{ "uniprot_canonical_ac": "A6NKB5-1", "uniprot_ac": "A6NKB5", "uniprot_id": "PCX2_HUMAN", "mass": { "chemical_mass": 237277.0, "monoisotopic_mass": 237277.0 }, "refseq": { "ac": "NP_055616", "name": "pecanex-like protein 2 isoform 1", "summary": "This gene contains coding mononucleotide repeats that are associated with tumors of high mcrosatellite instability (MSI-H). Defects in this gene are involved in the tumorigenesis of MSI-H colorectal carcinomas. [provided by RefSeq, Jun 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616" }, "gene_names": [ { "name": "PCNX2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6NKB5", "id": "A6NKB5" }, { "name": "KIAA0435", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6NKB5", "id": "A6NKB5" }, { "name": "PCNX2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616", "id": "NP_055616" }, { "name": "PCNXL2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616", "id": "NP_055616" }, { "name": "PCNXL2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6NKB5", "id": "A6NKB5" } ], "protein_names": [ { "name": "Pecanex-like protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A6NKB5" }, { "name": "Pecanex homolog protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6NKB5" }, { "name": "pecanex-like protein 2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616", "id": "NP_055616" }, { "name": "pecanex-like protein 2; pecanex homolog 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616", "id": "NP_055616" } ], "function": [ { "annotation": "Genetic polymorphisms in the PCNXL2 gene are risk factors for thyroid cancer in the Chinese population.", "evidence": [ { "database": "RefSeq", "id": "NP_055616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616" }, { "database": "PubMed", "id": "34747634", "url": "https://glygen.org/publication/PubMed/34747634" } ] }, { "annotation": "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability.", "evidence": [ { "database": "RefSeq", "id": "NP_055616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616" }, { "database": "PubMed", "id": "12140758", "url": "https://glygen.org/publication/PubMed/12140758" } ] }, { "annotation": "May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).", "evidence": [ { "database": "UniProtKB", "id": "A6NKB5", "url": "https://www.uniprot.org/uniprot/A6NKB5#function" }, { "database": "PubMed", "id": "12140758", "url": "https://glygen.org/publication/PubMed/12140758" }, { "database": "PubMed", "id": "14507650", "url": "https://glygen.org/publication/PubMed/14507650" } ] }, { "annotation": "This gene contains coding mononucleotide repeats that are associated with tumors of high mcrosatellite instability (MSI-H). Defects in this gene are involved in the tumorigenesis of MSI-H colorectal carcinomas. [provided by RefSeq, Jun 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_055616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1024209419", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1024209419" }, { "id": "rs1024209419", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1024209419#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 119, "end_pos": 119, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NSS).", "chr_id": "1", "chr_pos": "233262962", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P119", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "A6NKB5", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NKB5" } ], "glycoeffect": [], "start_pos": 135, "end_pos": 135, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", "chr_id": "1", "chr_pos": "233262121", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R135", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix uteri cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", 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"id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NKB5" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "A6NKB5", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NKB5" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": 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"MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "A6NKB5", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NKB5" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "A6NKB5", "url": "https://www.uniprot.org/uniprot/A6NKB5" } ], "common_name": "Human" } ], "gene": [ { "name": "PCNX2", "url": "https://www.uniprot.org/uniprot/A6NKB5", "locus": { "chromosome": "1", "start_pos": 232983435, "end_pos": 233295725, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000135749", "url": "https://www.ensembl.org/id/ENSG00000135749" } ] } } ], "crossref": [ { "id": "ENSG00000135749", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135749", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "A6NKB5", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NKB5", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "PCNX2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PCNX2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "80003", "url": "https://www.ncbi.nlm.nih.gov/gene/80003", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8736", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8736", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "A6NKB5", "url": "https://www.ebi.ac.uk/intact/interactors/id:A6NKB5*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR007735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:80003", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:80003", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "617656", "url": "http://www.omim.org/entry/617656", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_A6NKB5", "url": "https://www.nextprot.org/entry/NX_A6NKB5", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "NHKIPSN", "url": "https://omabrowser.org/oma/group/NHKIPSN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5473970at2759", "url": "http://www.orthodb.org/?query=5473970at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12372", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12372", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12372:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12372:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05041", "url": "http://pfam.xfam.org/family/PF05041", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A6NKB5", "url": "https://pharos.nih.gov/targets/A6NKB5", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_A6NKB5", "url": "http://purl.obolibrary.org/obo/PR_A6NKB5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_055616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6NKB5", "url": "https://www.uniprot.org/uniprot/A6NKB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6NKB5-1", "url": "https://www.uniprot.org/uniprot/A6NKB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6NKB5-2", "url": "https://www.uniprot.org/uniprot/A6NKB5-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6NKB5-3", "url": "https://www.uniprot.org/uniprot/A6NKB5-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6NKB5-4", "url": "https://www.uniprot.org/uniprot/A6NKB5-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6NKB5-5", "url": "https://www.uniprot.org/uniprot/A6NKB5-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EVZ6", "url": "https://www.uniprot.org/uniprot/E7EVZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EVZ6-1", "url": "https://www.uniprot.org/uniprot/E7EVZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAR6", "url": "https://www.uniprot.org/uniprot/H0YAR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAR6-1", "url": "https://www.uniprot.org/uniprot/H0YAR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAV6", "url": "https://www.uniprot.org/uniprot/H0YAV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAV6-1", "url": "https://www.uniprot.org/uniprot/H0YAV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YB15", "url": "https://www.uniprot.org/uniprot/H0YB15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YB15-1", "url": "https://www.uniprot.org/uniprot/H0YB15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YB30", "url": "https://www.uniprot.org/uniprot/H0YB30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YB30-1", "url": "https://www.uniprot.org/uniprot/H0YB30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBD1", "url": "https://www.uniprot.org/uniprot/H0YBD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBD1-1", "url": "https://www.uniprot.org/uniprot/H0YBD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBD6", "url": "https://www.uniprot.org/uniprot/H0YBD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBD6-1", "url": "https://www.uniprot.org/uniprot/H0YBD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBF4", "url": "https://www.uniprot.org/uniprot/H0YBF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBF4-1", "url": "https://www.uniprot.org/uniprot/H0YBF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSQVLQLLRQGVWAALTGGWYHDPEQSKFTNSCHLYLWLFLLLLPLALHLAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHLMFDKGEVIQQKPSRKEEKPNKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSAQETVEDLKGVILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQYDLLETDVSFQPWGSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSEVAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLESSLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGVPCPEGNGSERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGKEGQTNLDPSSCKSSHEKRHARVLSVDSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAKEGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEILENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQSVSDEQ", "length": 2137, "header": "sp|A6NKB5-1|PCX2_HUMAN Isoform 1 of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=3 CANONICAL=A6NKB5-1" }, "isoforms": [ { "isoform_ac": "A6NKB5-1", "url": "", "sequence": { "sequence": "MVSQVLQLLRQGVWAALTGGWYHDPEQSKFTNSCHLYLWLFLLLLPLALHLAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHLMFDKGEVIQQKPSRKEEKPNKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSAQETVEDLKGVILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQYDLLETDVSFQPWGSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSEVAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLESSLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGVPCPEGNGSERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGKEGQTNLDPSSCKSSHEKRHARVLSVDSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAKEGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEILENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQSVSDEQ", "length": 2137, "header": "sp|A6NKB5-1|PCX2_HUMAN Isoform 1 of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=3 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233295478, "end_pos": 232984307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000258229.14", "url": "https://www.ensembl.org/id/ENST00000258229.14" }, { "database": "Ensembl Peptide", "id": "ENSP00000258229.8", "url": "https://www.ensembl.org/id/ENSP00000258229.8" } ] } }, { "isoform_ac": "A6NKB5-2", "url": "", "sequence": { "sequence": "MHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIGKIMNSHKDFFTSEKKKDKIISAISSVIFLKSW", "length": 286, "header": "sp|A6NKB5-2|PCX2_HUMAN Isoform 2 of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=3 CANONICAL=A6NKB5-1" }, "locus": {} }, { "isoform_ac": "A6NKB5-3", "url": "", "sequence": { "sequence": "MTFYPFVASSSTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRVRGWAGLTRTGWDGGTGSWPERGTCLAFPPFCLQNPIPFSMGLPE", "length": 777, "header": "sp|A6NKB5-3|PCX2_HUMAN Isoform 3 of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=3 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233057322, "end_pos": 232985957, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000344698.6", "url": "https://www.ensembl.org/id/ENST00000344698.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000340759.2", "url": "https://www.ensembl.org/id/ENSP00000340759.2" } ] } }, { "isoform_ac": "A6NKB5-4", "url": "", "sequence": { "sequence": "MEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQSVSDEQ", "length": 675, "header": "sp|A6NKB5-4|PCX2_HUMAN Isoform 4 of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=3 CANONICAL=A6NKB5-1" }, "locus": {} }, { "isoform_ac": "A6NKB5-5", "url": "", "sequence": { "sequence": "MWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKVFLGYVRQK", "length": 421, "header": "sp|A6NKB5-5|PCX2_HUMAN Isoform 5 of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=3 CANONICAL=A6NKB5-1" }, "locus": {} }, { "isoform_ac": "E7EVZ6-1", "url": "", "sequence": { "sequence": "MWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKASELAIFFILTF", "length": 424, "header": "tr|E7EVZ6-1|PCX2_HUMAN Computationally mapped isoform of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233218087, "end_pos": 233134977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000488780.6", "url": "https://www.ensembl.org/id/ENST00000488780.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000430820.1", "url": "https://www.ensembl.org/id/ENSP00000430820.1" } ] } }, { "isoform_ac": "H0YAR6-1", "url": "", "sequence": { "sequence": "XFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKDGTHTQRG", "length": 109, "header": "tr|H0YAR6-1|H0YAR6_HUMAN Computationally mapped isoform of Pecanex-like protein OS=Homo sapiens OX=9606 GN=PCNX2 PE=3 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233139836, "end_pos": 233112941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000490102.6", "url": "https://www.ensembl.org/id/ENST00000490102.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000427962.1", "url": "https://www.ensembl.org/id/ENSP00000427962.1" } ] } }, { "isoform_ac": "H0YAV6-1", "url": "", "sequence": { "sequence": "EYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPRILSASIFTLQLRFTFYGSKLFIDPWQ", "length": 178, "header": "tr|H0YAV6-1|PCX2_HUMAN Computationally mapped isoform of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233160307, "end_pos": 233095675, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000484347.5", "url": "https://www.ensembl.org/id/ENST00000484347.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428134.1", "url": "https://www.ensembl.org/id/ENSP00000428134.1" } ] } }, { "isoform_ac": "H0YB15-1", "url": "", "sequence": { "sequence": "XLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFREYNILYGNVSQTPLLDQK", "length": 490, "header": "tr|H0YB15-1|PCX2_HUMAN Computationally mapped isoform of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233200191, "end_pos": 233017100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000462233.5", "url": "https://www.ensembl.org/id/ENST00000462233.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428488.1", "url": "https://www.ensembl.org/id/ENSP00000428488.1" } ] } }, { "isoform_ac": "H0YB30-1", "url": "", "sequence": { "sequence": "XDPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRMLPI", "length": 47, "header": "tr|H0YB30-1|PCX2_HUMAN Computationally mapped isoform of Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=1 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233177835, "end_pos": 233139842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000486012.5", "url": "https://www.ensembl.org/id/ENST00000486012.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428582.1", "url": "https://www.ensembl.org/id/ENSP00000428582.1" } ] } }, { "isoform_ac": "H0YBD1-1", "url": "", "sequence": { "sequence": "KVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAAL", "length": 181, "header": "tr|H0YBD1-1|H0YBD1_HUMAN Computationally mapped isoform of Pecanex-like protein OS=Homo sapiens OX=9606 GN=PCNX2 PE=3 SV=8 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233227269, "end_pos": 233198969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000518351.2", "url": "https://www.ensembl.org/id/ENST00000518351.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000429231.1", "url": "https://www.ensembl.org/id/ENSP00000429231.1" } ] } }, { "isoform_ac": "H0YBD6-1", "url": "", "sequence": { "sequence": "XMWVLLFCLVMASCQYSLLKSVQPDPASPIHGPKPGTLPVTLCMA", "length": 45, "header": "tr|H0YBD6-1|H0YBD6_HUMAN Computationally mapped isoform of Pecanex-like protein OS=Homo sapiens OX=9606 GN=PCNX2 PE=3 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233218089, "end_pos": 233208568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000517808.1", "url": "https://www.ensembl.org/id/ENST00000517808.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000429262.1", "url": "https://www.ensembl.org/id/ENSP00000429262.1" } ] } }, { "isoform_ac": "H0YBF4-1", "url": "", "sequence": { "sequence": "XPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEILENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRN", "length": 218, "header": "tr|H0YBF4-1|H0YBF4_HUMAN Computationally mapped isoform of Pecanex 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=4 SV=1 CANONICAL=A6NKB5-1" }, "locus": { "chromosome": "1", "start_pos": 233258152, "end_pos": 233218180, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000475463.6", "url": "https://www.ensembl.org/id/ENST00000475463.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000429360.1", "url": "https://www.ensembl.org/id/ENSP00000429360.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 136, "start_aa": "Asn", "end_pos": 136, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn136", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1412, "start_aa": "Asn", "end_pos": 1412, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1412", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1553, "start_aa": "Asn", "end_pos": 1553, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1553", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1818, "start_aa": "Asn", "end_pos": 1818, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1818", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 2054, "start_aa": "Asn", "end_pos": 2054, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2054", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 449, "start_aa": "Asn", "end_pos": 449, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn449", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 550, "start_aa": "Asn", "end_pos": 550, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn550", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 572, "start_aa": "Asn", "end_pos": 572, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn572", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 587, "start_aa": "Asn", "end_pos": 587, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn587", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 598, "start_aa": "Asn", "end_pos": 598, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn598", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 613, "start_aa": "Asn", "end_pos": 613, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn613", "evidence": [ { "id": "A6NKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKB5#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 1078, "end_pos": 1078, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6NKB5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6NKB5" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ], "site_lbl": "Ser1078" }, { "start_pos": 1536, "end_pos": 1536, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6NKB5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6NKB5" }, { "database": "PubMed", "id": "32387766", "url": "" } ], "site_lbl": "Ser1536" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability.", "journal": "Oncogene", "date": "2002", "authors": "Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H", "evidence": [ { "database": "UniProtKB", "id": "A6NKB5", "url": "https://www.uniprot.org/uniprot/A6NKB5" }, { "database": "RefSeq", "id": "NP_055616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616" } ], "reference": [ { "type": "PubMed", "id": "12140758", "url": "https://glygen.org/publication/PubMed/12140758" } ] }, { "title": "Chromosomal imbalances in the colorectal carcinomas with microsatellite instability.", "journal": "The American journal of pathology", "date": "2003-10", "authors": "Li Long Shan, Kim Nam-Gyun, Kim Se Hoon, Park Chanil, Kim Hyunki, Kang Hyun Ju, Koh Kwi Hye, Kim Soo Nyung, Kim Won Ho, Kim Nam Kyu, Kim Hoguen", "evidence": [ { "database": "UniProtKB", "id": "A6NKB5", "url": "https://www.uniprot.org/uniprot/A6NKB5" } ], "reference": [ { "type": "PubMed", "id": "14507650", "url": "https://glygen.org/publication/PubMed/14507650" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "A6NKB5-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6NKB5-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Genetic polymorphisms in the PCNXL2 gene are risk factors for thyroid cancer in the Chinese population.", "journal": "Future oncology (London, England)", "date": "2021", "authors": "Hao R, Han P, Zhang L, Bi Y, Yan J, Li H, Bai Y, Xu C, Li B, Li H", "evidence": [ { "database": "RefSeq", "id": "NP_055616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055616" } ], "reference": [ { "type": "PubMed", "id": "34747634", "url": "https://glygen.org/publication/PubMed/34747634" } ] } ], "pathway": [ { "id": "hsa:80003", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:80003", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AB99-1", "protein_name": "Pecanex-like protein", "gene_name": "Pcnx2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASQVLQLLRQGVWAALTGGWYHDPEHSKFTNSCHLYLWLFLLLLPLALHLAFPPNLLTALFYCGSVTIFFTVIKLISYRLHLMFDKGEVIQHRSPRKRSKRRPEGEASSQHPPRHKIPSNNRQIHSTKKEESRSLTTPPLCCSSRGQSVHSQHSSGPLELPAQETVEDLKGVVLSEDQPEALVSSTSPGMKSESLPASQGRTPEPTPRPPCPVKPVTTEIFPARRVKESGGTAQRPARHRSESGLVNTEALKKLPHLSLSQYDLLETDISFQPWGSEHSVLIPQPNCPHAPTRAQPQSRSPQDSQSSSFCQCNTVIAKPTEEELTRTSGQVELPSNPEVVDSDGEVEVTLIDTSQPGEPLSLHEPIRIVITMSSTPNSISDPESSLHLRVTSSDRTGVRPNAENAGPGGADPADPEQARIPLITLELTEDGRGGGGPSCPEGNGGERTPEKMEVMSPDRRSSSGVGECSTKDESPTPGPTFVPLTPRADPESEGSREGPANLDPASCKSSHEKRHARVLSVDSGTDVFLSRSTKEVVSDSEKPIPTSKSDLEAKEGQIPNESNFLEFVSLLESISTSKAVAPDSAAEQKGVNQGPEGHASPGIKEEAVENEKSNGRDPKPGKPDLPSQDPASASPVLTQPPKTTALFQGSRQRHIIYRVTSQQDSSVLQVISGPETSVQEEMSLDAMHIFIDEHGEVRSCYLKSGNQKEGSSQHPPLNPDCVSHAREILLSSSSTTTTGSPDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEDSSRSSAQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDVKENMVAVLLSVLVSLLGFLTLNRGFCRDLWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIIAYSRPIYFCMLCGLILLLDAGAKARHPPSYVVYGLKLFTPETLQSVRDHLIVFLCCFPAISLLGLFPQINTFCTYLLEQIDMLLFGGSAVSGITSAVYSVGRSVLAAALLHVFCFSAVKEPWSTQHIPALFSAFCGLLVALSYHLSRQSSDPSVLLSFIQCKLLPKCLHQNLDESAADPLPQRMKDSVKDVLRSDLIICSAAAVLSFAVSASTVFLSLRPFLSIVLFALAGTVGLITHHLLPQLRKHHPWMWISHPVLKSKEYQQREARDIAHLMWFERLYVWLQCFEKYLLYPAIVLNAVTLDAFSISNYRRLGTHWDIFLMITAGMKLLRTSFCNPVHQFANLGFTVVFFHFDYKDVSESFLLDFFMVSIVFTKLGDLLQKLQFVLAYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTFATSIFSTPLSPFLGSVIFITSYVRPVKFWERSYNTQRVDNSNTRLAVQMERDPGSDDGSLNSIFYEHLTRTLQDSLCGDLALGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEDDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITRTQYILEGYSIIDNNAATMLHVFDLRRVLIRYYIKSIIYYMVTSPKLASWVKNESLLKSLEPFAKWHHIERDLAMFNINIDDDYVPCLQGITRASYCSVFLEWIQYCAGKRQELSKTLDHVDSDEDSALVTLSFALCILGRRALGTAAHNMAMSLDSFLYGLHALFKGDFRVTARDEWVFADMDLLHKVVVPAIRMSLKLHQDQFTCPDEYEDPEILYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGANEYKVIMLHRGFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHKQLQSVWGGPITLNRVRTWFQTRWLRMRKDCSVGQRSGGNIEDGEGAVPPGGNAPSGESRDSSTEQPRKGGTQQWASPRGEAPRAGRRKGRSQSVQAHSAISQRRPTLSSSGPILESHQAFLQTSTSVHELAQRPSGSRPSLNTSAGSLHSQPPPVLTTGPYLGIQHQAEALIQSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAAARHFSEPCEPIDSPEQGQLQDGRLAEAAGENPRGVLCRRASQEDMGLDDTASQQSTSDEQ", "length": 2122 }, "evidence": [ { "id": "45927974", "url": "http://www.informatics.jax.org/homology/45927974", "database": "MGI" }, { "id": "A6NKB5", "url": "https://omabrowser.org/oma/group/A6NKB5/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5DU28-1", "protein_name": "Pecanex-like protein 2", "gene_name": "Pcnx2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 2122 }, "evidence": [ { "id": "45927974", "url": "http://www.informatics.jax.org/homology/45927974", "database": "MGI" }, { "id": "A6NKB5", "url": "https://omabrowser.org/oma/group/A6NKB5/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A6NKB5", "url": "https://www.uniprot.org/uniprot/A6NKB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1247, "end_pos": 1249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1412, "end_pos": 1414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1553, "end_pos": 1555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1818, "end_pos": 1820, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2054, "end_pos": 2056, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 587, "end_pos": 589, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 136, 449, 550, 572, 587, 598, 613, 1412, 1553, 1818, 2054 ], "o_linked_sites": [], "snv_sites": [ 119, 135, 136, 209, 298, 360, 381, 387, 403, 449, 451, 481, 482, 483, 589, 613, 615, 975, 1367, 1412, 1414, 1516, 1517, 1553, 1579, 1750, 1818, 1819, 1820, 1900, 1901, 1984, 2054, 2058, 2125 ], "glycation_sites": [], "phosphorylation_sites": [ 1078, 1536 ], "sequon_annotation_sites": [ { "start_pos": 1247, "end_pos": 1249 }, { "start_pos": 136, "end_pos": 138 }, { "start_pos": 1412, "end_pos": 1414 }, { "start_pos": 1553, "end_pos": 1555 }, { "start_pos": 1818, "end_pos": 1820 }, { "start_pos": 2054, "end_pos": 2056 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 550, "end_pos": 552 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 587, "end_pos": 589 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 613, "end_pos": 615 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 11 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 11 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 11 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 11 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", 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"sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }