{ "uniprot_canonical_ac": "P12882-1", "uniprot_ac": "P12882", "uniprot_id": "MYH1_HUMAN", "mass": { "chemical_mass": 223145.0, "monoisotopic_mass": 223145.0 }, "refseq": { "ac": "NP_005954", "name": "myosin-1", "summary": "Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" }, "gene_names": [ { "name": "MYH1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P12882", "id": "P12882" }, { "name": "HEL71; MYHa; MyHC-2x; MyHC-2X/D; MYHSA1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954", "id": "NP_005954" }, { "name": "MYH1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954", "id": "NP_005954" } ], "protein_names": [ { "name": "Myosin-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P12882" }, { "name": "MyHC-2x", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12882" }, { "name": "MyHC-IIx/d", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12882" }, { "name": "Myosin heavy chain 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12882" }, { "name": "Myosin heavy chain 2x", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12882" }, { "name": "Myosin heavy chain IIx/d", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12882" }, { "name": "Myosin heavy chain, skeletal muscle, adult 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12882" }, { "name": "myosin heavy chain IIx/d; myosin, heavy polypeptide 1, skeletal muscle, adult; myHC-IIx/d; myosin heavy chain 2x; myosin heavy chain, skeletal muscle, adult 1; epididymis luminal protein 71; myosin, heavy chain 1, skeletal muscle, adult", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954", "id": "NP_005954" }, { "name": "myosin-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954", "id": "NP_005954" } ], "function": [ { "annotation": "Adaptive response to reduced masticatory load was lower numerical and area proportion of MyHC-1 expressing fibres and higher numerical proportion of hybrid fibres in edentulous compared with dentate subjects", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" }, { "database": "PubMed", "id": "22489880", "url": "https://glygen.org/publication/PubMed/22489880" } ] }, { "annotation": "MYH1 is a candidate gene for recurrent rhabdomyolysis in humans.", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" }, { "database": "PubMed", "id": "33755318", "url": "https://glygen.org/publication/PubMed/33755318" } ] }, { "annotation": "Muscle contraction.", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882#function" } ] }, { "annotation": "Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" } ] }, { "annotation": "Myosin isoforms impact single-fiber force generation and may lead to alterations in whole skeletal muscle performance.", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" }, { "database": "PubMed", "id": "25567808", "url": "https://glygen.org/publication/PubMed/25567808" } ] }, { "annotation": "Transcriptional levels of MHC-I, MHC-IIa, and MHC-IIb in denervation groups were significantly down-regulated compared with controls", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" }, { "database": "PubMed", "id": "26059207", "url": "https://glygen.org/publication/PubMed/26059207" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1597438130", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1597438130" }, { "id": "rs1597438130", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1597438130" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1023, "end_pos": 1023, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TLT->NLT).", "chr_id": "17", "chr_pos": "10502781", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1023", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P12882", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P12882" } ], "glycoeffect": [], "start_pos": 1140, "end_pos": 1140, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "17", "chr_pos": "10501430", "ref_nt": "G", 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{ "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "69.34", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "29.94", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "42.84", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "55.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000109061", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000109061" } ] }, { "tissue": { "name": "Liver", 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"http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P12882", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P12882" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": 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"https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P12882" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P12882", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P12882" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant 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"length": 1939, "header": "sp|P12882-1|MYH1_HUMAN Isoform 1 of Myosin-1 OS=Homo sapiens OX=9606 GN=MYH1 PE=1 SV=3 CANONICAL=P12882-1" }, "isoforms": [ { "isoform_ac": "P12882-1", "url": "", "sequence": { "sequence": "MSSDSEMAIFGEAAPFLRKSERERIEAQNKPFDAKTSVFVVDPKESFVKATVQSREGGKVTAKTEAGATVTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEVTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIEILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLALLFVGATGAEAEAGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE", "length": 1939, "header": "sp|P12882-1|MYH1_HUMAN Isoform 1 of Myosin-1 OS=Homo sapiens OX=9606 GN=MYH1 PE=1 SV=3 CANONICAL=P12882-1" }, "locus": { "chromosome": "17", "start_pos": 10516642, "end_pos": 10492419, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000226207.6", "url": "https://www.ensembl.org/id/ENST00000226207.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000226207.5", "url": "https://www.ensembl.org/id/ENSP00000226207.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1832, "start_aa": "Ser", "end_pos": 1832, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1832", "evidence": [ { "id": "P12882", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12882" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 758, "start_aa": "Thr", "end_pos": 758, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr758", "evidence": [ { "id": "P12882", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12882" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "phosphorylation": [ { "start_pos": 1092, "end_pos": 1092, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1092" }, { "start_pos": 1096, "end_pos": 1096, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1096" }, { "start_pos": 1162, "end_pos": 1162, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1162" }, { "start_pos": 1237, "end_pos": 1237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" }, { "database": "iPTMnet", "id": "P12882", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12882" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser1237" }, { "start_pos": 1241, "end_pos": 1241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1241" }, { "start_pos": 1243, "end_pos": 1243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1243" }, { "start_pos": 1261, "end_pos": 1261, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1261" }, { "start_pos": 1265, "end_pos": 1265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1265" }, { "start_pos": 1286, "end_pos": 1286, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1286" }, { "start_pos": 1288, "end_pos": 1288, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1288" }, { "start_pos": 1292, "end_pos": 1292, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1292" }, { "start_pos": 1303, "end_pos": 1303, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1303" }, { "start_pos": 1306, "end_pos": 1306, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1306" }, { "start_pos": 1366, "end_pos": 1366, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P12882", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12882" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser1366" }, { "start_pos": 1467, "end_pos": 1467, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1467" }, { "start_pos": 1474, "end_pos": 1474, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1474" }, { "start_pos": 1492, "end_pos": 1492, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Tyr1492" }, { "start_pos": 1495, "end_pos": 1495, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1495" }, { "start_pos": 1501, "end_pos": 1501, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1501" }, { "start_pos": 1514, "end_pos": 1514, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1514" }, { "start_pos": 1517, "end_pos": 1517, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1517" }, { "start_pos": 1542, "end_pos": 1542, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1542" }, { "start_pos": 1554, "end_pos": 1554, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1554" }, { "start_pos": 1574, "end_pos": 1574, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1574" }, { "start_pos": 1600, "end_pos": 1600, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1600" }, { "start_pos": 1603, "end_pos": 1603, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1603" }, { "start_pos": 1714, "end_pos": 1714, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1714" }, { "start_pos": 1726, "end_pos": 1726, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1726" }, { "start_pos": 1730, "end_pos": 1730, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1730" }, { "start_pos": 1736, "end_pos": 1736, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr1736" }, { "start_pos": 1739, "end_pos": 1739, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Ser1739" }, { "start_pos": 389, "end_pos": 389, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Tyr389" }, { "start_pos": 419, "end_pos": 419, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr419" }, { "start_pos": 424, "end_pos": 424, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Tyr424" }, { "start_pos": 64, "end_pos": 64, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr64" }, { "start_pos": 69, "end_pos": 69, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "site_lbl": "Thr69" }, { "start_pos": 983, "end_pos": 983, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P12882", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12882" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr983" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.", "journal": "J. Mol. Biol.", "date": "1999", "authors": "Weiss A, Schiaffino S, Leinwand LA", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "reference": [ { "type": "PubMed", "id": "10388558", "url": "https://glygen.org/publication/PubMed/10388558" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.", "journal": "Nature", "date": "2008", "authors": "Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, Smith S, Hawkins A, Abbott S, Locke D, Hillier LW, Miner T, Fulton L, Magrini V, Wylie T, Glasscock J, Conyers J, Sander N, Shi X, Osborne JR, Minx P, Gordon D, Chinwalla A, Zhao Y, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson M, Baty J, Ivanovich J, Heath S, Shannon WD, Nagarajan R, Walter MJ, Link DC, Graubert TA, DiPersio JF, Wilson RK", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "reference": [ { "type": "PubMed", "id": "18987736", "url": "https://glygen.org/publication/PubMed/18987736" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "P12882", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12882" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.", "journal": "Nature", "date": "2011", "authors": "Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR, Futreal PA", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "reference": [ { "type": "PubMed", "id": "21248752", "url": "https://glygen.org/publication/PubMed/21248752" } ] }, { "title": "Wearing of complete dentures reduces slow fibre and enhances hybrid fibre fraction in masseter muscle.", "journal": "Journal of oral rehabilitation", "date": "2012", "authors": "Cvetko E, Karen P, Erzen I", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" } ], "reference": [ { "type": "PubMed", "id": "22489880", "url": "https://glygen.org/publication/PubMed/22489880" } ] }, { "title": "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.", "journal": "Nucleic Acids Res.", "date": "1986", "authors": "Saez L, Leinwand LA", "evidence": [ { "database": "UniProtKB", "id": "P12882", "url": "https://www.uniprot.org/uniprot/P12882" } ], "reference": [ { "type": "PubMed", "id": "2421254", "url": "https://glygen.org/publication/PubMed/2421254" } ] }, { "title": "Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.", "journal": "American journal of physiology. Cell physiology", "date": "2015", "authors": "Miller MS, Bedrin NG, Ades PA, Palmer BM, Toth MJ", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" } ], "reference": [ { "type": "PubMed", "id": "25567808", "url": "https://glygen.org/publication/PubMed/25567808" } ] }, { "title": "Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.", "journal": "European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery", "date": "2015", "authors": "Qiu X, Chen D, Li M, Gao Y, Liu F, Zheng H, Chen S", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" } ], "reference": [ { "type": "PubMed", "id": "26059207", "url": "https://glygen.org/publication/PubMed/26059207" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12882", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12882" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "MYH1 is a candidate gene for recurrent rhabdomyolysis in humans.", "journal": "American journal of medical genetics. Part A", "date": "2021", "authors": "Alsaif HS, Alshehri A, Sulaiman RA, Al-Hindi H, Guzman-Vega FJ, Arold ST, Alkuraya FS", "evidence": [ { "database": "RefSeq", "id": "NP_005954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005954" } ], "reference": [ { "type": "PubMed", "id": "33755318", "url": "https://glygen.org/publication/PubMed/33755318" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "P12882", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P12882" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "pathway": [ { "id": "hsa:4619", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4619", "resource": 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