{ "uniprot_canonical_ac": "A4D2P6-1", "uniprot_ac": "A4D2P6", "uniprot_id": "GRD2I_HUMAN", "mass": { "chemical_mass": 132276.0, "monoisotopic_mass": 132276.0 }, "refseq": { "ac": "NP_001138590", "name": "delphilin isoform 1", "summary": "Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" }, "gene_names": [ { "name": "GRID2IP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4D2P6", "id": "A4D2P6" }, { "name": "DELPHILIN", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590", "id": "NP_001138590" }, { "name": "GRID2IP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590", "id": "NP_001138590" } ], "protein_names": [ { "name": "Delphilin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A4D2P6" }, { "name": "Glutamate receptor, ionotropic, delta 2-interacting protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A4D2P6" }, { "name": "delphilin isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590", "id": "NP_001138590" }, { "name": "glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; glutamate receptor, ionotropic, delta 2-interacting protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590", "id": "NP_001138590" } ], "function": [ { "annotation": "Delphilin is an actin nucleator that does not accelerate elongation. Delphilin exhibits a preference for actin isoforms, nucleating nonmuscle actin but not muscle actin.", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" }, { "database": "PubMed", "id": "29282276", "url": "https://glygen.org/publication/PubMed/29282276" } ] }, { "annotation": "Delphilin isoforms with differential palmitoylation and clustering capabilities may provide two separate intracellular and surface GluRdelta2 pools and may control GluRdelta2 signaling in Purkinje cells", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" }, { "database": "PubMed", "id": "16835239", "url": "https://glygen.org/publication/PubMed/16835239" } ] }, { "annotation": "Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" } ] }, { "annotation": "Grid2 interacting protein is a potential biomarker related to immune infiltration in colorectal cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" }, { "database": "PubMed", "id": "37964339", "url": "https://glygen.org/publication/PubMed/37964339" } ] }, { "annotation": "Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6#function" } ] }, { "annotation": "Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin.", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" }, { "database": "PubMed", "id": "17027646", "url": "https://glygen.org/publication/PubMed/17027646" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "56.82", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "46.25", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "55.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "53.57", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "57.15", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "31.33", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "57.83", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "56.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000215045", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215045" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A4D2P6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D2P6" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "A4D2P6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D2P6" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { 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cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "A4D2P6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D2P6" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D2P6" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "A4D2P6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D2P6" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"MSCLGIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGLRSSGMVSPLAW", "length": 1020, "header": "tr|C9J5F6-1|C9J5F6_HUMAN Computationally mapped isoform of Grid2 interacting protein OS=Homo sapiens OX=9606 GN=GRID2IP PE=1 SV=1 CANONICAL=A4D2P6-1" }, "locus": { "chromosome": "7", "start_pos": 6536844, "end_pos": 6497777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452113.5", "url": "https://www.ensembl.org/id/ENST00000452113.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000397887.1", "url": "https://www.ensembl.org/id/ENSP00000397887.1" } ] } }, { "isoform_ac": "C9JNS8-1", "url": "", "sequence": { "sequence": "MGKDQGFSRHFRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGLRSSGMVSPLAW", "length": 1027, "header": "tr|C9JNS8-1|C9JNS8_HUMAN Computationally mapped isoform of Grid2 interacting protein OS=Homo sapiens OX=9606 GN=GRID2IP PE=1 SV=1 CANONICAL=A4D2P6-1" }, "locus": { "chromosome": "7", "start_pos": 6531102, "end_pos": 6497777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000435185.5", "url": "https://www.ensembl.org/id/ENST00000435185.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000408364.1", "url": "https://www.ensembl.org/id/ENSP00000408364.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 580, "end_pos": 580, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "site_lbl": "Ser580" }, { "start_pos": 621, "end_pos": 621, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "site_lbl": "Ser621" }, { "start_pos": 652, "end_pos": 652, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "site_lbl": "Ser652" }, { "start_pos": 655, "end_pos": 655, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "site_lbl": "Ser655" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico.", "journal": "Int. J. Mol. Med.", "date": "2003", "authors": "Katoh M, Katoh M", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "reference": [ { "type": "PubMed", "id": "14612983", "url": "https://glygen.org/publication/PubMed/14612983" } ] }, { "title": "Characterization of the delta2 glutamate receptor-binding protein delphilin: splicing variants with differential palmitoylation and an additional PDZ domain.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Matsuda K, Matsuda S, Gladding CM, Yuzaki M", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" }, { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" } ], "reference": [ { "type": "PubMed", "id": "16835239", "url": "https://glygen.org/publication/PubMed/16835239" } ] }, { "title": "Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Sonoda T, Mochizuki C, Yamashita T, Watanabe-Kaneko K, Miyagi Y, Shigeri Y, Yazama F, Okuda K, Kawamoto S", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" } ], "reference": [ { "type": "PubMed", "id": "17027646", "url": "https://glygen.org/publication/PubMed/17027646" } ] }, { "title": "The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongation.", "journal": "Molecular biology of the cell", "date": "2018", "authors": "Silkworth WT, Kunes KL, Nickel GC, Phillips ML, Quinlan ME, Vizcarra CL", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" } ], "reference": [ { "type": "PubMed", "id": "29282276", "url": "https://glygen.org/publication/PubMed/29282276" } ] }, { "title": "Grid2 interacting protein is a potential biomarker related to immune infiltration in colorectal cancer.", "journal": "European journal of medical research", "date": "2023-11-14", "authors": "Zhao Jiajing, Quan Jiazheng, Chen Weilin, Xie Xiaojun", "evidence": [ { "database": "RefSeq", "id": "NP_001138590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138590" } ], "reference": [ { "type": "PubMed", "id": "37964339", "url": "https://glygen.org/publication/PubMed/37964339" } ] } ], "pathway": [ { "id": "hsa:392862", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:392862", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A1R4-1", "protein_name": "Grid2 interacting protein", "gene_name": "Grid2ip", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPATNQGWPEDFGFQLGGSGPCFVIEVAEGSSAHAGGLRPGDQILEVEGLAVGGLSCEQLVRLARRCPRVPPSLGVLPGPEGGPTALTAAWLSPRFGRSFPLGRELLRLAGGARPDAVHRERRRKAQEFSCQVDDILGDQPTAKEQVFAALKQFAAEQRVDELVWTLILVLPSEAQGPVLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAAPRRPDEPPPRKAASLLGGRTGPGGPRRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHLLTPPERYGVCRALESFFQHRSIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQEKIACFLGYTAITEPESSLDLEPESTPEPTPEPQPRSSLRASSMCRRSLRSQGLEASLSCGPGDCSEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSGFKGKIGTVSKSRASPPVPSLVGTSGPRTLSGVSWPGDRLLPSPCYDPLCSGGLASPSSSESHPYASLDSSRAPSPQPGLGSIHPDSPPSPDPIRPPSRRKLFAFSRPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASECVSSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDPKPSSRTSDGPRGPPQSLTKPLTQISHPVPPPPPPPLPPPVPCAPPMISRGVGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTVDLADLHDTVSEIQVACQSMVPSSEDRFAVVMTSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFSEFMSKFERALSDLQAGDGPRSSGMVSPLAW", "length": 1203 }, "evidence": [ { "id": "45920163", "url": "http://www.informatics.jax.org/homology/45920163", "database": "MGI" }, { "id": "A4D2P6", "url": "https://omabrowser.org/oma/group/A4D2P6/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0QWG9-1", "protein_name": "Delphilin", "gene_name": "Grid2ip", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPATNQGWPEDFGFQLGGSGPCFVIEVAEGSSAHAGGLRPGDQILEVEGLAVGGLSRERIVRLARRCPRVPPSLGVLPGPEGGPTALTAAWLTRRFGRSLPLSRELLRLAGGPRPDAVHRERRRKAQEFSCQVDDILGDRLTAKEQVFTALKQFAAEQRVDELVWTLTLVLPSEAQGPVLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAAPRRPDEPPPRKATSLLGGRTGPGGPRRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHLLTPPERYGVCRALERFFQHRNIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQEKIACFLGYTAMTEPESSLDLEPESTPEPTPEPQPRSSLRASSMCRRSLRSQGLETSLSCGPGDCPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKIGTMSKSRASPPVPSLVGTSGPRTLSGVSWPSDRLLPSPCYDPLCSGGLASPSSSESHPYASLDSSRAPSPQPGLGSIHADSPPSPDPIRPPSRRKLFAFSRPVRSRDTDRFLDALSEQLGPRLSIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASECVSSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDPKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPPVPCAPPMLSRGVGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTGDLADLHDTVSEIQVACQSMAPSSEDRFAVVMASFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFSEFMSKFERALSDLQAGDGPRSSGMVSPLAW", "length": 1203 }, "evidence": [ { "id": "45920163", "url": "http://www.informatics.jax.org/homology/45920163", "database": "MGI" }, { "id": "A4D2P6", "url": "https://omabrowser.org/oma/group/A4D2P6/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" }, { "name": "postsynaptic density, intracellular component", "id": "GO:0099092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099092", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" }, { "name": "parallel fiber to Purkinje cell synapse", "id": "GO:0098688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098688", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" }, { "name": "cerebellar granule cell to Purkinje cell synapse", "id": "GO:0150048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150048", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "long-term synaptic depression", "id": "GO:0060292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060292", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" }, { "name": "regulation of postsynaptic membrane neurotransmitter receptor levels", "id": "GO:0099072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099072", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" }, { "name": "regulation of postsynaptic cytosolic calcium ion concentration", "id": "GO:0099566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099566", "evidence": [ { "database": "UniProtKB", "id": "A4D2P6", "url": "https://www.uniprot.org/uniprot/A4D2P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1038, "end_pos": 1040, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1052, "end_pos": 1054, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 564, "end_pos": 566, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 580, 621, 652, 655 ], "sequon_annotation_sites": [ { "start_pos": 1038, "end_pos": 1040 }, { "start_pos": 1052, "end_pos": 1054 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 564, "end_pos": 566 }, { "start_pos": 902, "end_pos": 904 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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"publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }