007", "authors": "Hammes SR, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "17916740", "url": "https://glygen.org/publication/PubMed/17916740" } ] }, { "title": "Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Li L, Hisamoto K, Kim KH, Haynes MP, Bauer PM, Sanjay A, Collinge M, Baron R, Sessa WC, Bender JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "17921256", "url": "https://glygen.org/publication/PubMed/17921256" } ] }, { "title": "PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast.", "journal": "International journal of chronic obstructive pulmonary disease", "date": "2007", "authors": "Boswell-Smith V, Spina D", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "18044684", "url": "https://glygen.org/publication/PubMed/18044684" } ] }, { "title": "Membrane association of estrogen receptor alpha and beta influences 17beta-estradiol-mediated cancer cell proliferation.", "journal": "Steroids", "date": "2008", "authors": "Marino M, Ascenzi P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "18206197", "url": "https://glygen.org/publication/PubMed/18206197" } ] }, { "title": "Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "18434541", "url": "https://glygen.org/publication/PubMed/18434541" } ] }, { "title": "Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.", "journal": "Diabetes", "date": "2008", "authors": "Edfalk S, Steneberg P, Edlund H", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "18519800", "url": "https://glygen.org/publication/PubMed/18519800" } ] }, { "title": "G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.", "journal": "Endocrinology", "date": "2008", "authors": "Otto C, Rohde-Schulz B, Schwarz G, Fuchs I, Klewer M, Brittain D, Langer G, Bader B, Prelle K, Nubbemeyer R, Fritzemeier KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "18566127", "url": "https://glygen.org/publication/PubMed/18566127" } ] }, { "title": "Dissociation of heterotrimeric g proteins in cells.", "journal": "Science signaling", "date": "2008", "authors": "Lambert NA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "18577758", "url": "https://glygen.org/publication/PubMed/18577758" } ] }, { "title": "Regulation of estrogen rapid signaling through arginine methylation by PRMT1.", "journal": "Molecular cell", "date": "2008", "authors": "Le Romancer M, Treilleux I, Leconte N, Robin-Lespinasse Y, Sentis S, Bouchekioua-Bouzaghou K, Goddard S, Gobert-Gosse S, Corbo L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "18657504", "url": "https://glygen.org/publication/PubMed/18657504" } ] }, { "title": "Nutritional regulation of glucagon-like peptide-1 secretion.", "journal": "The Journal of physiology", "date": "2009", "authors": "Tolhurst G, Reimann F, Gribble FM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "19001044", "url": "https://glygen.org/publication/PubMed/19001044" } ] }, { "title": "Molecular mechanism for the umami taste synergism.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Zhang F, Klebansky B, Fine RM, Xu H, Pronin A, Liu H, Tachdjian C, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "19104071", "url": "https://glygen.org/publication/PubMed/19104071" } ] }, { "title": "The efficacy and safety of cilomilast in COPD.", "journal": "Drugs", "date": "2008", "authors": "Rennard S, Knobil K, Rabe KF, Morris A, Schachter N, Locantore N, Canonica WG, Zhu Y, Barnhart F", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19105585", "url": "https://glygen.org/publication/PubMed/19105585" } ] }, { "title": "Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells.", "journal": "Steroids", "date": "2009", "authors": "Santen RJ, Fan P, Zhang Z, Bao Y, Song RX, Yue W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "19138696", "url": "https://glygen.org/publication/PubMed/19138696" } ] }, { "title": "Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2009", "authors": "Quinn JA, Graeber CT, Frackelton AR Jr, Kim M, Schwarzbauer JE, Filardo EJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "19342448", "url": "https://glygen.org/publication/PubMed/19342448" } ] }, { "title": "Phosphorylation of Gz in human platelets. Selectivity and site of modification.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Lounsbury KM, Casey PJ, Brass LF, Manning DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "1939224", "url": "https://glygen.org/publication/PubMed/1939224" } ] }, { "title": "Genetic and molecular basis of individual differences in human umami taste perception.", "journal": "PloS one", "date": "2009", "authors": "Shigemura N, Shirosaki S, Sanematsu K, Yoshida R, Ninomiya Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "19696921", "url": "https://glygen.org/publication/PubMed/19696921" } ] }, { "title": "Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30.", "journal": "American journal of physiology. Cell physiology", "date": "2009", "authors": "Ding Q, Gros R, Limbird LE, Chorazyczewski J, Feldman RD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "19741198", "url": "https://glygen.org/publication/PubMed/19741198" } ] }, { "title": "AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis.", "journal": "Current opinion in investigational drugs (London, England : 2000)", "date": "2009", "authors": "Nazarian R, Weinberg JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19876791", "url": "https://glygen.org/publication/PubMed/19876791" } ] }, { "title": "Cell proliferation regulated by estradiol receptor: Therapeutic implications.", "journal": "Steroids", "date": "2010", "authors": "Castoria G, Migliaccio A, Giovannelli P, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "19879889", "url": "https://glygen.org/publication/PubMed/19879889" } ] }, { "title": "Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease.", "journal": "Expert opinion on pharmacotherapy", "date": "2009", "authors": "Rolan P, Hutchinson M, Johnson K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19929708", "url": "https://glygen.org/publication/PubMed/19929708" } ] }, { "title": "Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish.", "journal": "Steroids", "date": "2010", "authors": "Thomas P, Alyea R, Pang Y, Peyton C, Dong J, Berg AH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "19931550", "url": "https://glygen.org/publication/PubMed/19931550" } ] }, { "title": "The molecular receptive ranges of human TAS2R bitter taste receptors.", "journal": "Chemical senses", "date": "2010", "authors": "Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "20022913", "url": "https://glygen.org/publication/PubMed/20022913" } ] }, { "title": "A sodium channel gene SCN9A polymorphism that increases nociceptor excitability.", "journal": "Annals of neurology", "date": "2009", "authors": "Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "20033988", "url": "https://glygen.org/publication/PubMed/20033988" } ] }, { "title": "The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.", "journal": "Pulmonary pharmacology & therapeutics", "date": "2010", "authors": "Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "20381629", "url": "https://glygen.org/publication/PubMed/20381629" } ] }, { "title": "Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Razandi M, Pedram A, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "20439495", "url": "https://glygen.org/publication/PubMed/20439495" } ] }, { "title": "The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway.", "journal": "Archives of biochemistry and biophysics", "date": "2010", "authors": "Liu M, Yang Y, Wang C, Sun L, Mei C, Yao W, Liu Y, Shi Y, Qiu S, Fan J, Cai X, Zha X", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "20650261", "url": "https://glygen.org/publication/PubMed/20650261" } ] }, { "title": "Minireview: Extranuclear steroid receptors: roles in modulation of cell functions.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2011", "authors": "Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "20861220", "url": "https://glygen.org/publication/PubMed/20861220" } ] }, { "title": "Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery.", "journal": "European journal of pharmacology", "date": "2011", "authors": "Yamazaki T, Anraku T, Matsuzawa S", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "21036126", "url": "https://glygen.org/publication/PubMed/21036126" } ] }, { "title": "Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function.", "journal": "Chemical senses", "date": "2011", "authors": "Raliou M, Grauso M, Hoffmann B, Schlegel-Le-Poupon C, Nespoulous C, Debat H, Belloir C, Wiencis A, Sigoillot M, Bano SP, Trotier D, Pernollet JC, Montmayeur JP, Faurion A, Briand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "21422378", "url": "https://glygen.org/publication/PubMed/21422378" } ] }, { "title": "beta-Arrestin: a protein that regulates beta-adrenergic receptor function.", "journal": "Science (New York, N.Y.)", "date": "1990", "authors": "Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2163110", "url": "https://glygen.org/publication/PubMed/2163110" } ] }, { "title": "Cracking the estrogen receptor's posttranslational code in breast tumors.", "journal": "Endocrine reviews", "date": "2011", "authors": "Le Romancer M, Poulard C, Cohen P, Sentis S, Renoir JM, Corbo L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "21680538", "url": "https://glygen.org/publication/PubMed/21680538" } ] }, { "title": "Molecular mechanism of species-dependent sweet taste toward artificial sweeteners.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2011", "authors": "Liu B, Ha M, Meng XY, Kaur T, Khaleduzzaman M, Zhang Z, Jiang P, Li X, Cui M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "21795555", "url": "https://glygen.org/publication/PubMed/21795555" } ] }, { "title": "The G-protein-coupled estrogen receptor GPER in health and disease.", "journal": "Nature reviews. Endocrinology", "date": "2011", "authors": "Prossnitz ER, Barton M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "21844907", "url": "https://glygen.org/publication/PubMed/21844907" } ] }, { "title": "Roles for oestrogen receptor beta in adult brain function.", "journal": "Journal of neuroendocrinology", "date": "2012", "authors": "Handa RJ, Ogawa S, Wang JM, Herbison AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "21851428", "url": "https://glygen.org/publication/PubMed/21851428" } ] }, { "title": "Minireview: Recent advances in extranuclear steroid receptor actions.", "journal": "Endocrinology", "date": "2011", "authors": "Hammes SR, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "22028449", "url": "https://glygen.org/publication/PubMed/22028449" } ] }, { "title": "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.", "journal": "Molecular biology of the cell", "date": "2012", "authors": "Pedram A, Razandi M, Deschenes RJ, Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "22031296", "url": "https://glygen.org/publication/PubMed/22031296" } ] }, { "title": "Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells.", "journal": "Oncogene", "date": "2012", "authors": "Castoria G, Giovannelli P, Lombardi M, De Rosa C, Giraldi T, de Falco A, Barone MV, Abbondanza C, Migliaccio A, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "22266855", "url": "https://glygen.org/publication/PubMed/22266855" } ] }, { "title": "Palmitoylation regulates 17beta-estradiol-induced estrogen receptor-alpha degradation and transcriptional activity.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2012", "authors": "La Rosa P, Pesiri V, Leclercq G, Marino M, Acconcia F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "22446104", "url": "https://glygen.org/publication/PubMed/22446104" } ] }, { "title": "Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.", "journal": "Endocrinology", "date": "2012", "authors": "Filardo EJ, Thomas P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "22495674", "url": "https://glygen.org/publication/PubMed/22495674" } ] }, { "title": "Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.", "journal": "Biochemical and biophysical research communications", "date": "2013", "authors": "Thalmann S, Behrens M, Meyerhof W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "23632330", "url": "https://glygen.org/publication/PubMed/23632330" } ] }, { "title": "Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor alpha (ERalpha).", "journal": "PloS one", "date": "2013", "authors": "Tsai CL, Wu HM, Lin CY, Lin YJ, Chao A, Wang TH, Hsueh S, Lai CH, Wang HS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "24039841", "url": "https://glygen.org/publication/PubMed/24039841" } ] }, { "title": "Novel SCN3A variants associated with focal epilepsy in children.", "journal": "Neurobiology of disease", "date": "2014", "authors": "Vanoye CG, Gurnett CA, Holland KD, George AL Jr, Kearney JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "24157691", "url": "https://glygen.org/publication/PubMed/24157691" } ] }, { "title": "Pharmacology of the bipyridines: amrinone and milrinone.", "journal": "Circulation", "date": "1986", "authors": "Alousi AA, Johnson DC", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2417744", "url": "https://glygen.org/publication/PubMed/2417744" } ] }, { "title": "Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, Ishimaru Y, Misaka T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "24214976", "url": "https://glygen.org/publication/PubMed/24214976" } ] }, { "title": "Impact of interleukin-6 in hematological malignancies.", "journal": "Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie", "date": "2013", "authors": "Burger R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "24273487", "url": "https://glygen.org/publication/PubMed/24273487" } ] }, { "title": "The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors.", "journal": "Food chemistry", "date": "2014", "authors": "Bassoli A, Borgonovo G, Caremoli F, Mancuso G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "24360415", "url": "https://glygen.org/publication/PubMed/24360415" } ] }, { "title": "Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells.", "journal": "Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas", "date": "2014", "authors": "Yang R, Lin Q, Gao HB, Zhang P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "24519125", "url": "https://glygen.org/publication/PubMed/24519125" } ] }, { "title": "Estrogen biology: new insights into GPER function and clinical opportunities.", "journal": "Molecular and cellular endocrinology", "date": "2014", "authors": "Prossnitz ER, Barton M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "24530924", "url": "https://glygen.org/publication/PubMed/24530924" } ] }, { "title": "L-Theanine elicits umami taste via the T1R1 + T1R3 umami taste receptor.", "journal": "Amino acids", "date": "2014", "authors": "Narukawa M, Toda Y, Nakagita T, Hayashi Y, Misaka T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "24633359", "url": "https://glygen.org/publication/PubMed/24633359" } ] }, { "title": "Advances in targeting cyclic nucleotide phosphodiesterases.", "journal": "Nature reviews. Drug discovery", "date": "2014", "authors": "Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "24687066", "url": "https://glygen.org/publication/PubMed/24687066" } ] }, { "title": "Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Graziano MP, Freissmuth M, Gilman AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2491850", "url": "https://glygen.org/publication/PubMed/2491850" } ] }, { "title": "G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "24962572", "url": "https://glygen.org/publication/PubMed/24962572" } ] }, { "title": "Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina.", "journal": "Neuron", "date": "1989", "authors": "Lerea CL, Bunt-Milam AH, Hurley JB", "evidence": [ { "database": "Reactome", "id": "R-HSA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594" } ], "reference": [ { "type": "PubMed", "id": "2534964", "url": "https://glygen.org/publication/PubMed/2534964" } ] }, { "title": "Pharmacology of positive inotropic phosphodiesterase III inhibitors.", "journal": "European heart journal", "date": "1989", "authors": "Honerjager P", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2553411", "url": "https://glygen.org/publication/PubMed/2553411" } ] }, { "title": "Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Mitsuhashi M, Mitsuhashi T, Payan DG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2553705", "url": "https://glygen.org/publication/PubMed/2553705" } ] }, { "title": "Extranuclear steroid receptors are essential for steroid hormone actions.", "journal": "Annual review of medicine", "date": "2015", "authors": "Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "25587652", "url": "https://glygen.org/publication/PubMed/25587652" } ] }, { "title": "Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2.", "journal": "PloS one", "date": "2015", "authors": "Shim J, Son HJ, Kim Y, Kim KH, Kim JT, Moon H, Kim MJ, Misaka T, Rhyu MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "25853419", "url": "https://glygen.org/publication/PubMed/25853419" } ] }, { "title": "The G-protein coupled estrogen receptor, GPER: The inside and inside-out story.", "journal": "Molecular and cellular endocrinology", "date": "2015", "authors": "Gaudet HM, Cheng SB, Christensen EM, Filardo EJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "26190834", "url": "https://glygen.org/publication/PubMed/26190834" } ] }, { "title": "Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor.", "journal": "Chemical senses", "date": "2015", "authors": "Maillet EL, Cui M, Jiang P, Mezei M, Hecht E, Quijada J, Margolskee RF, Osman R, Max M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "26377607", "url": "https://glygen.org/publication/PubMed/26377607" } ] }, { "title": "Pentoxifylline for intermittent claudication.", "journal": "The Cochrane database of systematic reviews", "date": "2015", "authors": "Salhiyyah K, Forster R, Senanayake E, Abdel-Hadi M, Booth A, Michaels JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "26417854", "url": "https://glygen.org/publication/PubMed/26417854" } ] }, { "title": "Estrogen Enhances Linkage in the Vascular Endothelial Calmodulin Network via a Feedforward Mechanism at the G Protein-coupled Estrogen Receptor 1.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Tran QK, Firkins R, Giles J, Francis S, Matnishian V, Tran P, VerMeer M, Jasurda J, Burgard MA, Gebert-Oberle B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "26987903", "url": "https://glygen.org/publication/PubMed/26987903" } ] }, { "title": "Rapid steroid hormone actions via membrane receptors.", "journal": "Biochimica et biophysica acta", "date": "2016", "authors": "Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "27288742", "url": "https://glygen.org/publication/PubMed/27288742" } ] }, { "title": "Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS.", "journal": "Neuropharmacology", "date": "2017", "authors": "Alexander A, Irving AJ, Harvey J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "27392633", "url": "https://glygen.org/publication/PubMed/27392633" } ] }, { "title": "Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye.", "journal": "Nucleic acids research", "date": "1989", "authors": "Van Dop C, Medynski DC, Apone LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594" } ], "reference": [ { "type": "PubMed", "id": "2748346", "url": "https://glygen.org/publication/PubMed/2748346" } ] }, { "title": "Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms.", "journal": "Frontiers in immunology", "date": "2016", "authors": "Luo Y, Zheng SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "28066415", "url": "https://glygen.org/publication/PubMed/28066415" } ] }, { "title": "Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures.", "journal": "Biological psychiatry", "date": "2017", "authors": "Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "28256214", "url": "https://glygen.org/publication/PubMed/28256214" } ] }, { "title": "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594" } ], "reference": [ { "type": "PubMed", "id": "2834384", "url": "https://glygen.org/publication/PubMed/2834384" } ] }, { "title": "G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Gonzalez de Valdivia E, Broselid S, Kahn R, Olde B, Leeb-Lundberg LMF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "28450397", "url": "https://glygen.org/publication/PubMed/28450397" } ] }, { "title": "G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].", "journal": "Endocrine journal", "date": "2017", "authors": "Goto K, Doi M, Wang T, Kunisue S, Murai I, Okamura H", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "28502923", "url": "https://glygen.org/publication/PubMed/28502923" } ] }, { "title": "Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.", "journal": "Physiological reviews", "date": "2017", "authors": "Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "28539435", "url": "https://glygen.org/publication/PubMed/28539435" } ] }, { "title": "A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis.", "journal": "The Journal of steroid biochemistry and molecular biology", "date": "2018", "authors": "Filardo EJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "28595943", "url": "https://glygen.org/publication/PubMed/28595943" } ] }, { "title": "Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1986", "authors": "Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2871555", "url": "https://glygen.org/publication/PubMed/2871555" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "A8MTJ3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A8MTJ3" }, { "database": "O-GlcNAc Atlas", "id": "A8MTJ3", "url": "https://oglcnac.org/atlas/detail/A8MTJ3" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Effect and safety of roflumilast for chronic obstructive pulmonary disease in Chinese patients.", "journal": "Medicine", "date": "2018", "authors": "Liu DY, Wang ZG, Gao Y, Zhang HM, Zhang YX, Wang XJ, Peng D", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "29443750", "url": "https://glygen.org/publication/PubMed/29443750" } ] }, { "title": "Mutations in SCN3A cause early infantile epileptic encephalopathy.", "journal": "Annals of neurology", "date": "2018", "authors": "Zaman T, Helbig I, Bozovic IB, DeBrosse SD, Bergqvist AC, Wallis K, Medne L, Maver A, Peterlin B, Helbig KL, Zhang X, Goldberg EM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "29466837", "url": "https://glygen.org/publication/PubMed/29466837" } ] }, { "title": "Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge.", "journal": "Journal of nanobiotechnology", "date": "2018", "authors": "Liu FC, Yu HP, Lin CY, Elzoghby AO, Hwang TL, Fang JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "29602314", "url": "https://glygen.org/publication/PubMed/29602314" } ] }, { "title": "beta1 subunit stabilises sodium channel Nav1.7 against mechanical stress.", "journal": "The Journal of physiology", "date": "2018", "authors": "Korner J, Meents J, Machtens JP, Lampert A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "29659026", "url": "https://glygen.org/publication/PubMed/29659026" } ] }, { "title": "Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer.", "journal": "Cancers", "date": "2018", "authors": "Zhu X, Bao Y, Guo Y, Yang W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "29738483", "url": "https://glygen.org/publication/PubMed/29738483" } ] }, { "title": "Co-expression of beta Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and Phosphorylation and Their Effects on Channel Pharmacology and Biophysics.", "journal": "Journal of molecular neuroscience : MN", "date": "2018", "authors": "Sokolov MV, Henrich-Noack P, Raynoschek C, Franzen B, Larsson O, Main M, Dabrowski M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "29744740", "url": "https://glygen.org/publication/PubMed/29744740" } ] }, { "title": "Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP3.", "journal": "Nature structural & molecular biology", "date": "2018", "authors": "Paknejad N, Hite RK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "30013099", "url": "https://glygen.org/publication/PubMed/30013099" } ] }, { "title": "All three IP3 receptor isoforms generate Ca(2+) puffs that display similar characteristics.", "journal": "Science signaling", "date": "2018", "authors": "Lock JT, Alzayady KJ, Yule DI, Parker I", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "30563861", "url": "https://glygen.org/publication/PubMed/30563861" } ] }, { "title": "Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes.", "journal": "Frontiers in endocrinology", "date": "2019", "authors": "Deacon CF", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "30828317", "url": "https://glygen.org/publication/PubMed/30828317" } ] }, { "title": "IL-12/IL-23p40 identified as a downstream target of apremilast in ex vivo models of arthritis.", "journal": "Therapeutic advances in musculoskeletal disease", "date": "2019", "authors": "Kragstrup TW, Adams M, Lomholt S, Nielsen MA, Heftdal LD, Schafer P, Deleuran B", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "30833991", "url": "https://glygen.org/publication/PubMed/30833991" } ] }, { "title": "Isolation and characterization of the human Gs alpha gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1988", "authors": "Kozasa T, Itoh H, Tsukamoto T, Kaziro Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "3127824", "url": "https://glygen.org/publication/PubMed/3127824" } ] }, { "title": "Crisaborole 2% ointment for the treatment of intertriginous, anogenital, and facial psoriasis: A double-blind, randomized, vehicle-controlled trial.", "journal": "Journal of the American Academy of Dermatology", "date": "2020", "authors": "Hashim PW, Chima M, Kim HJ, Bares J, Yao CJ, Singer G, Chen T, Genece J, Baum D, Kimmel GW, Nia JK, Gagliotti M, Lebwohl MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "31279028", "url": "https://glygen.org/publication/PubMed/31279028" } ] }, { "title": "Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD.", "journal": "Respiratory research", "date": "2019", "authors": "Singh D, Beeh KM, Colgan B, Kornmann O, Leaker B, Watz H, Lucci G, Geraci S, Emirova A, Govoni M, Nandeuil MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "31399091", "url": "https://glygen.org/publication/PubMed/31399091" } ] }, { "title": "Simple assessment of quality of life and lower limb functional capacity during cilostazol treatment - results of the SHort-tERm cIlostazol eFFicacy and quality of life (SHERIFF) study.", "journal": "VASA. Zeitschrift fur Gefasskrankheiten", "date": "2020", "authors": "Farkas K, Kolossvary E, Jarai Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "31983287", "url": "https://glygen.org/publication/PubMed/31983287" } ] }, { "title": "Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.", "journal": "Nutrients", "date": "2020", "authors": "Esberg A, Haworth S, Hasslof P, Lif Holgerson P, Johansson I", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" } ], "reference": [ { "type": "PubMed", "id": "32138214", "url": "https://glygen.org/publication/PubMed/32138214" } ] }, { "title": "Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases.", "journal": "Frontiers in pharmacology", "date": "2020", "authors": "Phillips JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32226383", "url": "https://glygen.org/publication/PubMed/32226383" } ] }, { "title": "Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19.", "journal": "Metabolism: clinical and experimental", "date": "2020", "authors": "Dalamaga M, Karampela I, Mantzoros CS", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32497535", "url": "https://glygen.org/publication/PubMed/32497535" } ] }, { "title": "Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19.", "journal": "Medical hypotheses", "date": "2020", "authors": "Maldonado V, Loza-Mejia MA, Chavez-Alderete J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32540603", "url": "https://glygen.org/publication/PubMed/32540603" } ] }, { "title": "COVID-19 patients with psoriasis and psoriatic arthritis on biologic immunosuppressant therapy vs apremilast in North Spain.", "journal": "Dermatologic therapy", "date": "2020", "authors": "Queiro Silva R, Armesto S, Gonzalez Vela C, Naharro Fernandez C, Gonzalez-Gay MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32618402", "url": "https://glygen.org/publication/PubMed/32618402" } ] }, { "title": "Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients.", "journal": "Pharmacology research & perspectives", "date": "2020", "authors": "Hendry BM, Stafford N, Arnold AD, Sangwaiya A, Manglam V, Rosen SD, Arnold J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32715661", "url": "https://glygen.org/publication/PubMed/32715661" } ] }, { "title": "Pentoxifylline: A Drug with Antiviral and Anti-Inflammatory Effects to Be Considered in the Treatment of Coronavirus Disease 2019.", "journal": "Medical principles and practice : international journal of the Kuwait University, Health Science Centre", "date": "2021", "authors": "Ghasemnejad-Berenji M, Pashapour S, Sadeghpour S", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "33049737", "url": "https://glygen.org/publication/PubMed/33049737" } ] }, { "title": "Intestinal alteration of alpha-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2021", "authors": "Le Gleau L, Rouault C, Osinski C, Prifti E, Soula HA, Debedat J, Busieau P, Amouyal C, Clement K, Andreelli F, Ribeiro A, Serradas P", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" } ], "reference": [ { "type": "PubMed", "id": "34338041", "url": "https://glygen.org/publication/PubMed/34338041" } ] }, { "title": "Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.", "journal": "Cardiovascular drugs and therapy", "date": "2023-06", "authors": "Zhou Shuang, Wang Zhe, Liu Zhiyan, Mu Guangyan, Xie Qiufen, Wang Zining, Xiang Qian, Gong Yanjun, Cui Yimin", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" } ], "reference": [ { "type": "PubMed", "id": "34860335", "url": "https://glygen.org/publication/PubMed/34860335" } ] }, { "title": "Worldwide diversity, association potential, and natural selection in the superimposed taste genes, CD36 and GNAT3.", "journal": "Chemical senses", "date": "2022", "authors": "Wooding SP, Ramirez VA", "evidence": [ { "database": "RefSeq", "id": "NP_001095856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095856" } ], "reference": [ { "type": "PubMed", "id": "34972209", "url": "https://glygen.org/publication/PubMed/34972209" } ] }, { "title": "Glucagon- and PP-related peptides of intestinal L cells and pancreatic/gastric A or PP cells. Possible interrelationships of peptides and cells during evolution, fetal development and tumor growth.", "journal": "Peptides", "date": "1985", "authors": "Solcia E, Fiocca R, Capella C, Usellini L, Sessa F, Rindi G, Schwartz TW, Yanaihara N", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "3841689", "url": "https://glygen.org/publication/PubMed/3841689" } ] }, { "title": "Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry.", "journal": "The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society", "date": "1985", "authors": "Varndell IM, Bishop AE, Sikri KL, Uttenthal LO, Bloom SR, Polak JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "3900195", "url": "https://glygen.org/publication/PubMed/3900195" } ] }, { "title": "The new inotropic phosphodiesterase inhibitors.", "journal": "Archives internationales de physiologie et de biochimie", "date": "1984", "authors": "el Allaf D, D'Orio V, Carlier J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "6085243", "url": "https://glygen.org/publication/PubMed/6085243" } ] }, { "title": "Nitric oxide: a physiologic messenger molecule.", "journal": "Annual review of biochemistry", "date": "1994", "authors": "Bredt DS, Snyder SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "7526779", "url": "https://glygen.org/publication/PubMed/7526779" } ] }, { "title": "Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Fields TA, Casey PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "7559455", "url": "https://glygen.org/publication/PubMed/7559455" } ] }, { "title": "G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "7568118", "url": "https://glygen.org/publication/PubMed/7568118" } ] }, { "title": "Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins.", "journal": "Journal of neurochemistry", "date": "1995", "authors": "Chan JS, Chiu TT, Wong YH", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "7595566", "url": "https://glygen.org/publication/PubMed/7595566" } ] }, { "title": "Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.", "journal": "Nature", "date": "1995", "authors": "van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "7651538", "url": "https://glygen.org/publication/PubMed/7651538" } ] }, { "title": "Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.", "journal": "The EMBO journal", "date": "1995", "authors": "Klugbauer N, Lacinova L, Flockerzi V, Hofmann F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9717207" } ], "reference": [ { "type": "PubMed", "id": "7720699", "url": "https://glygen.org/publication/PubMed/7720699" } ] }, { "title": "Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol.", "journal": "Endocrinology", "date": "1995", "authors": "Kleinman D, Karas M, Roberts CT Jr, LeRoith D, Phillip M, Segev Y, Levy J, Sharoni Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391" } ], "reference": [ { "type": "PubMed", "id": "7750475", "url": "https://glygen.org/publication/PubMed/7750475" } ] }, { "title": "Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1995", "authors": "Deacon CF, Johnsen AH, Holst JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "7883856", "url": "https://glygen.org/publication/PubMed/7883856" } ] }, { "title": "Mechanism of GTP hydrolysis by G-protein alpha subunits.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1994", "authors": "Kleuss C, Raw AS, Lee E, Sprang SR, Gilman AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597" } ], "reference": [ { "type": "PubMed", "id": "7937899", "url": "https://glygen.org/publication/PubMed/7937899" } ] }, { "title": "Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Dendorfer U, Oettgen P, Libermann TA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "8007951", "url": "https://glygen.org/publication/PubMed/8007951" } ] }, { "title": "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.", "journal": "Brain Res. Mol. Brain Res.", "date": "1994", "authors": "Takami S, Getchell TV, McLaughlin SK, Margolskee RF, Getchell ML", "evidence": [ { "database": "UniProtKB", "id": "A8MTJ3", "url": "https://www.uniprot.org/uniprot/A8MTJ3" }, { "database": "Reactome", "id": "R-HSA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594" } ], "reference": [ { "type": "PubMed", "id": "8015379", "url": "https://glygen.org/publication/PubMed/8015379" } ] }, { "title": "Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum.", "journal": "European journal of biochemistry", "date": "1993", "authors": "Mentlein R, Gallwitz B, Schmidt WE", "evidence": [ { "database": "Reactome", "id": "R-HSA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381771" } ], "reference": [ { "type": "PubMed", "id": "8100523", "url": "https://glygen.org/publication/PubMed/8100523" } 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cyclase by Gi alpha.", "journal": "Science (New York, N.Y.)", "date": "1993", "authors": "Taussig R, Iniguez-Lluhi JA, Gilman AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-170670", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170670" } ], "reference": [ { "type": "PubMed", "id": "8327893", "url": "https://glygen.org/publication/PubMed/8327893" } ] }, { "title": "Polypeptide variants of beta-arrestin and arrestin3.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Sterne-Marr R, Gurevich VV, Goldsmith P, Bodine RC, Sanders C, Donoso LA, Benovic JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "8340388", "url": "https://glygen.org/publication/PubMed/8340388" } ] }, { "title": "Characterization of the gene encoding human cone transducin alpha-subunit (GNAT2).", "journal": "Genomics", "date": "1993", "authors": "Morris TA, Fong SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594" } ], "reference": [ { "type": "PubMed", "id": "8406495", "url": "https://glygen.org/publication/PubMed/8406495" } ] }, { "title": "Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Richardson RM, Kim C, Benovic JL, Hosey MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "8514797", "url": "https://glygen.org/publication/PubMed/8514797" } ] }, { "title": "Characterization and expression of the human A2a adenosine receptor gene.", "journal": "Journal of neurochemistry", "date": "1996", "authors": "Peterfreund RA, MacCollin M, Gusella J, Fink JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "8522976", "url": "https://glygen.org/publication/PubMed/8522976" } ] }, { "title": "Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets.", "journal": "British journal of clinical pharmacology", "date": "1995", "authors": "Cooper JA, Hill SJ, Alexander SP, Rubin PC, Horn EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9660821", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660821" } ], "reference": [ { "type": "PubMed", "id": "8527267", "url": "https://glygen.org/publication/PubMed/8527267" } ] }, { "title": "The human platelet ADP receptor activates Gi2 proteins.", "journal": "The Biochemical journal", "date": "1995", "authors": "Ohlmann P, Laugwitz KL, Nurnberg B, Spicher K, Schultz G, Cazenave JP, Gachet C", "evidence": [ { "database": "Reactome", "id": "R-HSA-392170", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392170" } ], "reference": [ { "type": "PubMed", "id": "8554519", "url": "https://glygen.org/publication/PubMed/8554519" } ] }, { "title": "Fibronectin fibrils and growth factors stimulate anchorage-independent growth of a murine mammary carcinoma.", "journal": "Experimental cell research", "date": "1996", "authors": "Saulnier R, Bhardwaj B, Klassen J, Leopold D, Rahimi N, Tremblay E, Mosher D, Elliott B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "8598224", "url": "https://glygen.org/publication/PubMed/8598224" } ] }, { "title": "Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.", "journal": "Biochemistry", "date": "1996", "authors": "Menard L, Ferguson SS, Barak LS, Bertrand L, Premont RT, Colapietro AM, Lefkowitz RJ, Caron MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "8672451", "url": "https://glygen.org/publication/PubMed/8672451" } ] }, { "title": "Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634597", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634597" } ], "reference": [ { "type": "PubMed", "id": "8702633", "url": "https://glygen.org/publication/PubMed/8702633" } ] }, { "title": "Determination of nitric oxide synthase cofactors: heme, FAD, FMN, and tetrahydrobiopterin.", "journal": "Methods in enzymology", 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