{ "uniprot_canonical_ac": "A0A3B3IS91-1", "uniprot_ac": "A0A3B3IS91", "uniprot_id": "PLGRF_HUMAN", "mass": { "chemical_mass": 25527.0, "monoisotopic_mass": 25527.0 }, "refseq": {}, "gene_names": [ { "name": "POLGARF", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91", "id": "A0A3B3IS91" } ], "protein_names": [ { "name": "POLG alternative reading frame", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A3B3IS91" }, { "name": "ORF-Y", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A3B3IS91" }, { "name": "POLGARF", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A3B3IS91" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91" } ], "common_name": "Human" } ], "gene": [ { "name": "POLGARF", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91", "locus": { "chromosome": "15", "start_pos": 89330208, "end_pos": 89333809, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000291307", "url": "https://www.ensembl.org/id/ENSG00000291307" } ] } } ], "crossref": [ { "id": "ENSG00000140521", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140521", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "POLGARF", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=POLGARF", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "56246", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=56246", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B3IS91-1", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPKARCSDSQRGGPCTNHEPPALEEGGRRHRRARAGSSSGALGLQLRPRVRPQRRAAAAAAAAAAAAAAATAASAAASAILGGRAAAAQPIGHPDALERAARANLRARRGDAWRGRGAPQRRAPAEARALGAASRALARRGAAPAAPLRGQPGPALPPPGPEAEPALPGGGQLAVAGPAAPEAPGLGLGGGLDPVRPRGGGRTRGHPRGAGPGVRRGGLLGRGNLPHIGGGHIPLGLVFLVQPAAGGRALLLDQPAVAG", "length": 260, "header": "sp|A0A3B3IS91-1|PLGRF_HUMAN Isoform 1 of POLG alternative reading frame OS=Homo sapiens OX=9606 GN=POLGARF PE=1 SV=2 CANONICAL=A0A3B3IS91-1" }, "isoforms": [ { "isoform_ac": "A0A3B3IS91-1", "url": "", "sequence": { "sequence": "MEPKARCSDSQRGGPCTNHEPPALEEGGRRHRRARAGSSSGALGLQLRPRVRPQRRAAAAAAAAAAAAAAATAASAAASAILGGRAAAAQPIGHPDALERAARANLRARRGDAWRGRGAPQRRAPAEARALGAASRALARRGAAPAAPLRGQPGPALPPPGPEAEPALPGGGQLAVAGPAAPEAPGLGLGGGLDPVRPRGGGRTRGHPRGAGPGVRRGGLLGRGNLPHIGGGHIPLGLVFLVQPAAGGRALLLDQPAVAG", "length": 260, "header": "sp|A0A3B3IS91-1|PLGRF_HUMAN Isoform 1 of POLG alternative reading frame OS=Homo sapiens OX=9606 GN=POLGARF PE=1 SV=2 CANONICAL=A0A3B3IS91-1" }, "locus": { "chromosome": "15", "start_pos": 89333809, "end_pos": 89330211, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000706918.1", "url": "https://www.ensembl.org/id/ENST00000706918.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000516626.1", "url": "https://www.ensembl.org/id/ENSP00000516626.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon.", "journal": "BMC Genet.", "date": "2020", "authors": "Khan Yousuf A, Jungreis Irwin, Wright James C, Mudge Jonathan M, Choudhary Jyoti S, Firth Andrew E, Kellis Manolis", "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91" } ], "reference": [ { "type": "PubMed", "id": "32138667", "url": "https://glygen.org/publication/PubMed/32138667" } ] }, { "title": "Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "Loughran G, Zhdanov AV, Mikhaylova MS, Rozov FN, Datskevich PN, Kovalchuk SI, Serebryakova MV, Kiniry SJ, Michel AM, O'Connor PBF, Papkovsky DB, Atkins JF, Baranov PV, Shatsky IN, Andreev DE", "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91" } ], "reference": [ { "type": "PubMed", "id": "32958672", "url": "https://glygen.org/publication/PubMed/32958672" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Undergoes proteolytic cleavage to produce a secreted C-terminal fragment.", "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IS91", "url": "https://www.uniprot.org/uniprot/A0A3B3IS91" }, { "database": "PubMed", "id": "32958672", "url": "https://glygen.org/publication/PubMed/32958672" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }