{ "uniprot_canonical_ac": "A0A5B9-1", "uniprot_ac": "A0A5B9", "uniprot_id": "TRBC2_HUMAN", "mass": { "chemical_mass": 19968.0, "monoisotopic_mass": 19968.0 }, "refseq": {}, "gene_names": [ { "name": "TRBC2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A5B9", "id": "A0A5B9" }, { "name": "TCRBC2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A5B9", "id": "A0A5B9" } ], "protein_names": [ { "name": "T cell receptor beta constant 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A5B9" } ], "function": [ { "annotation": "Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9#function" }, { "database": "PubMed", "id": "23524462", "url": "https://glygen.org/publication/PubMed/23524462" }, { "database": "PubMed", "id": "25493333", "url": "https://glygen.org/publication/PubMed/25493333" }, { "database": "PubMed", "id": "15040585", "url": "https://glygen.org/publication/PubMed/15040585" }, { "database": "PubMed", "id": "24600447", "url": "https://glygen.org/publication/PubMed/24600447" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "79.89", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "74.04", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "59.27", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "81.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "76.47", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "83.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "83.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "A0A5B9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A5B9" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "common_name": "Human" } ], "gene": [ { "name": "TRBC2", "url": "https://www.uniprot.org/uniprot/A0A5B9", "locus": { "chromosome": "HSCHR7_2_CTG6", "start_pos": 825718, "end_pos": 824014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000276849", "url": "https://www.ensembl.org/id/ENSG00000276849" } ] } } ], "crossref": [ { "id": "ENSG00000211772", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "TRBC2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRBC2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "12157", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12157", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "615445", "url": "http://www.omim.org/entry/615445", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_A0A5B9", "url": "https://www.nextprot.org/entry/NX_A0A5B9", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "NISASAW", "url": "https://omabrowser.org/oma/group/NISASAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23411:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23411:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1AO7", "url": "https://www.rcsb.org/structure/1AO7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1BD2", "url": "https://www.rcsb.org/structure/1BD2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2EYR", "url": "https://www.rcsb.org/structure/2EYR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2EYS", "url": "https://www.rcsb.org/structure/2EYS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2EYT", "url": "https://www.rcsb.org/structure/2EYT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3KXF", "url": "https://www.rcsb.org/structure/3KXF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3O6F", "url": "https://www.rcsb.org/structure/3O6F", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3O8X", "url": "https://www.rcsb.org/structure/3O8X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3O9W", "url": "https://www.rcsb.org/structure/3O9W", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3QUX", "url": "https://www.rcsb.org/structure/3QUX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3T0E", "url": "https://www.rcsb.org/structure/3T0E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3TA3", "url": "https://www.rcsb.org/structure/3TA3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3TVM", "url": "https://www.rcsb.org/structure/3TVM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4C56", "url": "https://www.rcsb.org/structure/4C56", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4MVB", "url": "https://www.rcsb.org/structure/4MVB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4MXQ", "url": "https://www.rcsb.org/structure/4MXQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4N0C", "url": "https://www.rcsb.org/structure/4N0C", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4N5E", "url": "https://www.rcsb.org/structure/4N5E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4NHU", "url": "https://www.rcsb.org/structure/4NHU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4ONH", "url": "https://www.rcsb.org/structure/4ONH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4P4K", "url": "https://www.rcsb.org/structure/4P4K", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4UDT", "url": "https://www.rcsb.org/structure/4UDT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4UDU", "url": "https://www.rcsb.org/structure/4UDU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WW1", "url": "https://www.rcsb.org/structure/4WW1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WW2", "url": "https://www.rcsb.org/structure/4WW2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WWK", "url": "https://www.rcsb.org/structure/4WWK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4Y16", "url": "https://www.rcsb.org/structure/4Y16", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4Y2D", "url": "https://www.rcsb.org/structure/4Y2D", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4Y4F", "url": "https://www.rcsb.org/structure/4Y4F", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4Y4H", "url": "https://www.rcsb.org/structure/4Y4H", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4Y4K", "url": "https://www.rcsb.org/structure/4Y4K", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4ZAK", "url": "https://www.rcsb.org/structure/4ZAK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5BRZ", "url": "https://www.rcsb.org/structure/5BRZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5BS0", "url": "https://www.rcsb.org/structure/5BS0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5C07", "url": "https://www.rcsb.org/structure/5C07", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5C08", "url": "https://www.rcsb.org/structure/5C08", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5C09", "url": "https://www.rcsb.org/structure/5C09", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5C0A", "url": "https://www.rcsb.org/structure/5C0A", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5C0B", "url": "https://www.rcsb.org/structure/5C0B", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5C0C", "url": "https://www.rcsb.org/structure/5C0C", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5EU6", "url": "https://www.rcsb.org/structure/5EU6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5FK9", "url": "https://www.rcsb.org/structure/5FK9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5FKA", "url": "https://www.rcsb.org/structure/5FKA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5HHM", "url": "https://www.rcsb.org/structure/5HHM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5HHO", "url": "https://www.rcsb.org/structure/5HHO", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5HYJ", "url": "https://www.rcsb.org/structure/5HYJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5KS9", "url": "https://www.rcsb.org/structure/5KS9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5KSA", "url": "https://www.rcsb.org/structure/5KSA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5KSB", "url": "https://www.rcsb.org/structure/5KSB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CPH", "url": "https://www.rcsb.org/structure/6CPH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CQL", "url": "https://www.rcsb.org/structure/6CQL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CQN", "url": "https://www.rcsb.org/structure/6CQN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CQQ", "url": "https://www.rcsb.org/structure/6CQQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CQR", "url": "https://www.rcsb.org/structure/6CQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MIY", "url": "https://www.rcsb.org/structure/6MIY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MJ4", "url": "https://www.rcsb.org/structure/6MJ4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MJ6", "url": "https://www.rcsb.org/structure/6MJ6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MJA", "url": "https://www.rcsb.org/structure/6MJA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MJI", "url": "https://www.rcsb.org/structure/6MJI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MJJ", "url": "https://www.rcsb.org/structure/6MJJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6MJQ", "url": "https://www.rcsb.org/structure/6MJQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7NDT", "url": "https://www.rcsb.org/structure/7NDT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07654", "url": "http://pfam.xfam.org/family/PF07654", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A0A5B9", "url": "https://pharos.nih.gov/targets/A0A5B9", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_A0A5B9", "url": "http://purl.obolibrary.org/obo/PR_A0A5B9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "A0A0G2JMB4", "url": "https://www.uniprot.org/uniprot/A0A0G2JMB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JMB4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JMB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5B9-1", "url": "https://www.uniprot.org/uniprot/A0A5B9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5H1ZRR3", "url": "https://www.uniprot.org/uniprot/A0A5H1ZRR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5H1ZRR3-1", "url": "https://www.uniprot.org/uniprot/A0A5H1ZRR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG", "length": 178, "header": "sp|A0A5B9-1|TRBC2_HUMAN Isoform 1 of T cell receptor beta constant 2 OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JMB4-1", "url": "", "sequence": { "sequence": "XDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG", "length": 179, "header": "tr|A0A0G2JMB4-1|A0A0G2JMB4_HUMAN Computationally mapped isoform of T cell receptor beta constant 2 OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1" }, "locus": { "chromosome": "HSCHR7_2_CTG6", "start_pos": 825500, "end_pos": 824014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000622053.4", "url": "https://www.ensembl.org/id/ENST00000622053.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000478873.3", "url": "https://www.ensembl.org/id/ENSP00000478873.3" } ] } }, { "isoform_ac": "A0A5B9-1", "url": "", "sequence": { "sequence": "DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG", "length": 178, "header": "sp|A0A5B9-1|TRBC2_HUMAN Isoform 1 of T cell receptor beta constant 2 OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1" }, "locus": {} }, { "isoform_ac": "A0A5H1ZRR3-1", "url": "", "sequence": { "sequence": "XDLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG", "length": 179, "header": "tr|A0A5H1ZRR3-1|TRBC2_HUMAN Computationally mapped isoform of T cell receptor beta constant 2 OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=1 CANONICAL=A0A5B9-1" }, "locus": { "chromosome": "7", "start_pos": 142802527, "end_pos": 142801041, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000466254.1", "url": "https://www.ensembl.org/id/ENST00000466254.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000417300.1", "url": "https://www.ensembl.org/id/ENSP00000417300.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 69, "start_aa": "Asn", "end_pos": 69, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn69", "evidence": [ { "id": "A0A5B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A5B9#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "The many important facets of T-cell repertoire diversity.", "journal": "Nature reviews. Immunology", "date": "2004-02", "authors": "Nikolich-Zugich Janko, Slifka Mark K, Messaoudi Ilhem", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "15040585", "url": "https://glygen.org/publication/PubMed/15040585" } ] }, { "title": "A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.", "journal": "J. Exp. Med.", "date": "2006", "authors": "Kjer-Nielsen Lars, Borg Natalie A, Pellicci Daniel G, Beddoe Travis, Kostenko Lyudmila, Clements Craig S, Williamson Nicholas A, Smyth Mark J, Besra Gurdyal S, Reid Hugh H, Bharadwaj Mandvi, Godfrey Dale I, Rossjohn Jamie, McCluskey James", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "16505140", "url": "https://glygen.org/publication/PubMed/16505140" } ] }, { "title": "Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.", "journal": "Cold Spring Harb. Perspect. Biol.", "date": "2010", "authors": "Wucherpfennig Kai W, Gagnon Etienne, Call Melissa J, Huseby Eric S, Call Matthew E", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "20452950", "url": "https://glygen.org/publication/PubMed/20452950" } ] }, { "title": "Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2010", "authors": "Burrows Scott R, Chen Zhenjun, Archbold Julia K, Tynan Fleur E, Beddoe Travis, Kjer-Nielsen Lars, Miles John J, Khanna Rajiv, Moss Denis J, Liu Yu Chih, Gras Stephanie, Kostenko Lyudmila, Brennan Rebekah M, Clements Craig S, Brooks Andrew G, Purcell Anthony W, McCluskey James, Rossjohn Jamie", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "20483993", "url": "https://glygen.org/publication/PubMed/20483993" } ] }, { "title": "The Valpha14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.", "journal": "J. Exp. Med.", "date": "2010", "authors": "Li Yali, Girardi Enrico, Wang Jing, Yu Esther Dawen, Painter Gavin F, Kronenberg Mitchell, Zajonc Dirk M", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "20921281", "url": "https://glygen.org/publication/PubMed/20921281" } ] }, { "title": "Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.", "journal": "EMBO J.", "date": "2011", "authors": "Yin Yiyuan, Li Yili, Kerzic Melissa C, Martin Roland, Mariuzza Roy A", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "21297580", "url": "https://glygen.org/publication/PubMed/21297580" } ] }, { "title": "Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.", "journal": "EMBO J.", "date": "2011", "authors": "Aspeslagh Sandrine, Li Yali, Yu Esther Dawen, Pauwels Nora, Trappeniers Matthias, Girardi Enrico, Decruy Tine, Van Beneden Katrien, Venken Koen, Drennan Michael, Leybaert Luc, Wang Jing, Franck Richard W, Van Calenbergh Serge, Zajonc Dirk M, Elewaut Dirk", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "21552205", "url": "https://glygen.org/publication/PubMed/21552205" } ] }, { "title": "Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.", "journal": "PLoS Biol.", "date": "2011", "authors": "Girardi Enrico, Yu Esther Dawen, Li Yali, Tarumoto Norihito, Pei Bo, Wang Jing, Illarionov Petr, Kinjo Yuki, Kronenberg Mitchell, Zajonc Dirk M", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "22069376", "url": "https://glygen.org/publication/PubMed/22069376" } ] }, { "title": "Glycolipids that elicit IFN-gamma-biased responses from natural killer T cells.", "journal": "Chem. Biol.", "date": "2011", "authors": "Tyznik Aaron J, Farber Elisa, Girardi Enrico, Birkholz Alysia, Li Yali, Chitale Sampada, So Regina, Arora Pooja, Khurana Archana, Wang Jing, Porcelli Steven A, Zajonc Dirk M, Kronenberg Mitchell, Howell Amy R", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "22195564", "url": "https://glygen.org/publication/PubMed/22195564" } ] }, { "title": "Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2012", "authors": "Yin Yiyuan, Wang Xin Xiang, Mariuzza Roy A", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "22431638", "url": "https://glygen.org/publication/PubMed/22431638" } ] }, { "title": "T cell receptor signalling networks: branched, diversified and bounded.", "journal": "Nature reviews. Immunology", "date": "2013-04", "authors": "Brownlie Rebecca J, Zamoyska Rose", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "23524462", "url": "https://glygen.org/publication/PubMed/23524462" } ] }, { "title": "Immunoglobulin and T Cell Receptor Genes: IMGT(\u00ae) and the Birth and Rise of Immunoinformatics.", "journal": "Frontiers in immunology", "date": "2014", "authors": "Lefranc Marie-Paule", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "24600447", "url": "https://glygen.org/publication/PubMed/24600447" } ] }, { "title": "Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.", "journal": "Cell", "date": "2014", "authors": "Clayton Gina M, Wang Yang, Crawford Frances, Novikov Andrey, Wimberly Brian T, Kieft Jeffrey S, Falta Michael T, Bowerman Natalie A, Marrack Philippa, Fontenot Andrew P, Dai Shaodong, Kappler John W", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "24995984", "url": "https://glygen.org/publication/PubMed/24995984" } ] }, { "title": "Structure of the superantigen staphylococcal enterotoxin B in complex with TCR and peptide-MHC demonstrates absence of TCR-peptide contacts.", "journal": "J. Immunol.", "date": "2014", "authors": "R\u00f6dstr\u00f6m Karin E J, Elbing Karin, Lindkvist-Petersson Karin", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "25015819", "url": "https://glygen.org/publication/PubMed/25015819" } ] }, { "title": "Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by alphabeta T cells.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2014", "authors": "Roy Sobhan, Ly Dalam, Li Nan-Sheng, Altman John D, Piccirilli Joseph A, Moody D Branch, Adams Erin J", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "25298532", "url": "https://glygen.org/publication/PubMed/25298532" } ] }, { "title": "T cell antigen receptor recognition of antigen-presenting molecules.", "journal": "Annual review of immunology", "date": "2015", "authors": "Rossjohn Jamie, Gras Stephanie, Miles John J, Turner Stephen J, Godfrey Dale I, McCluskey James", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "25493333", "url": "https://glygen.org/publication/PubMed/25493333" } ] }, { "title": "Lipid and Carbohydrate Modifications of alpha-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.", "journal": "J. Biol. Chem.", "date": "2015", "authors": "Birkholz Alysia, Nem\u010dovi\u010d Marek, Yu Esther Dawen, Girardi Enrico, Wang Jing, Khurana Archana, Pauwels Nora, Farber Elisa, Chitale Sampada, Franck Richard W, Tsuji Moriya, Howell Amy, Van Calenbergh Serge, Kronenberg Mitchell, Zajonc Dirk M", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "26018083", "url": "https://glygen.org/publication/PubMed/26018083" } ] }, { "title": "A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-gamma Production.", "journal": "J. Immunol.", "date": "2015", "authors": "Birkholz Alysia M, Girardi Enrico, Wingender Gerhard, Khurana Archana, Wang Jing, Zhao Meng, Zahner Sonja, Illarionov Petr A, Wen Xiangshu, Li Michelle, Yuan Weiming, Porcelli Steven A, Besra Gurdyal S, Zajonc Dirk M, Kronenberg Mitchell", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "26078271", "url": "https://glygen.org/publication/PubMed/26078271" } ] }, { "title": "Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.", "journal": "PLoS ONE", "date": "2015", "authors": "R\u00f6dstr\u00f6m Karin E J, Regenthal Paulina, Lindkvist-Petersson Karin", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "26147596", "url": "https://glygen.org/publication/PubMed/26147596" } ] }, { "title": "Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.", "journal": "Sci. Rep.", "date": "2016", "authors": "Raman Marine C C, Rizkallah Pierre J, Simmons Ruth, Donnellan Zoe, Dukes Joseph, Bossi Giovanna, Le Provost Gabrielle S, Todorov Penio, Baston Emma, Hickman Emma, Mahon Tara, Hassan Namir, Vuidepot Annelise, Sami Malkit, Cole David K, Jakobsen Bent K", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "26758806", "url": "https://glygen.org/publication/PubMed/26758806" } ] }, { "title": "Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.", "journal": "Nat. Commun.", "date": "2016", "authors": "Le Nours J\u00e9r\u00f4me, Praveena T, Pellicci Daniel G, Gherardin Nicholas A, Ross Fiona J, Lim Ricky T, Besra Gurdyal S, Keshipeddy Santosh, Richardson Stewart K, Howell Amy R, Gras Stephanie, Godfrey Dale I, Rossjohn Jamie, Uldrich Adam P", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "26875526", "url": "https://glygen.org/publication/PubMed/26875526" } ] }, { "title": "A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.", "journal": "J. Biol. Chem.", "date": "2016", "authors": "Bianchi Valentina, Bulek Anna, Fuller Anna, Lloyd Angharad, Attaf Meriem, Rizkallah Pierre J, Dolton Garry, Sewell Andrew K, Cole David K", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "26917722", "url": "https://glygen.org/publication/PubMed/26917722" } ] }, { "title": "Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2016", "authors": "Valkenburg Sophie A, Josephs Tracy M, Clemens E Bridie, Grant Emma J, Nguyen Thi H O, Wang George C, Price David A, Miller Adrian, Tong Steven Y C, Thomas Paul G, Doherty Peter C, Rossjohn Jamie, Gras Stephanie, Kedzierska Katherine", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "27036003", "url": "https://glygen.org/publication/PubMed/27036003" } ] }, { "title": "Two common structural motifs for TCR recognition by staphylococcal enterotoxins.", "journal": "Sci. Rep.", "date": "2016", "authors": "R\u00f6dstr\u00f6m Karin E J, Regenthal Paulina, Bahl Christopher, Ford Alex, Baker David, Lindkvist-Petersson Karin", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "27180909", "url": "https://glygen.org/publication/PubMed/27180909" } ] }, { "title": "A 'hotspot' for autoimmune T cells in type 1 diabetes.", "journal": "J. Clin. Invest.", "date": "2016", "authors": "Stadinski Brian D, Obst Reinhard, Huseby Eric S", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "27183386", "url": "https://glygen.org/publication/PubMed/27183386" } ] }, { "title": "Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.", "journal": "J. Clin. Invest.", "date": "2016", "authors": "Cole David K, Bulek Anna M, Dolton Garry, Schauenberg Andrea J, Szomolay Barbara, Rittase William, Trimby Andrew, Jothikumar Prithiviraj, Fuller Anna, Skowera Ania, Rossjohn Jamie, Zhu Cheng, Miles John J, Peakman Mark, Wooldridge Linda, Rizkallah Pierre J, Sewell Andrew K", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "27183389", "url": "https://glygen.org/publication/PubMed/27183389" } ] }, { "title": "Diverse T cell receptor gene usage in HLA-DQ8-associated celiac disease converges into a consensus binding solution.", "journal": "Structure", "date": "2016", "authors": "Petersen Jan, Kooy-Winkelaar Yvonne, Loh Khai Lee, Tran Mai, van Bergen Jeroen, Koning Frits, Rossjohn Jamie, Reid Hugh H", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "27568928", "url": "https://glygen.org/publication/PubMed/27568928" } ] }, { "title": "CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.", "journal": "Sci. Immunol.", "date": "2018", "authors": "Galperin M, Farenc C, Mukhopadhyay M, Jayasinghe D, Decroos A, Benati D, Tan LL, Ciacchi L, Reid HH, Rossjohn J, Chakrabarti LA, Gras S", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JMB4", "url": "https://www.uniprot.org/uniprot/A0A0G2JMB4" } ], "reference": [ { "type": "PubMed", "id": "29884618", "url": "https://glygen.org/publication/PubMed/29884618" } ] }, { "title": "Sequence and evolution of the human T-cell antigen receptor beta-chain genes.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1985", "authors": "Tunnacliffe A, Kefford R, Milstein C, Forster A, Rabbitts TH", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "3860845", "url": "https://glygen.org/publication/PubMed/3860845" } ] }, { "title": "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.", "journal": "Science", "date": "1996", "authors": "Rowen L, Koop BF, Hood L", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "8650574", "url": "https://glygen.org/publication/PubMed/8650574" } ] }, { "title": "Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.", "journal": "Nature", "date": "1996", "authors": "Garboczi D N, Ghosh P, Utz U, Fan Q R, Biddison W E, Wiley D C", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "8906788", "url": "https://glygen.org/publication/PubMed/8906788" } ] }, { "title": "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.", "journal": "Immunity", "date": "1998", "authors": "Ding Y H, Smith K J, Garboczi D N, Utz U, Biddison W E, Wiley D C", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "reference": [ { "type": "PubMed", "id": "9586631", "url": "https://glygen.org/publication/PubMed/9586631" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "pmid": "" }, { "name": "alpha-beta T cell receptor complex", "id": "GO:0042105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042105", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "alpha-beta T cell activation", "id": "GO:0046631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046631", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0A5B9", "url": "https://www.uniprot.org/uniprot/A0A5B9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [ 69 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 32 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }