{ "uniprot_canonical_ac": "P12955-1", "uniprot_ac": "P12955", "uniprot_id": "PEPD_HUMAN", "mass": { "chemical_mass": 54548.0, "monoisotopic_mass": 54548.0 }, "refseq": { "ac": "NP_000276", "name": "xaa-Pro dipeptidase isoform 1", "summary": "This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" }, "gene_names": [ { "name": "PEPD", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P12955", "id": "P12955" }, { "name": "PEPD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276", "id": "NP_000276" }, { "name": "PRD", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P12955", "id": "P12955" }, { "name": "PROLIDASE", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276", "id": "NP_000276" } ], "protein_names": [ { "name": "Xaa-Pro dipeptidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P12955" }, { "name": "3.4.13.9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12955" }, { "name": "Imidodipeptidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12955" }, { "name": "Peptidase D", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12955" }, { "name": "Prolidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12955" }, { "name": "Proline dipeptidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12955" }, { "name": "X-Pro dipeptidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12955" }, { "name": "proline dipeptidase; xaa-Pro dipeptidase; imidodipeptidase; aminoacyl-L-proline hydrolase; X-Pro dipeptidase; testicular tissue protein Li 138", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276", "id": "NP_000276" }, { "name": "xaa-Pro dipeptidase isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276", "id": "NP_000276" } ], "function": [ { "annotation": "Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654).", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955#function" }, { "database": "PubMed", "id": "35165443", "url": "https://glygen.org/publication/PubMed/35165443" }, { "database": "PubMed", "id": "2925654", "url": "https://glygen.org/publication/PubMed/2925654" }, { "database": "PubMed", "id": "17081196", "url": "https://glygen.org/publication/PubMed/17081196" } ] }, { "annotation": "Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" }, { "database": "PubMed", "id": "34880421", "url": "https://glygen.org/publication/PubMed/34880421" } ] }, { "annotation": "Prolidase as a marker of fibrogenesis in idiopathic primary ovarian insufficiency.", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" }, { "database": "PubMed", "id": "36521400", "url": "https://glygen.org/publication/PubMed/36521400" } ] }, { "annotation": "The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia.", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" }, { "database": "PubMed", "id": "36591822", "url": "https://glygen.org/publication/PubMed/36591822" } ] }, { "annotation": "This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" } ] } ], "disease": [ { "disease_id": "DOID:0111540", "recommended_name": { "id": "DOID:0111540", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111540", "name": "prolidase deficiency", "description": "An amino acid metabolic disorder characterized by massive imidodipeptiduria, chronic and slowly healing ulcerations, recurrent infections, dysmorphic facial features, variable cognitive impairment, splenomegaly, and lack of or reduced prolidase activity that has_material_basis_in homozygous or compound heterozygous mutation in the PEPD gene on chromosome 19q13.11." }, "synonyms": [ { "id": "DOID:0111540", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111540", "name": "hyperimidodipeptiduria", "description": "" }, { "id": "DOID:0111540", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111540", "name": "imidodipeptidase deficiency", "description": "" }, { "id": "DOID:0111540", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111540", "name": "peptidase deficiency", "description": "" }, { "id": "MONDO:0008221", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008221", "name": "prolidase deficiency", "description": "An inherited disorder of peptide metabolism characterized by severe skin lesions, recurrent infections (involving mainly the skin and respiratory system), dysmorphic facial features, variable cognitive impairment, and splenomegaly." }, { "id": "MONDO:0008221", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008221", "name": "hyperimidodipeptiduria", "description": "" }, { "id": "MONDO:0008221", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008221", "name": "prolidase deficiency", "description": "" }, { "id": "MONDO:0008221", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008221", "name": "Imidodipeptidase deficiency", "description": "" }, { "id": "MONDO:0008221", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008221", "name": "Peptidase deficiency", "description": "" }, { "id": "MIM:170100", "resource": "MIM", "url": "https://www.omim.org/entry/170100", "name": "Prolidase deficiency", "description": "Prolidase deficiency" } ], "evidence": [ { "id": "170100", "database": "MIM", "url": "https://www.omim.org/entry/170100" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "98.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "84.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "88.94", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "79.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "96.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "85.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "88.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "82.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "95.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.55", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000124299", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000124299" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P12955", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P12955" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P12955", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P12955" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { 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"categories": [ "3D Structure" ] }, { "id": "6SRE", "url": "https://www.rcsb.org/structure/6SRE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6SRF", "url": "https://www.rcsb.org/structure/6SRF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6SRG", "url": "https://www.rcsb.org/structure/6SRG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00557", "url": "http://pfam.xfam.org/family/PF00557", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05195", "url": "http://pfam.xfam.org/family/PF05195", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P12955", "url": "https://pharos.nih.gov/targets/P12955", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P12955", "url": "http://purl.obolibrary.org/obo/PR_P12955", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "76407", "url": "https://www.rhea-db.org/rhea/76407", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A494C165", "url": "https://www.uniprot.org/uniprot/A0A494C165", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C165-1", "url": "https://www.uniprot.org/uniprot/A0A494C165-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C194", "url": "https://www.uniprot.org/uniprot/A0A494C194", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C194-1", "url": "https://www.uniprot.org/uniprot/A0A494C194-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLL9", "url": "https://www.uniprot.org/uniprot/A0A8V8TLL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLL9-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLN7", "url": "https://www.uniprot.org/uniprot/A0A8V8TLN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLN7-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLP2", "url": "https://www.uniprot.org/uniprot/A0A8V8TLP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLP2-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLP4", "url": "https://www.uniprot.org/uniprot/A0A8V8TLP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLP4-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLR1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLR1-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLR6", "url": "https://www.uniprot.org/uniprot/A0A8V8TLR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLR6-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TLR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TM81", "url": "https://www.uniprot.org/uniprot/A0A8V8TM81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TM81-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TM81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TM86", "url": "https://www.uniprot.org/uniprot/A0A8V8TM86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TM86-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TM86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TN48", "url": "https://www.uniprot.org/uniprot/A0A8V8TN48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TN48-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TN48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TN70", "url": "https://www.uniprot.org/uniprot/A0A8V8TN70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TN70-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TN70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TNF2", "url": "https://www.uniprot.org/uniprot/A0A8V8TNF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TNF2-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TNF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TNH5", "url": "https://www.uniprot.org/uniprot/A0A8V8TNH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TNH5-1", "url": "https://www.uniprot.org/uniprot/A0A8V8TNH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ES25", "url": "https://www.uniprot.org/uniprot/K7ES25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ES25-1", "url": "https://www.uniprot.org/uniprot/K7ES25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P12955-1", "url": "https://www.uniprot.org/uniprot/P12955-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P12955-2", "url": "https://www.uniprot.org/uniprot/P12955-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P12955-3", "url": "https://www.uniprot.org/uniprot/P12955-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYE4", "url": "https://www.uniprot.org/uniprot/V9GYE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYE4-1", "url": "https://www.uniprot.org/uniprot/V9GYE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYL0", "url": "https://www.uniprot.org/uniprot/V9GYL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYL0-1", "url": "https://www.uniprot.org/uniprot/V9GYL0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 493, "header": "sp|P12955-1|PEPD_HUMAN Isoform 1 of Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3 CANONICAL=P12955-1" }, "isoforms": [ { "isoform_ac": "A0A494C165-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGDGASPLSRNRQRSCKTPARSRGSHPPGKDRVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 523, "header": "tr|A0A494C165-1|A0A494C165_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=2 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000651901.2", "url": "https://www.ensembl.org/id/ENST00000651901.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000498922.2", "url": "https://www.ensembl.org/id/ENSP00000498922.2" } ] } }, { "isoform_ac": "A0A494C194-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELER", "length": 224, "header": "tr|A0A494C194-1|A0A494C194_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=2 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33462994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000651646.2", "url": "https://www.ensembl.org/id/ENST00000651646.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000498950.2", "url": "https://www.ensembl.org/id/ENSP00000498950.2" } ] } }, { "isoform_ac": "A0A8V8TLL9-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGRACCRRMGFDHPPPALCSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 510, "header": "tr|A0A8V8TLL9-1|A0A8V8TLL9_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698360.1", "url": "https://www.ensembl.org/id/ENST00000698360.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513683.1", "url": "https://www.ensembl.org/id/ENSP00000513683.1" } ] } }, { "isoform_ac": "A0A8V8TLN7-1", "url": "", "sequence": { "sequence": "MGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 386, "header": "tr|A0A8V8TLN7-1|A0A8V8TLN7_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33511035, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698426.1", "url": "https://www.ensembl.org/id/ENST00000698426.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513713.1", "url": "https://www.ensembl.org/id/ENSP00000513713.1" } ] } }, { "isoform_ac": "A0A8V8TLP2-1", "url": "", "sequence": { "sequence": "XPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 430, "header": "tr|A0A8V8TLP2-1|PEPD_HUMAN Computationally mapped isoform of Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33512776, "end_pos": 33387345, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698432.1", "url": "https://www.ensembl.org/id/ENST00000698432.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513718.1", "url": "https://www.ensembl.org/id/ENSP00000513718.1" } ] } }, { "isoform_ac": "A0A8V8TLP4-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGAKSWAFQTLLAEVRYSLVAKALFFHQQKLAANCFHLFQAWSASTSPACGACALHGTCSQAWCSPWSRASTSSTTSWMRPWRTRPAPPSLTARSCSAFAVLAGSASRRTSW", "length": 495, "header": "tr|A0A8V8TLP4-1|A0A8V8TLP4_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698361.1", "url": "https://www.ensembl.org/id/ENST00000698361.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513684.1", "url": "https://www.ensembl.org/id/ENSP00000513684.1" } ] } }, { "isoform_ac": "A0A8V8TLR1-1", "url": "", "sequence": { "sequence": "MGVPAGPRVRASAGVAECRGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 507, "header": "tr|A0A8V8TLR1-1|A0A8V8TLR1_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521695, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698427.1", "url": "https://www.ensembl.org/id/ENST00000698427.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513714.1", "url": "https://www.ensembl.org/id/ENSP00000513714.1" } ] } }, { "isoform_ac": "A0A8V8TLR6-1", "url": "", "sequence": { "sequence": "MAAATGIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFT", "length": 195, "header": "tr|A0A8V8TLR6-1|A0A8V8TLR6_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33401791, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698435.1", "url": "https://www.ensembl.org/id/ENST00000698435.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513719.1", "url": "https://www.ensembl.org/id/ENSP00000513719.1" } ] } }, { "isoform_ac": "A0A8V8TM81-1", "url": "", "sequence": { "sequence": "XVDTGKSTLFVPRLPASHATWMGKDGVSPC", "length": 30, "header": "tr|A0A8V8TM81-1|A0A8V8TM81_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33511096, "end_pos": 33501491, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698430.1", "url": "https://www.ensembl.org/id/ENST00000698430.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513716.1", "url": "https://www.ensembl.org/id/ENSP00000513716.1" } ] } }, { "isoform_ac": "A0A8V8TM86-1", "url": "", "sequence": { "sequence": "GNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEVRSQQYHSSPRDR", "length": 133, "header": "tr|A0A8V8TM86-1|A0A8V8TM86_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33512760, "end_pos": 33478052, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698439.1", "url": "https://www.ensembl.org/id/ENST00000698439.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513721.1", "url": "https://www.ensembl.org/id/ENSP00000513721.1" } ] } }, { "isoform_ac": "A0A8V8TN48-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGRGAHRRARPAEPAHCTAPAARHGAHRGAGHLLHRPPPG", "length": 361, "header": "tr|A0A8V8TN48-1|A0A8V8TN48_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387966, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698362.1", "url": "https://www.ensembl.org/id/ENST00000698362.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513685.1", "url": "https://www.ensembl.org/id/ENSP00000513685.1" } ] } }, { "isoform_ac": "A0A8V8TN70-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQAAMVSSMLTLGSRPCLCPGFLPAMPPGWERSIPRSTSRRSMPWTTSST", "length": 115, "header": "tr|A0A8V8TN70-1|A0A8V8TN70_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33500946, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698436.1", "url": "https://www.ensembl.org/id/ENST00000698436.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513720.1", "url": "https://www.ensembl.org/id/ENSP00000513720.1" } ] } }, { "isoform_ac": "A0A8V8TNF2-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISNRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 478, "header": "tr|A0A8V8TNF2-1|A0A8V8TNF2_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698359.1", "url": "https://www.ensembl.org/id/ENST00000698359.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513682.1", "url": "https://www.ensembl.org/id/ENSP00000513682.1" } ] } }, { "isoform_ac": "A0A8V8TNH5-1", "url": "", "sequence": { "sequence": "ESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLVRSQQYHSSPRDR", "length": 93, "header": "tr|A0A8V8TNH5-1|A0A8V8TNH5_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33511155, "end_pos": 33478052, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698431.1", "url": "https://www.ensembl.org/id/ENST00000698431.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513717.1", "url": "https://www.ensembl.org/id/ENSP00000513717.1" } ] } }, { "isoform_ac": "K7ES25-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGARTGRTVFSVGTMSTPPAGRNGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 515, "header": "tr|K7ES25-1|K7ES25_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=4 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588328.7", "url": "https://www.ensembl.org/id/ENST00000588328.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000468516.4", "url": "https://www.ensembl.org/id/ENSP00000468516.4" } ] } }, { "isoform_ac": "P12955-1", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 493, "header": "sp|P12955-1|PEPD_HUMAN Isoform 1 of Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000244137.12", "url": "https://www.ensembl.org/id/ENST00000244137.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000244137.5", "url": "https://www.ensembl.org/id/ENSP00000244137.5" } ] } }, { "isoform_ac": "P12955-2", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 452, "header": "sp|P12955-2|PEPD_HUMAN Isoform 2 of Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000397032.8", "url": "https://www.ensembl.org/id/ENST00000397032.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000380226.3", "url": "https://www.ensembl.org/id/ENSP00000380226.3" } ] } }, { "isoform_ac": "P12955-3", "url": "", "sequence": { "sequence": "MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK", "length": 429, "header": "sp|P12955-3|PEPD_HUMAN Isoform 3 of Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33521760, "end_pos": 33387347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000436370.7", "url": "https://www.ensembl.org/id/ENST00000436370.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000391890.2", "url": "https://www.ensembl.org/id/ENSP00000391890.2" } ] } }, { "isoform_ac": "V9GYE4-1", "url": "", "sequence": { "sequence": "IASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECWEL", "length": 55, "header": "tr|V9GYE4-1|V9GYE4_HUMAN Computationally mapped isoform of Peptidase D OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33493337, "end_pos": 33477290, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590755.6", "url": "https://www.ensembl.org/id/ENST00000590755.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000476667.1", "url": "https://www.ensembl.org/id/ENSP00000476667.1" } ] } }, { "isoform_ac": "V9GYL0-1", "url": "", "sequence": { "sequence": "XAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKLPAS", "length": 42, "header": "tr|V9GYL0-1|PEPD_HUMAN Computationally mapped isoform of Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=1 CANONICAL=P12955-1" }, "locus": { "chromosome": "19", "start_pos": 33511138, "end_pos": 33493323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590408.1", "url": "https://www.ensembl.org/id/ENST00000590408.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000476869.1", "url": "https://www.ensembl.org/id/ENSP00000476869.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P12955", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12955" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" } ] } ], "phosphorylation": [ { "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P12955", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12955" } ], "site_lbl": "Ser167" }, { "start_pos": 188, "end_pos": 188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P12955", "url": "http://phospho.elm.eu.org/byAccession/P12955.html" }, { "database": "iPTMnet", "id": "P12955", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12955" }, { "database": "PubMed", "id": "16097034", "url": "https://glygen.org/publication/PubMed/16097034" } ], "site_lbl": "Thr188" }, { "start_pos": 487, "end_pos": 487, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P12955", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12955" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" }, { "database": "phospho.ELM", "id": "P12955", "url": "http://phospho.elm.eu.org/byAccession/P12955.html" } ], "site_lbl": "Thr487" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Cluster analysis of an extensive human breast cancer cell line protein expression map database.", "journal": "Proteomics", "date": "2002", "authors": "Harris RA, Yang A, Stein RC, Lucy K, Brusten L, Herath A, Parekh R, Waterfield MD, O'Hare MJ, Neville MA, Page MJ, Zvelebil MJ", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "11840567", "url": "https://glygen.org/publication/PubMed/11840567" } ] }, { "title": "Mutation analysis of five new patients affected by prolidase deficiency: the lack of enzyme activity causes necrosis-like cell death in cultured fibroblasts.", "journal": "Human genetics", "date": "2002", "authors": "Forlino A, Lupi A, Vaghi P, Icaro Cornaglia A, Calligaro A, Campari E, Cetta G", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "12384772", "url": "https://glygen.org/publication/PubMed/12384772" } ] }, { "title": "Large-scale characterization of HeLa cell nuclear phosphoproteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "P12955-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12955-1" } ], "reference": [ { "type": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ] }, { "title": "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.", "journal": "Proteomics", "date": "2005", "authors": "Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J", "evidence": [ { "database": "iPTMnet", "id": "P12955", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12955" } ], "reference": [ { "type": "PubMed", "id": "16097034", "url": "https://glygen.org/publication/PubMed/16097034" } ] }, { "title": "Human recombinant prolidase from eukaryotic and prokaryotic sources. Expression, purification, characterization and long-term stability studies.", "journal": "The FEBS journal", "date": "2006-12", "authors": "Lupi Anna, Della Torre Sara, Campari Elena, Tenni Ruggero, Cetta Giuseppe, Rossi Antonio, Forlino Antonella", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "17081196", "url": "https://glygen.org/publication/PubMed/17081196" } ] }, { "title": "Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "22223895", "url": "https://glygen.org/publication/PubMed/22223895" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12955", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12955" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "A single nucleotide change in the prolidase gene in fibroblasts from two patients with polypeptide positive prolidase deficiency. Expression of the mutant enzyme in NIH 3T3 cells.", "journal": "The Journal of clinical investigation", "date": "1990", "authors": "Tanoue A, Endo F, Kitano A, Matsuda I", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "2365824", "url": "https://glygen.org/publication/PubMed/2365824" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" }, { "database": "iPTMnet", "id": "P12955", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12955" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.", "journal": "Electrophoresis", "date": "2016", "authors": "Li S, Zhu H, Wang J, Wang X, Li X, Ma C, Wen L, Yu B, Wang Y, Li J, Wang PG", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12955", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12955" } ], "reference": [ { "type": "PubMed", "id": "26853435", "url": "https://glygen.org/publication/PubMed/26853435" } ] }, { "title": "Substrate specificity and reaction mechanism of human prolidase.", "journal": "FEBS J.", "date": "2017", "authors": "Wilk P, Uehlein M, Kalms J, Dobbek H, Mueller U, Weiss MS", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "28677335", "url": "https://glygen.org/publication/PubMed/28677335" } ] }, { "title": "Primary structure and gene localization of human prolidase.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Endo F, Tanoue A, Nakai H, Hata A, Indo Y, Titani K, Matsuda I", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "2925654", "url": "https://glygen.org/publication/PubMed/2925654" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12955", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12955" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12955", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12955" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants.", "journal": "Communications biology", "date": "2021", "authors": "Yang L, Li Y, Bhattacharya A, Zhang Y", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" } ], "reference": [ { "type": "PubMed", "id": "34880421", "url": "https://glygen.org/publication/PubMed/34880421" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12955", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12955" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.", "journal": "Nature chemical biology", "date": "2022-05", "authors": "Rao Sahana D, Chen Qifeng, Wang Qinghui, Orth-He Elizabeth L, Saoi Michelle, Griswold Andrew R, Bhattacharjee Abir, Ball Daniel P, Huang Hsin-Che, Chui Ashley J, Covelli Dominic J, You Shaochen, Cross Justin R, Bachovchin Daniel A", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "35165443", "url": "https://glygen.org/publication/PubMed/35165443" } ] }, { "title": "Prolidase as a marker of fibrogenesis in idiopathic primary ovarian insufficiency.", "journal": "European journal of obstetrics, gynecology, and reproductive biology", "date": "2022-12-10", "authors": "Erol Koc Esin Merve, Ceyhan Meryem, Yaman Selen, Neselioglu Salim, Erel Ozcan, Ozaksit Muzeyyen Gulnur", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" } ], "reference": [ { "type": "PubMed", "id": "36521400", "url": "https://glygen.org/publication/PubMed/36521400" } ] }, { "title": "The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia.", "journal": "European review for medical and pharmacological sciences", "date": "2022-12", "authors": "Ozturk A, Agbektas T, Tas A, Gul M A, Karadag A, Silig Y", "evidence": [ { "database": "RefSeq", "id": "NP_000276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276" } ], "reference": [ { "type": "PubMed", "id": "36591822", "url": "https://glygen.org/publication/PubMed/36591822" } ] }, { "title": "Four novel PEPD alleles causing prolidase deficiency.", "journal": "American journal of human genetics", "date": "1994", "authors": "Ledoux P, Scriver C, Hechtman P", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "8198124", "url": "https://glygen.org/publication/PubMed/8198124" } ] }, { "title": "Expression and molecular analysis of mutations in prolidase deficiency.", "journal": "American journal of human genetics", "date": "1996", "authors": "Ledoux P, Scriver CR, Hechtman P", "evidence": [ { "database": "UniProtKB", "id": "P12955", "url": "https://www.uniprot.org/uniprot/P12955" } ], "reference": [ { "type": "PubMed", "id": "8900231", "url": "https://glygen.org/publication/PubMed/8900231" } ] } ], "pathway": [ { "id": "hsa:5184", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5184", 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