{ "uniprot_canonical_ac": "A6NET4-1", "uniprot_ac": "A6NET4", "uniprot_id": "OR5K3_HUMAN", "mass": { "chemical_mass": 36711.0, "monoisotopic_mass": 36711.0 }, "refseq": { "ac": "NP_001005516", "name": "olfactory receptor 5K3", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005516" }, "gene_names": [ { "name": "OR5K3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6NET4", "id": "A6NET4" }, { "name": "OR5K3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005516", "id": "NP_001005516" } ], "protein_names": [ { "name": "Olfactory receptor 5K3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A6NET4" }, { "name": "olfactory receptor 5K3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005516", "id": "NP_001005516" } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A6NET4", "url": "https://www.uniprot.org/uniprot/A6NET4#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001005516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005516" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "A6NET4", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NET4" } ], "glycoeffect": [], "start_pos": 44, "end_pos": 44, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "G", "sequence_mut": "D", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "98390796", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "G44", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": 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"https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:403277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NX_A6NET4", "url": "https://www.nextprot.org/entry/NX_A6NET4", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "RITLYEC", "url": "https://omabrowser.org/oma/group/RITLYEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5401587at2759", "url": "http://www.orthodb.org/?query=5401587at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018:SF105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018:SF105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "http://pfam.xfam.org/family/PF13853", "database": "Pfam", 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PE=3 SV=1 CANONICAL=A6NET4-1" }, "locus": { "chromosome": "3", "start_pos": 98391628, "end_pos": 98390666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000383695.1", "url": "https://www.ensembl.org/id/ENST00000383695.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000373194.1", "url": "https://www.ensembl.org/id/ENSP00000373194.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 5, "start_aa": "Asn", "end_pos": 5, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn5", "evidence": [ { "id": "A6NET4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NET4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Profiling of olfactory receptor gene expression in whole human olfactory mucosa.", "journal": "PloS one", "date": "2014", "authors": "Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "24800820", "url": "https://glygen.org/publication/PubMed/24800820" } ] }, { "title": "The human olfactory transcriptome.", "journal": "BMC genomics", "date": "2016", "authors": "Olender T, Keydar I, Pinto JM, Tatarskyy P, Alkelai A, Chien MS, Fishilevich S, Restrepo D, Matsunami H, Gilad Y, Lancet D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "27515280", "url": "https://glygen.org/publication/PubMed/27515280" } ] }, { "title": "Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "Ikegami K, de March CA, Nagai MH, Ghosh S, Do M, Sharma R, Bruguera ES, Lu YE, Fukutani Y, Vaidehi N, Yohda M, Matsunami H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "31974307", "url": "https://glygen.org/publication/PubMed/31974307" } ] }, { "title": "Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.", "journal": "Nature neuroscience", "date": "2020", "authors": "Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "32066986", "url": "https://glygen.org/publication/PubMed/32066986" } ] } ], "pathway": [ { "id": "hsa:403277", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:403277", "resource": "KEGG Pathway" }, { "id": "R-HSA-9752946", "name": "Expression and translocation of olfactory receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946", "resource": "Reactome", "description": "Expression and translocation of olfactory receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140T8K4-1", "protein_name": "Olfactory receptor", "gene_name": "Or5k8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTEDNYSLTTEFILIGFSDHPDLKILLFLVLSTIYLVTMVGNLGLVALIYMEPRLHTPMYIFLGNLALMDSCCSCAITPKMLENFFSVNRRISLYECMAQFYFLCLAETADCFLLAAMAYDRYVAICNPLQYHTMMSKKLCLQMTTGAYIAGNLHSMIHIGFLFRLIFCRSHVIKHFFCDVLPLYRLSCVDPYINELMILIFSGSVQTFSIIIVLISYFCILFTIFTMKSREGRSKALSTCASHFLSVSIFYGSLLYTYIRPSSINEGNEDIPVAIFYTLVIPLLNPFIYSLRNKEVINAIKRTMNKG", "length": 308 }, "evidence": [ { "id": 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