{ "uniprot_canonical_ac": "A0A0G2JSW9-1", "uniprot_ac": "A0A0G2JSW9", "uniprot_id": "A0A0G2JSW9_RAT", "mass": { "chemical_mass": 30322.0, "monoisotopic_mass": 30322.0 }, "refseq": {}, "gene_names": [ { "name": "Cbr1l3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9", "id": "A0A0G2JSW9" }, { "name": "LOC100360601", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9", "id": "A0A0G2JSW9" } ], "protein_names": [ { "name": "Carbonyl reductase (NADPH)", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JSW9/entry#names_and_taxonomy", "id": "A0A0G2JSW9" }, { "name": "1.1.1.184", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JSW9/entry#names_and_taxonomy", "id": "A0A0G2JSW9" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JSW9", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Cbr1l3", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9", "locus": {} } ], "crossref": [ { "id": "cd05324", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05324", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GWPEMAY", "url": "https://omabrowser.org/oma/group/GWPEMAY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR43963", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43963", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43963:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43963:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "http://pfam.xfam.org/family/PF00106", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "2321756", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2321756", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "19257", "url": "https://www.rhea-db.org/rhea/19257", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JSW9", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JSW9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSYNRVALVTGANKGIGFAITRDLCRKFPGDVVLTARDEARGRAAVQQLQAEGLSPRFHQLDIDNPQSICALRDFLRKEYGGLDVLVNNAGIGTDLNHFHIQREAAMKTNFFGTQAVCTELLPLIKTQGRVVNVSSLISLEALKNCSPELRQKFRSETITEEELVGLMNKFVEDAKEGVHEKEGWPNSAYAVSKIGVTVLSRIYARKLNEERRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLTPDAEGPHGQFVQDKKVEQW", "length": 274, "header": "tr|A0A0G2JSW9-1|A0A0G2JSW9_RAT Isoform 1 of Carbonyl reductase (NADPH) OS=Rattus norvegicus OX=10116 GN=Cbr1l3 PE=1 SV=1 CANONICAL=A0A0G2JSW9-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JSW9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JSW9/entry#A0A0G2JSW9-1", "sequence": { "sequence": "MPSYNRVALVTGANKGIGFAITRDLCRKFPGDVVLTARDEARGRAAVQQLQAEGLSPRFHQLDIDNPQSICALRDFLRKEYGGLDVLVNNAGIGTDLNHFHIQREAAMKTNFFGTQAVCTELLPLIKTQGRVVNVSSLISLEALKNCSPELRQKFRSETITEEELVGLMNKFVEDAKEGVHEKEGWPNSAYAVSKIGVTVLSRIYARKLNEERRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLTPDAEGPHGQFVQDKKVEQW", "length": 274, "header": "tr|A0A0G2JSW9-1|A0A0G2JSW9_RAT Isoform 1 of Carbonyl reductase (NADPH) OS=Rattus norvegicus OX=10116 GN=Cbr1l3 PE=1 SV=1 CANONICAL=A0A0G2JSW9-1" }, "locus": { "chromosome": "11", "start_pos": 32991997, "end_pos": 32985707, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000041838.6", "url": "https://www.ensembl.org/id/ENSRNOT00000041838.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000051107.5", "url": "https://www.ensembl.org/id/ENSRNOP00000051107.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JSW9", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JSW9", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbonyl reductase (NADPH) activity", "id": "GO:0004090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004090", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JSW9", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19257", "name": "", "equation": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P47727-1", "Q8VID1-1", "A0A0G2JSW9-1", "B2GV72-1" ], "evidence": [ { "id": "19257", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19257" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JSW9", "gene_name": "Cbr1l3", "activity": [ { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "A0A0G2JSW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "A0A0G2JSW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JSW9" } ] } ] }, { "uniprot_ac": "B2GV72", "gene_name": "Cbr3", "activity": [ { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "B2GV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV72" } ] }, { "ec_number": "1.6.5.10", "activity": "a quinone + H(+) + NADPH = a quinol + NADP(+).", "evidence": [ { "id": "B2GV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV72" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "B2GV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV72" } ] } ] }, { "uniprot_ac": "P47727", "gene_name": "Cbr1", "activity": [ { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "P47727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47727" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "P47727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47727" } ] }, { "ec_number": "1.1.1.189", "activity": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2.", "evidence": [ { "id": "P47727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47727" } ] }, { "ec_number": "1.1.1.197", "activity": "NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH.", "evidence": [ { "id": "P47727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47727" } ] }, { "ec_number": "1.1.1.196", "activity": "NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH.", "evidence": [ { "id": "P47727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47727" } ] }, { "ec_number": "1.1.1.71", "activity": "a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH.", "evidence": [ { "id": "P47727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47727" } ] } ] }, { "uniprot_ac": "Q8VID1", "gene_name": "Dhrs4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] } ] } ], "biomarkers": 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