{ "uniprot_canonical_ac": "A6H8M9-1", "uniprot_ac": "A6H8M9", "uniprot_id": "CDHR4_HUMAN", "mass": { "chemical_mass": 85827.0, "monoisotopic_mass": 85827.0 }, "refseq": { "ac": "NP_001007541", "name": "cadherin-related family member 4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541" }, "gene_names": [ { "name": "CDHR4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6H8M9", "id": "A6H8M9" }, { "name": "CDH29; PRO34300", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541", "id": "NP_001007541" }, { "name": "CDH29", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6H8M9", "id": "A6H8M9" }, { "name": "CDHR4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541", "id": "NP_001007541" }, { "name": "PRO34300", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6H8M9", "id": "A6H8M9" } ], "protein_names": [ { "name": "Cadherin-related family member 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A6H8M9" }, { "name": "Cadherin-like protein 29", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6H8M9" }, { "name": "cadherin-like 29; cadherin-like protein 29; Cadherin-like protein UNQ9392/PRO34300; VLLR9392", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541", "id": "NP_001007541" }, { "name": "cadherin-related family member 4 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541", "id": "NP_001007541" } ], "function": [ { "annotation": "Cadherins are calcium-dependent cell adhesion proteins. 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "A6H8M9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8M9" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "A6H8M9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8M9" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "A6H8M9", "url": "https://www.uniprot.org/uniprot/A6H8M9" } ], "common_name": "Human" } ], "gene": [ { "name": "CDHR4", "url": "https://www.uniprot.org/uniprot/A6H8M9", "locus": { "chromosome": "3", "start_pos": 49790732, "end_pos": 49799873, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000187492", "url": "https://www.ensembl.org/id/ENSG00000187492" } ] } } ], "crossref": [ { "id": "ENSG00000187492", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000187492", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "A6H8M9", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8M9", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CDHR4", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDHR4", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "389118", "url": "https://www.ncbi.nlm.nih.gov/gene/389118", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "34527", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=34527", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:389118", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:389118", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NX_A6H8M9", "url": "https://www.nextprot.org/entry/NX_A6H8M9", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "APRMEMP", "url": "https://omabrowser.org/oma/group/APRMEMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5313831at2759", "url": "http://www.orthodb.org/?query=5313831at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "http://pfam.xfam.org/family/PF00028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A6H8M9", "url": "https://pharos.nih.gov/targets/A6H8M9", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_A6H8M9", "url": "http://purl.obolibrary.org/obo/PR_A6H8M9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001007541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6H8M9", "url": "https://www.uniprot.org/uniprot/A6H8M9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H8M9-1", "url": "https://www.uniprot.org/uniprot/A6H8M9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H8M9-2", "url": "https://www.uniprot.org/uniprot/A6H8M9-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PFE8", "url": "https://www.uniprot.org/uniprot/E9PFE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PFE8-1", "url": "https://www.uniprot.org/uniprot/E9PFE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C4N6", "url": "https://www.uniprot.org/uniprot/H7C4N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C4N6-1", "url": "https://www.uniprot.org/uniprot/H7C4N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C5B2", "url": "https://www.uniprot.org/uniprot/H7C5B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C5B2-1", "url": "https://www.uniprot.org/uniprot/H7C5B2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQAPSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNTHTGARRWL", "length": 788, "header": "sp|A6H8M9-1|CDHR4_HUMAN Isoform 1 of Cadherin-related family member 4 OS=Homo sapiens OX=9606 GN=CDHR4 PE=2 SV=1 CANONICAL=A6H8M9-1" }, "isoforms": [ { "isoform_ac": "A6H8M9-1", "url": "", "sequence": { "sequence": "MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQAPSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNTHTGARRWL", "length": 788, "header": "sp|A6H8M9-1|CDHR4_HUMAN Isoform 1 of Cadherin-related family member 4 OS=Homo sapiens OX=9606 GN=CDHR4 PE=2 SV=1 CANONICAL=A6H8M9-1" }, "locus": { "chromosome": "3", "start_pos": 49799812, "end_pos": 49790835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000412678.7", "url": "https://www.ensembl.org/id/ENST00000412678.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000391409.2", "url": "https://www.ensembl.org/id/ENSP00000391409.2" } ] } }, { "isoform_ac": "A6H8M9-2", "url": "", "sequence": { "sequence": "MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPGEARGSRQGGGRHGLSRSSLTSTLASWGNDSGARDSHTWGSAVHSAPPRPRTPRSAGKPRTWDGG", "length": 199, "header": "sp|A6H8M9-2|CDHR4_HUMAN Isoform 2 of Cadherin-related family member 4 OS=Homo sapiens OX=9606 GN=CDHR4 PE=2 SV=1 CANONICAL=A6H8M9-1" }, "locus": { "chromosome": "3", "start_pos": 49799812, "end_pos": 49798800, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000343366.8", "url": "https://www.ensembl.org/id/ENST00000343366.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000341302.4", "url": "https://www.ensembl.org/id/ENSP00000341302.4" } ] } }, { "isoform_ac": "E9PFE8-1", "url": "", "sequence": { "sequence": "MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQVSPEHGTVGDRMGVGGWRE", "length": 184, "header": "tr|E9PFE8-1|CDHR4_HUMAN Computationally mapped isoform of Cadherin-related family member 4 OS=Homo sapiens OX=9606 GN=CDHR4 PE=2 SV=1 CANONICAL=A6H8M9-1" }, "locus": { "chromosome": "3", "start_pos": 49799812, "end_pos": 49798769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000487256.1", "url": "https://www.ensembl.org/id/ENST00000487256.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000420677.1", "url": "https://www.ensembl.org/id/ENSP00000420677.1" } ] } }, { "isoform_ac": "H7C4N6-1", "url": "", "sequence": { "sequence": "QELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVGPAAASTQQTSPGFAAKQHPGN", "length": 134, "header": "tr|H7C4N6-1|H7C4N6_HUMAN Computationally mapped isoform of Cadherin related family member 4 OS=Homo sapiens OX=9606 GN=CDHR4 PE=4 SV=1 CANONICAL=A6H8M9-1" }, "locus": { "chromosome": "3", "start_pos": 49793272, "end_pos": 49791790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000460430.5", "url": "https://www.ensembl.org/id/ENST00000460430.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000417753.1", "url": "https://www.ensembl.org/id/ENSP00000417753.1" } ] } }, { "isoform_ac": "H7C5B2-1", "url": "", "sequence": { "sequence": "XSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQAPSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLQHFDGRAQDSRTGRDYLFNTHTGARRWL", "length": 151, "header": "tr|H7C5B2-1|CDHR4_HUMAN Computationally mapped isoform of Cadherin-related family member 4 OS=Homo sapiens OX=9606 GN=CDHR4 PE=2 SV=1 CANONICAL=A6H8M9-1" }, "locus": { "chromosome": "3", "start_pos": 49792932, "end_pos": 49790833, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000487666.5", "url": "https://www.ensembl.org/id/ENST00000487666.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000419433.1", "url": "https://www.ensembl.org/id/ENSP00000419433.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 242, "start_aa": "Asn", "end_pos": 242, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn242", "evidence": [ { "id": "A6H8M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H8M9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "A6H8M9", "url": "https://www.uniprot.org/uniprot/A6H8M9" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Association analysis of 3p21 with Crohn's disease in a New Zealand population.", "journal": "Human immunology", "date": "2010", "authors": "Morgan AR, Han DY, Lam WJ, Fraser AG, Ferguson LR", "evidence": [ { "database": "RefSeq", "id": "NP_001007541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007541" } ], "reference": [ { "type": "PubMed", "id": "20307617", "url": "https://glygen.org/publication/PubMed/20307617" } ] } ], "pathway": [ { "id": "hsa:389118", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:389118", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JUE2-1", "protein_name": "Cadherin-related family member 4", "gene_name": "Cdhr4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMMLRLLEFLFALLIPVFPSLPWSTDILESKGPGTVLQTFLFNCSSYMPTLELLSVKPPTSFFNKPSLQGQKGLYRGKVTLSSSARLDALAVNYYELQLRYTCGNFVVDGSFFVHVLRDPGRIHCTGAFASPAGEFIYVPETVTPGALLYTLLLPGLGGQRAQMNITSAQDPPVFPGPFSIDEHGLLRAPSQGLRGQAQKTFQLQILVSLGKSQRCKGMLTVKVLPAPPSHVSFLKKAQSITIAEDLVPGSEVVQVQARGLNLLYEIISPRPSPLYSIGQADGVVRTTAPLDLVRVQGAVVTKLQVKAFERLRPWASAVSDLTVIVRAVNQRPPRCHPALLVTQIPETALEGTVLDTLTCVDPDSAGAPLDYQLRFHSPPDSASLRLRGRTLEVNATLDCDAPGACFQHLASILVSDGGQPQMTAEVPVLVMVTPVNEFSPSCMPHTFRVREDAGPYTLLGSIVGTDVDHPRNSLEYHISGGLSTFAVDRLSGELHLLGPLDYEQQRLYRIVILLIDHSQDWDLNSHRSGSCTITIEVEDVNDHAPECEPPFQELTIYTALGRSMEVTKVSCWIPQEPQRLTLSYSIMGGNSQSRFRLQGTILVYNDTVLGPPWPEPPSTHELLIHVADMGPSTPHLSTTATIIVHLVPWKASTVATSTHQSTVSSTMTPLIVTDVEAFWKPEPWFVVVLTATGAVLLLALGWLLGRILRRLAQSLQAPSKPARAQLLNSIQGSRGSIERQMEAPSMEMSKQHFDGRAQDVCNFSEAPVVPDDDPDLVLSQLFGEGKGDGGKGRAPLIFQLHQ", "length": 803 }, "evidence": [ { "id": "45933296", "url": "http://www.informatics.jax.org/homology/45933296", "database": "MGI" }, { "id": "A6H8M9", "url": "https://omabrowser.org/oma/group/A6H8M9/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "H3BJZ2-1", "protein_name": "Cadherin-related family member 4", "gene_name": "Cdhr4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALLRLLEFLFALLIPVLYSLPWTMYISENNGPGTVLRPFSFNCSSYMPTLELLSVRPPTSFFNKPSMHGDKGVYLVMVSLSSSARLDALAVNQYELQLQYRCGNFVVDGSIFVHVQRDPGRIRCTGAFASPAGEFIYVPETITPGALVYTLLLPGVQRAQINITSAQNPSPGPFSIDEQGLLRAPSQGLRGQAQKTFQLQISVSFEKNQSCRGMLTVKVLPAPSSQVSFLQKAQSITISEDLVPGSEVVRVQATGFNLLYEIISPRPSLFYSIGQADGVVRTTAPLDLARVQGAMVTKLQVRAFERPRPWASAVFDLTVSVRAVNQWPPRCHPALLVTQIPETSLVGTVLDALTCVDPDSAGRPLDYQLRFHSPPDSASLRLRDRILEVNATLDCDTPGACFQHSASILVVDGGQPQMTTEIPVLVMVTPVNEFSPACVPRTFRVQEDTGPHTLLGSIVGTDMDYPRNSLEYYISGGPSTFAVDRLSGELHLLGPLDYEQQRLYKITILLIDHSQDWDLNSHRSGSCTITIEVEDVNDHAPECEPPFQELTIYTPMGHSMEVTKVSCWIPQEPQRLTLSYSIVGGNSQSRFRLQGAILVYNDTVLGPPWPEQPCTYELLIHVADVGPSIPHLSTTTTIIVHLVPWKASTVATSTHQSTVSSTMTPLIVTELEAFWKPEPWFVVVLTATGAVLLLALGWLLSRILRGLAPSLQAPSKPAKAQLLNSIQGNEGPIERQMEAPRIEMSQVPRTAMSLQHFDGRAQDVCMGRDYLFNTLTGARRWL", "length": 783 }, "evidence": [ { "id": "A6H8M9", "url": "https://omabrowser.org/oma/group/A6H8M9/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A6H8M9", "url": "https://www.uniprot.org/uniprot/A6H8M9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A6H8M9", "url": "https://www.uniprot.org/uniprot/A6H8M9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A6H8M9", "url": "https://www.uniprot.org/uniprot/A6H8M9" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A6H8M9", "url": 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