{ "uniprot_canonical_ac": "A5PLK6-1", "uniprot_ac": "A5PLK6", "uniprot_id": "RGSL_HUMAN", "mass": { "chemical_mass": 125688.0, "monoisotopic_mass": 125688.0 }, "refseq": { "ac": "NP_001131141", "name": "regulator of G-protein signaling protein-like isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141" }, "gene_names": [ { "name": "RGSL1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A5PLK6", "id": "A5PLK6" }, { "name": "RGSL1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141", "id": "NP_001131141" }, { "name": "RGSL2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A5PLK6", "id": "A5PLK6" }, { "name": "RGSL; RGSL2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141", "id": "NP_001131141" }, { "name": "RGSL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A5PLK6", "id": "A5PLK6" } ], "protein_names": [ { "name": "Regulator of G-protein signaling protein-like", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A5PLK6" }, { "name": "regulator of G-protein signaling like 2; regulator of G-protein signaling protein-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141", "id": "NP_001131141" }, { "name": "regulator of G-protein signaling protein-like isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141", "id": "NP_001131141" } ], "function": [ { "annotation": "A detailed mapping of the breakpoints revealed intragenic microdeletions affecting the coding regions of RGSL2, RGSL1.", "evidence": [ { "database": "RefSeq", "id": "NP_001131141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141" }, { "database": "PubMed", "id": "18521847", "url": "https://glygen.org/publication/PubMed/18521847" } ] }, { "annotation": "Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.", "evidence": [ { "database": "RefSeq", "id": "NP_001131141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141" }, { "database": "PubMed", "id": "23248035", "url": "https://glygen.org/publication/PubMed/23248035" } ] }, { "annotation": "Missense mutations in RGSL1 gene is associated with breast cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001131141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141" }, { "database": "PubMed", "id": "21135262", "url": "https://glygen.org/publication/PubMed/21135262" } ] }, { "annotation": "Observational study of gene-disease association. 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"description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "A5PLK6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "A5PLK6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "A5PLK6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of 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"MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant 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"length": 1076, "header": "sp|A5PLK6-1|RGSL_HUMAN Isoform 1 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "isoforms": [ { "isoform_ac": "A0A0U1RQD8-1", "url": "", "sequence": { "sequence": "MQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQL", "length": 81, "header": "tr|A0A0U1RQD8-1|A0A0U1RQD8_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=1 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182473885, "end_pos": 182473643, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000634758.1", "url": "https://www.ensembl.org/id/ENST00000634758.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488942.1", "url": "https://www.ensembl.org/id/ENSP00000488942.1" } ] } }, { "isoform_ac": "A0A0U1RRA3-1", "url": "", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPLCFAGFWSDTILYC", "length": 46, "header": "tr|A0A0U1RRA3-1|A0A0U1RRA3_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182458347, "end_pos": 182450166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000635407.1", "url": "https://www.ensembl.org/id/ENST00000635407.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489421.1", "url": "https://www.ensembl.org/id/ENSP00000489421.1" } ] } }, { "isoform_ac": "A0A0U1RRF3-1", "url": "", "sequence": { "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYLTG", "length": 31, "header": "tr|A0A0U1RRF3-1|A0A0U1RRF3_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182471379, "end_pos": 182471287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000634626.1", "url": "https://www.ensembl.org/id/ENST00000634626.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489498.1", "url": "https://www.ensembl.org/id/ENSP00000489498.1" } ] } }, { "isoform_ac": "A0A0U1RRF6-1", "url": "", "sequence": { "sequence": "MDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQ", "length": 166, "header": "tr|A0A0U1RRF6-1|A0A0U1RRF6_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=1 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182473966, "end_pos": 182472452, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000634679.1", "url": "https://www.ensembl.org/id/ENST00000634679.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489502.1", "url": "https://www.ensembl.org/id/ENSP00000489502.1" } ] } }, { "isoform_ac": "A0A0U1RRG0-1", "url": "", "sequence": { "sequence": "XRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGNLIQPIQTKG", "length": 57, "header": "tr|A0A0U1RRG0-1|RGSL_HUMAN Computationally mapped isoform of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182560310, "end_pos": 182553470, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000634801.1", "url": "https://www.ensembl.org/id/ENST00000634801.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489508.1", "url": "https://www.ensembl.org/id/ENSP00000489508.1" } ] } }, { "isoform_ac": "A0A0U1RRN0-1", "url": "", "sequence": { "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEEL", "length": 37, "header": "tr|A0A0U1RRN0-1|A0A0U1RRN0_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=2 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182472406, "end_pos": 182471287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000634723.1", "url": "https://www.ensembl.org/id/ENST00000634723.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489611.1", "url": "https://www.ensembl.org/id/ENSP00000489611.1" } ] } }, { "isoform_ac": "A0A3B3ISC9-1", "url": "", "sequence": { "sequence": "MLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEK", "length": 270, "header": "tr|A0A3B3ISC9-1|A0A3B3ISC9_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=1 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182530361, "end_pos": 182488285, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000648414.1", "url": "https://www.ensembl.org/id/ENST00000648414.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000497245.1", "url": "https://www.ensembl.org/id/ENSP00000497245.1" } ] } }, { "isoform_ac": "A5PLK6-1", "url": "", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK", "length": 1076, "header": "sp|A5PLK6-1|RGSL_HUMAN Isoform 1 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182556054, "end_pos": 182450166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000294854.13", "url": "https://www.ensembl.org/id/ENST00000294854.13" }, { "database": "Ensembl Peptide", "id": "ENSP00000457748.1", "url": "https://www.ensembl.org/id/ENSP00000457748.1" } ] } }, { "isoform_ac": "A5PLK6-2", "url": "", "sequence": { "sequence": "MLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK", "length": 599, "header": "sp|A5PLK6-2|RGSL_HUMAN Isoform 2 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": {} }, { "isoform_ac": "A5PLK6-3", "url": "", "sequence": { "sequence": "MSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK", "length": 500, "header": "sp|A5PLK6-3|RGSL_HUMAN Isoform 3 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": {} }, { "isoform_ac": "A5PLK6-4", "url": "", "sequence": { "sequence": "MSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKR", "length": 402, "header": "sp|A5PLK6-4|RGSL_HUMAN Isoform 4 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": {} }, { "isoform_ac": "A5PLK6-5", "url": "", "sequence": { "sequence": "MLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVLFLEGNPLLLTV", "length": 472, "header": "sp|A5PLK6-5|RGSL_HUMAN Isoform 5 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": {} }, { "isoform_ac": "A5PLK6-6", "url": "", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGAKMMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTVGRTLG", "length": 539, "header": "sp|A5PLK6-6|RGSL_HUMAN Isoform 6 of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": {} }, { "isoform_ac": "H3BNQ0-1", "url": "", "sequence": { "sequence": "AQKEICKMLSPWYDEFLDEEDYWFLLFTT", "length": 29, "header": "tr|H3BNQ0-1|H3BNQ0_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=2 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182493024, "end_pos": 182474522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000415960.6", "url": "https://www.ensembl.org/id/ENST00000415960.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000454954.2", "url": "https://www.ensembl.org/id/ENSP00000454954.2" } ] } }, { "isoform_ac": "H3BNR3-1", "url": "", "sequence": { "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEELVDFWILAENILSIDEMDLEVRDYYLSL", "length": 64, "header": "tr|H3BNR3-1|H3BNR3_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182472487, "end_pos": 182471287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437548.5", "url": "https://www.ensembl.org/id/ENST00000437548.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454969.1", "url": "https://www.ensembl.org/id/ENSP00000454969.1" } ] } }, { "isoform_ac": "H3BNS3-1", "url": "", "sequence": { "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYL", "length": 29, "header": "tr|H3BNS3-1|H3BNS3_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=8 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182471373, "end_pos": 182471287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000447374.5", "url": "https://www.ensembl.org/id/ENST00000447374.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454981.1", "url": "https://www.ensembl.org/id/ENSP00000454981.1" } ] } }, { "isoform_ac": "H3BRN5-1", "url": "", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGEARVSLLKSNWWWCWRDSQEDDEIGSTRNLFPHLDNNCTGRICMICSVPGMMSF", "length": 154, "header": "tr|H3BRN5-1|H3BRN5_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182488312, "end_pos": 182450166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000422241.2", "url": "https://www.ensembl.org/id/ENST00000422241.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000456332.1", "url": "https://www.ensembl.org/id/ENSP00000456332.1" } ] } }, { "isoform_ac": "H3BU64-1", "url": "", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGAKMMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVLFLEGNPLLLTV", "length": 984, "header": "tr|H3BU64-1|RGSL_HUMAN Computationally mapped isoform of Regulator of G-protein signaling protein-like OS=Homo sapiens OX=9606 GN=RGSL1 PE=2 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182551138, "end_pos": 182450166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000443996.6", "url": "https://www.ensembl.org/id/ENST00000443996.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000457491.1", "url": "https://www.ensembl.org/id/ENSP00000457491.1" } ] } }, { "isoform_ac": "H3BVE8-1", "url": "", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNINAQSLV", "length": 160, "header": "tr|H3BVE8-1|H3BVE8_HUMAN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Homo sapiens OX=9606 GN=RGSL1 PE=4 SV=1 CANONICAL=A5PLK6-1" }, "locus": { "chromosome": "1", "start_pos": 182488301, "end_pos": 182450166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416676.5", "url": "https://www.ensembl.org/id/ENST00000416676.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000458086.1", "url": "https://www.ensembl.org/id/ENSP00000458086.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC).", "journal": "Genomics", "date": "1999", "authors": "Rubio JP, Levy ER, Dobson-Stone C, Monaco AP", "evidence": [ { "database": "Reactome", "id": "R-HSA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416476" } ], "reference": [ { "type": "PubMed", "id": "10191087", "url": "https://glygen.org/publication/PubMed/10191087" } ] }, { "title": "Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T", "evidence": [ { "database": "Reactome", "id": "R-HSA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416476" } ], "reference": [ { "type": "PubMed", "id": "10567430", "url": "https://glygen.org/publication/PubMed/10567430" } ] }, { "title": "Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.", "journal": "Molecular pharmacology", "date": "2000", "authors": "Sallese M, Mariggio S, D'Urbano E, Iacovelli L, De Blasi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416476" } ], "reference": [ { "type": "PubMed", "id": "10727532", "url": "https://glygen.org/publication/PubMed/10727532" } ] }, { "title": "G protein-coupled receptor 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