{
    "uniprot_canonical_ac": "A0A1W2PR82-1",
    "uniprot_ac": "A0A1W2PR82",
    "uniprot_id": "PERC1_HUMAN",
    "mass": {
        "chemical_mass": 29212.0,
        "monoisotopic_mass": 29212.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "PERCC1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82",
            "id": "A0A1W2PR82"
        }
    ],
    "protein_names": [
        {
            "name": "Protein PERCC1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A1W2PR82"
        },
        {
            "name": "Proline and glutamage-rich protein with a coiled coil domain",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A1W2PR82"
        }
    ],
    "function": [
        {
            "annotation": "Plays a critical role in intestinal function (PubMed:31217582). Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is thereby required for normal enteroendocrine peptide hormone secretion (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PR82",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR82#function"
                },
                {
                    "database": "PubMed",
                    "id": "31217582",
                    "url": "https://glygen.org/publication/PubMed/31217582"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A286YDK6",
                    "url": "https://www.uniprot.org/uniprot/A0A286YDK6#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "MONDO:0032857",
            "recommended_name": {
                "id": "MONDO:0032857",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0032857",
                "name": "diarrhea 11, malabsorptive, congenital",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "MONDO:0032857",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032857",
                    "name": "DIAR11",
                    "description": ""
                },
                {
                    "id": "MONDO:0032857",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032857",
                    "name": "DIARRHEA 11, MALABSORPTIVE, CONGENITAL",
                    "description": ""
                },
                {
                    "id": "MONDO:0032857",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032857",
                    "name": "Intractable Diarrhea of Infancy Syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0032857",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032857",
                    "name": "Intractable Diarrhoea of Infancy Syndrome",
                    "description": ""
                },
                {
                    "id": "MIM:618662",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/618662",
                    "name": "Diarrhea 11, malabsorptive, congenital",
                    "description": "Diarrhea 11, malabsorptive, congenital"
                }
            ],
            "evidence": [
                {
                    "id": "618662",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/618662"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PR82",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "PERCC1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82",
            "locus": {
                "chromosome": "16",
                "start_pos": 1434441,
                "end_pos": 1431078,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000284395",
                        "url": "https://www.ensembl.org/id/ENSG00000284395"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000284395",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000284395",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "PERCC1",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PERCC1",
            "database": "GeneCards",
            "categories": [
                "Gene Annotation",
                "Organism-specific"
            ]
        },
        {
            "id": "52293",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=52293",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "618656",
            "url": "http://www.omim.org/entry/618656",
            "database": "MIM",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "618662",
            "url": "http://www.omim.org/entry/618662",
            "database": "MIM",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "NX_A0A1W2PR82",
            "url": "https://www.nextprot.org/entry/NX_A0A1W2PR82",
            "database": "neXtProt",
            "categories": [
                "Protein",
                "Organism-specific"
            ]
        },
        {
            "id": "ACNIYED",
            "url": "https://omabrowser.org/oma/group/ACNIYED/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5398027at2759",
            "url": "http://www.orthodb.org/?query=5398027at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0A1W2PR82",
            "url": "http://purl.obolibrary.org/obo/PR_A0A1W2PR82",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "XP_011521082",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011521082",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1W2PR82",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1W2PR82-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAGVIRPLCDFQLPLLRHHPFLPSDPEPPETSEEEEEEEEEEEEEEGEGEGLGGCGRILPSSGRAEATEEAAPEGPGSPETPLQLLRFSELISDDIRRYFGRKDKGQDPDACDVYADSRPPRSTARELYYADLVRLARGGSLEDEDTPEPRVPQGQVCRPGLSGDRAQPLGPLAELFDYGLQQYWGSRAAAGWSLTLERKYGHITPMAQRKLPPSFWKEPTPSPLGLLHPGTPDFSDLLASWSTEACPELPGRGTPALEGARPAEA",
        "length": 267,
        "header": "sp|A0A1W2PR82-1|PERC1_HUMAN Isoform 1 of Protein PERCC1  OS=Homo sapiens OX=9606 GN=PERCC1 PE=3 SV=1 CANONICAL=A0A1W2PR82-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1W2PR82-1",
            "url": "",
            "sequence": {
                "sequence": "MAAGVIRPLCDFQLPLLRHHPFLPSDPEPPETSEEEEEEEEEEEEEEGEGEGLGGCGRILPSSGRAEATEEAAPEGPGSPETPLQLLRFSELISDDIRRYFGRKDKGQDPDACDVYADSRPPRSTARELYYADLVRLARGGSLEDEDTPEPRVPQGQVCRPGLSGDRAQPLGPLAELFDYGLQQYWGSRAAAGWSLTLERKYGHITPMAQRKLPPSFWKEPTPSPLGLLHPGTPDFSDLLASWSTEACPELPGRGTPALEGARPAEA",
                "length": 267,
                "header": "sp|A0A1W2PR82-1|PERC1_HUMAN Isoform 1 of Protein PERCC1  OS=Homo sapiens OX=9606 GN=PERCC1 PE=3 SV=1 CANONICAL=A0A1W2PR82-1"
            },
            "locus": {
                "chromosome": "16",
                "start_pos": 1433394,
                "end_pos": 1432594,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000640283.2",
                        "url": "https://www.ensembl.org/id/ENST00000640283.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000492108.2",
                        "url": "https://www.ensembl.org/id/ENSP00000492108.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Noncoding deletions reveal a gene that is critical for intestinal function.",
            "journal": "Nature",
            "date": "2019-07",
            "authors": "Oz-Levi Danit, Olender Tsviya, Bar-Joseph Ifat, Zhu Yiwen, Marek-Yagel Dina, Barozzi Iros, Osterwalder Marco, Alkelai Anna, Ruzzo Elizabeth K, Han Yujun, Vos Erica S M, Reznik-Wolf Haike, Hartman Corina, Shamir Raanan, Weiss Batia, Shapiro Rivka, Pode-Shakked Ben, Tatarskyy Pavlo, Milgrom Roni, Schvimer Michael, Barshack Iris, Imai Denise M, Coleman-Derr Devin, Dickel Diane E, Nord Alex S, Afzal Veena, van Bueren Kelly Lammerts, Barnes Ralston M, Black Brian L, Mayhew Christopher N, Kuhar Matthew F, Pitstick Amy, Tekman Mehmet, Stanescu Horia C, Wells James M, Kleta Robert, de Laat Wouter, Goldstein David B, Pras Elon, Visel Axel, Lancet Doron, Anikster Yair, Pennacchio Len A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PR82",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31217582",
                    "url": "https://glygen.org/publication/PubMed/31217582"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A286YDK6-1",
            "protein_name": "Protein PERCC1",
            "gene_name": "Percc1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAAGVIRSVCDFRLPLPSHESFLPIDLEAPEISEEEEEEEEEEEEEEEEEEVDQDQQGEGSQGCGPDSQSSGVVPQDPSSPETPMQLLRFSELISGDIQRYFGRKDTGQDPDAQDIYADSQPASCSARDLYYADLVCLAQDGPPEDEEAAEFRMHLPGGPEGQVHRLGHRGDRVPPLGPLAELFDYGLRQFSRPRISACRRLRLERKYSHITPMTQRKLPPSFWKEPVPNPLGLLHVGTPDFSDLLASWSAEGGSELQSGGTQGLEGTQLAEV",
                "length": 273
            },
            "evidence": [
                {
                    "id": "A0A1W2PR82",
                    "url": "https://omabrowser.org/oma/group/A0A1W2PR82/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "A0A8I6A4Y8-1",
            "protein_name": "Proline and glutamate rich with coiled coil 1",
            "gene_name": "Percc1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAAGVIRSVCGFRLPLPSHKSFLFTDLEATETSEEEEGEEEEEEEEEEEEEEGDQDLQGEGSQGCSPDSQSSGVVPQGPSSPETPVQLLRFSELISGDIQRYFGRKDTGQDPDAQDIYADSQAASCSARDLYYADLVCLAQDGPPEDEAAAELRMHSPGVPEGQVHRLGHRGDRVPPLGPLAELFDYGLRQFSRPRVSACRRLRLERKYSHITPMTQRKLPPSFWKEPVPNPLGLLHPGTPDFSDLLASWSAEGGSELQSGGTQVLEGTQLAEI",
                "length": 274
            },
            "evidence": [
                {
                    "id": "A0A1W2PR82",
                    "url": "https://omabrowser.org/oma/group/A0A1W2PR82/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "digestive tract morphogenesis",
                        "id": "GO:0048546",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048546",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PR82",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "enteroendocrine cell differentiation",
                        "id": "GO:0035883",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035883",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PR82",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": []
    },
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