{ "uniprot_canonical_ac": "P13584-1", "uniprot_ac": "P13584", "uniprot_id": "CP4B1_HUMAN", "mass": { "chemical_mass": 58991.0, "monoisotopic_mass": 58991.0 }, "refseq": { "ac": "NP_000770", "name": "cytochrome P450 4B1 isoform b", "summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" }, "gene_names": [ { "name": "CYP4B1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P13584", "id": "P13584" }, { "name": "CYP4B1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770", "id": "NP_000770" }, { "name": "CYPIVB1; P-450HP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770", "id": "NP_000770" } ], "protein_names": [ { "name": "Cytochrome P450 4B1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P13584" }, { "name": "1.14.14.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13584" }, { "name": "CYPIVB1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13584" }, { "name": "Cytochrome P450-HP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13584" }, { "name": "cytochrome P450 4B1 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770", "id": "NP_000770" }, { "name": "microsomal monooxygenase; cytochrome P450, subfamily IVB, polypeptide 1; cytochrome P450 4B1; cytochrome P450-HP; cytochrome P450, family 4, subfamily B, polypeptide 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770", "id": "NP_000770" } ], "function": [ { "annotation": "CYP4B1 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" }, { "database": "PubMed", "id": "33592039", "url": "https://glygen.org/publication/PubMed/33592039" } ] }, { "annotation": "CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" }, { "database": "PubMed", "id": "38041008", "url": "https://glygen.org/publication/PubMed/38041008" } ] }, { "annotation": "Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" }, { "database": "PubMed", "id": "36307788", "url": "https://glygen.org/publication/PubMed/36307788" } ] }, { "annotation": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584#function" } ] }, { "annotation": "Missense variants in CYP4B1 associated with increased risk of lung cancer among Chinese Han population. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" }, { "database": "PubMed", "id": "37950293", "url": "https://glygen.org/publication/PubMed/37950293" } ] }, { "annotation": "Reviews ability of CYP4B1 to hydroxylate fatty acids and fatty alcohols, its role in xenobiotic and endobiotic metabolism, and its unusual heme-binding characteristics Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" }, { "database": "PubMed", "id": "36768362", "url": "https://glygen.org/publication/PubMed/36768362" } ] }, { "annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_000770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000770" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P13584", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P13584" } ], "glycoeffect": [], "start_pos": 188, "end_pos": 188, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "1", "chr_pos": "46813549", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A188", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P13584", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13584" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P13584", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13584" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSTIMTSSTGSPHMAAASCGPARWPMTIQTRSSGSGRQPCRMRRCGRRSRTGGTWTSWTFSWVPGMKMTSNCQMQTSGLKWTHSCLKAMTPPPVVSPGFSTAWPCTLSTSIVVERRSARS", "length": 325, "header": "tr|E9PML0-1|CP4B1_HUMAN Computationally mapped isoform of Cytochrome P450 4B1 OS=Homo sapiens OX=9606 GN=CYP4B1 PE=1 SV=1 CANONICAL=P13584-1" }, "locus": { "chromosome": "1", "start_pos": 46815239, "end_pos": 46799082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000464439.6", "url": "https://www.ensembl.org/id/ENST00000464439.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000433068.1", "url": "https://www.ensembl.org/id/ENSP00000433068.1" } ] } }, { "isoform_ac": "F5H1Q8-1", "url": "", "sequence": { "sequence": "MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYH", "length": 70, "header": "tr|F5H1Q8-1|CP4B1_HUMAN Computationally mapped isoform of Cytochrome P450 4B1 OS=Homo sapiens OX=9606 GN=CYP4B1 PE=1 SV=1 CANONICAL=P13584-1" }, "locus": { "chromosome": "1", "start_pos": 46813987, "end_pos": 46812618, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000526297.5", "url": "https://www.ensembl.org/id/ENST00000526297.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000438995.1", "url": "https://www.ensembl.org/id/ENSP00000438995.1" } ] } }, { "isoform_ac": "F5H5Q6-1", "url": "", "sequence": { "sequence": "MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGGGCVSFVSHLAMSSDTSSWTQALWVQLRYRN", "length": 138, "header": "tr|F5H5Q6-1|CP4B1_HUMAN Computationally mapped isoform of Cytochrome P450 4B1 OS=Homo sapiens OX=9606 GN=CYP4B1 PE=1 SV=1 CANONICAL=P13584-1" }, "locus": { "chromosome": "1", "start_pos": 46812268, "end_pos": 46799082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000529715.5", "url": "https://www.ensembl.org/id/ENST00000529715.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000443212.1", "url": "https://www.ensembl.org/id/ENSP00000443212.1" } ] } }, { "isoform_ac": "P13584-1", "url": "", "sequence": { "sequence": "MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK", "length": 511, "header": "sp|P13584-1|CP4B1_HUMAN Isoform 1 of Cytochrome P450 4B1 OS=Homo sapiens OX=9606 GN=CYP4B1 PE=1 SV=2 CANONICAL=P13584-1" }, "locus": { "chromosome": "1", "start_pos": 46818811, "end_pos": 46799082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000271153.8", "url": "https://www.ensembl.org/id/ENST00000271153.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000271153.4", "url": "https://www.ensembl.org/id/ENSP00000271153.4" } ] } }, { "isoform_ac": "P13584-2", "url": "", "sequence": { "sequence": "MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK", "length": 512, "header": "sp|P13584-2|CP4B1_HUMAN Isoform 2 of Cytochrome P450 4B1 OS=Homo sapiens OX=9606 GN=CYP4B1 PE=1 SV=2 CANONICAL=P13584-1" }, "locus": { "chromosome": "1", "start_pos": 46818811, "end_pos": 46799082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000371923.9", "url": "https://www.ensembl.org/id/ENST00000371923.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000360991.4", "url": "https://www.ensembl.org/id/ENSP00000360991.4" } ] } }, { "isoform_ac": "Q8IZB0-1", "url": "", "sequence": { "sequence": "MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK", "length": 497, "header": "tr|Q8IZB0-1|Q8IZB0_HUMAN Computationally mapped isoform of Pulmonary cytochrome P450 4B1 variant OS=Homo sapiens OX=9606 GN=CYP4B1 PE=1 SV=1 CANONICAL=P13584-1" }, "locus": { "chromosome": "1", "start_pos": 46818811, "end_pos": 46799082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000371919.8", "url": "https://www.ensembl.org/id/ENST00000371919.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000360987.4", "url": "https://www.ensembl.org/id/ENSP00000360987.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 301, "end_pos": 301, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P13584", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P13584" }, { "database": "PubMed", "id": "35494241", "url": "" } ], "site_lbl": "Ser301" }, { "start_pos": 436, "end_pos": 436, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "site_lbl": "Ser436" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.", "journal": "Journal of lipid research", "date": "1999", "authors": "Sjolinder M, Tornhamre S, Claesson HE, Hydman J, Lindgren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "10064732", "url": "https://glygen.org/publication/PubMed/10064732" } ] }, { "title": "Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Bylund J, Finnstrom N, Oliw EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-211979", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211979" } ], "reference": [ { "type": "PubMed", "id": "10405341", "url": "https://glygen.org/publication/PubMed/10405341" } ] }, { "title": "5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Werz O, Klemm J, Samuelsson B, Radmark O", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "10779545", "url": "https://glygen.org/publication/PubMed/10779545" } ] }, { "title": "Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Bylund J, Hidestrand M, Ingelman-Sundberg M, Oliw EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-211979", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211979" } ], "reference": [ { "type": "PubMed", "id": "10791960", "url": "https://glygen.org/publication/PubMed/10791960" } ] }, { "title": "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.", "journal": "Molecular pharmacology", "date": "2001", "authors": "Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "11160876", "url": "https://glygen.org/publication/PubMed/11160876" } ] }, { "title": "cDna cloning and expression of CYP4F12, a novel human cytochrome P450.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Bylund J, Bylund M, Oliw EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-211935", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211935" } ], "reference": [ { "type": "PubMed", "id": "11162607", "url": "https://glygen.org/publication/PubMed/11162607" } ] }, { "title": "Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Werz O, Szellas D, Steinhilber D, Radmark O", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "11844797", "url": "https://glygen.org/publication/PubMed/11844797" } ] }, { "title": "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant.", "journal": "Pharmacogenetics", "date": "2002", "authors": "Lo-Guidice JM, Allorge D, Cauffiez C, Chevalier D, Lafitte JJ, Lhermitte M, Broly F", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "reference": [ { "type": "PubMed", "id": "12142726", "url": "https://glygen.org/publication/PubMed/12142726" } ] }, { "title": "Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole.", "journal": "Mol. Pharmacol.", "date": "2003", "authors": "Carr Brian A, Ramakanth Swayampakula, Dannan Ghazi A, Yost Garold S", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "reference": [ { "type": "PubMed", "id": "12695542", "url": "https://glygen.org/publication/PubMed/12695542" } ] }, { "title": "Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.", "journal": "Lancet (London, England)", "date": "2003", "authors": "Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson J, Ibbotson SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "12711469", "url": "https://glygen.org/publication/PubMed/12711469" } ] }, { "title": "5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease.", "journal": "Agents and actions", "date": "1992", "authors": "Rask-Madsen J, Bukhave K, Laursen LS, Lauritsen K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "1359745", "url": "https://glygen.org/publication/PubMed/1359745" } ] }, { "title": "CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "14660610", "url": "https://glygen.org/publication/PubMed/14660610" } ] }, { "title": "Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids.", "journal": "Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics", "date": "2004", "authors": "Ashkar S, Mesentsev A, Zhang WX, Mastyugin V, Dunn MW, Laniado-Schwartzman M", "evidence": [ { "database": "Reactome", "id": "R-HSA-211935", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211935" } ], "reference": [ { "type": "PubMed", "id": "15006160", "url": "https://glygen.org/publication/PubMed/15006160" } ] }, { "title": "CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.", "journal": "Cancer research", "date": "2004", "authors": "Zeigler-Johnson C, Friebel T, Walker AH, Wang Y, Spangler E, Panossian S, Patacsil M, Aplenc R, Wein AJ, Malkowicz SB, Rebbeck TR", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "15548719", "url": "https://glygen.org/publication/PubMed/15548719" } ] }, { "title": "Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.", "journal": "Dermatology (Basel, Switzerland)", "date": "2005", "authors": "Zouboulis ChC, Saborowski A, Boschnakow A", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "15604543", "url": "https://glygen.org/publication/PubMed/15604543" } ] }, { "title": "Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.", "journal": "Human molecular genetics", "date": "2006", "authors": "Lefevre C, Bouadjar B, Ferrand V, Tadini G, Megarbane A, Lathrop M, Prud'homme JF, Fischer J", "evidence": [ { "database": "Reactome", "id": "R-HSA-211979", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211979" } ], "reference": [ { "type": "PubMed", "id": "16436457", "url": "https://glygen.org/publication/PubMed/16436457" } ] }, { "title": "Enzymatic properties of human CYP2W1 expressed in Escherichia coli.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Yoshioka H, Kasai N, Ikushiro S, Shinkyo R, Kamakura M, Ohta M, Inouye K, Sakaki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "16677611", "url": "https://glygen.org/publication/PubMed/16677611" } ] }, { "title": "Efficacy and tolerability of olsalazine (dipentum) in the treatment of patients with ulcerative colitis--results of a field study.", "journal": "Hepato-gastroenterology", "date": "2006", "authors": "Singer MV, Schmausser H, Schonfeld G", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "16795963", "url": "https://glygen.org/publication/PubMed/16795963" } ] }, { "title": "Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.", "journal": "Journal of lipid research", "date": "2008", "authors": "Dhar M, Sepkovic DW, Hirani V, Magnusson RP, Lasker JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "18065749", "url": "https://glygen.org/publication/PubMed/18065749" } ] }, { "title": "Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Feltenmark S, Gautam N, Brunnstrom A, Griffiths W, Backman L, Edenius C, Lindbom L, Bjorkholm M, Claesson HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "18184802", "url": "https://glygen.org/publication/PubMed/18184802" } ] }, { "title": "5-lipoxygenase inhibitory activity of zileuton.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "1991", "authors": "Carter GW, Young PR, Albert DH, Bouska J, Dyer R, Bell RL, Summers JB, Brooks DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "1848634", "url": "https://glygen.org/publication/PubMed/1848634" } ] }, { "title": "Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.", "journal": "The FEBS journal", "date": "2008", "authors": "Claesson HE, Griffiths WJ, Brunnstrom A, Schain F, Andersson E, Feltenmark S, Johnson HA, Porwit A, Sjoberg J, Bjorkholm M", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "18647347", "url": "https://glygen.org/publication/PubMed/18647347" } ] }, { "title": "Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis.", "journal": "Expert opinion on drug metabolism & toxicology", "date": "2009", "authors": "Wiggins JB, Rajapakse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "19743890", "url": "https://glygen.org/publication/PubMed/19743890" } ] }, { "title": "Zileuton, a new efficient and safe systemic anti-acne drug.", "journal": "Dermato-endocrinology", "date": "2009", "authors": "Zouboulis CC", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": 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Gene structure and expression.", "journal": "Eur. J. 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"MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKPLGPGSGK", "length": 511 }, "evidence": [ { "id": "45930006", "url": "http://www.informatics.jax.org/homology/45930006", "database": "MGI" }, { "id": "P13584", "url": "https://omabrowser.org/oma/group/P13584/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "aromatase activity", "id": "GO:0070330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "heterocyclic compound binding", "id": "GO:1901363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901363", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" }, { "name": "biphenyl metabolic process", "id": "GO:0018879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018879", "evidence": [ { "database": "UniProtKB", "id": "P13584", "url": "https://www.uniprot.org/uniprot/P13584" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 434, "end_pos": 436, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17149", "name": "", "equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11711-1", "P05182-1", "A0A8I6A0P6-1", "P10633-1", "P51538-1", "P00176-1", "P05178-1", "P10610-1", "P13107-1", "P20812-1", "P33272-1", "P51870-1", "P00185-1", "Q64581-1", "P05179-1", "P51871-1", "P04167-1", "P04800-1", "P05183-1", "P10634-1", "P11510-1", "P12938-1", "P12939-1", "P15129-1", "P15149-1", "P20814-1", "P33273-1", "P51590-1", "Q64583-1", "Q64680-1", "P04799-1", "Q64678-1", "P08683-1", "P24464-1", "D4A820-1", "A0A0G2K5K4-1", "F1LT33-1", "G3V9D2-1", "Q9QXF7-1", "A0A8I5ZZ08-1", "P05181-1", "A0A087X1C5-1", "P08684-1", "P20853-1", "P04798-1", "P05177-1", "P33261-1", "Q86W10-1", "Q16678-1", "P98187-1", "P10632-1", "P24462-1", "Q9HB55-1", "P13584-1", "Q16696-1", "Q9HCS2-1", "P33260-1", "Q02928-1", "Q08477-1", "Q9HBI6-1", "P78329-1", "P11712-1", "P24903-1", "P20815-1", "Q6V0L0-1", "P20852-1", "O09158-1", "O55071-1", "Q64459-1", "Q64481-1", "O54749-1", "P15392-1", "Q8CIM7-1", "P56654-1", "P56655-1", "P56656-1", "P12791-1", "P56593-1", "O54750-1", "Q91WL5-1", "Q91X77-1", "Q64458-1", "P00186-1", "P00184-1", "Q6XVG2-1", "Q9D816-1", "P11714-1", "P12790-1", "P24457-1", "Q9JMA7-1", "P24456-1", "Q64462-1", "Q64464-1", "Q05421-1", "Q64429-1", "D3YYZ0-1", "D3Z2W7-1", "B2RXZ2-1", "Q9WV19-1", "Q9DBX6-1", "E9Q593-1", "A2A974-1", "A6H6J2-1", "Q9EQW4-1", "B2RXA7-1" ], "evidence": [ { "id": "17149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17149" } ] }, { "id": "R-HSA-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "equation": "", "summary": "Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-266056" ], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-211873", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211873" } ] }, { "id": "R-HSA-211924", "name": "CYP4B1 12-hydroxylates ARA", "equation": "", "summary": "Injury to the eye's surface provokes an inflammatory response, mediated, in part, by 12-hydroxyeicosanoids. CYP4B1 catalyses the 12-hydroxylation of arachidonic acid (ARA) to 12-HETE and 12-HETrE (12-hydroxy-5,8,10,14-eicosatetraenoic acid and 12-hydroxy-5,8,14-eicosatrienoic acid respectively). Both these metabolites possess potent inflammatory and angiogenic properties (Ashkar et al. 2004). The example of 12-HETE formation only is shown here.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [], "output_participant_list": [ "R-ALL-215075" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-211924", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211924" } ] }, { "id": "R-HSA-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "equation": "", "summary": "Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-216621" ], "output_participant_list": [ "R-ALL-216612" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-211962", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211962" } ] }, { "id": "R-HSA-215526", "name": "CYP4F3 20-hydroxylates LTB4", "equation": "", "summary": "Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4). This deactivation can be carried out by CYP4F3 in addition to CYP4F2 (Kikuta et al. 1998).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-215557" ], "output_participant_list": [ "R-ALL-571314" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-215526", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-215526" } ] }, { "id": "R-HSA-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "equation": "", "summary": "The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-2161636" ], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-2161745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161745" } ] }, { "id": "R-HSA-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "equation": "", "summary": "The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise 20-aldehyde leukotriene B4 (20cho-LTB4) to form 20-carboxy leukotriene B4 (20cooh-LTB4) (Soberman et al. 1988).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-2142740" ], "output_participant_list": [ "R-ALL-2161582" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-2161792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161792" } ] }, { "id": "R-HSA-76466", "name": "CYP4A11 12-hydroxylates DDCX", "equation": "", "summary": "Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-33549" ], "output_participant_list": [ "R-ALL-42373" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-76466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76466" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2142740", "participant_name": "20cho-LTB4 [cytosol]", "crossref": [ { "id": "63979", "database": "ChEBI", "url": "" }, { "id": "HMDB0012641", "database": "HMDB Metabolite", "url": "" }, { "id": "000033985160", "database": "ZINC", "url": "" }, { "id": "63979", "database": "ChEBI", "url": "" }, { "id": "HMDB0012641", "database": "HMDB Metabolite", "url": "" }, { "id": "000033985160", "database": "ZINC", "url": "" }, { "id": "63979", "database": "ChEBI", "url": "" }, { "id": "HMDB0012641", "database": "HMDB Metabolite", "url": "" }, { "id": "000033985160", "database": "ZINC", "url": "" }, { "id": "63979", "database": "ChEBI", "url": "" }, { "id": "HMDB0012641", "database": "HMDB Metabolite", "url": "" }, { "id": "000033985160", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-215075", "participant_name": "12-HETE [endoplasmic reticulum lumen]", "crossref": [ { "id": "19138", "database": "ChEBI", "url": "" }, { "id": "000033838755", "database": "ZINC", "url": "" }, { "id": "000033838754", "database": "ZINC", "url": "" }, { "id": "HMDB0244455", "database": "HMDB Metabolite", "url": "" }, { "id": "19138", "database": "ChEBI", "url": "" }, { "id": "000033838754", "database": "ZINC", "url": "" }, { "id": "HMDB0244455", "database": "HMDB Metabolite", "url": "" }, { "id": "000033838755", "database": "ZINC", "url": "" }, { "id": "000033838755", "database": "ZINC", "url": "" }, { "id": "HMDB0244455", "database": "HMDB Metabolite", "url": "" }, { "id": "000033838754", "database": "ZINC", "url": "" }, { "id": "19138", "database": "ChEBI", "url": "" }, { "id": "19138", "database": "ChEBI", "url": "" }, { "id": "000033838755", "database": "ZINC", "url": "" }, { "id": "000033838754", "database": "ZINC", "url": "" }, { "id": "HMDB0244455", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-215557", "participant_name": "LTB4 [endoplasmic reticulum lumen]", "crossref": [ { "id": "HMDB0001085", "database": "HMDB Metabolite", "url": "" }, { "id": "2487", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C02165", "database": "COMPOUND", "url": "" }, { "id": "000004623738", "database": "ZINC", "url": "" }, { "id": "HMDB0002995", "database": "HMDB Metabolite", "url": "" }, { "id": "15647", "database": "ChEBI", "url": "" }, { "id": "C02165", "database": "COMPOUND", "url": "" }, { "id": "15647", "database": "ChEBI", "url": "" }, { "id": "HMDB0001085", 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"participant_id": "R-ALL-2161582", "participant_name": "20cooh-LTB4 [cytosol]", "crossref": [ { "id": "27562", "database": "ChEBI", "url": "" }, { "id": "000004632132", "database": "ZINC", "url": "" }, { "id": "C05950", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006059", "database": "HMDB Metabolite", "url": "" }, { "id": "27562", "database": "ChEBI", "url": "" }, { "id": "C05950", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006059", "database": "HMDB Metabolite", "url": "" }, { "id": "000004632132", "database": "ZINC", "url": "" }, { "id": "27562", "database": "ChEBI", "url": "" }, { "id": "C05950", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006059", "database": "HMDB Metabolite", "url": "" }, { "id": "000004632132", "database": "ZINC", "url": "" }, { "id": "27562", "database": "ChEBI", "url": "" }, { "id": "000004632132", "database": "ZINC", "url": "" }, { "id": "C05950", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006059", "database": "HMDB Metabolite", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] } ] }, { "uniprot_ac": "P00185", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] } ] }, { "uniprot_ac": "P00186", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] } ] }, { "uniprot_ac": "P04167", "gene_name": "Cyp2b2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] } ] }, { "uniprot_ac": "P04798", "gene_name": "CYP1A1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] } ] }, { "uniprot_ac": "P04799", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] } ] }, { "uniprot_ac": "P04800", "gene_name": "Cyp3a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] } ] }, { "uniprot_ac": "P05177", "gene_name": "CYP1A2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] } ] }, { "uniprot_ac": "P05178", "gene_name": "Cyp2c6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] } ] }, { "uniprot_ac": "P05179", "gene_name": "Cyp2c7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] } ] }, { "uniprot_ac": "P05181", "gene_name": "CYP2E1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] } ] }, { "uniprot_ac": "P05182", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] } ] }, { "uniprot_ac": "P05183", "gene_name": "Cyp3a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] } ] }, { "uniprot_ac": "P08683", "gene_name": "Cyp2c11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] } ] }, { "uniprot_ac": "P08684", "gene_name": "CYP3A4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.55", "activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.56", "activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] } ] }, { "uniprot_ac": "P10610", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] } ] }, { "uniprot_ac": "P10632", "gene_name": "CYP2C8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] } ] }, { "uniprot_ac": "P10633", "gene_name": "Cyp2d1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] } ] }, { "uniprot_ac": "P10634", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] } ] }, { "uniprot_ac": "P11510", "gene_name": "Cyp2c12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] } ] }, { "uniprot_ac": "P11711", "gene_name": "Cyp2a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] } ] }, { "uniprot_ac": "P11712", "gene_name": "CYP2C9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] } ] }, { "uniprot_ac": "P11714", "gene_name": "Cyp2d9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] } ] }, { "uniprot_ac": "P12790", "gene_name": "Cyp2b9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] } ] }, { "uniprot_ac": "P12791", "gene_name": "Cyp2b10", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] } ] }, { "uniprot_ac": "P12938", "gene_name": "Cyp2d3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] } ] }, { "uniprot_ac": "P12939", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] } ] }, { "uniprot_ac": "P13107", "gene_name": "Cyp2b3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] } ] }, { "uniprot_ac": "P13584", "gene_name": "CYP4B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] } ] }, { "uniprot_ac": "P15129", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] } ] }, { "uniprot_ac": "P15149", "gene_name": "Cyp2a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] } ] }, { "uniprot_ac": "P15392", "gene_name": "Cyp2a4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] } ] }, { "uniprot_ac": "P20812", "gene_name": "Cyp2a3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] } ] }, { "uniprot_ac": "P20814", "gene_name": "Cyp2c13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] } ] }, { "uniprot_ac": "P20815", "gene_name": "CYP3A5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] } ] }, { "uniprot_ac": "P20852", "gene_name": "Cyp2a5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] } ] }, { "uniprot_ac": "P20853", "gene_name": "CYP2A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] } ] }, { "uniprot_ac": "P24456", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] } ] }, { "uniprot_ac": "P24457", "gene_name": "Cyp2d11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] } ] }, { "uniprot_ac": "P24462", "gene_name": "CYP3A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] } ] }, { "uniprot_ac": "P24464", "gene_name": "Cyp4a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] } ] }, { "uniprot_ac": "P24903", "gene_name": "CYP2F1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] } ] }, { "uniprot_ac": "P33260", "gene_name": "CYP2C18", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] } ] }, { "uniprot_ac": "P33261", "gene_name": "CYP2C19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.75", "activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] } ] }, { "uniprot_ac": "P33272", "gene_name": "Cyp2b12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] } ] }, { "uniprot_ac": "P33273", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] } ] }, { "uniprot_ac": "P51538", "gene_name": "Cyp3a9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] } ] }, { "uniprot_ac": "P51590", "gene_name": "Cyp2j3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] } ] }, { "uniprot_ac": "P51870", "gene_name": "Cyp4f5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] } ] }, { "uniprot_ac": "P51871", "gene_name": "Cyp4f6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] } ] }, { "uniprot_ac": "P56593", "gene_name": "Cyp2a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] } ] }, { "uniprot_ac": "P56654", "gene_name": "Cyp2c37", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] } ] }, { "uniprot_ac": "P56655", "gene_name": "Cyp2c38", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] } ] }, { "uniprot_ac": "P56656", "gene_name": "Cyp2c39", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] } ] }, { "uniprot_ac": "P78329", "gene_name": "CYP4F2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] } ] }, { "uniprot_ac": "P98187", "gene_name": "CYP4F8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] } ] }, { "uniprot_ac": "Q02928", "gene_name": "CYP4A11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] } ] }, { "uniprot_ac": "Q05421", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] } ] }, { "uniprot_ac": "Q08477", "gene_name": "CYP4F3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] } ] }, { "uniprot_ac": "Q16678", "gene_name": "CYP1B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] } ] }, { "uniprot_ac": "Q16696", "gene_name": "CYP2A13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] } ] }, { "uniprot_ac": "Q5TCH4", "gene_name": "CYP4A22", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q5TCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TCH4" } ] } ] }, { "uniprot_ac": "Q64429", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] } ] }, { "uniprot_ac": "Q64458", "gene_name": "Cyp2c29", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] } ] }, { "uniprot_ac": "Q64459", "gene_name": "Cyp3a11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] } ] }, { "uniprot_ac": "Q64462", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] } ] }, { "uniprot_ac": "Q64464", "gene_name": "Cyp3a13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] } ] }, { "uniprot_ac": "Q64481", "gene_name": "Cyp3a16", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] } ] }, { "uniprot_ac": "Q64581", "gene_name": "Cyp3a18", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] } ] }, { "uniprot_ac": "Q64583", "gene_name": "Cyp2b15", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] } ] }, { "uniprot_ac": "Q64678", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] } ] }, { "uniprot_ac": "Q64680", "gene_name": "Cyp2d4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64680" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64680" } ] } ] }, { "uniprot_ac": "Q6NT55", "gene_name": "CYP4F22", "activity": [ { "ec_number": "1.14.14.177", "activity": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6NT55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT55" } ] }, { "ec_number": "1.14.14.177", "activity": "", "evidence": [ { "id": "Q6NT55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT55" } ] } ] }, { "uniprot_ac": "Q6V0L0", "gene_name": "CYP26C1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] } ] }, { "uniprot_ac": "Q6XVG2", "gene_name": "Cyp2c54", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6XVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XVG2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6XVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XVG2" } ] } ] }, { "uniprot_ac": "Q86W10", "gene_name": "CYP4Z1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] }, { "ec_number": "1.14.14.130", "activity": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] } ] }, { "uniprot_ac": "Q8CIM7", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] } ] }, { "uniprot_ac": "Q91WL5", "gene_name": "Cyp4a12a", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q91WL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WL5" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q91WL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WL5" } ] } ] }, { "uniprot_ac": "Q91X77", "gene_name": "Cyp2c50", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q91X77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X77" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q91X77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X77" } ] } ] }, { "uniprot_ac": "Q9D816", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9D816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D816" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9D816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D816" } ] } ] }, { "uniprot_ac": "Q9DBX6", "gene_name": "Cyp2s1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] } ] }, { "uniprot_ac": "Q9EQW4", "gene_name": "Cyp3a44", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9EQW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQW4" } ] } ] }, { "uniprot_ac": "Q9HB55", "gene_name": "CYP3A43", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HB55" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HB55" } ] } ] }, { "uniprot_ac": "Q9HBI6", "gene_name": "CYP4F11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] } ] }, { "uniprot_ac": "Q9HCS2", "gene_name": "CYP4F12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HCS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCS2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HCS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCS2" } ] } ] }, { "uniprot_ac": "Q9JMA7", "gene_name": "Cyp3a41a", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9JMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9JMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMA7" } ] } ] }, { "uniprot_ac": "Q9QXF7", "gene_name": "CYP2J4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9QXF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXF7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9QXF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXF7" } ] } ] }, { "uniprot_ac": "Q9WV19", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9WV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV19" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9WV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV19" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 188, 293, 429 ], "glycation_sites": [], "phosphorylation_sites": [ 301, 436 ], "sequon_annotation_sites": [ { "start_pos": 434, "end_pos": 436 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 63 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }