{ "uniprot_canonical_ac": "A0A286ZPW1-1", "uniprot_ac": "A0A286ZPW1", "uniprot_id": "A0A286ZPW1_PIG", "mass": { "chemical_mass": 200775.0, "monoisotopic_mass": 200775.0 }, "refseq": {}, "gene_names": [ { "name": "UBR1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1", "id": "A0A286ZPW1" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A286ZPW1/entry#names_and_taxonomy", "id": "A0A286ZPW1" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A286ZPW1/entry#names_and_taxonomy", "id": "A0A286ZPW1" } ], "function": [ { "annotation": "Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1#function" }, { "database": "UniProtKB", "id": "RU366018", "url": "https://www.uniprot.org/uniprot/RU366018#function" }, { "database": "UniProtKB", "id": "A0A8D1GPT3", "url": "https://www.uniprot.org/uniprot/A0A8D1GPT3#function" }, { "database": "UniProtKB", "id": "A0A5G2RBU8", "url": "https://www.uniprot.org/uniprot/A0A5G2RBU8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "gene": [ { "name": "UBR1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1", "locus": { "chromosome": "1", "start_pos": 128474302, "end_pos": 128319311, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSSSCG00000004717", "url": "https://www.ensembl.org/id/ENSSSCG00000004717" } ] } } ], "crossref": [ { "id": "ENSSSCG00000004717", "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000004717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19678", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19678", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TWMKLLA", "url": "https://omabrowser.org/oma/group/TWMKLLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "51389at2759", "url": "http://www.orthodb.org/?query=51389at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21497", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21497", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21497:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21497:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02207", "url": "http://pfam.xfam.org/family/PF02207", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02617", "url": "http://pfam.xfam.org/family/PF02617", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18995", "url": "http://pfam.xfam.org/family/PF18995", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-SSC-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286ZPW1-1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5G2RBU8", "url": "https://www.uniprot.org/uniprot/A0A5G2RBU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5G2RBU8-1", "url": "https://www.uniprot.org/uniprot/A0A5G2RBU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8D1GPT3", "url": "https://www.uniprot.org/uniprot/A0A8D1GPT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8D1GPT3-1", "url": "https://www.uniprot.org/uniprot/A0A8D1GPT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEEAGGAERMEVSTELPQTPQRLASWWDQQVDFYTSFLNHLAQLVPEIYFAEMDPDLEKQEESIQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCLSHEPGRAGTTKESLRCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQIREKNDRYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKTGAFSACQEAKEDIKSHSENVSQHPLHVEVLHSEVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKFFAMEFVKYYKQLQKDYISDDHDRSISVTALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPTVWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFVSSSKTVLQLCGHTLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNRFLLLVLQRYELADAFNKTIATKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLRDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLNCDVMMYILRTIFERAVDPDSNLWTEGMLQMAFHILALGLLEEKQQLQKSPEEEVTFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEIIHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDSTSEMSGKEDSIMEEESTPGVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTTLTQHRGKPIELSGETLDPLFMDSDLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQRINSENTEALAQLLTLARWIQTVLARIRGYNVKHAKGEHATVPFLFDQGMGDSTFEFHSILSFGVQSSIKYSNSIKEMVILFATTIYRIGLKMPPDETDPRIPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAIAQRITCSQVLIQKHLIRLLSVVLPILKSDDTPCLLSIDLFHVLVGAVLAFPSLYWDDAVDLQPSSVSSSYNHLYLFHLITMAHMFQILLTIDTGLPLAQTQEESEEAHSASSFLAEVSQYTNGYVGCGIPGWYLWVSLKNGIIPYLRCAALFFHYLLGITPPEDLFTNSAESEYSALCSYLSLPTNLFLLFQKYWDTIRPLLQRWCADPALLNCLKQKSTIVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSSDDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1753, "header": "tr|A0A286ZPW1-1|A0A286ZPW1_PIG Isoform 1 of E3 ubiquitin-protein ligase OS=Sus scrofa OX=9823 GN=UBR1 PE=3 SV=1 CANONICAL=A0A286ZPW1-1" }, "isoforms": [ { "isoform_ac": "A0A286ZPW1-1", "url": "https://www.uniprot.org/uniprotkb/A0A286ZPW1/entry#A0A286ZPW1-1", "sequence": { "sequence": "MAEEEAGGAERMEVSTELPQTPQRLASWWDQQVDFYTSFLNHLAQLVPEIYFAEMDPDLEKQEESIQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCLSHEPGRAGTTKESLRCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQIREKNDRYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKTGAFSACQEAKEDIKSHSENVSQHPLHVEVLHSEVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKFFAMEFVKYYKQLQKDYISDDHDRSISVTALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPTVWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFVSSSKTVLQLCGHTLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNRFLLLVLQRYELADAFNKTIATKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLRDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLNCDVMMYILRTIFERAVDPDSNLWTEGMLQMAFHILALGLLEEKQQLQKSPEEEVTFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEIIHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDSTSEMSGKEDSIMEEESTPGVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTTLTQHRGKPIELSGETLDPLFMDSDLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQRINSENTEALAQLLTLARWIQTVLARIRGYNVKHAKGEHATVPFLFDQGMGDSTFEFHSILSFGVQSSIKYSNSIKEMVILFATTIYRIGLKMPPDETDPRIPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAIAQRITCSQVLIQKHLIRLLSVVLPILKSDDTPCLLSIDLFHVLVGAVLAFPSLYWDDAVDLQPSSVSSSYNHLYLFHLITMAHMFQILLTIDTGLPLAQTQEESEEAHSASSFLAEVSQYTNGYVGCGIPGWYLWVSLKNGIIPYLRCAALFFHYLLGITPPEDLFTNSAESEYSALCSYLSLPTNLFLLFQKYWDTIRPLLQRWCADPALLNCLKQKSTIVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSSDDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1753, "header": "tr|A0A286ZPW1-1|A0A286ZPW1_PIG Isoform 1 of E3 ubiquitin-protein ligase OS=Sus scrofa OX=9823 GN=UBR1 PE=3 SV=1 CANONICAL=A0A286ZPW1-1" }, "locus": {} }, { "isoform_ac": "A0A5G2RBU8-1", "url": "https://www.uniprot.org/uniprotkb/A0A286ZPW1/entry#A0A5G2RBU8-1", "sequence": { "sequence": "MAEEEAGGAERMEVSTELPQTPQRLASWWDQQVDFYTSFLNHLAQLVPEIYFAEMDPDLEKQEESIQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCLSHEPGRAGTTKESLRCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQIREKNDRYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKTGAFSACQEAKEDIKSHSENVSQHPLHVEVLHSEVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKFFAMEFVKYYKQLQKDYISDDHDRSISVTALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPTVWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFVSSSKTVLQLCGHTLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNRFLLLVLQRYELADAFNKTIATKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLRDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLNCDVMMYILRTIFERAVDPDSNLWTEGMLQMAFHILALGLLEEKQQLQKSPEEEVTFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEIIHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDSTSEMSGKEDSIMEEESTPGVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTTLTQHRGKPIELSGETLDPLFMDSDLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQRINSENTEALAQLLTLARWIQTVLARIRGYNVKHAKGEHATVPFLFDQGMGDSTFEFHSILSFGVQSSIKYSNSIKEMVILFATTIYRIGLKMPPDETDPRIPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAIAQRITCSQVLIQKHLIRLLSVVLPILKSDDTPCLLSIDLFHVLVGAVLAFPSLYWDDAVDLQPSSVSSSYNHLYLFHLITMAHMFQILLTIDTGLPLAQTQEESEEAHSASSFLAEVSQYTNGYVGCGIPGWYLWVSLKNGIIPYLRCAALFFHYLLGITPPEDLFTNSAESEYSALCSYLSLPTNLFLLFQKYWDTIRPLLQRCPRSSDDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1708, "header": "tr|A0A5G2RBU8-1|A0A5G2RBU8_PIG Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Sus scrofa OX=9823 GN=UBR1 PE=3 SV=2 CANONICAL=A0A286ZPW1-1" }, "locus": {} }, { "isoform_ac": "A0A8D1GPT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A286ZPW1/entry#A0A8D1GPT3-1", "sequence": { "sequence": "MAEEEAGGAERMEVSTELPQTPQRLASWWDQQVDFYTSFLNHLAQLVPEIYFAEMDPDLEKQEESIQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCLSHEPGRAGTTKESLRCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQIREKNDRYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKTGAFSACQEAKEDIKSHSENVSQHPLHVEVLHSEVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKFFAMEFVKYYKQLQKDYISDDHDRSISVTALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPTVWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFVSSSKTVLQLCGHTLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNRFLLLVLQRYELADAFNKTIATKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLRDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLNCDVMMYILRTIFERAVDPDSNLWTEGMLQMAFHILALGLLEEKQQLQKSPEEEVTFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEIIHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDSTSEMSGKEDSIMEEESTPGVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTTLTQHRGKPIELSGETLDPLFMDSDLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQRINSENTEALAQLLTLARWIQTVLARIRGYNVKHAKGEHATVPFLFDQGMGDSTFEFHSILSFGVQSSIKYSNSIKEMVILFATTIYRIGLKMPPDETDPRIPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAIAQRITCSQVLIQKHLIRLLSAFPSLYWDDAVDLQPSSVSSSYNHLYLFHLITMAHMFQILLTIDTGLPLAQTQEESEEAHSASSFLAEVSQYTNGYVGCGIPGWYLWVSLKNGIIPYLRCAALFFHYLLGITPPEDLFTNSAESEYSALCSYLSLPTNLFLLFQKYWDTIRPLLQRWCADPALLNCLKQKSTIVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSSDDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1725, "header": "tr|A0A8D1GPT3-1|A0A286ZPW1_PIG Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Sus scrofa OX=9823 GN=UBR1 PE=3 SV=1 CANONICAL=A0A286ZPW1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.", "journal": "PeerJ", "date": "2019", "authors": "Gilbert Donald G", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "reference": [ { "type": "PubMed", "id": "30723633", "url": "https://glygen.org/publication/PubMed/30723633" } ] } ], "pathway": [ { "id": "R-SSC-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZZN6-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "Ubr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADEEMDGAERMDVSPEPPLAPQPPASWWDQQGDFYTAFLHHLAKLVPEIYFAEMDPDLEKQEENVQMSIFTPLEWYLFGEDPDVCLERLKHSAAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCMDHEPGRAGTTKETLHCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQRREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGVYSACQEAKEDIKSHSENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLIEEPGSEHPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSISITALSVQVFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPLVWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTKTVVQLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVFQDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELADAFNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVIMREITHLLCIEPMPHSAIARNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVTDLLNCDIMMHILRTIFERAVDPESNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLVVASTSGLESIKSEEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEITGKEDSIMEEESPSAVSECSRIALGPKRGPALTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQHRGKPAGLLGESLDPLFMDPDLAHGTYAGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENAEALSQLLTLARWIQTVLARISGYNMKHAKGEAPAVPVLFNQGMGDSTFEFHSILSFGVQSSVKYSNSIKEMVILFATTIYRIGLKVPPDELDPRVPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRTTCPQVLIQKHLVRLLSVVLPNLQSENTPCLLSVDLFHVLVGAVLAFPSLYWDDTVDLQPSPLSSSYSHLYLFHLVTMAHMLQILLTVDADQSPGLPLNEGGEDSEEARCASALFVEVSQHTDGLIGCGAPGWYLWLSLRNGITPYLRCAALLFHYLLGVTPPEELFANSAEGEFSALCSYLSLPTNLFLLFQEYWDTIRPLLQRWCGDPALLNSLKQKSALVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSSDDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACVFHALQCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1757 }, "evidence": [ { "id": "A0A286ZPW1", "url": "https://omabrowser.org/oma/group/A0A286ZPW1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O70481-1", "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "Ubr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADEEMDGAERMDVSPEPPLAPQRPASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSILTPLEWYLFGEDPDICLEKLKHSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVDHEPGRAGTTKESLHCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGVYATCQEAKEDIKSHSENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLVEEPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSISITALSVQMLTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPVIWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTKTVVQLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELTDAFNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTREEVIMREITHLLCIEPMPHSAIARNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLSCDVMMYILRTIFERAVDMESNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLESQKDMITWILQMFDTVKRLREKSCLVVATTSGLECVKSEEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEVTGKEDSIMEEESTSAVSEASRIALGPKRGPAVTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQHRGKPVDHLGETLDPLFMDPDLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENAEALAQLLTLARWIQTVLARISGYNIKHAKGEAPAVPVLFNQGMGDSTFEFHSILSFGVQSSVKYSNSIKEMVILFATTIYRIGLKVPPDELDPRVPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRTTCPQVLIHKHLARLLSVILPNLQSENTPGLLSVDLFHVLVGAVLAFPSLYWDDTVDLQPSPLSSSYNHLYLFHLITMAHMLQILLTTDTDLSSGPPLAEGEEDSEEARCASAFFVEVSQHTDGLAGCGAPGWYLWLSLRNGITPYLRCAALLFHYLLGVAPPEELFANSAEGEFSALCSYLSLPTNLFLLFQEYWDTIRPLLQRWCGDPALLKSLKQKSAVVRYPRKRNSLIELPEDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACVFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1757 }, "evidence": [ { "id": "A0A286ZPW1", "url": "https://omabrowser.org/oma/group/A0A286ZPW1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IWV7-1", "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "UBR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRCPLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRVSEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAIDTDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIFFNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPMLTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVRLLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFHLITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVSLKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDTVRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "length": 1749 }, "evidence": [ { "id": "A0A286ZPW1", "url": "https://omabrowser.org/oma/group/A0A286ZPW1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "leucine binding", "id": "GO:0070728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070728", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the N-end rule pathway", "id": "GO:0071596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071596", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "cellular response to leucine", "id": "GO:0071233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071233", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" }, { "name": "proteasome complex", "id": "GO:0000502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000502", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZPW1", "url": "https://www.uniprot.org/uniprot/A0A286ZPW1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 722, "end_pos": 724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 796, "end_pos": 798, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-SSC-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983140" } ] }, { "id": "R-SSC-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983147" } ] }, { "id": "R-SSC-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983156" } ] }, { "id": "R-SSC-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 292, "end_pos": 294 }, { "start_pos": 722, "end_pos": 724 }, { "start_pos": 761, "end_pos": 763 }, { "start_pos": 796, "end_pos": 798 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }