{ "uniprot_canonical_ac": "A0A286ZP18-1", "uniprot_ac": "A0A286ZP18", "uniprot_id": "A0A286ZP18_PIG", "mass": { "chemical_mass": 46563.0, "monoisotopic_mass": 46563.0 }, "refseq": {}, "gene_names": [ { "name": "KLHDC1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A286ZP18", "id": "A0A286ZP18" } ], "protein_names": [ { "name": "Kelch domain containing 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A286ZP18/entry#names_and_taxonomy", "id": "A0A286ZP18" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "A0A286ZP18", "url": "https://www.uniprot.org/uniprot/A0A286ZP18" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "gene": [ { "name": "KLHDC1", "url": "https://www.uniprot.org/uniprot/A0A286ZP18", "locus": { "chromosome": "1", "start_pos": 179605628, "end_pos": 179540547, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSSSCG00000032489", "url": "https://www.ensembl.org/id/ENSSSCG00000032489" } ] } } ], "crossref": [ { "id": "ENSSSCG00000032489", "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000032489", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GYMSVAD", "url": "https://omabrowser.org/oma/group/GYMSVAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2906516at2759", "url": "http://www.orthodb.org/?query=2906516at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46228:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46228:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "http://pfam.xfam.org/family/PF01344", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13418", "url": "http://pfam.xfam.org/family/PF13418", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13854", "url": "http://pfam.xfam.org/family/PF13854", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A0A286ZP18", "url": "https://www.uniprot.org/uniprot/A0A286ZP18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286ZP18-1", "url": "https://www.uniprot.org/uniprot/A0A286ZP18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286ZYK3", "url": "https://www.uniprot.org/uniprot/A0A286ZYK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286ZYK3-1", "url": "https://www.uniprot.org/uniprot/A0A286ZYK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8W4FPJ6", "url": "https://www.uniprot.org/uniprot/A0A8W4FPJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8W4FPJ6-1", "url": "https://www.uniprot.org/uniprot/A0A8W4FPJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWTMHLMEGELPTSMSGSCGACINGKLYVFGGYDDKGYSNRLYFVNLRTRDGTYIWEKITNFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHNELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQSWLQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRIPVNGENPKHRSWHTLTPIADDTLFLFGGLSADNVPLSDGWIHNVITNCWKQLTHLPKTKPRLWHTACLGKENEIMVFGGSKDDLLSLDTGHCNDLLIFQTQPYSLLRLCLDCIGKNAIILESQISLLPPKLLQQVLKKITFWTAANHREEQRAQKEETENKYQWISGN", "length": 406, "header": "tr|A0A286ZP18-1|A0A286ZP18_PIG Isoform 1 of Kelch domain containing 1 OS=Sus scrofa OX=9823 GN=KLHDC1 PE=4 SV=1 CANONICAL=A0A286ZP18-1" }, "isoforms": [ { "isoform_ac": "A0A286ZP18-1", "url": "https://www.uniprot.org/uniprotkb/A0A286ZP18/entry#A0A286ZP18-1", "sequence": { "sequence": "MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWTMHLMEGELPTSMSGSCGACINGKLYVFGGYDDKGYSNRLYFVNLRTRDGTYIWEKITNFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHNELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQSWLQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRIPVNGENPKHRSWHTLTPIADDTLFLFGGLSADNVPLSDGWIHNVITNCWKQLTHLPKTKPRLWHTACLGKENEIMVFGGSKDDLLSLDTGHCNDLLIFQTQPYSLLRLCLDCIGKNAIILESQISLLPPKLLQQVLKKITFWTAANHREEQRAQKEETENKYQWISGN", "length": 406, "header": "tr|A0A286ZP18-1|A0A286ZP18_PIG Isoform 1 of Kelch domain containing 1 OS=Sus scrofa OX=9823 GN=KLHDC1 PE=4 SV=1 CANONICAL=A0A286ZP18-1" }, "locus": {} }, { "isoform_ac": "A0A286ZYK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A286ZP18/entry#A0A286ZYK3-1", "sequence": { "sequence": "MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWTMHLMEGELPTSMSGSCGACINGKLYVFGGYDDKGYSNRLYFVNLRTRDGTYIWEKITNFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHNELQDCFDVHDASWVRLPELFIAQTGFCMREEQIFWGWHNDVHIFDTKTQSWLQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRIPVNGENPKHRSWHTLTPIADDTLFLFGGLSADNVPLSDGWIHNVITNCWKQLTHLPKTKPRLWHTACLGKENEIMVFGGSKDDLLSLDTGHCNDLLIFQTQPYSLLRLCLDCIGKNAIILESQISLLPPKLLQQVLKKITFWTAANHREEQRAQKEETENKYQWISGN", "length": 422, "header": "tr|A0A286ZYK3-1|A0A286ZYK3_PIG Computationally mapped isoform of Kelch domain-containing protein 1 OS=Sus scrofa OX=9823 GN=KLHDC1 PE=4 SV=2 CANONICAL=A0A286ZP18-1" }, "locus": {} }, { "isoform_ac": "A0A8W4FPJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A286ZP18/entry#A0A8W4FPJ6-1", "sequence": { "sequence": "MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWTMHLMEGELPTSMSGSCGACINGKLYVFGGYDDKGYSNRLYFVNLRTRDGTYIWEKITNFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHNELQDCFDVHDASWGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRIPVNGENPKHRSWHTLTPIADDTLFLFGGLSADNVPLSDGWIHNVITNCWKQLTHLPKTKPRLWHTACLGKENEIMVFGGSKDDLLSLDTGHCNDLLIFQTQPYSLLRLCLDCIGKNAIILESQISLLPPKLLQQVLKKITFWTAANHREEQRAQKEETENKYQWISGN", "length": 378, "header": "tr|A0A8W4FPJ6-1|A0A8W4FPJ6_PIG Computationally mapped isoform of Kelch domain containing 1 OS=Sus scrofa OX=9823 GN=KLHDC1 PE=4 SV=1 CANONICAL=A0A286ZP18-1" }, "locus": { "chromosome": "1", "start_pos": 179604213, "end_pos": 179540635, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSSSCT00000104441.1", "url": "https://www.ensembl.org/id/ENSSSCT00000104441.1" }, { "database": "Ensembl Peptide", "id": "ENSSSCP00000081123.1", "url": "https://www.ensembl.org/id/ENSSSCP00000081123.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.", "journal": "PeerJ", "date": "2019", "authors": "Gilbert Donald G", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZYK3", "url": "https://www.uniprot.org/uniprot/A0A286ZYK3" } ], "reference": [ { "type": "PubMed", "id": "30723633", "url": "https://glygen.org/publication/PubMed/30723633" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KAE3-1", "protein_name": "Kelch domain containing 1", "gene_name": "Klhdc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEIWTYDVDSGLWKMHLMEGELPPSMSGSCGACINGRLYVFGGYDDKGYSNRLYFVDLRTRDGTYIWEKITKFEGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAIADDKLFLFGGLSADNIPLSDGWIHNIITNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVFQKITFWTAANYRKEQRIQKGETENKQPRVSSC", "length": 406 }, "evidence": [ { "id": "A0A286ZP18", "url": "https://omabrowser.org/oma/group/A0A286ZP18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80YG3-1", "protein_name": "Kelch domain-containing protein 1", "gene_name": "Klhdc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADPQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEMWTYDIDSGLWKMHLMEGELPPSMSGSCGACIHGRLYVFGGYDDKGYSNRLYFVNLRTRDGTYTWEKITKFDGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSDGWIHNITTNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVLKKITFWTAANYRKEQRIRKEETENNQPRVSSC", "length": 406 }, "evidence": [ { "id": "A0A286ZP18", "url": "https://omabrowser.org/oma/group/A0A286ZP18/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N7A1-1", "protein_name": "Kelch domain-containing protein 1", "gene_name": "KLHDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLESQISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN", "length": 406 }, "evidence": [ { "id": "A0A286ZP18", "url": "https://omabrowser.org/oma/group/A0A286ZP18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZP18", "url": "https://www.uniprot.org/uniprot/A0A286ZP18" } ], "pmid": "" }, { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZP18", "url": "https://www.uniprot.org/uniprot/A0A286ZP18" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZP18", "url": "https://www.uniprot.org/uniprot/A0A286ZP18" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "id": "GO:0140627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140627", "evidence": [ { "database": "UniProtKB", "id": "A0A286ZP18", "url": "https://www.uniprot.org/uniprot/A0A286ZP18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], 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