{ "uniprot_canonical_ac": "A1A4Y4-1", "uniprot_ac": "A1A4Y4", "uniprot_id": "IRGM_HUMAN", "mass": { "chemical_mass": 20142.0, "monoisotopic_mass": 20142.0 }, "refseq": { "ac": "NP_001139277", "name": "immunity-related GTPase family M protein isoform 2", "summary": "This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, "gene_names": [ { "name": "IRGM", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A1A4Y4", "id": "A1A4Y4" }, { "name": "IBD19; IFI1; IRGM1; LRG-47; LRG47", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277", "id": "NP_001139277" }, { "name": "IFI1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A1A4Y4", "id": "A1A4Y4" }, { "name": "IRGM1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A1A4Y4", "id": "A1A4Y4" }, { "name": "IRGM", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277", "id": "NP_001139277" }, { "name": "LRG47", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A1A4Y4", "id": "A1A4Y4" } ], "protein_names": [ { "name": "Immunity-related GTPase family M protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A1A4Y4" }, { "name": "3.6.5.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1A4Y4" }, { "name": "Immunity-related GTPase family M protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1A4Y4" }, { "name": "Interferon-inducible protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1A4Y4" }, { "name": "LPS-stimulated RAW 264.7 macrophage protein 47 homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1A4Y4" }, { "name": "LRG-47", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1A4Y4" }, { "name": "immunity-related GTPase family M protein isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277", "id": "NP_001139277" }, { "name": "immunity-related GTPase family, M1; LRG-47-like protein; immunity-related GTPase family M protein; interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277", "id": "NP_001139277" } ], "function": [ { "annotation": "(Microbial infection) Following infection by hepatitis C virus (HCV), promotes HCV-triggered membrane remodeling, leading to autophagy and Golgi fragmentation, a step required for HCV replication.", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4#function" }, { "database": "PubMed", "id": "28389568", "url": "https://glygen.org/publication/PubMed/28389568" } ] }, { "annotation": "Acts as a positive regulator of mitophagy in response to intracellular mycobacteria infection: specifically binds cardiolipin, leading to its translocation to mitochondria, where it promotes affected mitochondrial fission and mitophagy.", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4#function" }, { "database": "PubMed", "id": "21102437", "url": "https://glygen.org/publication/PubMed/21102437" } ] }, { "annotation": "Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study.", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "36999177", "url": "https://glygen.org/publication/PubMed/36999177" } ] }, { "annotation": "Genetic evidence implicates IRGM defects in the early immune response in individuals with Crohn's disease.", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "17554261", "url": "https://glygen.org/publication/PubMed/17554261" } ] }, { "annotation": "IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "37993085", "url": "https://glygen.org/publication/PubMed/37993085" } ] }, { "annotation": "IRGM is significantly associated with Crohn disease.", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "17921695", "url": "https://glygen.org/publication/PubMed/17921695" } ] }, { "annotation": "Identified a function for IRGM in the control of intracellular pathogens and report that IRGM plays a role in autophagy and in the reduction of intracellular Mycobacterium var. bovis BCG load", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "16888103", "url": "https://glygen.org/publication/PubMed/16888103" } ] }, { "annotation": "Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:16888103, PubMed:19165925, PubMed:25891078). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosome regulatory proteins, thereby promoting the fusion of phagosomes with lysosomes for efficient degradation of cargo including microbes (PubMed:16888103, PubMed:25891078, PubMed:29420192, PubMed:32939830). Regulates selective autophagy, including xenophagy and mitophagy, both directly and indirectly (PubMed:16888103, PubMed:25891078, PubMed:29420192, PubMed:32939830). Directly regulates autophagy by acting as a molecular adapter that promotes the coassembly of the core autophagy machinery to mediate antimicrobial defense: IRGM (1) activates AMPK, which in turn phosphorylates ULK1 and BECN1 to induce autophagy, (2) promotes the coassembly of ULK1 and BECN1, enhancing BECN1-interacting partners and (3) influences the composition of the BECN1 complex, by competing with the negative regulators BCL2 and RUBCN, to trigger autophagy (PubMed:25891078). Also activates autophagy by promoting recruitment of STX17 to autophagosomes (PubMed:29420192). In collaboration with ATG8 proteins, regulate lysosomal biogenesis, a fundamental process for any autophagic pathway, by promoting TFEB dephosphorylation (PubMed:32753672). Also modulates autophagy by assisting with autophagosome formation and preventing lysosomal deacidification (By similarity). While activating autophagy, acts as a key negative regulator of the inflammatory and interferon responses both by (1) promoting mitophagy and (2) mediating autophagy-dependent degradation of effectors of the inflammatory response (PubMed:30612879, PubMed:32715615, PubMed:36221902). Promotes degradation of damaged and IFNG/IFN-gamma-stressed mitochondria via mitophagy, preventing cytosolic release of ligands that activate inflammation (PubMed:32715615). Acts as a suppressor of inflammation by promoting recruitment of inflammation effectors, such as CGAS, RIGI/RIG-I and NLRP3, to autophagosome membranes, leading to their SQSTM1/p62-dependent autophagic degradation (PubMed:30612879, PubMed:32715615). Also directly inhibits assembly of the NLRP3 inflammasome by preventing the association between NLRP3 and PYCARD (PubMed:30612879). Acts as a negative regulator of antiviral innate immune response by suppressing the RIPK2-dependent pro-inflammatory response: mediates recruitment of RIPosomes, composed of RIPK2 and NOD1 or NOD2, to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation (PubMed:34467632, PubMed:36221902).", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4#function" }, { "database": "PubMed", "id": "16888103", "url": "https://glygen.org/publication/PubMed/16888103" }, { "database": "PubMed", "id": "29420192", "url": "https://glygen.org/publication/PubMed/29420192" }, { "database": "PubMed", "id": "32715615", "url": "https://glygen.org/publication/PubMed/32715615" }, { "database": "PubMed", "id": "30612879", "url": "https://glygen.org/publication/PubMed/30612879" }, { "database": "PubMed", "id": "25891078", "url": "https://glygen.org/publication/PubMed/25891078" }, { "database": "PubMed", "id": "36221902", "url": "https://glygen.org/publication/PubMed/36221902" }, { "database": "PubMed", "id": "32753672", "url": "https://glygen.org/publication/PubMed/32753672" }, { "database": "UniProtKB", "id": "Q60766", "url": "https://www.uniprot.org/uniprot/Q60766#function" }, { "database": "PubMed", "id": "32939830", "url": "https://glygen.org/publication/PubMed/32939830" }, { "database": "PubMed", "id": "34467632", "url": "https://glygen.org/publication/PubMed/34467632" }, { "database": "PubMed", "id": "19165925", "url": "https://glygen.org/publication/PubMed/19165925" } ] }, { "annotation": "Race-specific association of an IRGM risk allele with cytokine expression in human subjects. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "37558924", "url": "https://glygen.org/publication/PubMed/37558924" } ] }, { "annotation": "TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "37705061", "url": "https://glygen.org/publication/PubMed/37705061" } ] }, { "annotation": "The unusual evolutionary history of the IRGM locus and the important role of the IRGM gene in autophagy and Crohn's disease in response to pathogenesis. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" }, { "database": "PubMed", "id": "20737271", "url": "https://glygen.org/publication/PubMed/20737271" } ] }, { "annotation": "This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ] } ], "disease": [ { "disease_id": "DOID:0110890", "recommended_name": { "id": "DOID:0110890", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110890", "name": "inflammatory bowel disease 19", "description": "An inflammatory bowel disease that has_material_basis_in variation in the chromosome region 5q33.1." }, "synonyms": [ { "id": "DOID:0110890", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110890", "name": "IBD19", "description": "" }, { "id": "DOID:0110890", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110890", "name": "inflammatory bowel disease (Crohn disease) 19", "description": "" }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "inflammatory bowel disease 19", "description": "Any inflammatory bowel disease in which the cause of the disease is a mutation in the IRGM gene." }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "IBD19", "description": "" }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "IRGM inflammatory bowel disease", "description": "" }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "inflammatory bowel disease (Crohn disease) 19", "description": "" }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "inflammatory bowel disease 19", "description": "" }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "inflammatory bowel disease caused by mutation in IRGM", "description": "" }, { "id": "MONDO:0012845", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012845", "name": "inflammatory bowel disease type 19", "description": "" }, { "id": "MIM:612278", "resource": "MIM", "url": "https://www.omim.org/entry/612278", "name": "Inflammatory bowel disease 19", "description": "Inflammatory bowel disease 19" } ], "evidence": [ { "id": "612278", "database": "MIM", "url": "https://www.omim.org/entry/612278" } ] }, { "disease_id": "MONDO:0011940", "recommended_name": { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "mycobacterium tuberculosis, susceptibility to", "description": "" }, "synonyms": [ { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "tuberculosis, susceptibility to", "description": "" }, { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "mycobacterium tuberculosis, susceptibility to", "description": "" }, { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "tuberculosis infection, protection against", "description": "" }, { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "tuberculosis, protection against", "description": "" }, { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "Mycobacterium tuberculosis, protection against", "description": "" }, { "id": "MONDO:0011940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011940", "name": "Mycobacterium tuberculosis, susceptibility to infection by", "description": "" } ], "evidence": [ { "id": "607948", "database": "MIM", "url": "https://www.omim.org/entry/607948" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 47, "end_pos": 47, "sequence_org": "S", "sequence_mut": "N", "comment": "Abolished GTPase activity, preventing interaction with STX17 and/or NLRP3.", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" }, { "database": "PubMed", "id": "29420192", "url": "https://glygen.org/publication/PubMed/29420192" }, { "database": "PubMed", "id": "30612879", "url": "https://glygen.org/publication/PubMed/30612879" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "34.03", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "41.27", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "16.41", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "62.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "57.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "47.27", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "49.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "36.11", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "52.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "52.23", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A1A4Y4", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4Y4" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "A1A4Y4", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4Y4" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "A1A4Y4", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4Y4" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "common_name": "Human" } ], "gene": [ { "name": "IRGM", "url": "https://www.uniprot.org/uniprot/A1A4Y4", "locus": { "chromosome": "5", "start_pos": 150900736, "end_pos": 150846521, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000237693", "url": "https://www.ensembl.org/id/ENSG00000237693" } ] } } ], "crossref": [ { "id": "ENSG00000237693", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000237693", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL5169093", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL5169093", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "IRGM", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=IRGM", "database": "GeneCards", "categories": [ 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"https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:345611", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "607948", "url": "http://www.omim.org/entry/607948", "database": "MIM", "categories": [ "Other" ] }, { "id": "608212", "url": "http://www.omim.org/entry/608212", "database": "MIM", "categories": [ "Other" ] }, { "id": "612278", "url": "http://www.omim.org/entry/612278", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_A1A4Y4", "url": "https://www.nextprot.org/entry/NX_A1A4Y4", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "KEQVCEH", "url": "https://omabrowser.org/oma/group/KEQVCEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4586265at2759", "url": "http://www.orthodb.org/?query=4586265at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32341", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32341", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32341:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32341:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05049", "url": "http://pfam.xfam.org/family/PF05049", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A1A4Y4", "url": "https://pharos.nih.gov/targets/A1A4Y4", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_A1A4Y4", "url": "http://purl.obolibrary.org/obo/PR_A1A4Y4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A9H4B933", "url": "https://www.uniprot.org/uniprot/A0A9H4B933", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A9H4B933-1", "url": "https://www.uniprot.org/uniprot/A0A9H4B933-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4Y4-1", "url": "https://www.uniprot.org/uniprot/A1A4Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4Y4-2", "url": "https://www.uniprot.org/uniprot/A1A4Y4-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4Y4-3", "url": "https://www.uniprot.org/uniprot/A1A4Y4-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4Y4-4", "url": "https://www.uniprot.org/uniprot/A1A4Y4-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERVCEY", "length": 181, "header": "sp|A1A4Y4-1|IRGM_HUMAN Isoform 1 of Immunity-related GTPase family M protein OS=Homo sapiens OX=9606 GN=IRGM PE=1 SV=2 CANONICAL=A1A4Y4-1" }, "isoforms": [ { "isoform_ac": "A0A9H4B933-1", "url": "", "sequence": { "sequence": "XNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERSSRNQQVYPNHSHVPLAC", "length": 71, "header": "tr|A0A9H4B933-1|A0A9H4B933_HUMAN Computationally mapped isoform of Immunity related GTPase M OS=Homo sapiens OX=9606 GN=IRGM PE=3 SV=1 CANONICAL=A1A4Y4-1" }, "locus": { "chromosome": "5", "start_pos": 150878034, "end_pos": 150848497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000520549.1", "url": "https://www.ensembl.org/id/ENST00000520549.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000429819.1", "url": "https://www.ensembl.org/id/ENSP00000429819.1" } ] } }, { "isoform_ac": "A1A4Y4-1", "url": "", "sequence": { "sequence": "MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERVCEY", "length": 181, "header": "sp|A1A4Y4-1|IRGM_HUMAN Isoform 1 of Immunity-related GTPase family M protein OS=Homo sapiens OX=9606 GN=IRGM PE=1 SV=2 CANONICAL=A1A4Y4-1" }, "locus": { "chromosome": "5", "start_pos": 150848666, "end_pos": 150848124, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522154.2", "url": "https://www.ensembl.org/id/ENST00000522154.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000428220.1", "url": "https://www.ensembl.org/id/ENSP00000428220.1" } ] } }, { "isoform_ac": "A1A4Y4-2", "url": "", "sequence": { "sequence": "MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERLACHEKYLKSTPENSTRPRNIPSRRKLYVNLLRIFNS", "length": 214, "header": "sp|A1A4Y4-2|IRGM_HUMAN Isoform 2 of Immunity-related GTPase family M protein OS=Homo sapiens OX=9606 GN=IRGM PE=1 SV=2 CANONICAL=A1A4Y4-1" }, "locus": {} }, { "isoform_ac": "A1A4Y4-3", "url": "", "sequence": { "sequence": "MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERSSRNQQVYPNHSHVPLAC", "length": 195, "header": "sp|A1A4Y4-3|IRGM_HUMAN Isoform 3 of Immunity-related GTPase family M protein OS=Homo sapiens OX=9606 GN=IRGM PE=1 SV=2 CANONICAL=A1A4Y4-1" }, "locus": {} }, { "isoform_ac": "A1A4Y4-4", "url": "", "sequence": { "sequence": "MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERLACHEKYLKSTPENSTRPRNINLCS", "length": 202, "header": "sp|A1A4Y4-4|IRGM_HUMAN Isoform 4 of Immunity-related GTPase family M protein OS=Homo sapiens OX=9606 GN=IRGM PE=1 SV=2 CANONICAL=A1A4Y4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.", "journal": "Genome Biol.", "date": "2005", "authors": "Bekpen Cemalettin, Hunn Julia P, Rohde Christoph, Parvanova Iana, Guethlein Libby, Dunn Diane M, Glowalla Eva, Leptin Maria, Howard Jonathan C", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "16277747", "url": "https://glygen.org/publication/PubMed/16277747" } ] }, { "title": "Human IRGM induces autophagy to eliminate intracellular mycobacteria.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Singh SB, Davis AS, Taylor GA, Deretic V", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" }, { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "16888103", "url": "https://glygen.org/publication/PubMed/16888103" } ] }, { "title": "Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.", "journal": "Nat. Genet.", "date": "2007", "authors": "Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC, Cardon L, Mathew CG", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" }, { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "17554261", "url": "https://glygen.org/publication/PubMed/17554261" } ] }, { "title": "Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease.", "journal": "Autophagy", "date": "2007", "authors": "Massey DC, Parkes M", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "17921695", "url": "https://glygen.org/publication/PubMed/17921695" } ] }, { "title": "Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.", "journal": "Nature genetics", "date": "2008-09", "authors": "McCarroll Steven A, Huett Alan, Kuballa Petric, Chilewski Shannon D, Landry Aimee, Goyette Philippe, Zody Michael C, Hall Jennifer L, Brant Steven R, Cho Judy H, Duerr Richard H, Silverberg Mark S, Taylor Kent D, Rioux John D, Altshuler David, Daly Mark J, Xavier Ramnik J", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "19165925", "url": "https://glygen.org/publication/PubMed/19165925" } ] }, { "title": "Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.", "journal": "Am. J. Gastroenterol.", "date": "2009", "authors": "Weersma RK, Stokkers PC, Cleynen I, Wolfkamp SC, Henckaerts L, Schreiber S, Dijkstra G, Franke A, Nolte IM, Rutgeerts P, Wijmenga C, Vermeire S", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "19174780", "url": "https://glygen.org/publication/PubMed/19174780" } ] }, { "title": "Death and resurrection of the human IRGM gene.", "journal": "PLoS Genet.", "date": "2009", "authors": "Bekpen Cemalettin, Marques-Bonet Tomas, Alkan Can, Antonacci Francesca, Leogrande Maria Bruna, Ventura Mario, Kidd Jeffrey M, Siswara Priscillia, Howard Jonathan C, Eichler Evan E", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "19266026", "url": "https://glygen.org/publication/PubMed/19266026" } ] }, { "title": "Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.", "journal": "PLoS Pathog.", "date": "2009", "authors": "Intemann Christopher D, Thye Thorsten, Niemann Stefan, Browne Edmund N L, Amanua Chinbuah Margaret, Enimil Anthony, Gyapong John, Osei Ivy, Owusu-Dabo Ellis, Helm Susanne, R\u00fcsch-Gerdes Sabine, Horstmann Rolf D, Meyer Christian G", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "19750224", "url": "https://glygen.org/publication/PubMed/19750224" } ] }, { "title": "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.", "journal": "Hum. Mol. Genet.", "date": "2010", "authors": "Prescott Natalie J, Dominy Katherine M, Kubo Michiaki, Lewis Cathryn M, Fisher Sheila A, Redon Richard, Huang Ni, Stranger Barbara E, Blaszczyk Katarzyna, Hudspith Barry, Parkes Gareth, Hosono Naoya, Yamazaki Keiko, Onnie Clive M, Forbes Alastair, Dermitzakis Emmanouil T, Nakamura Yusuke, Mansfield John C, Sanderson Jeremy, Hurles Matthew E, Roberts Roland G, Mathew Christopher G", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "20106866", "url": "https://glygen.org/publication/PubMed/20106866" } ] }, { "title": "Human IRGM gene `to be or not to be`.", "journal": "Seminars in immunopathology", "date": "2010", "authors": "Bekpen C, Xavier RJ, Eichler EE", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "20737271", "url": "https://glygen.org/publication/PubMed/20737271" } ] }, { "title": "Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria.", "journal": "Nature cell biology", "date": "2010-12", "authors": "Singh Sudha B, Ornatowski Wojciech, Vergne Isabelle, Naylor John, Delgado Monica, Roberts Esteban, Ponpuak Marisa, Master Sharon, Pilli Manohar, White Eileen, Komatsu Masaaki, Deretic Vojo", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "21102437", "url": "https://glygen.org/publication/PubMed/21102437" } ] }, { "title": "A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.", "journal": "Nat. Genet.", "date": "2011", "authors": "Brest Patrick, Lapaquette Pierre, Souidi Mouloud, Lebrigand Kevin, Cesaro Annabelle, Vouret-Craviari Val\u00e9rie, Mari Bernard, Barbry Pascal, Mosnier Jean-Fran\u00e7ois, H\u00e9buterne Xavier, Harel-Bellan Annick, Mograbi Baharia, Darfeuille-Michaud Arlette, Hofman Paul", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "21278745", "url": "https://glygen.org/publication/PubMed/21278745" } ] }, { "title": "IRGM governs the core autophagy machinery to conduct antimicrobial defense.", "journal": "Molecular cell", "date": "2015", "authors": "Chauhan S, Mandell MA, Deretic V", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "25891078", "url": "https://glygen.org/publication/PubMed/25891078" } ] }, { "title": "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2017", "authors": "Hansen MD, Johnsen IB, Stiberg KA, Sherstova T, Wakita T, Richard GM, Kandasamy RK, Meurs EF, Anthonsen MW", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "28389568", "url": "https://glygen.org/publication/PubMed/28389568" } ] }, { "title": "Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.", "journal": "The Journal of cell biology", "date": "2018-03-05", "authors": "Kumar Suresh, Jain Ashish, Farzam Farzin, Jia Jingyue, Gu Yuexi, Choi Seong Won, Mudd Michal H, Claude-Taupin Aurore, Wester Michael J, Lidke Keith A, Rusten Tor-Erik, Deretic Vojo", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "29420192", "url": "https://glygen.org/publication/PubMed/29420192" } ] }, { "title": "The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.", "journal": "Molecular cell", "date": "2019", "authors": "Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "30612879", "url": "https://glygen.org/publication/PubMed/30612879" } ] }, { "title": "Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.", "journal": "EMBO reports", "date": "2020", "authors": "Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "32715615", "url": "https://glygen.org/publication/PubMed/32715615" } ] }, { "title": "Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens.", "journal": "Nature cell biology", "date": "2020-08", "authors": "Kumar Suresh, Jain Ashish, Choi Seong Won, da Silva Gustavo Peixoto Duarte, Allers Lee, Mudd Michal H, Peters Ryan Scott, Anonsen Jan Haug, Rusten Tor-Erik, Lazarou Michael, Deretic Vojo", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "32753672", "url": "https://glygen.org/publication/PubMed/32753672" } ] }, { "title": "IRGM promotes the PINK1-mediated mitophagy through the degradation of Mitofilin in SH-SY5Y cells.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2020", "authors": "Guo X, Zhang W, Wang C, Zhang B, Li R, Zhang L, Zhao K, Li Y, Tian L, Li B, Cheng H, Li L, Pei C, Xu H", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "32939830", "url": "https://glygen.org/publication/PubMed/32939830" } ] }, { "title": "Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses.", "journal": "EMBO reports", "date": "2021-11-04", "authors": "Nath Parej, Chauhan Nishant Ranjan, Jena Kautilya Kumar, Datey Ankita, Kumar Nilima Dinesh, Mehto Subhash, De Saikat, Nayak Tapas Kumar, Priyadarsini Swatismita, Rout Kshitish, Bal Ramyasingh, Murmu Krushna C, Kalia Manjula, Patnaik Srinivas, Prasad Punit, Reggiori Fulvio, Chattopadhyay Soma, Chauhan Santosh", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "34467632", "url": "https://glygen.org/publication/PubMed/34467632" } ] }, { "title": "Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection.", "journal": "The EMBO journal", "date": "2022-12-01", "authors": "Mehto Subhash, Jena Kautilya Kumar, Yadav Rina, Priyadarsini Swatismita, Samal Pallavi, Krishna Sivaram, Dhar Kollori, Jain Ashish, Chauhan Nishant Ranjan, Murmu Krushna C, Bal Ramyasingh, Sahu Rinku, Jaiswal Pundrik, Sahoo Bhabani Sankar, Patnaik Srinivas, Kufer Thomas A, Rusten Tor Erik, Chauhan Swati, Prasad Punit, Chauhan Santosh", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "reference": [ { "type": "PubMed", "id": "36221902", "url": "https://glygen.org/publication/PubMed/36221902" } ] }, { "title": "Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study.", "journal": "Current rheumatology reviews", "date": "2023", "authors": "Ali Ahmed Y, Medhat Basma M, Ashour Sara S, Badr Amul M, Dorgham Dalia, Ramadan Hala, Behiry Mervat E", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "36999177", "url": "https://glygen.org/publication/PubMed/36999177" } ] }, { "title": "Race-specific association of an IRGM risk allele with cytokine expression in human subjects.", "journal": "Scientific reports", "date": "2023-08-09", "authors": "Ajayi Teminioluwa, Rai Prashant, Shi Min, Gabor Kristin A, Karmaus Peer W F, Meacham Julie M, Katen Kevin, Madenspacher Jennifer H, Schurman Shepherd H, Fessler Michael B", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "37558924", "url": "https://glygen.org/publication/PubMed/37558924" } ] }, { "title": "TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.", "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)", "date": "2023-10", "authors": "Sun Mingchuang, Li Zhaoxing, Wang Xiaoyuan, Zhao Meirong, Chu Yuan, Zhang Zehua, Fang Kang, Zhao Ziying, Feng Anqi, Leng Zhuyun, Shi Jianing, Zhang Li, Chen Tao, Xu Meidong", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "37705061", "url": "https://glygen.org/publication/PubMed/37705061" } ] }, { "title": "IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.", "journal": "Cancer letters", "date": "2024-01-28", "authors": "Ru Junnan, Lu Jiahua, Ge Jiangzhen, Ding Bo, Su Rong, Jiang Yifan, Sun Yujing, Ma Jun, Li Yu, Sun Jingqi, Xu Guangming, Tong Rongliang, Zheng Shusen, Yang Beng, Wu Jian", "evidence": [ { "database": "RefSeq", "id": "NP_001139277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139277" } ], "reference": [ { "type": "PubMed", "id": "37993085", "url": "https://glygen.org/publication/PubMed/37993085" } ] } ], "pathway": [ { "id": "hsa:345611", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:345611", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140LIF8-1", "protein_name": "Immunity-related GTPase family M protein 2", "gene_name": "Irgm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEGEVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRTTQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFLVSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNLHTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDDWVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSIPHP", "length": 395 }, "evidence": [ { "id": "45934171", "url": "http://www.informatics.jax.org/homology/45934171", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8I5ZSB0-1", "protein_name": "Interferon gamma induced GTPase", "gene_name": "Igtp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQSPGPTWQRERTNSHRVFYPRLFVWEQTQDCQEARMLTVFNLVLKKRPCLRPPWLLPPLLLLQLLAAAPAKAEAKEESEESDEDQPTLPYNFVVSCDCCVYVAVGIEPWTQGKLVSCALTAMGQSSSKPDAKAHNMASSFNEFFKSFKMESKILSEETINSIQSCVQEGDIQKGISIINAALADIEKAPLNIAVTGETGAGKSTFINALRGVGHEESESAKIGAVETTMDKFPKFPNVTIWDLPGVGTCNFKPEEYLKKLRFQEYDFFLIISATRFRENDAQLAKAIKKMKKNFYFVRTKIDSDLWNQKKCKPKSYNKEKILEEIRKDCVEKLQNARVASARVFLVSSVEVAQFDFPELESTLLEELPAHKRHVFMQCLPSITERAIDRRRDALRQKIWLEALKYGASATIPMMCFFNDDIEELEKILTHYRGSFGLDDESLKNMASEWSMSVEELKSFINSPHLLSCEMNESVSDKMVKPYRAELYRVTIPQHRAAIQDRTWTGVQRVTFVPGQQETKEAIPSEPQKVSMSQGDNWGVFTPFINMAKPLKPPLFKSITAGESSYSSQNSSSPEVIEKVGKAVAEGDLQKVIYTVKEEMQSKSRYTVKIAVTGDSGNGMSSFVNALRLIGHEEEDSAPTGVVRTTQKPACYSSFHFPYVELWDLPGTGVTAQSMESYLDEMQFSAYDLIIIIASEQFSSNHVKLAEAMQRMRKRFYVVWTKLDRDISTSTFPEPQLLQSIQKNIRENLQKAQVRDPPIFLVSCFSPSFHDFLDLRETLRKDIHNIRYRDPLETLSQVCDKCINNKALSLKEDLMFTKHLEAAVSPPYDIADLERSLDTYQKLFGVDNESLRRVAQSTGRPEMSTRALQFQDLIKMDRRLRLMMCFVVNILLRVLGSPWWFGLWDVVTRYFRHQRQKRIIEIVAKNTKTSLRRALEDYTLPPEILCEGSGVPSSGIQAASGSFCIEGQEVGGFRQFRADSSRGLEKETQLLGLFLSLPDRIGLTLCEPVRKEKKSCQGTVFPVCACLHSVPTPFPLQVAPLLTSMEEAVGLPEDKQFACLSDAVFISKDNSILSVEVIKSIQAAVAGGNGVEVVSIVKEIVQKVSRTTMKIAVTGDSGNGMSSFVNALRLIGHEEEDSAPTGVVRTTQKPACYSSSHFPYVELWDLPGIGTTAQSMESYLDEMQFSAYDLIIIIASEQFSSNHVKLAEAMQRMRKKFYVVWTKLDRDISTSTFPEPQLLQSIQKNIRENLQKGKVKEPPIFLVSIMKPLLHDFERLRETLRKDLSDIKYHGLLETLYQICENTINERVESIKKIIDENNLQREFGILTPDNLTETRKVFQEIFGVDDQSLSQVSRSMEKPDTHYKASIESQEIQGYQQDGWPLVWLHRPVIQFFSTGLDRVPCCFYSPHHRYTQQKGVLDETAGKTKNFLWKILKDSISHLQKT", "length": 1444 }, "evidence": [ { "id": "45934172", "url": "http://www.informatics.jax.org/homology/45934172", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q60766-1", "protein_name": "Immunity-related GTPase family M protein 1", "gene_name": "Irgm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPSHSSCEAAPLLPNMAETHYAPLSSAFPFVTSYQTGSSRLPEVSRSTERALREGKLLELVYGIKETVATLSQIPVSIFVTGDSGNGMSSFINALRVIGHDEDASAPTGVVRTTKTRTEYSSSHFPNVVLWDLPGLGATAQTVEDYVEEMKFSTCDLFIIIASEQFSSNHVKLSKIIQSMGKRFYIVWTKLDRDLSTSVLSEVRLLQNIQENIRENLQKEKVKYPPVFLVSSLDPLLYDFPKLRDTLHKDLSNIRCCEPLKTLYGTYEKIVGDKVAVWKQRIANESLKNSLGVRDDDNMGECLKVYRLIFGVDDESVQQVAQSMGTVVMEYKDNMKSQNFYTLRREDWKLRLMTCAIVNAFFRLLRFLPCVCCCLRRLRHKRMLFLVAQDTKNILEKILRDSIFPPQI", "length": 409 }, "evidence": [ { "id": "45934173", "url": "http://www.informatics.jax.org/homology/45934173", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYC2-1", "protein_name": "Immunity-related GTPase family M protein", "gene_name": "Irgm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPSHKSCEAAPLLPKMPETSTHNAPLNLSFPSVPSYQIGCSSLPEISRSTERALKEGKLPELVYGVKETVATLSQIPVSIFVTGDSGNGMSSFINALRIIGHEEDASAPTGVVRTTQTRAEYSSSHFPNVVLWDLPGLGATAQTVENYIEEMKFSTCDLFIIVASEQFSSNHVKLAKIIQSMGKRFYVIWTKLDRDLSTSVLSEVRLIQNIQENIRENLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSNIRCCEPLKTLYVIYEKIIGDKVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESLQQIAHGMGTVVMEYKANIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHKRMLLLVAKDTKNILKKILMDAVSPPQI", "length": 411 }, "evidence": [ { "id": "45934173", "url": "http://www.informatics.jax.org/homology/45934173", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DCE9-1", "protein_name": "Immunity-related GTPase family M protein 3", "gene_name": "Igtp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLVTKLPQNIWKTFTLFINMANYLKRLISPWSKSMTAGESLYSSQNSSSPEVIEDIGKAVTEGNLQKVIGIVKDEIQSKSRYRVKIAVTGDSGNGMSSFINALRFIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDLPGLGATAQSVESYLEEMQISTFDLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRENLQQAQVRDPPLFLISCFSPSFHDFPELRNTLQKDIFSIRYRDPLEIISQVCDKCISNKAFSLKEDQMLMKDLEAAVSSEDDTANLERGLQTYQKLFGVDDGSLQQVARSTGRLEMGSRALQFQDLIKMDRRLELMMCFAVNKFLRLLESSWWYGLWNVVTRYFRHQRHKLVIEIVAENTKTSLRKALKDSVLPPEIH", "length": 423 }, "evidence": [ { "id": "45934172", "url": "http://www.informatics.jax.org/homology/45934172", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 40, "go_terms": [ { "name": "defense response to other organism", "id": "GO:0098542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098542", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "nucleotide-binding oligomerization domain containing 2 signaling pathway", "id": "GO:0070431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070431", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of macrophage activation", "id": "GO:0043032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043032", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of mitophagy", "id": "GO:1901526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901526", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-threonine phosphorylation", "id": "GO:0010800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010800", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-serine phosphorylation", "id": "GO:0033138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033138", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of type II interferon production", "id": "GO:0032689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032689", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "CAMKK-AMPK signaling cascade", "id": "GO:0061762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061762", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of autophagosome maturation", "id": "GO:1901098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901098", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "protein lipidation involved in autophagosome assembly", "id": "GO:0061739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061739", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "cellular response to interferon-beta", "id": "GO:0035458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "regulation of protein-containing complex assembly", "id": "GO:0043254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043254", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "protein destabilization", "id": "GO:0031648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "protein targeting to vacuole involved in autophagy", "id": "GO:0071211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071211", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial fission", "id": "GO:0090141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090141", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of defense response to virus", "id": "GO:0050687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050687", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "regulation of protein complex stability", "id": "GO:0061635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061635", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of xenophagy", "id": "GO:1904417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904417", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of NLRP3 inflammasome complex assembly", "id": "GO:1900226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900226", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of type II interferon-mediated signaling pathway", "id": "GO:0060335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060335", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "selective autophagy", "id": "GO:0061912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061912", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "positive regulation of lysosome organization", "id": "GO:1905673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905673", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "negative regulation of cGAS/STING signaling pathway", "id": "GO:0160049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160049", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0001891", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A1A4Y4", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": 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"P61011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61011" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61011" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "P61011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61011" } ] } ] }, { "uniprot_ac": "P61018", "gene_name": "RAB4B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61018" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61018" } ] } ] }, { "uniprot_ac": "P61019", "gene_name": "RAB2A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61019" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61019" } ] } ] }, { "uniprot_ac": "P61020", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61020" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61020" } ] } ] }, { "uniprot_ac": "P61021", "gene_name": "Rab5b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61021" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61021" } ] } ] }, { "uniprot_ac": "P61026", "gene_name": "RAB10", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61026" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61026" } ] } ] }, { "uniprot_ac": "P61027", "gene_name": "Rab10", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61027", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61027" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61027", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61027" } ] } ] }, { "uniprot_ac": "P61209", "gene_name": "Arf1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61209" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61209" } ] } ] }, { "uniprot_ac": "P61221", "gene_name": "ABCE1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61221", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61221" } ] } ] }, { "uniprot_ac": "P61222", "gene_name": "Abce1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61222" } ] } ] }, { "uniprot_ac": "P61224", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61224" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61224" } ] } ] }, { "uniprot_ac": "P61225", "gene_name": "RAP2B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61225" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61225" } ] } ] }, { "uniprot_ac": "P61226", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61226" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61226" } ] } ] }, { "uniprot_ac": "P61227", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61227" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61227" } ] } ] }, { "uniprot_ac": "P61294", "gene_name": "Rab6b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61294" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61294" } ] } ] }, { "uniprot_ac": "P61586", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61586" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61586" } ] } ] }, { "uniprot_ac": "P61589", "gene_name": "Rhoa", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] } ] }, { "uniprot_ac": "P62070", "gene_name": "RRAS2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62070" } ] } ] }, { "uniprot_ac": "P62071", "gene_name": "Rras2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62071" } ] } ] }, { "uniprot_ac": "P62330", "gene_name": "ARF6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62330" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62330" } ] } ] }, { "uniprot_ac": "P62331", "gene_name": "Arf6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62331" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62331" } ] } ] }, { "uniprot_ac": "P62332", "gene_name": "Arf6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62332" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62332" } ] } ] }, { "uniprot_ac": "P62491", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62491" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62491" } ] } ] }, { "uniprot_ac": "P62492", "gene_name": "Rab11a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62492" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62492" } ] } ] }, { "uniprot_ac": "P62494", "gene_name": "Rab11a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62494" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62494" } ] } ] }, { "uniprot_ac": "P62630", "gene_name": "Eef1a1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62630" } ] } ] }, { "uniprot_ac": "P62820", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62820" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62820" } ] } ] }, { "uniprot_ac": "P62821", "gene_name": "Rab1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62821" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62821" } ] } ] }, { "uniprot_ac": "P62826", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62826", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62826" } ] } ] }, { "uniprot_ac": "P62827", "gene_name": "Ran", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62827" } ] } ] }, { "uniprot_ac": "P62828", "gene_name": "Ran", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62828" } ] } ] }, { "uniprot_ac": "P62834", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62834" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62834" } ] } ] }, { "uniprot_ac": "P62835", "gene_name": "Rap1a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62835" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62835" } ] } ] }, { "uniprot_ac": "P62836", "gene_name": "Rap1a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62836", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62836" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62836", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62836" } ] } ] }, { "uniprot_ac": "P63000", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] } ] }, { "uniprot_ac": "P63001", "gene_name": "Rac1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63001", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63001" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63001", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63001" } ] } ] }, { "uniprot_ac": "P63321", "gene_name": "Rala", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63321" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63321" } ] } ] }, { "uniprot_ac": "P63322", "gene_name": "Rala", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63322" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63322" } ] } ] }, { "uniprot_ac": "P68104", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68104" } ] } ] }, { "uniprot_ac": "P68363", "gene_name": "TUBA1B", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68363", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68363" } ] } ] }, { "uniprot_ac": "P68366", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68366", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68366" } ] } ] }, { "uniprot_ac": "P68368", "gene_name": "Tuba4a", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68368" } ] } ] }, { "uniprot_ac": "P68369", "gene_name": "Tuba1a", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68369" } ] } ] }, { "uniprot_ac": "P68370", "gene_name": "Tuba1a", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68370" } ] } ] }, { "uniprot_ac": "P68373", "gene_name": "Tuba1c", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68373" } ] } ] }, { "uniprot_ac": "P70425", "gene_name": "Rit2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P70425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70425" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P70425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70425" } ] } ] }, { "uniprot_ac": "P70426", "gene_name": "Rit1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P70426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70426" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P70426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70426" } ] } ] }, { "uniprot_ac": "P81795", "gene_name": "Eif2s3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P81795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P81795" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P81795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P81795" } ] } ] }, { "uniprot_ac": "P84077", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) 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"id": "P84079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P84079" } ] } ] }, { "uniprot_ac": "P97538", "gene_name": "Mras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P97538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97538" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P97538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97538" } ] } ] }, { "uniprot_ac": "P97687", "gene_name": "Entpd1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.", "evidence": [ { "id": "P97687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97687" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "P97687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97687" } ] } ] }, { 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"ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q54Y30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Y30" } ] } ] }, { "uniprot_ac": "Q55AX0", "gene_name": "dlpC", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q55AX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q55AX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AX0" } ] } ] }, { "uniprot_ac": "Q55BW0", "gene_name": "rapC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q55BW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55BW0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q55BW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55BW0" } ] } ] }, { "uniprot_ac": "Q55CA9", 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