{ "uniprot_canonical_ac": "A6ND36-1", "uniprot_ac": "A6ND36", "uniprot_id": "FA83G_HUMAN", "mass": { "chemical_mass": 90835.0, "monoisotopic_mass": 90835.0 }, "refseq": { "ac": "NP_001035088", "name": "protein FAM83G", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, "gene_names": [ { "name": "FAM83G", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6ND36", "id": "A6ND36" }, { "name": "FAM83G", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088", "id": "NP_001035088" }, { "name": "PAWS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088", "id": "NP_001035088" }, { "name": "PAWS1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6ND36", "id": "A6ND36" } ], "protein_names": [ { "name": "Protein FAM83G", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A6ND36" }, { "name": "Protein associated with SMAD1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6ND36" }, { "name": "protein FAM83G", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088", "id": "NP_001035088" }, { "name": "protein associated with SMAD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088", "id": "NP_001035088" } ], "function": [ { "annotation": "FAM83G Is a Novel Inducer of Apoptosis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "PubMed", "id": "32570757", "url": "https://glygen.org/publication/PubMed/32570757" } ] }, { "annotation": "FAM83G promotes proliferation, invasion, and metastasis by regulating PI3K/AKT signaling in hepatocellular carcinoma cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "PubMed", "id": "34144502", "url": "https://glygen.org/publication/PubMed/34144502" } ] }, { "annotation": "PAWS1 interacts and co-localises with the alpha isoform of casein kinase 1 (CK1), and that PAWS1 mutations incapable of binding CK1 fail both to activate Wnt signalling and to elicit axis duplication in Xenopus embryos.", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "PubMed", "id": "29514862", "url": "https://glygen.org/publication/PubMed/29514862" } ] }, { "annotation": "PAWS1 regulates the expression of some SMAD4-independent BMP target genes as well as some BMP-independent genes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ] }, { "annotation": "Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways.", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36#function" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 610, "end_pos": 610, "sequence_org": "S", "sequence_mut": "A", "comment": "Completely abolishes phosphorylation by ALK3 in vitro. NEDD9 and ASNS activation in response to BMPs is abolished.", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "73.61", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "78.41", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "82.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "69.42", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "77.98", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "68.1", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "74.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "81.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "73.02", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "69.18", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000188522", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188522" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A6ND36", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6ND36" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"BioXpress", "id": "A6ND36", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6ND36" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"isoform_ac": "A6ND36-1", "url": "", "sequence": { "sequence": "MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKNLRVRSSGGTEFFTRSATKFKGALAQKFMFVDGDRAVCGSYSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSHSVSLKGIPMEKEPEPEPIVLPSVVPLVPAGTVAKKLVNPKYALVKAKSVDEIAKISSEKQEAKKPLGLKGPALAEHPGELPELLPPIHPGLLHLERANMFEYLPTWVEPDPEPGSDILGYINIIDPNIWNPQPSQMNRIKIRDTSQASAQHQLWKQSQDSRPRPEPCPPPEPSAPQDGVPAENGLPQGDPEPLPPVPKPRTVPVADVLARDSSDIGWVLELPKEEAPQNGTDHRLPRMAGPGHAPLQRQLSVTQDDPESLGVGLPNGLDGVEEEDDDDYVTLSDQDSHSGSSGRGPGPRRPSVASSVSEEYFEVREHSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKRMQAQRSTDKEAQGQQFHHHRVPASGTRDKDGFPGPPRYRSAADSVQSSTRNAGPAMAGPHHWQAKGGQVPRLLPDPGSPRLAQNARPMTDGRATEEHPSPFGIPYSKLSQSKHLKARTGGSQWASSDSKRRAQAPRDRKDP", "length": 823, "header": "sp|A6ND36-1|FA83G_HUMAN Isoform 1 of Protein FAM83G OS=Homo sapiens OX=9606 GN=FAM83G PE=1 SV=2 CANONICAL=A6ND36-1" }, "locus": { "chromosome": "17", "start_pos": 19004041, "end_pos": 18971362, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000388995.11", "url": "https://www.ensembl.org/id/ENST00000388995.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000373647.5", "url": "https://www.ensembl.org/id/ENSP00000373647.5" } ] } }, { "isoform_ac": "A6ND36-2", "url": "", "sequence": { "sequence": "MGARGLGGGSRVMCLTSAPSLCCSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSHSVSLKGIPMEKEPEPEPIVLPSVVPLVPAGTVAKKLVNPKYALVKAKSVDEIAKISSEKQEAKKPLGLKGPALAEHPGELPELLPPIHPGLLHLERANMFEYLPTWVEPDPEPGSDILGYINIIDPNIWNPQPSQMNRIKIRDTSQASAQHQLWKQSQDSRPRPEPCPPPEPSAPQDGVPAENGLPQGDPEPLPPVPKPRTVPVADVLARDSSDIGWVLELPKEEAPQNGTDHRLPRMAGPGHAPLQRQLSVTQDDPESLGVGLPNGLDGVEEEDDDDYVTLSDQDSHSGSSGRGPGPRRPSVASSVSEEYFEVREHSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKRMQAQRSTDKEAQVGQGPCTPGVTSPSLPATQELELLSSGLPCP", "length": 477, "header": "sp|A6ND36-2|FA83G_HUMAN Isoform 2 of Protein FAM83G OS=Homo sapiens OX=9606 GN=FAM83G PE=1 SV=2 CANONICAL=A6ND36-1" }, "locus": {} }, { "isoform_ac": "K7EKG0-1", "url": "", "sequence": { "sequence": "XDSHSGSSGRGPGPRRPSVASSVSEEYFEVREHSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKRMQAQRSTDKEAQDKVPEPWVPCSLGSVPGARPTWEQCAADHARHDDQAHGEH", "length": 142, "header": "tr|K7EKG0-1|FA83G_HUMAN Computationally mapped isoform of Protein FAM83G OS=Homo sapiens OX=9606 GN=FAM83G PE=1 SV=1 CANONICAL=A6ND36-1" }, "locus": { "chromosome": "17", "start_pos": 18977888, "end_pos": 18976931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000580115.1", "url": "https://www.ensembl.org/id/ENST00000580115.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000465602.1", "url": "https://www.ensembl.org/id/ENSP00000465602.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "site_lbl": "Ser124" }, { "start_pos": 127, "end_pos": 127, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ], "site_lbl": "Ser127" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "phospho.ELM", "id": "A6ND36", "url": "http://phospho.elm.eu.org/byAccession/A6ND36.html" }, { "database": "PubMed", "id": "32570757", "url": "https://glygen.org/publication/PubMed/32570757" } ], "site_lbl": "Ser356" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "site_lbl": "Ser4" }, { "start_pos": 610, "end_pos": 610, "kinase_uniprot_canonical_ac": "P36894-1", "kinase_gene_name": "BMPR1A", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ], "site_lbl": "Ser610" }, { "start_pos": 610, "end_pos": 610, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "site_lbl": "Ser610" }, { "start_pos": 613, "end_pos": 613, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ], "site_lbl": "Ser613" }, { "start_pos": 614, "end_pos": 614, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" }, { "database": "PubMed", "id": "29514862", "url": "https://glygen.org/publication/PubMed/29514862" }, { "database": "PubMed", "id": "31656861", "url": "https://glygen.org/publication/PubMed/31656861" } ], "site_lbl": "Ser614" }, { "start_pos": 616, "end_pos": 616, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "site_lbl": "Ser616" }, { "start_pos": 650, "end_pos": 650, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "site_lbl": "Ser650" }, { "start_pos": 666, "end_pos": 666, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" }, { "database": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" }, { "database": "phospho.ELM", "id": "A6ND36", "url": "http://phospho.elm.eu.org/byAccession/A6ND36.html" } ], "site_lbl": "Ser666" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.", "journal": "Nature biotechnology", "date": "2006", "authors": "Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "iPTMnet", "id": "A6ND36-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36-1" } ], "reference": [ { "type": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" } ] }, { "title": "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.", "journal": "Journal of proteome research", "date": "2008", "authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "iPTMnet", "id": "A6ND36-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "A6ND36-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36-1" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "A6ND36-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.", "journal": "Open biology", "date": "2014", "authors": "Vogt J, Dingwell KS, Herhaus L, Gourlay R, Macartney T, Campbell D, Smith JC, Sapkota GP", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ] }, { "title": "Joubert Syndrome in French Canadians and Identification of Mutations in CEP104.", "journal": "American journal of human genetics", "date": "2015", "authors": "Srour M, Hamdan FF, McKnight D, Davis E, Mandel H, Schwartzentruber J, Martin B, Patry L, Nassif C, Dionne-Laporte A, Ospina LH, Lemyre E, Massicotte C, Laframboise R, Maranda B, Labuda D, Decarie JC, Rypens F, Goldsher D, Fallet-Bianco C, Soucy JF, Laberge AM, Maftei C, Boycott K, Brais B, Boucher RM, Rouleau GA, Katsanis N, Majewski J, Elpeleg O, Kukolich MK, Shalev S, Michaud JL", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "26477546", "url": "https://glygen.org/publication/PubMed/26477546" } ] }, { "title": "PAWS1 controls Wnt signalling through association with casein kinase 1alpha.", "journal": "EMBO reports", "date": "2018", "authors": "Bozatzi P, Dingwell KS, Wu KZ, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Smith JC, Sapkota GP", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "29514862", "url": "https://glygen.org/publication/PubMed/29514862" } ] }, { "title": "Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1\u03b1 association and attenuate Wnt signalling.", "journal": "Wellcome open research", "date": "2019", "authors": "Wu Kevin Z L, Jones Rebecca A, Tachie-Menson Theresa, Macartney Thomas J, Wood Nicola T, Varghese Joby, Gourlay Robert, Soares Renata F, Smith James C, Sapkota Gopal P", "evidence": [ { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "31656861", "url": "https://glygen.org/publication/PubMed/31656861" } ] }, { "title": "FAM83G Is a Novel Inducer of Apoptosis.", "journal": "Molecules (Basel, Switzerland)", "date": "2020", "authors": "Okada J, Sunaga N, Yamada E, Saito T, Ozawa A, Nakajima Y, Okada K, Pessin JE, Okada S, Yamada M", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" }, { "database": "iPTMnet", "id": "A6ND36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6ND36" } ], "reference": [ { "type": "PubMed", "id": "32570757", "url": "https://glygen.org/publication/PubMed/32570757" } ] }, { "title": "FAM83G promotes proliferation, invasion, and metastasis by regulating PI3K/AKT signaling in hepatocellular carcinoma cells.", "journal": "Biochemical and biophysical research communications", "date": "2021", "authors": "Liu C, Huang XY, Huang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001035088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035088" } ], "reference": [ { "type": "PubMed", "id": "34144502", "url": "https://glygen.org/publication/PubMed/34144502" } ] } ], "pathway": [ { "id": "hsa:644815", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:644815", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZN30-1", "protein_name": "Family with sequence similarity 83, member G", "gene_name": "Fam83g", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVAQGRDAFYEVLKRENIRDFLSELELSRIVEAIEVYDPGSEDPRVSGRRSELQDNGGVDASEDTSAAGGPPATAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQPHIKEVVRKMVSQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERARMHLGHLKNLRVRSSGGTEFFTRSATKFKGVLAQKFMFVDGDRAVCGSYSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSQSVSLKDIPMEKEPEPEPIVLPSVVPLVPTGTMAKKLVNPKYALVKAKSVDEIAKTSSDKQEVTRPPGLRGPAVAERPGDLSELLPPVHPGLLNLERANMFEYLPTWVEPDPEPGSDILGYINIIDPKIWNPQPNQMNRIKIRDTAHASTQHQLWKQSQGARPCPEPCLPPAPRDSQDIVPAENGFSQGNSEPQAPVPKPRTVPVASVLAQDGSDIGWALDTPEKETPQNGIDPKLPSTTSESQVPQQQQLPVTQDDPDDLETGLPNGLYEDEDEDDDDYVTLSDQDSLSGSSGPGPGHRRPSVASSMSDEYFEVRERSVPLQRRHSEQVANGPSHPPRRQLSAPHVTRGTFGGPLSGPLWAQGRGREDIDASRIQAQRPVDRQAQGQHFHRHGSTTSRTPGPPRYRPAADGTQSSSKKASPATAGPNHWQPKGSPTPRMLPDPGSPRPTRNTRLRAELRATEEHPSPFGIPYSKLSQSKHLKARAGGSQWVPSDSKRRARDHKEP", "length": 814 }, "evidence": [ { "id": "A6ND36", "url": "https://omabrowser.org/oma/group/A6ND36/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SWY7-1", "protein_name": "Protein FAM83G", "gene_name": "Fam83g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELSRIVEAIEVYDPGSEDPRVSGRRPEPQDNGGADASEETSAAGGPPATETLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQPHIKEVVRKMVSQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERARMHLGHLKNLRVRSSGGTEFFTRSATKFKGVLAQKFMFVDGDRAVCGSYSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSQSVSLKDIPMEKEPEPEPIVLPSVVPLVPTGTMAKKLVNPKYALVKAKSVDEIAKSSSDKQEVTRPPGLRGPAVAERPGDLSELLPPVHPGLLNLERANMFEYLPTWVEPDPEPGSDILGYINIIDPNIWNPQPNQMNRIKIRDTAHASAQHQLWKQSQGARPCPAPCPPPAPRDSQGVVPAENGFPQGNPEPQAPVPKPRTVPVASVLARDGSDIGWALDTPEKETPQNGIDPRLPSTASESEVPQQQHSSMTQDDPDGLERGLPNGLDEDEDDDDDYVTLSDQDSLSGSSGPGPGHRRPSVASSMSDEYFEVRERSVPLQRRHSEQMANGPGHPPRRQLSAPHVTRGTFGGPLSSPLWAQGRSREDVDASRIQGQRPMDRQAQGQHFHRHGSTTSRTPGPPRFRPAADGTQSSSKKASPAAAGPHHWQPKGSPTPRMLPDPGSPRPTRNTRLRAELRATEEHASPFGIPYSKLSQSKHLKARAGGSQWAPSDSKRRARDHKEP", "length": 812 }, "evidence": [ { "id": "45923628", "url": "http://www.informatics.jax.org/homology/45923628", "database": "MGI" }, { "id": "A6ND36", "url": "https://omabrowser.org/oma/group/A6ND36/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 537, "end_pos": 539, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "BMP signaling induces the phosphorylation by BMPR1A at Ser-610, Ser-614 and Ser-616. Phosphorylation at Ser-610 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS.", "evidence": [ { "database": "UniProtKB", "id": "A6ND36", "url": "https://www.uniprot.org/uniprot/A6ND36" }, { "database": "PubMed", "id": "24554596", "url": "https://glygen.org/publication/PubMed/24554596" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 4, 124, 127, 356, 610, 613, 614, 616, 650, 666 ], "sequon_annotation_sites": [ { "start_pos": 537, "end_pos": 539 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 14 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }