{ "uniprot_canonical_ac": "A6H8Y1-1", "uniprot_ac": "A6H8Y1", "uniprot_id": "BDP1_HUMAN", "mass": { "chemical_mass": 293885.0, "monoisotopic_mass": 293885.0 }, "refseq": { "ac": "NP_060899", "name": "transcription factor TFIIIB component B'' homolog", "summary": "The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" }, "gene_names": [ { "name": "BDP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1" }, { "name": "BDP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899", "id": "NP_060899" }, { "name": "DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB''; TFIIIB150; TFIIIB90; TFNR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899", "id": "NP_060899" }, { "name": "KIAA1241", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1" }, { "name": "KIAA1689", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1" }, { "name": "TFNR", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1" } ], "protein_names": [ { "name": "Transcription factor TFIIIB component B'' homolog", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A6H8Y1" }, { "name": "TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1; transcription factor-like nuclear regulator; transcription factor IIIB 150; RNA polymerase III transcription initiation factor B''", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899", "id": "NP_060899" }, { "name": "TFIIIB150", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6H8Y1" }, { "name": "Transcription factor IIIB 150", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6H8Y1" }, { "name": "Transcription factor-like nuclear regulator", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6H8Y1" }, { "name": "transcription factor TFIIIB component B'' homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899", "id": "NP_060899" } ], "function": [ { "annotation": "DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" }, { "database": "PubMed", "id": "32504003", "url": "https://glygen.org/publication/PubMed/32504003" } ] }, { "annotation": "Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" }, { "database": "PubMed", "id": "28743884", "url": "https://glygen.org/publication/PubMed/28743884" } ] }, { "annotation": "General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1#function" }, { "database": "PubMed", "id": "11040218", "url": "https://glygen.org/publication/PubMed/11040218" } ] }, { "annotation": "Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" }, { "database": "PubMed", "id": "24312468", "url": "https://glygen.org/publication/PubMed/24312468" } ] }, { "annotation": "Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers.", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" }, { "database": "PubMed", "id": "32853945", "url": "https://glygen.org/publication/PubMed/32853945" } ] }, { "annotation": "The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" } ] } ], "disease": [ { "disease_id": "DOID:0111637", "recommended_name": { "id": "DOID:0111637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111637", "name": "autosomal recessive nonsyndromic deafness 112", "description": "An autosomal recessive nonsyndromic deafness characterized by postlingual progressive sensorineural hearing impairment that has_material_basis_in homozygous or compound heterozygous mutation in the BDP1 gene on chromosome 5q13.2." }, "synonyms": [ { "id": "DOID:0111637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111637", "name": "DFNB112", "description": "" }, { "id": "DOID:0111637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111637", "name": "autosomal recessive deafness 112", "description": "" }, { "id": "MONDO:0032639", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032639", "name": "hearing loss, autosomal recessive 112", "description": "" }, { "id": "MONDO:0032639", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032639", "name": "DFNB112", "description": "" }, { "id": "MONDO:0032639", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032639", "name": "deafness, autosomal recessive 112", "description": "" }, { "id": "MIM:618257", "resource": "MIM", "url": "https://www.omim.org/entry/618257", "name": "Deafness, autosomal recessive, 112", "description": "Deafness, autosomal recessive, 112" } ], "evidence": [ { "id": "618257", "database": "MIM", "url": "https://www.omim.org/entry/618257" } ] } ], "snv": [ { "evidence": [ { "id": "rs766248392", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766248392" }, { "id": "rs766248392", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766248392" }, { "id": "rs766248392", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs766248392#frequency_tab" }, { "id": "rs766248392", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs766248392" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1010, "end_pos": 1010, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->K).", "chr_id": "5", "chr_pos": "71510121", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1010", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "A6H8Y1", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 108, "end_pos": 108, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (SVS->NVS).", "chr_id": "5", "chr_pos": "71458689", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S108", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs768443760", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768443760" }, { "id": "rs768443760", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768443760" }, { "id": "rs768443760", "database": "gnomAD", "url": 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"null", "minor_allelic_frequency": "", "site_lbl": "D1394", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1163921849", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1163921849" }, { "id": "rs1163921849", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1163921849" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1446, "end_pos": 1446, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLA->NLT).", "chr_id": "5", "chr_pos": "71513273", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A1446", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs908980816", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs908980816" }, { "id": "rs908980816", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs908980816#frequency_tab" }, { "id": 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"glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1557, "end_pos": 1557, "sequence_org": "F", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTF->NTS).", "chr_id": "5", "chr_pos": "71516081", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "F1557", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1424099760", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1424099760" }, { "id": "rs1424099760", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1424099760#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1782, "end_pos": 1782, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSP->NSS).", "chr_id": "5", "chr_pos": "71522906", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P1782", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs762053262", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762053262" }, { "id": "rs762053262", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762053262" }, { "id": "rs762053262", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs762053262" }, { "id": "23033341", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23033341" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1805, "end_pos": 1805, "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SYS->NYS).", "chr_id": "5", "chr_pos": "71523965", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1805", "keywords": [ "ebi", "somatic" ] }, { "evidence": [ { "id": "rs1036891302", "database": "dbSNP", "url": 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CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-426; A-437 and A-446.", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "PubMed", "id": "15469824", "url": "https://glygen.org/publication/PubMed/15469824" } ] }, { "start_pos": 437, "end_pos": 437, "sequence_org": "T", "sequence_mut": "A", "comment": "Not phosphorylated by CSNK2A1; when associated with A-390; A-426; A-431 and A-446. CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-426; A-431 and A-446.", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "PubMed", "id": "15469824", "url": "https://glygen.org/publication/PubMed/15469824" } ] }, { "start_pos": 446, "end_pos": 446, "sequence_org": "S", "sequence_mut": "A", "comment": "Not phosphorylated by CSNK2A1; when associated with A-390; A-426; A-431 and A-437. CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-426; A-431 and A-437.", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "PubMed", "id": "15469824", "url": "https://glygen.org/publication/PubMed/15469824" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "82.56", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "89.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "78.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "84.62", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "83.32", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "84.88", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "84.38", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "88.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "80.41", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "84.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000145734", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A6H8Y1", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8Y1" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "A6H8Y1", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8Y1" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "A6H8Y1", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8Y1" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8Y1" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "A6H8Y1", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8Y1" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YCV8-1", "url": "https://www.uniprot.org/uniprot/H0YCV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C5U4", "url": "https://www.uniprot.org/uniprot/H7C5U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C5U4-1", "url": "https://www.uniprot.org/uniprot/H7C5U4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE", "length": 2624, "header": "sp|A6H8Y1-1|BDP1_HUMAN Isoform 1 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "isoforms": [ { "isoform_ac": "A0A0A0MRX7-1", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILSLGKWRQH", "length": 846, "header": "tr|A0A0A0MRX7-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1" }, "locus": { "chromosome": "HSCHR5_2_CTG1_1", "start_pos": 1508116, "end_pos": 1454363, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000616093.1", "url": "https://www.ensembl.org/id/ENST00000616093.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000479517.1", "url": "https://www.ensembl.org/id/ENSP00000479517.1" } ] } }, { "isoform_ac": "A0A0G2JN16-1", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPEPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILSLGKWRQH", "length": 846, "header": "tr|A0A0G2JN16-1|A0A0G2JN16_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1" }, "locus": { "chromosome": "HSCHR5_1_CTG1_1", "start_pos": 1039606, "end_pos": 985862, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000613844.2", "url": "https://www.ensembl.org/id/ENST00000613844.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000480411.1", "url": "https://www.ensembl.org/id/ENSP00000480411.1" } ] } }, { "isoform_ac": "A0A0G2JNU3-1", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPEPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE", "length": 2624, "header": "tr|A0A0G2JNU3-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1" }, "locus": { "chromosome": "HSCHR5_1_CTG1_1", "start_pos": 1094857, "end_pos": 985862, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000611966.3", "url": "https://www.ensembl.org/id/ENST00000611966.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000482112.2", "url": "https://www.ensembl.org/id/ENSP00000482112.2" } ] } }, { "isoform_ac": "A6H8Y1-1", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE", "length": 2624, "header": "sp|A6H8Y1-1|BDP1_HUMAN Isoform 1 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": { "chromosome": "5", "start_pos": 71564882, "end_pos": 71455878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000358731.9", "url": "https://www.ensembl.org/id/ENST00000358731.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000351575.4", "url": "https://www.ensembl.org/id/ENSP00000351575.4" } ] } }, { "isoform_ac": "A6H8Y1-2", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEVKECTV", "length": 2254, "header": "sp|A6H8Y1-2|BDP1_HUMAN Isoform 2 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "A6H8Y1-3", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQVCIFLSFKSFLNAFSEEINNSMIILSLSPTTLKNL", "length": 1388, "header": "sp|A6H8Y1-3|BDP1_HUMAN Isoform 3 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "A6H8Y1-4", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQVCIFLSFKSFLNAFFRGNK", "length": 1372, "header": "sp|A6H8Y1-4|BDP1_HUMAN Isoform 4 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "A6H8Y1-5", "url": "", "sequence": { "sequence": "MLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQVCIFLSFKSFLNAFSEEINNSMIILSLSPTTFKNL", "length": 778, "header": "sp|A6H8Y1-5|BDP1_HUMAN Isoform 5 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "A6H8Y1-6", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE", "length": 2604, "header": "sp|A6H8Y1-6|BDP1_HUMAN Isoform 6 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "A6H8Y1-7", "url": "", "sequence": { "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQRPF", "length": 2552, "header": "sp|A6H8Y1-7|BDP1_HUMAN Isoform 7 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "A6H8Y1-8", "url": "", "sequence": { "sequence": "MLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVFVYQQLQLVKMPWVYLFLEEIILKSRLIIWILYLGRDFNAGLIKMTTFLLPKNVHSL", "length": 463, "header": "sp|A6H8Y1-8|BDP1_HUMAN Isoform 8 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1" }, "locus": {} }, { "isoform_ac": "H0YCV8-1", "url": "", "sequence": { "sequence": "TDVTTEEMKQEENLSVPFEMTTSEHIQDEPGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQRPF", "length": 606, "header": "tr|H0YCV8-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1" }, "locus": { "chromosome": "HSCHR5_2_CTG1_1", "start_pos": 1561268, "end_pos": 1530859, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000614425.1", "url": "https://www.ensembl.org/id/ENST00000614425.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000479247.1", "url": "https://www.ensembl.org/id/ENSP00000479247.1" } ] } }, { "isoform_ac": "H7C5U4-1", "url": "", "sequence": { "sequence": "XRKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVFVYQQLQLVKMPWVYLFLEEIILKSRLIIWILYLGRDFNAGLIKMTTFLLPKNVHSL", "length": 583, "header": "tr|H7C5U4-1|H7C5U4_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1" }, "locus": { "chromosome": "HSCHR5_1_CTG1_1", "start_pos": 1083264, "end_pos": 1052768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000628099.2", "url": "https://www.ensembl.org/id/ENST00000628099.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000485731.1", "url": "https://www.ensembl.org/id/ENSP00000485731.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1010, "start_aa": "Thr", "end_pos": 1010, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1010", "evidence": [ { "id": "A6H8Y1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6H8Y1" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "A6H8Y1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A6H8Y1" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 22, "start_aa": "Ser", "end_pos": 22, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser22", "evidence": [ { "id": "A6H8Y1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A6H8Y1" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 23, "start_aa": "Thr", "end_pos": 23, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr23", "evidence": [ { "id": "A6H8Y1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A6H8Y1" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 385, "start_aa": "Ser", "end_pos": 385, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser385", "evidence": [ { "id": "A6H8Y1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6H8Y1" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "A6H8Y1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A6H8Y1" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 809, "start_aa": "Thr", "end_pos": 809, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr809", "evidence": [ { "id": "A6H8Y1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6H8Y1" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "A6H8Y1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A6H8Y1" } ] } ], "phosphorylation": [ { "start_pos": 1198, "end_pos": 1198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1198" }, { "start_pos": 1203, "end_pos": 1203, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1203" }, { "start_pos": 1883, "end_pos": 1883, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser1883" }, { "start_pos": 2086, "end_pos": 2086, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr2086" }, { "start_pos": 2088, "end_pos": 2088, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser2088" }, { "start_pos": 2181, "end_pos": 2181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser2181" }, { "start_pos": 2196, "end_pos": 2196, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "17525332", "url": "https://glygen.org/publication/PubMed/17525332" } ], "site_lbl": "Ser2196" }, { "start_pos": 299, "end_pos": 299, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Tyr299" }, { "start_pos": 300, "end_pos": 300, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser300" }, { "start_pos": 316, "end_pos": 316, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser316" }, { "start_pos": 915, "end_pos": 915, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" } ], "site_lbl": "Thr915" }, { "start_pos": 938, "end_pos": 938, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A6H8Y1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1" }, { "database": "PubMed", "id": "33936100", "url": "" } ], "site_lbl": "Ser938" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "SNAP(c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain.", "journal": "Genes & development", "date": "1999", "authors": "Mittal V, Ma B, Hernandez N", "evidence": [ { "database": "Reactome", "id": "R-HSA-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76071" } ], "reference": [ { "type": "PubMed", "id": "10421633", "url": "https://glygen.org/publication/PubMed/10421633" } ] }, { "title": "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters.", "journal": "Genes & development", "date": "2000-10-15", "authors": "Schramm L, Pendergrast P S, Sun Y, Hernandez N", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "11040218", "url": "https://glygen.org/publication/PubMed/11040218" } ] }, { "title": "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ma B, Hernandez N", "evidence": [ { "database": "Reactome", "id": "R-HSA-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76071" } ], "reference": [ { "type": "PubMed", "id": "11056176", "url": "https://glygen.org/publication/PubMed/11056176" } ] }, { "title": "A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Teichmann M, Wang Z, Roeder RG", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "11121026", "url": "https://glygen.org/publication/PubMed/11121026" } ] }, { "title": "The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1.", "journal": "Genomics", "date": "2000", "authors": "Kelter AR, Herchenbach J, Wirth B", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "11161782", "url": "https://glygen.org/publication/PubMed/11161782" } ] }, { "title": "The RNA polymerase III transcription apparatus.", "journal": "Journal of molecular biology", "date": "2001", "authors": "Geiduschek EP, Kassavetis GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-76066", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76066" } ], "reference": [ { "type": "PubMed", "id": "11419933", "url": "https://glygen.org/publication/PubMed/11419933" } ] }, { "title": "A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain.", "journal": "Molecular cell", "date": "2001", "authors": "Zhao X, Pendergrast PS, Hernandez N", "evidence": [ { "database": "Reactome", "id": "R-HSA-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76071" } ], "reference": [ { "type": "PubMed", "id": "11463379", "url": "https://glygen.org/publication/PubMed/11463379" } ] }, { "title": "Recruitment of RNA polymerase III to its target promoters.", "journal": "Genes & development", "date": "2002", "authors": "Schramm L, Hernandez N", "evidence": [ { "database": "Reactome", "id": "R-HSA-76066", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76066" } ], "reference": [ { "type": "PubMed", "id": "12381659", "url": "https://glygen.org/publication/PubMed/12381659" } ] }, { "title": "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.", "journal": "EMBO J.", "date": "2003", "authors": "Fairley Jennifer A, Scott Pamela H, White Robert J", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "14592981", "url": "https://glygen.org/publication/PubMed/14592981" } ] }, { "title": "Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Weser Stephan, Gruber Christin, Hafner Heike M, Teichmann Martin, Roeder Robert G, Seifart Klaus H, Meissner Wolfgang", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "15096501", "url": "https://glygen.org/publication/PubMed/15096501" } ] }, { "title": "CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression.", "journal": "Molecular cell", "date": "2004", "authors": "Hu P, Samudre K, Wu S, Sun Y, Hernandez N", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "15469824", "url": "https://glygen.org/publication/PubMed/15469824" } ] }, { "title": "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB.", "journal": "Biol. Chem.", "date": "2006", "authors": "Schoenen F, Wirth B", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "16542149", "url": "https://glygen.org/publication/PubMed/16542149" } ] }, { "title": "A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes.", "journal": "Gene", "date": "2006", "authors": "Emran F, Florens L, Ma B, Swanson SK, Washburn MP, Hernandez N", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "16769183", "url": "https://glygen.org/publication/PubMed/16769183" } ] }, { "title": "Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III.", "journal": "J. Biol. 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"title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "iPTMnet", "id": "A6H8Y1-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A6H8Y1-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1991", "authors": "Flores O, Lu H, Killeen M, Greenblatt J, Burton ZF, Reinberg D", "evidence": [ { "database": "Reactome", "id": "R-HSA-76061", "url": 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Guillory J, Bhatt D, Vartanian S, Walter K, Chan J, Holcomb T, Dijkgraaf P, Johnson S, Koeman J, Minna JD, Gazdar AF, Stern HM, Hoeflich KP, Wu TD, Settleman J, de Sauvage FJ, Gentleman RC, Neve RM, Stokoe D, Modrusan Z, Seshagiri S, Shames DS, Zhang Z", "evidence": [ { "database": "dbSNP", "id": "rs762053262", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762053262" } ], "reference": [ { "type": "PubMed", "id": "23033341", "url": "https://glygen.org/publication/PubMed/23033341" } ] }, { "title": "S. cerevisiae TFIIIB is the transcription initiation factor proper of RNA polymerase III, while TFIIIA and TFIIIC are assembly factors.", "journal": "Cell", "date": "1990", "authors": "Kassavetis GA, Braun BR, Nguyen LH, Geiduschek EP", "evidence": [ { "database": "Reactome", "id": "R-HSA-76061", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76061" } ], "reference": [ { "type": "PubMed", "id": "2404611", "url": "https://glygen.org/publication/PubMed/2404611" } ] }, { "title": "Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.", "journal": "PLoS ONE", "date": "2013", "authors": "Girotto G, Abdulhadi K, Buniello A, Vozzi D, Licastro D, d'Eustacchio A, Vuckovic D, Alkowari MK, Steel KP, Badii R, Gasparini P", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" } ], "reference": [ { "type": "PubMed", "id": "24312468", "url": "https://glygen.org/publication/PubMed/24312468" } ] }, { "title": "Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.", "journal": "Nature communications", "date": "2017", "authors": "Gouge J, Guthertz N, Kramm K, Dergai O, Abascal-Palacios G, Satia K, Cousin P, Hernandez N, Grohmann D, Vannini A", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": 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"journal": "Nature communications", "date": "2020", "authors": "Kramm K, Schroder T, Gouge J, Vera AM, Gupta K, Heiss FB, Liedl T, Engel C, Berger I, Vannini A, Tinnefeld P, Grohmann D", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" } ], "reference": [ { "type": "PubMed", "id": "32504003", "url": "https://glygen.org/publication/PubMed/32504003" } ] }, { "title": "Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers.", "journal": "Pathology, research and practice", "date": "2020", "authors": "Son HJ, Mo HY, Yoo NJ, Lee SH", "evidence": [ { "database": "RefSeq", "id": "NP_060899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899" } ], "reference": [ { "type": "PubMed", "id": "32853945", "url": "https://glygen.org/publication/PubMed/32853945" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "A6H8Y1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6H8Y1" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Cloning, expression, and function of TFC5, the gene encoding the B` component of the Saccharomyces cerevisiae RNA polymerase III transcription factor TFIIIB.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Kassavetis GA, Nguyen ST, Kobayashi R, Kumar A, Geiduschek EP, Pisano M", "evidence": [ { "database": "Reactome", "id": "R-HSA-76061", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76061" } ], "reference": [ { "type": "PubMed", "id": "7568218", "url": 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Oct-1.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N", "evidence": [ { "database": "Reactome", "id": "R-HSA-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76071" } ], "reference": [ { "type": "PubMed", "id": "9418884", "url": "https://glygen.org/publication/PubMed/9418884" } ] } ], "pathway": [ { "id": "hsa:55814", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:55814", "resource": "KEGG Pathway" }, { "id": "R-HSA-749476", "name": "RNA Polymerase III Abortive And Retractive Initiation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-749476", "resource": "Reactome", "description": "RNA Polymerase III Abortive And Retractive Initiation" }, { "id": "R-HSA-76061", "name": "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76061", "resource": "Reactome", 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"MFRRARLSVKPNVRPGVGTRGSAAPNPQRGPEAPRPPEPATGSAPKPAEPTDVPAVDSGGAEPQEQAPGSSNNEKTGDGSNVEESSTLPSAASQRRKRVSGTSSLGQPPVSAPSQSRPLSTVNHDAPQPNPTPAKEKQPCSDRYRIYKARKLREMLKEELRKEKKQWKNKFATNESQRPPDRSKMTMRDFIYYLPDSNPMTSSVEQEKKCEKSLAPTPTRDRQENQSTQDANDNEDVEEEVDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSTKCQNVKEKAPKPRKNAKAKTVNREEVNDDPDESVNSDTADPERPQKDARTVREEQLPSSSAQHLHLAVLEQEQEQEQSQDKRRRNQGKANKREATTVLESVLDHSSPPAAEIHKSTCPSEENENECNKEQTPSFTQNTEDIAGLASCEETLMRMDPSPSTCNHQDIMPLASESSEPCAADLPVSEPGGAVSGDVNNAEPGGAVSGDVNNAESGCAGAGSADLKTKSPETEQTDSVKPKSRSRLQRPKPNLSRPVGKKSVVSQDRQDGSNKDSPSETAATKNHMEKERVTESENFVTENTERESPSAGTVSDLSEKSSAQEDSQTKVLRPTRLMRSRMQRPKPNVVKAAERKQILTSQEKVGSHVEKIEDDSCVVVPPQMGNESHKNLQCEGAASEPEQKDPVESLQSEQPRALSECPSIQEDNKGNKLKQAPIVRTRFQKPKPNTGRRRRRRRSSKEGIPVDMPVSGDLTATREEIPRPDTSPREEVPSVPLAPLTATASTMELESGVKDSSRNDTASNVKMPEMADVTMEIDTGLETTGRDTCPGEMEAEMIDIPMETEASLKASLNETPPMEKMPELIDNTGEICTNLGETARKEIFLQENGSKEVSPVSEPETGLQETGKKLAVKESTSDMMDGTEEREADSEETERQEISAPVKEAEEAKARGEVDSPLEEIGGETSQQAIAAGAPVEQSASEEDLGDSAGVEEVEVESTVGGKELKLKDAGEGHVSLMVVVSGEKTAIEETIGHLKEKERESSVPWERRSGEIDVGEEMVADLEKTEKVDVSPRDSEPEEQTSGQPEAEVIPSRSDGSTGPPQDRENISNKISVIPTLLEEKETTDKEVSSHGESSSQNSGHHVADQGTQLLDVQEQFSDTNLSKPLPQEQKPLQVKPAPFLRSRFKKPKPNLSRAALKRATLEAEHCVPGKKPEAYKMETVVLQQDRDQAASFSSPHNVPSLMASRENEKSGHEEEEEAVVLPCTQIEKDPSPPNSCEPKEDSQLTQNQEDSLVSPIGTPTVNMVPQETKPNVVQTTLPVRGRLQRPRPNVQKARQRQTVEKGKAEGITKNEGPELQKDEAKTCLTVANSSGVESEVAVEVSSRVSEFKVNESQGHVVPVENLSINKTSVLREQIRHENKPYVPSPALLIRRRFQKAKPNLGGARHKDEQPGVEKGPTSENTALTTEDHLLQKGDCDTQLSVQAREKTEMPLEVSMRKDCVHSEESGSDRNDAQLKAGPSGGAREEIAQEPTFSSSLEEQSLSKQISRPQLLKESSYSKTVPPRRTTVPSASECEIDHSGKRAHRKMKASVTKARGSKRIRGKTAKKEPRASKSVLVTLRASQKDDEDDAEDFESDYEEETCHLAPEELNKAPVFVPVGLRSPEPVSAQIEETMEELEITMDGADLGCLTVVDHQLSHVDIAARDEQPEKAVYPSSFEVVIGEQPQEEPGPGDGSTEAAITLLTMGDIVLQSEIIPGQGDVGVCVFPDDHSKDKNHVPFIPDNVNQKTVHDYQEVCSPVISMSHVSFEDNKIVLEEQSIREAAVLGEAMEEPLSTRDTACTMSTPLRMESMLVTPKAGSERILEISEPDGHQEVASLCMTKGTEVEIQRETEENDSTAVELDDKSLEPVPAAETKEQEQLLCVHGVEGARVSQEAILPARTEEHEDDLQGLQTLGAAVASSEIGQHTLESGQSLGDSVAEEALRESPEGSVVPMLHVPESVPSNIPEAQHENISPQDDTVNLFANVQQDGEDEQAFILTLVEIPTNTTEGFTDASMHLMPSSLLPAPILVRSGNAVERVDLSGSLQASSVVQDVTCSSPSRSGDSEKPPAIVELTSRKRFCCSPDESIHVPPAKKSSIAPGIDYQNCTSGVCSEELNVFEKTEESCMGQGIFPTSESTHATSKPQKEHSEQTSQNTGSSGSLGEIKDACVENTMTELPQSEVVSDKEEKTDPASNSKQRDSVTSSSKPPLTRPGRRPLGFLSLICPKNSLESDEVTQTHSKKRLKPHIPVSRRNLKKPNPLHASQKKNQESSDPLPPPSVTETVSDNTGSSESSAAEVSSDQPLVEEEKCKNGPKGASEEEVTTVSEFVFSDIFIEVDETE", "length": 2486 }, "evidence": [ { "id": "A6H8Y1", "url": "https://omabrowser.org/oma/group/A6H8Y1/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q571C7-1", "protein_name": "Transcription factor TFIIIB component B'' homolog", "gene_name": "Bdp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 2467 }, "evidence": [ { "id": "45931845", "url": "http://www.informatics.jax.org/homology/45931845", "database": "MGI" }, { "id": "A6H8Y1", "url": "https://omabrowser.org/oma/group/A6H8Y1/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "pmid": "" }, { "name": "transcription factor TFIIIB complex", "id": "GO:0000126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000126", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "TFIIIC-class transcription factor complex binding", "id": "GO:0001156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001156", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "RNA polymerase III preinitiation complex assembly", "id": "GO:0070898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070898", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1013, "end_pos": 1015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1354, "end_pos": 1356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1414, "end_pos": 1416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1522, "end_pos": 1524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1543, "end_pos": 1545, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1644, "end_pos": 1646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1657, "end_pos": 1659, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1660, "end_pos": 1662, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1802, "end_pos": 1804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1839, "end_pos": 1841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1959, "end_pos": 1961, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2079, "end_pos": 2081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2142, "end_pos": 2144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2184, "end_pos": 2186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2549, "end_pos": 2551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2574, "end_pos": 2576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 740, "end_pos": 742, "annotation": "n_glycosylation_sequon" }, { "start_pos": 772, "end_pos": 774, "annotation": "n_glycosylation_sequon" }, { "start_pos": 962, "end_pos": 964, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.", "evidence": [ { "database": "UniProtKB", "id": "A6H8Y1", "url": "https://www.uniprot.org/uniprot/A6H8Y1" }, { "database": "PubMed", "id": "15469824", "url": "https://glygen.org/publication/PubMed/15469824" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 22, 23, 385, 809, 1010 ], "snv_sites": [ 22, 70, 87, 108, 180, 200, 207, 234, 262, 281, 385, 418, 481, 557, 609, 740, 1010, 1327, 1380, 1394, 1446, 1464, 1557, 1782, 1805, 2020, 2153, 2175, 2410, 2461, 2616 ], "glycation_sites": [], "phosphorylation_sites": [ 299, 300, 316, 915, 938, 1198, 1203, 1883, 2086, 2088, 2181, 2196 ], "sequon_annotation_sites": [ { "start_pos": 1013, "end_pos": 1015 }, { "start_pos": 1354, "end_pos": 1356 }, { "start_pos": 1414, "end_pos": 1416 }, { "start_pos": 1522, "end_pos": 1524 }, { "start_pos": 1543, "end_pos": 1545 }, { "start_pos": 1644, "end_pos": 1646 }, { "start_pos": 1657, "end_pos": 1659 }, { "start_pos": 1660, "end_pos": 1662 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 1802, "end_pos": 1804 }, { 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"sort_fields": [ "title", "journal", "date", "authors" ] } ] }